Glycoside Hydrolase Family 5 / Subf 7

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (504); Uniprot accession (158); PDB accession (26); 3D entries (10); cryst (0)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 mannanase   Achaetomium sp. Xz-8 / Xz8 AHK22783.1     7
 endo-β-mannanase (Man1)   Actinidia arguta ACN78662.1 C7A7X6   7
 β-mannanase (Cel4A) 3.2.1.78 Agaricus bisporus C54-CARB8 CAB76904.1
ABJ41267.1
Q9P893   7
 β-mannanase (Cel4;Cel4b) 3.2.1.78 Agaricus bisporus D649 CAA90423.1 Q92401   7
 CEL4a mannanase (fragment)   Agaricus subrufescens WC837 AIU39657.1     7
 CEL4a mannanase (fragment)   Agaricus subrufescens WC837-S03 AIU39658.1     7
 Man5   Alternaria sp. DW1 AKT45095.1     7
 At3g10900 (AtMan4)   Arabidopsis thaliana AAF19559.1
AEE74968.1
NP_187701.1
Q9SG95   7
 At3g10890 (AtMan3)   Arabidopsis thaliana AAF19560.1
AEE74967.1
NP_187700.1
Q9SG94   7
 At4g28320 (AtMan5)   Arabidopsis thaliana CAB79634.1
ABG48480.1
AEE85469.1
BAF00634.1
NP_194561.1
Q9M0H6   7
 At5g01930 (AtMan6)   Arabidopsis thaliana AAO64766.1
AED90411.1
BAE99339.1
CAB82763.1
NP_195813.1
Q9LZV3   7
 At3g30540 (AtManP) (probable fragment)   Arabidopsis thaliana NP_189675.1
AEE77650.1
BAB01021.1
Q9LW44   7
 endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310) 3.2.1.78 Arabidopsis thaliana AAN72165.1
AAG00883.1
AAL91241.1
AEE27414.1
ANM59069.1
NP_171733.1
NP_171733.2
Q9FZ29   7
 β-mannanase 2 (AtMan2;AtMan5-2;At2g20680) 3.2.1.78 Arabidopsis thaliana AAP40422.1
AAD20927.1
ABG25077.1
AEC07056.1
BAF00487.1
NP_179660.2
Q7Y223
Q9SKU9
  7
 At5g66460 (AtMan7)   Arabidopsis thaliana BAB10922.1
AAN17429.1
AAP49511.1
AED98217.1
NP_201447.1
Q9FJZ3   7
 β-mannanase (PM;Man47;AtMAN47) 3.2.1.78 Armillariella tabescens EJLY2098 ABB88954.1 A1X5Y1   7
 EGX54367.1   Arthrobotrys oligospora ATCC 24927 EGX54367.1     7
 EGX49029.1   Arthrobotrys oligospora ATCC 24927 EGX49029.1     7
 EGX46850.1   Arthrobotrys oligospora ATCC 24927 EGX46850.1     7
 EGX45355.1   Arthrobotrys oligospora ATCC 24927 EGX45355.1     7
 β-mannanase (Man1) 3.2.1.78 Aspergillus aculeatus KSM 510 / MRC11624 AAA67426.1 Q00012   7
 β-mannanase (Man5P1;NFIA_113780) 3.2.1.78 Aspergillus fischeri NRRL 181 NRRL 181 / P1 XP_001262744.1     7
 endo-β-1,4-mannosidase (ManAF)   Aspergillus flavus UKM-1 ADZ75457.1     7
 endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030) 3.2.1.78 Aspergillus fumigatus Af293 EAL85463.1 Q4WBS1   7
 endo-β-1,4-mannanase (ManF;Man I;Man II) (partial) 3.2.1.78 Aspergillus fumigatus IMI 385708 ACH58410.1
ACH58411.1
B5LZ77
B5LZ78
Q4WBS1
  7
 AN2709.2 (frameshift)   Aspergillus nidulans FGSC A4 EAA63111.1 C8VKA9
Q5B9S1
  7
 AN7639.2   Aspergillus nidulans FGSC A4 EAA61825.1 Q5AVP1   7
 AN9276.2   Aspergillus nidulans FGSC A4 EAA66343.1 Q5AR04   7
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1
Q5B7X2   7
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1
Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1
Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) (partial) 3.2.1.78 Aspergillus nidulans XZ3 AGG69666.1     7
 β-mannanase, partial   Aspergillus niger AKC57288.1     7
 endo-β-1,4-mannanase   Aspergillus niger 128 ADK88903.1 D9ZKR5   7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.1     7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.2     7
 β-mannanase   Aspergillus niger BCC4525 AJZ68815.2     7
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1
    7
 AO090038000444 (ManD)   Aspergillus oryzae RIB40 BAE64232.1 Q2U2I3   7
 AO090010000122 (ManG)   Aspergillus oryzae RIB40 BAE66031.1 Q2TXJ2   7
 endo-β-1,4-mannanase (partial) 3.2.1.78 Aspergillus sp. T16 AHA38074.1     7
 β-mannanase (MANN) 3.2.1.78 Aspergillus sulphureus ABC59553.1 Q2LE69   7
 β-mannanase (AuMan5A) (Man5A) 3.2.1.78 Aspergillus usamii E001 / YL-01-78 ADZ99027.1     7
 ORF (fragment)   Auxenochlorella protothecoides 0710 AFX97746.1     7
 Bathy08g02370   Bathycoccus prasinos RCC1105 CCO17574.1     7
 Bathy18g00620 (fragment)   Bathycoccus prasinos RCC1105 CCO20705.1     7
 Bathy18g00630 (fragment)   Bathycoccus prasinos RCC1105 CCO20718.1     7
 Bathy14g01780   Bathycoccus prasinos RCC1105 CCO19655.1     7
 endo-β-1,4-mannanase (Man5) 3.2.1.78 Bispora antennata CBS 126.38 AFJ68087.1     7
 endo-β-1,4-mannanase 5A (Man5A) 3.2.1.78 Bispora sp. MEY-1 ACH56965.1 B5LXD7   7
 glycoside hydrolase family 5 protein (Bofut4_p061530.1)   Botrytis cinerea T4 CCD43943.1     7
 BofuT4P67000004001   Botrytis cinerea T4 CCD53723.2     7
 β-mannanase (CsMan5A) (Man5A) 3.2.1.78 Chaetomium sp. CQ31 ADW82104.1     7
 ManB (fragment)   Chlorella vulgaris C-169 BAA99563.1 Q9LRG5   7
 endo-β-1,4-mannanase (ManA;CaMANA) 3.2.1.78 Coffea arabica CAC08208.1
AAX01860.1
Q9FT02   7
 endo-β-1-4-mannanase (ManB;CaMANB) 3.2.1.78 Coffea arabica CAC08442.1 Q9FT03   7
 endo-β-mannanase (Man;CmMAN)   Cucumis melo subsp. melo ADN34185.1 E5GCI6   7
 endo-β-mannanase (Man;DfMAN) (fragment)   Datura ferox AAO06964.1 Q8GTA2   7
 endo-β-mannanase (DcMan1) 3.2.1.78 Daucus carota AAN34823.1 Q8H6B4   7
 mannosidase 1, partial   Diospyros kaki AOR05814.1     7
 Man1 (fragment)   Eucalyptus globulus subsp. globulus ABD47729.1 Q27U85   7
 Man2 (fragment)   Eucalyptus globulus subsp. globulus ABD47730.1
BAM05595.1
Q27U84   7
 Man3 (fragment)   Eucalyptus globulus subsp. globulus ABD47731.1 Q27U83   7
 (1-4)-β-mannan endohydrolase (Man2) (fragment)   Eucalyptus pilularis BAM05593.1     7
 (1-4)-β-mannan endohydrolase (Man2) (fragment)   Eucalyptus pyrocarpa BAM05594.1     7
 unnamed protein product   Eutrema halophilum BAJ34043.1 E4MWR0   7
 Th18   Eutrema halophilum ABB45852.1 Q0ZR47   7
 FFUJ_03705   Fusarium fujikuroi IMI 58289 CCT65024.1     7
 unnamed protein product   Fusarium graminearum PH-1 CEF88482.1     7
 unnamed protein product   Fusarium graminearum PH-1 CEF79732.1     7
 β-mannanase (GLOTRDRAFT_110405) (Man5A) 3.2.1.78 Gloeophyllum trabeum ATCC 11539 / CBS900.73 EPQ57046.1     7
 JCVI-FLGm-24C18   Glycine max ACU17987.1 C6T835   7
 JCVI-FLGm-24P8   Glycine max ACU18982.1 C6TAY0   7
 JCVI-FLGm-19N17   Glycine max ACU19893.1 C6TDJ1   7
 endo-β-1,4-mannanase (GmMan1) 3.2.1.78 Glycine max ABG88068.1 Q0PKY2   7
 NIASHv2104N09 (fragment)   Hordeum vulgare subsp. vulgare BAK01294.1     7
 endo-β-1,4-mannanase (Man1;HvMAN1) 3.2.1.78 Hordeum vulgare subsp. vulgare BAK05001.1
ABC87082.1
Q2I011   7
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 Humicola insolens Y1 ADZ99301.1     7
 Man5A   Irpex lacteus AGV52632.1     7
 Man5B (short fragment)   Irpex lacteus AGV52633.1     7
 endo-β-1,4-mannanase (Man1) 3.2.1.78 Lactuca sativa CAC51690.3 Q93X40   7
 Man7 / LesaMAN7 (fragment)   Lepidium sativum AED01931.1     7
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX93149.1 E4ZPC4   7
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX96078.1 E4ZWV2   7
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBY01903.1 E5AFB4   7
 β-mannosidase   Lichtheimia corymbifera CGMCC 4974 AMB61311.1     7
 LRAMOSA05721   Lichtheimia ramosa CDS13545.1     7
 LRAMOSA04528   Lichtheimia ramosa CDS12333.1     7
 LRAMOSA09878   Lichtheimia ramosa CDS08517.1     7
 unknown   Lotus japonicus AFK43830.1     7
 unknown   Lotus japonicus AFK46805.1     7
 unknown (fragment)   Lotus japonicus AFK34066.1     7
 MG05844.4   Magnaporthe oryzae 70-15 XP_369620.1     7
 MG09342.4 (fragment)   Magnaporthe oryzae 70-15 XP_364584.1 G4NI55   7
 endo-β-mannanase (Man2;MdMAN2)   Malus domestica ACN78664.1 C7A7X8   7
 endo-β-mannanase (Man3;MdMAN3)   Malus domestica ACN78665.1 C7A7X9   7
 endo-β-mannanase (Man1;MdMAN1)   Malus domestica ACN78663.1 C7A7X7   7
 MtrDRAFT_AC137669g17v2   Medicago truncatula ABO79647.1     7
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