Activities in Family	Chondroitinase / chondroitin hydrolase (EC 3.2.1.-); Hyaluronidase / hyaluronoglucosaminidase (EC 3.2.1.35);
Mechanism	Retaining e
3D Structure Status	( β / α ) 7 barrel
Catalytic Nucleophile/Base	carbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (536); Uniprot accession (63); PDB accession (6); 3D entries (3); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
PH-20 (fragment)		Saimiri sciureus	ABD94487.1
hyaluronidase-2 (Hyal2)		Salmo salar	ACI32917.1
hyaluronidase-2 (Hyal2)		Salmo salar	ACI33835.1
hyaluronidase-2 (Hyal2)		Salmo salar	ACI33947.1 ACN10738.1
SMAX5B_011659		Scophthalmus maximus	AWP07919.1
SMAX5B_011659		Scophthalmus maximus	AWP07919.1
SMAX5B_011659		Scophthalmus maximus	AWP07919.1
SMAX5B_002348		Scophthalmus maximus	AWP02649.1
SMAX5B_002348		Scophthalmus maximus	AWP02649.1
SMAX5B_002219		Scophthalmus maximus	AWP02765.1
SMAX5B_007737		Scophthalmus maximus	AWO98026.1
SMAX5B_002682		Scophthalmus maximus	AWP09387.1
SMAX5B_002618		Scophthalmus maximus	AWP09369.1
PH-20		Semnopithecus entellus	ACV60223.1
PH-20 (fragment)		Semnopithecus entellus	ABD94491.1
salivary hyaluronidase, partial (fragment)		Sergentomyia schwetzi	QHO60719.1
salivary hyaluronidase, partial (fragment)		Sergentomyia schwetzi	QHO60720.1
salivary hyaluronidase		Sergentomyia schwetzi	QHO60718.1
salivary hyaluronidase		Simulium guianense	AEB96520.1
Hyal1 (fragment)		Sousa chinensis	ADZ57823.1
SPEXI_ LOCUS 6935		Spodoptera exigua	CAH0697278.1
SPLIT_ LOCUS 7052		Spodoptera littoralis	CAH1641696.1
Hyal1 (fragment)		Stenella attenuata	ADZ57820.1
Hyal1 (fragment)		Stenella coeruleoalba	ADZ57822.1
SRAE_2000096800		Strongyloides ratti ED321 Heterogonic	CEF66298.1
SRAE_X000016600		Strongyloides ratti ED321 Heterogonic	CEF70836.1
SRAE_2000275100		Strongyloides ratti ED321 Heterogonic	CEF68093.1
SRAE_X000016700		Strongyloides ratti ED321 Heterogonic	CEF70837.1
SRAE_X000016500 (fragment)		Strongyloides ratti ED321 Heterogonic	CEF70835.1
sperm adhesion molecule 1 (SPAM-1)		Sus scrofa	CAC83973.2
hyaluronoglucosaminidase 3		Sus scrofa	AAR91601.1 AAR33037.1
hyaluronoglucosaminidase 1		Sus scrofa	AAR91599.1 ACH56985.1 ACH56986.1
hyaluronidase 2 (Hyal2)		Sus scrofa	AAR91600.1 ACH56987.1
Hyal1 (fragment)		Sus scrofa	AEB78447.1
hyaluronidase PH-20, partial		Symphalangus syndactylus	AEH95769.1
hyaluronidase (HYA1;SfHya1)	3.2.1.35	Synanceia horrida	AAO74499.1	Q801Z8
hyaluronidase (Hya1;SvHya1;Sv-Hya)		Synanceia verrucosa	BAJ54082.1
hyaluronidase TY / allergen (Tab y 2)		Tabanus yao	ADM18346.1
TDIB3V08_LOCUS196		Timema douglasi	CAD7193756.1
TSIB3V08_LOCUS1818 (fragment)		Timema shepardi	CAD7257560.1
ORF		Tityus cisandinus	WDU65909.1
ORF		Tityus melici	WLF82748.1 WLF82749.1 WLF82750.1 WLF82751.1 WLF82752.1 WLF82753.1
ORF		Tityus serrulatus	QPD99039.2 QPD99039.1
ORF		Tityus serrulatus	QPD99040.2 QPD99040.1
hyaluronidase 2 (Hyal-2;TsHyal-2)	3.2.1.35	Tityus serrulatus	AHF72516.1	W0HFN9
hyaluronidase 1 (Hya; Hyal-1; TsHyal-1)	3.2.1.35	Tityus serrulatus	AHF72517.1	P85841
Hyal1 (fragment)		Tursiops aduncus	ADZ57821.1
Hyal1 (fragment)		Tursiops truncatus	AEB78444.1
PH-20 (fragment)		Varecia variegata	ABD94484.1
hyaluronidase (Vesp ma 2)	3.2.1.35	Vespa magnifica	CBY83816.1	P86875
hyaluronidase type B (HAase b; VesT2b)		Vespa tropica	UYX46121.1
hyaluronidase (Ves g 2a)		Vespula germanica	CAL59818.1
Ves g 2b (fragment)		Vespula germanica	CAL59819.1
hyaluronidase b (Hya_B;Ves v 2b)		Vespula vulgaris	AAX14718.1 CAI77218.1
hyaluronidase (Ves v 2 allergen)	3.2.1.35	Vespula vulgaris	AAB48073.1 AAR78244.1 ABH87700.1	P49370	2ATM[A]
hyaluronidase		Vipera anatolica senliki	QHR82765.1
fPH-20 protein		Vulpes vulpes	AAB86588.1
hyaluronidase XKH1	3.2.1.35	Xenopus laevis	AAL67683.1 AAI69767.1 AAI69795.1	B7ZQD4 Q8UVT7
lysosomal hyaluronidase (Hyal2)	3.2.1.35	Xenopus laevis	AAL55823.1	Q8UVY6
ORF		Xenopus laevis	AAH47252.1
hyaluronidase (embryonic) XEH1	3.2.1.35	Xenopus laevis	AAD28281.1	Q9W6K5
Unknown (protein for MGC:121214)		Xenopus tropicalis	AAI35205.1
Unknown (protein for MGC:184955)		Xenopus tropicalis	AAI58240.1
XNOV1_A013835		Xyrichtys novacula	CAJ1056044.1
XNOV1_A023686		Xyrichtys novacula	CAJ1056045.1
XNOV1_A010219		Xyrichtys novacula	CAJ1056046.1
XNOV1_A041606		Xyrichtys novacula	CAJ1055492.1
XNOV1_A032864		Xyrichtys novacula	CAJ1055469.1
XNOV1_A010277		Xyrichtys novacula	CAJ1056047.1
XNOV1_A006631		Xyrichtys novacula	CAJ1050702.1
XNOV1_A021649		Xyrichtys novacula	CAJ1054934.1
XNOV1_A017468		Xyrichtys novacula	CAJ1050570.1
XNOV1_A037184		Xyrichtys novacula	CAJ1050569.1
XNOV1_A037184		Xyrichtys novacula	CAJ1050569.1
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