Glycoside Hydrolase Family 56

Activities in Familyhyaluronidase (EC 3.2.1.35); chondroitin hydrolase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesPRINTS;
Statistics GenBank accession (377); Uniprot accession (143); PDB accession (6); 3D entries (3); cryst (0)
All (216) Eukaryota (214) Viruses (2) Structure (3) Characterized (34)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 hyaluronidase   Ampulex compressa ARK19841.1    
 venom hyaluronidase, partial (fragment)   Androctonus bicolor AIX87602.1    
 hyaluronidase (HyaL)   Anoplius samariensis BAF93867.1 A9EDG0  
 hyaluronidase 2   Apis cerana cerana AAK51798.2 Q95PD7  
 hyaluronidase (HYA;Api m 2;Apim2;LOC406146) 3.2.1.35 Apis mellifera AAA27730.1
AAB45920.1
AAR78242.1
ABH87698.1
NP_001011619.1
Q08169 1FCQ[A]
1FCU[A]
1FCV[A]
2J88[A]
 hyaluronidase   Apis mellifera carnica AFI40555.1    
 ORF   Ascaris suum ADY46439.1    
 Hyal1 (fragment)   Balaenoptera acutorostrata AEB78445.1    
 Hyal1 (fragment)   Balaenoptera omurai ADZ57824.1    
 LolHyaz (fragment)   Bichromomyia olmeca ANW11472.1    
 hyaluronidase (partial)   Bitis arietans ABI33944.1
ABI33945.1
ABI33946.1
ABI33947.1
ABI33948.1
A3QVN9  
 Hyal2   Bos taurus AAL78385.1
AAI02043.1
AAX46601.1
AAX46657.1
ABG66994.1
NP_776772.1
Q8SQG8  
 hyaluronidase (Spam1;PH-20;p80;bovHyal) 3.2.1.35 Bos taurus AAI10184.1
AAP55713.1
AAV41022.1
Q2YDK3
Q7YS45
 
 HYAL1 (fragment)   Bos taurus AAX08792.1 Q5E985  
 HYAL1   Bos taurus AAX09052.1
AAI02474.1
Q5E985  
 hyaluronidase (Hyase;BpHyase) (fragment)   Bothrops neuwiedi pauloensis ACN58137.1 C0L2W4  
 hyaluronidase (Hyal;BvHyal) (partial) 3.2.1.35 Brachypelma vagans AFS33217.1    
 hyaluronidase PH-20, partial (fragment)   Bubalus bubalis bubalis ANC49763.1    
 hyaluronidase PH-20, partial (fragment)   Bubalus bubalis bubalis ANC49764.1    
 hyaluronidase / chondroitinase (Hyα-1;T22C8.2) 3.2.1.-
3.2.1.35
Caenorhabditis elegans Bristol N2 CAA88874.1
BAG48551.1
NP_495830.1
G5ECE8
Q22675
 
 PH-20   Callimico goeldii ACV60225.1    
 PH-20 (fragment)   Callimico goeldii ABD94489.1 A4K509  
 HYAL3-like protein (fragment)   Callithrix jacchus ABQ22669.1 A6MKS8  
 ORF   Callorhinchus milii AFO99844.1    
 ORF   Callorhinchus milii AFO97416.1    
 ORF   Callorhinchus milii AFP02624.1    
 Hyal1 (fragment)   Camelus bactrianus AEB78448.1    
 sperm membrane protein (PH-20) (fragment)   Capra hircus ABI31753.1 Q0GIJ1  
 hyaluronidase PH-20 3.2.1.35 Cavia porcellus CAA39768.1
AAB45922.1
P23613  
 hyaluronidase   Cerastes cerastes ABI33938.1
ABI33939.1
ABI33940.1
A3QVN3  
 Hyal1 (fragment)   Ceratotherium simum AEB78449.1    
 PH-20   Cercopithecus mitis ACV60221.1    
 PH-20 (fragment)   Cercopithecus mitis ABD94493.1 A4K513  
 venom protein (A4YE08CM1) (fragment)   Chelonus inanitus CBN72517.1 E3PQY1  
 venom protein (A3YM10CM1) (fragment)   Chelonus inanitus CBN72518.1 E3PQY2  
 venom protein (A2YM17CM2) (fragment)   Chelonus inanitus CBN72519.1 E3PQY3  
 venom protein (A1YB14CM3) (fragment)   Chelonus inanitus CBN72520.1 E3PQY4  
 posterior head protein 20, partial (Ph-20)   Chlorocebus aethiops AEX20366.1    
 posterior head protein 20, partial (Ph-20)   Colobus guereza AEX20365.1    
 Conohyal-Ad1 (fragment)   Conus adamsonii AFH78529.1 I0CME8  
 hyaluronidase (Conohyal-Cn1) 3.2.1.35 Conus consors IV AFH78528.1 I0CME7  
 ORF (fragment)   Coptotermes formosanus AGM32945.1    
 hyaluronidase (fragment)   Crotalus adamanteus AEJ31976.1    
 hyaluronidase 1   Crotalus adamanteus AFJ49188.1 J3S820  
 ORF (fragment)   Crotalus adamanteus AFJ49189.1    
 hyaluronidase (Hya1;CdtHya1) (peptide fragment) 3.2.1.35 Crotalus durissus terrificus B3EWP2.1    
 ORF (probable fragment)   Culex quinquefasciatus VERO BEACH AAR18444.1 Q6TRZ3  
 hyaluronidase   Culicoides nubeculosus ACM40915.1 B9URL8  
 hyaluronidase / allergen (Cul n 2)   Culicoides nubeculosus ADJ67266.1 D9IL12  
 hyaluronidase / allergen (Cul o 2)   Culicoides obsoletus AGI16775.1    
 hyaluronidase (Hgs1;CsHGS1) (fragment)   Culicoides sonorensis AAU06477.1 Q66UD2  
 hyaluronidase / endo-β-N-acetyl-hexosaminidase (CsHyal) 3.2.1.35 Cupiennius salei CUH74573.1    
 Unknown (protein for MGC:136804)   Danio rerio AAI14278.1 Q29RC1  
 DKEY-42I9.14-001 (Hyal2)   Danio rerio CAK11026.1 Q1LXC3  
 DKEY-72L14.3-001   Danio rerio CAK11158.1 Q1LVE3  
 Unknown (protein for MGC:158626)   Danio rerio AAI29331.1 A1L235  
 Unknown (protein for MGC:158668)   Danio rerio AAI29368.1
AAI52242.1
A1L264  
 DKEY-20D21.13-001   Danio rerio CAP19590.1 A9C3S9  
 Hyal1 (fragment)   Delphinapterus leucas ADZ57829.1    
 Hyal1 (fragment)   Delphinus capensis ADZ57818.1    
 hyaluronidase (Dol m 2) 3.2.1.35 Dolichovespula maculata AAA68279.1
AAR78243.1
ABH87699.1
CAJ98548.1
P49371  
 hyaluronidase (fragment)   Echis carinatus sochureki ABI33949.1 A3QVP4  
 hyaluronidase (fragment)   Echis carinatus sochureki ABI33950.1 A3QVP5  
 hyaluronidase (fragment)   Echis ocellatus ABI33937.1 A3QVN2  
 hyaluronidase (fragment)   Echis pyramidum leakeyi ABI33941.1 A3QVN6  
 hyaluronidase (fragment)   Echis pyramidum leakeyi ABI33942.1
ABI33943.1
A3QVN7  
 Hyal1 (fragment)   Elaphurus davidianus ADZ57827.1    
 hyaluronoglucosaminidase 1 (Has1)   Eospalax fontanierii baileyi ANJ16065.1    
 sperm adhesion molecule 1 (Spam1) (fragment)   Equus caballus AET34452.1    
 hyaluronoglucosaminidase 1, partial (Hyal1) (fragment)   Erinaceus europaeus AEA40788.1    
 PH-20   Erythrocebus patas ACV60222.1    
 PH-20 (fragment)   Erythrocebus patas ABD94492.1 A4K512  
 v-hyaluronidase-Lio1 (fragment)   Erythrolamprus poecilogyrus ABU68570.1 A7XQ50  
 venom hyaluronidase (Hya1)   Eumenes pomiformis ACZ37402.1 D1MEJ6  
 hyaluronidase-Ginf1 (fragment)   Gerrhonotus infernalis ADK39240.1 E2E4F9  
 hyaluronoglucosaminidase   Gloydius intermedius ALB06111.1    
 GFP_L7_0750 (possible fragment)   Glyptapanteles flavicoxis ACE75133.1 B7S8A9  
 GFP_L7_0760 (possible fragment)   Glyptapanteles flavicoxis ACE75134.1 B7S8B0  
 GFP_L7_0770 (fragment)   Glyptapanteles flavicoxis ACE75135.1 B7S8B1  
 GIP_L1_00710   Glyptapanteles indiensis ABK57057.1 A0JCZ2  
 posterior head protein 20, partial (Ph-20)   Gorilla gorilla AEX20363.1    
 Hyal1 (fragment)   Grampus griseus ADZ57819.1    
 hyaluronidase toxin (fragment)   Heloderma suspectum cinctum ACE95063.1 C6EVG3  
 venom toxin   Hemiscorpius lepturus API81375.1    
 Hyal1 (fragment)   Hippopotamus amphibius AEB78446.1    
 hyaluronidase (PH-20;SPAM1;HYAL3;PH20;HuPH20) (sperm) 3.2.1.35 Homo sapiens AAH26163.1
AAC16482.1
AAC60607.2
AAQ96882.1
AAX13985.1
AAX13986.1
AAX13987.1
AAX13988.1
AAY03322.1
ABJ38775.1
ACJ13740.1
ACM84481.1
BAF84918.1
CAA59086.1
NP_003108.2
NP_694859.1
P38567
Q5D1J4
Q8TC30
 
 chondroitin sulfate hydrolase / hyaluronidase 3 (HYAL3;LUCA-3;LUCA14.2) 3.2.1.-
3.2.1.35
Homo sapiens AAC70915.1
AAC02729.1
AAD04257.1
AAH05896.1
AAH12892.1
AAM60775.1
AAM60776.1
AAM60777.1
AAM60778.1
ABA67787.1
BAG36242.1
NP_003540.2
O43820
O60540
Q8NFK2
Q8NFK3
Q8NFK4
Q96E56
Q9BRW9
 
 chondroitin sulfate hydrolase / hyaluronidase 1 (HYAL1;Hyal-1;LUCA1;LUCA-1) 3.2.1.-
3.2.1.35
Homo sapiens AAD09137.2
AAB67046.1
AAC02730.1
AAD04190.1
AAD53277.1
AAE60457.1
AAE60459.1
AAH25774.1
AAH35695.1
AAM60770.1
AAM60771.1
AAM60772.1
AAM60773.1
AAM60774.1
ABJ38770.1
ABJ38772.1
ACK03148.1
ALQ33600.1
ALQ33601.1
BAF83505.1
BAG53447.1
CAC60225.1
CAG46731.1
NP_009296.1
NP_149349.2
NP_695013.1
NP_695014.1
NP_695015.1
NP_695016.1
NP_695017.1
NP_695018.1
Q12794
Q6FH23
2PE4[A]
 chondroitin sulfate hydrolase / hyaluronidase 2 (Hyal2;LUCA2;LUCA-2) 3.2.1.-
3.2.1.35
Homo sapiens AAH00692.1
AAB67045.1
AAC28656.1
AAC62823.1
ABA82488.1
ACK03149.1
BAG52554.1
BAG54602.1
CAA03924.1
NP_003764.3
NP_149348.2
B3KRZ2
Q12891
 
 chondroitin sulfate hydrolase / hyaluronoglucosaminidase 4 / hyaluronidase 4 (Hyal4;HYAL4;HYAL-4) 3.2.1.- Homo sapiens AAC98883.1
AAD43186.1
AAI04789.1
AAI04791.1
ACM81328.1
ACM82678.1
ACV97636.1
BAI49593.1
NP_036401.1
D0VXG1
Q2M3T9
Q9UL99
 
 ENSP00000194108 (fragment)   Homo sapiens XP_069745.1
XP_069745.2
   
 ORF (fragment)   Hottentotta judaicus ADY39497.1    
 PH-20   Hylobates lar ACV60218.1    
 PH-20 (fragment)   Hylobates lar ABD94497.1 A4K517  
 ORF (Hyal2)   Ictalurus punctatus AHH39098.1    
 ORF (Hyal1)   Ictalurus punctatus AHH42852.1    
 Hyal1 (fragment)   Kogia sima ADZ57825.1    
 PH-20 (fragment)   Lemur catta ABD94483.1 A4K503  
 Hyal1 (fragment)   Lipotes vexillifer ADZ57817.1    
 PH-20   Lophocebus aterrimus ACV60228.1    
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