Glycoside Hydrolase Family 56

Activities in Familyhyaluronidase (EC 3.2.1.35); chondroitin hydrolase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesPRINTS;
Statistics GenBank accession (377); Uniprot accession (143); PDB accession (6); 3D entries (3); cryst (0)
All (216) Eukaryota (214) Viruses (2) Structure (3) Characterized (34)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 hyaluronidase (HYA;Api m 2;Apim2;LOC406146) 3.2.1.35 Apis mellifera AAA27730.1
AAB45920.1
AAR78242.1
ABH87698.1
NP_001011619.1
Q08169 1FCQ[A]
1FCU[A]
1FCV[A]
2J88[A]
 hyaluronidase (Spam1;PH-20;p80;bovHyal) 3.2.1.35 Bos taurus AAI10184.1
AAP55713.1
AAV41022.1
Q2YDK3
Q7YS45
 
 hyaluronidase (Hyal;BvHyal) (partial) 3.2.1.35 Brachypelma vagans AFS33217.1    
 hyaluronidase / chondroitinase (Hyα-1;T22C8.2) 3.2.1.-
3.2.1.35
Caenorhabditis elegans Bristol N2 CAA88874.1
BAG48551.1
NP_495830.1
G5ECE8
Q22675
 
 hyaluronidase PH-20 3.2.1.35 Cavia porcellus CAA39768.1
AAB45922.1
P23613  
 hyaluronidase (Conohyal-Cn1) 3.2.1.35 Conus consors IV AFH78528.1 I0CME7  
 hyaluronidase (Hya1;CdtHya1) (peptide fragment) 3.2.1.35 Crotalus durissus terrificus B3EWP2.1    
 hyaluronidase / endo-β-N-acetyl-hexosaminidase (CsHyal) 3.2.1.35 Cupiennius salei CUH74573.1    
 hyaluronidase (Dol m 2) 3.2.1.35 Dolichovespula maculata AAA68279.1
AAR78243.1
ABH87699.1
CAJ98548.1
P49371  
 hyaluronidase (PH-20;SPAM1;HYAL3;PH20;HuPH20) (sperm) 3.2.1.35 Homo sapiens AAH26163.1
AAC16482.1
AAC60607.2
AAQ96882.1
AAX13985.1
AAX13986.1
AAX13987.1
AAX13988.1
AAY03322.1
ABJ38775.1
ACJ13740.1
ACM84481.1
BAF84918.1
CAA59086.1
NP_003108.2
NP_694859.1
P38567
Q5D1J4
Q8TC30
 
 chondroitin sulfate hydrolase / hyaluronidase 3 (HYAL3;LUCA-3;LUCA14.2) 3.2.1.-
3.2.1.35
Homo sapiens AAC70915.1
AAC02729.1
AAD04257.1
AAH05896.1
AAH12892.1
AAM60775.1
AAM60776.1
AAM60777.1
AAM60778.1
ABA67787.1
BAG36242.1
NP_003540.2
O43820
O60540
Q8NFK2
Q8NFK3
Q8NFK4
Q96E56
Q9BRW9
 
 chondroitin sulfate hydrolase / hyaluronidase 1 (HYAL1;Hyal-1;LUCA1;LUCA-1) 3.2.1.-
3.2.1.35
Homo sapiens AAD09137.2
AAB67046.1
AAC02730.1
AAD04190.1
AAD53277.1
AAE60457.1
AAE60459.1
AAH25774.1
AAH35695.1
AAM60770.1
AAM60771.1
AAM60772.1
AAM60773.1
AAM60774.1
ABJ38770.1
ABJ38772.1
ACK03148.1
ALQ33600.1
ALQ33601.1
BAF83505.1
BAG53447.1
CAC60225.1
CAG46731.1
NP_009296.1
NP_149349.2
NP_695013.1
NP_695014.1
NP_695015.1
NP_695016.1
NP_695017.1
NP_695018.1
Q12794
Q6FH23
2PE4[A]
 chondroitin sulfate hydrolase / hyaluronidase 2 (Hyal2;LUCA2;LUCA-2) 3.2.1.-
3.2.1.35
Homo sapiens AAH00692.1
AAB67045.1
AAC28656.1
AAC62823.1
ABA82488.1
ACK03149.1
BAG52554.1
BAG54602.1
CAA03924.1
NP_003764.3
NP_149348.2
B3KRZ2
Q12891
 
 chondroitin sulfate hydrolase / hyaluronoglucosaminidase 4 / hyaluronidase 4 (Hyal4;HYAL4;HYAL-4) 3.2.1.- Homo sapiens AAC98883.1
AAD43186.1
AAI04789.1
AAI04791.1
ACM81328.1
ACM82678.1
ACV97636.1
BAI49593.1
NP_036401.1
D0VXG1
Q2M3T9
Q9UL99
 
 hyaluronidase 3.2.1.35 Loxosceles intermedia AGH25912.1 R4J7Z9  
 hyaluronidase 3.2.1.35 Macaca fascicularis ABD94494.1
BAE01371.1
P38568  
 hyaluronidase (Hya1;BmHYA1) (partial) 3.2.1.35 Mesobuthus martensii ACY69673.1
AHA36327.1
D1MBU1
P86100
 
 hyaluronidase (Spam1;PH-20;Spam) 3.2.1.35 Mus musculus AAA76603.1
AAP49832.1
AAX13989.1
AAX13990.1
BAB24161.1
BAC55070.1
NP_033267.1
P48794
Q5D1J0
 
 hyaluronoglucosaminidase 1 (Hyal1;Hyal-1) 3.2.1.35 Mus musculus AAC15949.1
AAH21636.1
AAL17822.1
BAC26206.1
CAP19319.1
CAP19320.1
CAP19321.1
CAP19322.1
NP_032343.2
O70229
Q8CE62
Q8VDK0
Q91ZJ9
 
 hyaluronidase 2 (Hyal2;Hyal-2) 3.2.1.35 Mus musculus AAK28482.1
AAH60047.1
AAK28481.1
AAL17823.1
AAO49503.1
BAC39851.1
BAC40583.1
BAE21913.1
CAA03888.1
CAA03889.1
NP_034619.1
O35632
Q3UZE4
Q8C309
 
 chondroitin sulfate hydrolase (Hyal4;mHYAL4) 3.2.1.- Mus musculus C57BL/6J BAB29454.1
AAI25403.1
AAI32097.1
BAM45641.1
Q05A56
Q9D660
 
 hyaluronidase (Hyal1;Spam1;PH20) 3.2.1.35 Oryctolagus cuniculus AAA88913.1 P38566  
 hyaluronidase (Pol a 2) 3.2.1.35 Polistes annularis AAD52616.1
AAR78239.1
ABH87695.1
Q9U6V9  
 hyaluronidase 3.2.1.35 Pterois antennata BAM66299.1    
 hyaluronidase 3.2.1.35 Pterois volitans BAM66300.1    
 hyaluronidase 2 (Hyal2) 3.2.1.35 Rattus norvegicus AAD01980.1
AAH62410.1
AAO49504.1
NP_742037.1
Q80ZC7
Q9Z2Q3
 
 hyaluronidase (HYA1;SfHya1) 3.2.1.35 Synanceia horrida AAO74499.1 Q801Z8  
 hyaluronidase 2 (Hyal-2;TsHyal-2) 3.2.1.35 Tityus serrulatus AHF72516.1 W0HFN9  
 hyaluronidase 1 (Hya;Hyal-1;TsHyal-1) (partial) 3.2.1.35 Tityus serrulatus AHF72517.1 P85841  
 hyaluronidase (Vesp ma 2) 3.2.1.35 Vespa magnifica CBY83816.1 P86875  
 hyaluronidase (Ves v 2 allergen) 3.2.1.35 Vespula vulgaris AAB48073.1
AAR78244.1
ABH87700.1
P49370 2ATM[A]
 hyaluronidase XKH1 3.2.1.35 Xenopus laevis AAL67683.1
AAI69767.1
AAI69795.1
Q8UVT7  
 lysosomal hyaluronidase (Hyal2) 3.2.1.35 Xenopus laevis AAL55823.1 Q8UVY6  
 hyaluronidase (embryonic) XEH1 3.2.1.35 Xenopus laevis AAD28281.1 Q9W6K5  
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