Glycoside Hydrolase Family 5 / Subf 7

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (504); Uniprot accession (158); PDB accession (26); 3D entries (10); cryst (0)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 MICPUN_58085   Micromonas commoda sp. RCC299 ACO62742.1 C1E4L9   7
 MICPUN_83090 (fragment)   Micromonas commoda sp. RCC299 ACO64669.1 C1E9E6   7
 endo-β-1,4-mannosidase   Morus alba var. multicaulis AGG82699.1     7
 MA4_25J11.12   Musa acuminata ABF69949.1 Q1EPK8   7
 NCU08412.1   Neurospora crassa OR74A XP_329458.1
EAA34048.1
    7
 endo-β-1,4-mannanase (Man5) (partial)   Neurospora sitophila CCI55471.1   4AWE[A] 7
 β-mannanase (ManA) 3.2.1.78 Orpinomyces sp. PC-2 AAL01213.1 Q96V96   7
 OSNPB_100164700 (Os10g0164700) (fragment)   Oryza sativa Japonica Group BAT10030.1     7
 Os03g0828500   Oryza sativa Japonica Group AAL79758.1
ABF99676.1
BAF13691.1
BAS87176.1
Q10B67   7
 Os03g0828300   Oryza sativa Japonica Group AAL79761.1
BAF13690.1
BAS87175.1
A3APA9
Q0DM48
  7
 Os01g0663300   Oryza sativa Japonica Group BAB91747.1
BAF05699.1
BAS73552.1
A2ZW94
Q0JKM9
Q8LR27
  7
 Os02g0766900   Oryza sativa Japonica Group BAD17320.1
BAD17132.1
BAF10140.1
BAS81070.1
A3ABP6
Q6Z310
  7
 Os06g0311600   Oryza sativa Japonica Group BAD61770.1
BAF19398.1
BAS97441.1
Q0DCM5   7
 OSJNBb0006B22.2 or OSJNBb0059K16.9   Oryza sativa Japonica Group AAV44080.1
AAV44120.1
BAS93345.1
Q5W6G0   7
 Os11g0118200 (fragment)   Oryza sativa Japonica Group BAF27440.1
BAG97285.1
BAT12428.1
B7EY38
Q2RBB1
  7
 endo-β-1,4-mannanase 8 (OsMan8;Os12g0117300;LOC_Os12g02520)   Oryza sativa Japonica Group ABA95648.1
BAF29018.1
BAT15617.1
A3CED8
Q0IQJ7
Q2QYI9
  7
 Os01g0746700   Oryza sativa Japonica Group BAB56016.1
BAC05600.1
BAF06144.1
BAS74321.1
Q0JJD4   7
 OSTLU_4036 (fragment)   Ostreococcus lucimarinus CCE9901 ABO94548.1 A4RSG2   7
 OSTLU_3863 (fragment)   Ostreococcus lucimarinus CCE9901 ABO95765.1 A4RVU7   7
 OSTLU_42201 (fragment)   Ostreococcus lucimarinus CCE9901 ABP00730.1 A4SAC9   7
 Ot20g00120   Ostreococcus tauri OTTH0595 CAL56661.1 Q00S04   7
 Ot04g01830   Ostreococcus tauri OTTH0595 CAL51581.1 Q01B66   7
 Ot02g07200   Ostreococcus tauri OTTH0595 CAL52595.1 Q01DK8   7
 endo-β-mannanase (Ma;PoMan5A) (Man5A) 3.2.1.78 Penicillium oxalicum GZ-2 AGW24296.1     7
 Pc12g07900   Penicillium rubens Wisconsin 54-1255 CAP80417.1 B6GXM2   7
 Pc21g05470   Penicillium rubens Wisconsin 54-1255 CAP95444.1 B6HHJ3   7
 Pc21g14050   Penicillium rubens Wisconsin 54-1255 CAP96302.1 B6HNS9   7
 β-mannanase (Man5C6;Man5) 3.2.1.78 Penicillium sp. enrichment culture clone C6 / ACCC32495 AEV41143.1     7
 endo-β-1,4-mannanase (Man5F63) 3.2.1.78 Penicillium sp. F63 XC-2012 / CGMCC 1669 AFC38441.1     7
 ORF   Phakopsora pachyrhizi ALL40863.1     7
 β-mannanase 5D (Man5D) 3.2.1.78 Phanerochaete chrysosporium RP78 ABG79370.1 Q0PQY8   7
 β-mannanase 5C (Man5C)   Phanerochaete chrysosporium RP78 ABG79371.1 Q0PQY7   7
 endo-β-1,4-mannanase   Phaseolus vulgaris AHA84179.1     7
 endo-β-1,4-mannanase (Man5AP13) (Man5A) 3.2.1.78 Phialophora sp. CGMCC 3329 / P13 ADF28533.1 D5IF02   7
 unknown   Picea sitchensis ADE76368.1 D5A9Z9   7
 0_5745_01 (fragment)   Pinus radiata AEW07580.1     7
 UMN_3888_01 (fragment)   Pinus radiata AEW09318.1     7
 0_5745_01 (fragment)   Pinus taeda AFG66898.1
AFG66893.1
AFG66894.1
AFG66895.1
AFG66896.1
AFG66899.1
AFG66900.1
    7
 UMN_3888_01 (fragment)   Pinus taeda AFG68308.1
AFG68305.1
AFG68306.1
AFG68309.1
AFG68310.1
AFG68311.1
AFG68312.1
AFG68313.1
AFG68314.1
AFG68315.1
AFG68316.1
AFG68317.1
AFG68318.1
AFG68319.1
AFG68320.1
AFG68321.1
    7
 UMN_3888_01 (fragment)   Pinus taeda AFG68307.1     7
 0_5745_01 (short fragment)   Pinus taeda AFG66897.1     7
 0_4090_01 (fragment)   Pinus taeda AFG50042.1
AFG50043.1
AFG50044.1
AFG50045.1
AFG50046.1
AFG50047.1
AFG50048.1
AFG50049.1
    7
 Pa_3_10640   Podospora anserina S mat+ CAP61340.1
CDP27695.1
B2AD25   7
 endo-β-1,4-mannanase (PaMan5A;Pa_6_490) (Man5A) 3.2.1.78 Podospora anserina S mat+ CAP71606.1
ADO14134.1
CDP31001.1
B2B3C0 3ZIZ[A] 7
 endo-β-1,4-mannanase (Man6;PtrMan6) 3.2.1.78 Populus trichocarpa AFX59322.1
EEF05441.1
    7
 PtrMan4   Populus trichocarpa EEE92714.1     7
 unknown (WS0124_C10)   Populus trichocarpa ABK95661.1 A9PH08   7
 unknown (WS0126_F13)   Populus trichocarpa ABK95966.1 A9PHW3   7
 endo-1,4-β-mannosidase 2 (Man2)   Prunus persica ABV32548.1 B2BMQ0   7
 endo-1,4-β-mannosidase 1 (Man1)   Prunus persica ABV32547.1 B2BMP9   7
 mannanase   Prunus salicina ABY58035.1 B0FPH4   7
 β-mannanase (RmMan5B) (Man5B) 3.2.1.78 Rhizomucor miehei CAU432 AGV01048.1   4LYP[A,B]
4LYQ[A]
4LYR[A]
4NRR[A,B]
4NRS[A,B]
7
 β-mannanase (RmMan5A) (Man5A) 3.2.1.78 Rhizomucor miehei CAU432 / CGMCC 4967 AGC24277.1   4L3M[A]
4QP0[A]
7
 sscle_03g024710   Sclerotinia sclerotiorum 1980 UF-70 APA07701.1     7
 sscle_10g075470   Sclerotinia sclerotiorum 1980 UF-70 APA12777.1     7
 PIIN_05969   Serendipita indica DSM 11827 CCA72034.1     7
 PIIN_07208   Serendipita indica DSM 11827 CCA73253.1     7
 PIIN_07207 (fragment)   Serendipita indica DSM 11827 CCA73252.1     7
 PIIN_07895   Serendipita indica DSM 11827 CCA73942.1     7
 endo-β-1,4-mannanase (Man6) (fragment)   Sisymbrium officinale AFY10516.1     7
 endo-β-1,4-mannanase (Man7) (fragment)   Sisymbrium officinale AFY10517.1     7
 endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4;LeMan4;LeMAN4a;LeMAN4i;MTH) 3.2.1.78
2.4.1.-
Solanum lycopersicum AAK97760.1
AAK56557.1
AAK97759.2
Q8L5J1
Q8RVL3
Q93WT4
1RH9[A] 7
 β-mannanase (Man1;LeMAN1) 3.2.1.78 Solanum lycopersicum AAB87859.2 O48540   7
 endo-β-1,4-mannanase (Man3;LeMAN3)   Solanum lycopersicum AAG14352.1 Q9FUQ6   7
 endo-β-1,4-mannanase (Man5;LeMAN5) 3.2.1.78 Solanum lycopersicum AAM26920.1 Q6YM50   7
 endo-β-1,4-mannanase (Man2;LeMAN2) 3.2.1.78 Solanum lycopersicum AAG00315.2
AAG00315.1
Q9FZ03   7
 sr12670   Sporisorium reilianum SRZ2 CBQ71814.1     7
 SPSC_05227   Sporisorium scitamineum SscI8 CDR88623.1     7
 Man5B   Staphylotrichum coccosporum D AKT45098.1     7
 Man5A   Staphylotrichum coccosporum D AKT45097.1     7
 β-mannanase (Man5A) 3.2.1.78 Talaromyces leycettanus JCM12802 AJF11663.1     7
 β-mannanase (Man5C1) (acidic) 3.2.1.78 Talaromyces pinophilus C1 AEV40667.1     7
 β-mannanase 3.2.1.78 Talaromyces trachyspermus ATCC 24792 BAP19029.1   3WFL[A] 7
 MYCTH_74462   Thermothelomyces thermophila ATCC 42464 AEO60897.1     7
 mannanase (Man2;MYCTH_84297)   Thermothelomyces thermophila ATCC 42464 AEO62161.1     7
 β-mannanase (Man2;bMan2) 3.2.1.78 Thermothelomyces thermophila C1 AFJ59924.1     7
 β-mannanase (Man5;Man5XZ7) 3.2.1.78 Thielavia arenaria XZ7 AGG69667.1     7
 THITE_2114474   Thielavia terrestris NRRL 8126 AEO66394.1     7
 THITE_2124772   Thielavia terrestris NRRL 8126 AEO71901.1     7
 THITE_2117076   Thielavia terrestris NRRL 8126 AEO67907.1     7
 β-mannanase (ThMan5A) (Man5A) 3.2.1.78 Trichoderma harzianum MGQ2 AGH62580.1     7
 β-mannanase (Man1) 3.2.1.78 Trichoderma longibrachiatum DSM 63060 ADN93457.1 E2FZU3   7
 β-mannanase (TrMan5A) (Man5A) 3.2.1.78 Trichoderma reesei RUTC-30 AAA34208.1
ABJ41268.1
Q99036 1QNO[A]
1QNP[A]
1QNQ[A]
1QNR[A]
1QNS[A]
7
 endo-β-mannanase   Trichoderma virens UKM1 ALG64172.1     7
 endo-β-1,4-mannanase (Man5A)   Trichoderma viride WL 0422 AFP95336.1     7
 Sequence 108383 from patent US 7214786   Triticum aestivum ABT20913.1     7
 AAA17YJ10FL   uncultured eukaryote CCA94935.1     7
 endo-β-mannanase (Man1)   Vaccinium corymbosum ACN78666.1 C7A7Y0   7
 VIGAN_11175000 (Vigan.11g175000)   Vigna angularis var. angularis BAU02258.1     7
 VIGAN_09003000 (Vigan.09g003000)   Vigna angularis var. angularis BAT96746.1     7
 VIGAN_10160100 (Vigan.10g160100)   Vigna angularis var. angularis BAU00044.1     7
 VIGAN_06132000 (Vigan.06g132000)   Vigna angularis var. angularis BAT90136.1     7
 VIGAN_03283600 (Vigan.03g283600)   Vigna angularis var. angularis BAT82775.1     7
 VIGAN_02034400 (Vigan.02g034400)   Vigna angularis var. angularis BAT77749.1     7
 VIGAN_04376600 (Vigan.04g376600)   Vigna angularis var. angularis BAT86142.1     7
 VIGAN_03283800 (Vigan.03g283800) (fragment)   Vigna angularis var. angularis BAT82777.1     7
 VIGAN_04114500 (Vigan.04g114500)   Vigna angularis var. angularis BAT83903.1     7
 VIGAN_04380200 (Vigan.04g380200)   Vigna angularis var. angularis BAT86176.1     7
 VITISV_020441 (short fragment)   Vitis vinifera CAN62216.1 A5C9G4   7
 VITISV_015565 (short fragment)   Vitis vinifera CAN71607.1 A5AS93   7
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