Glycoside Hydrolase Family 56

Activities in Familyhyaluronidase (EC 3.2.1.35); chondroitin hydrolase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesPRINTS;
Statistics GenBank accession (377); Uniprot accession (143); PDB accession (6); 3D entries (3); cryst (0)
All (216) Eukaryota (214) Viruses (2) Structure (3) Characterized (34)
| 1 | 2 | 3 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 PH-20 (fragment)   Lophocebus aterrimus ABD94495.1 A4K515  
 hyaluronidase 3.2.1.35 Loxosceles intermedia AGH25912.1 R4J7Z9  
 hyaluronidase (HyaL)   Lutzomyia longipalpis AAD32195.1 Q9XZ48  
 hyaluronidase 3.2.1.35 Macaca fascicularis ABD94494.1
BAE01371.1
P38568  
 PH-20   Macaca fascicularis ACV60220.1    
 hyaluronidase-2 (Hyal2)   Macaca mulatta AFI35008.1
AFE69962.1
   
 hyaluronidase, partial (fragment)   Macrovipera lebetina AHJ80887.1    
 Hyal1 (fragment)   Manis pentadactyla AEB78450.1    
 hyaluronidase (Hya1;BmHYA1) (partial) 3.2.1.35 Mesobuthus martensii ACY69673.1
AHA36327.1
D1MBU1
P86100
 
 SPAM1   Mesocricetus auratus ADB94578.1 D6C448  
 hyaluronidase 5 (Hyal5)   Mesocricetus auratus ADB94579.1 D6C449  
 hyaluronoglucosaminidase 1 (Hyal1) (fragment)   Mesoplodon densirostris ADZ53990.1    
 hyaluronidase   Meteorus pulchricornis BAL70300.1    
 PH-20 (fragment)   Microcebus murinus ABD94486.1 A4K506  
 Hyal1 (fragment)   Moschus moschiferus ADZ57828.1    
 hyaluronidase 3 (Hyal3)   Mus musculus AAH18457.1
AAL06145.1
CAP19324.1
NP_821139.1
Q8VEI3  
 hyaluronidase (Spam1;PH-20;Spam) 3.2.1.35 Mus musculus AAA76603.1
AAP49832.1
AAX13989.1
AAX13990.1
BAB24161.1
BAC55070.1
NP_033267.1
P48794
Q5D1J0
 
 hyaluronoglucosaminidase 1 (Hyal1;Hyal-1) 3.2.1.35 Mus musculus AAC15949.1
AAH21636.1
AAL17822.1
BAC26206.1
CAP19319.1
CAP19320.1
CAP19321.1
CAP19322.1
NP_032343.2
O70229
Q8CE62
Q8VDK0
Q91ZJ9
 
 hyaluronidase (Hyal-5;Hyal5)   Mus musculus BAC55071.1
AAI45993.1
AAI45995.1
BAB30602.2
BAB30602.3
BAE21628.1
Q812F3
Q9CUA5
 
 hyaluronidase 2 (Hyal2;Hyal-2) 3.2.1.35 Mus musculus AAK28482.1
AAH60047.1
AAK28481.1
AAL17823.1
AAO49503.1
BAC39851.1
BAC40583.1
BAE21913.1
CAA03888.1
CAA03889.1
NP_034619.1
O35632
Q3UZE4
Q8C309
 
 4932701A20 or 4930503G08   Mus musculus C57BL/6J BAB30316.1
BAC26578.1
Q8CDQ9
Q9D4E9
 
 chondroitin sulfate hydrolase (Hyal4;mHYAL4) 3.2.1.- Mus musculus C57BL/6J BAB29454.1
AAI25403.1
AAI32097.1
BAM45641.1
Q05A56
Q9D660
 
 ORF (fragment)   Mustela putorius furo AER99997.1    
 hyaluronoglucosaminidase 1 (fragment)   Mustela putorius furo AER99995.1    
 hyaluronoglucosaminidase 2   Mustela putorius furo AER99996.1    
 ORF (fragment)   Mustela putorius furo AES10768.1    
 ORF (fragment)   Mustela putorius furo AES10769.1    
 posterior head protein 20, partial (Ph-20)   Nasalis larvatus AEX20364.1    
 Hyal1 (fragment)   Neophocaena phocaenoides ADZ57816.1    
 hyaluronidase (fragment)   Nyssomyia intermedia AFP99265.1    
 hyaluronidase   Orancistrocerus drewseni ACD61711.1 B2ZP63  
 hyauronidase, partial   Ornithorhynchus anatinus AFV61285.1    
 hyaluronidase 2 (Hyal2)   Oryctolagus cuniculus AAT35556.1 Q6J2L1  
 hyaluronidase (Hyal1;Spam1;PH20) 3.2.1.35 Oryctolagus cuniculus AAA88913.1 P38566  
 PH-20 (fragment)   Otolemur crassicaudatus ABD94481.1 A4K501  
 Hyal2   Ovis aries AAL78386.1 Q8SQG7  
 hyaluronidase 2 / hyaluronoglucosaminidase 2 (Hyal2)   Ovis aries AFP89957.1    
 hyaluronidase   Ovophis okinavensis BAN89413.1
BAN89414.1
   
 ORF   Pan troglodytes BAK64019.1    
 ORF   Pan troglodytes BAK62198.1    
 ORF (fragment)   Pan troglodytes BAK62386.1    
 PH-20 (fragment)   Pan troglodytes ABD94498.1 A4K518  
 PH-20   Papio hamadryas ACV60219.1    
 PH-20 (fragment)   Papio hamadryas ABD94496.1 A4K516  
 PH-20 (fragment)   Perodicticus potto ABD94482.1 A4K502  
 salivary hyaluronidase   Phlebotomus arabicus ACS93505.1 C6FX65  
 salivary hyaluronidase (fragment)   Phlebotomus orientalis Addis Zemen AGT96452.1    
 salivary hyaluronidase (fragment)   Phlebotomus orientalis Melka Werer AGT96475.1    
 hyaluronidase   Phlebotomus perniciosus ALL27024.1    
 ORF (fragment)   Phlebotomus tobbi AEK98519.1    
 ORF (fragment)   Pipa carvalhoi AEQ16640.1    
 Hyal1 (fragment)   Platanista gangetica ADZ57826.1    
 hyaluronidase (Pol a 2) 3.2.1.35 Polistes annularis AAD52616.1
AAR78239.1
ABH87695.1
Q9U6V9  
 Hyal / Pp-Hyal (partial)   Polybia paulista ADL09135.1 E0AD89  
 DKFZp469J0738   Pongo abelii CAH89756.1 Q5REQ1  
 PH-20 (fragment)   Propithecus verreauxi ABD94485.1 A4K505  
 hyaluronidase, partial (fragment)   Protobothrops flavoviridis BAN89379.1
BAP39986.1
   
 hyaluronidase 3.2.1.35 Pterois antennata BAM66299.1    
 hyaluronidase 3.2.1.35 Pterois volitans BAM66300.1    
 PH-20   Pygathrix nemaeus ACV60224.1    
 PH-20 (fragment)   Pygathrix nemaeus ABD94490.1 A4K510  
 hyaluronidase 1 (Hyal1)   Rattus norvegicus BAD14368.1 Q76HN1  
 hyaluronidase 4 (Hyal4) (fragment)   Rattus norvegicus BAD14369.1 Q76HN0  
 hyaluronidase 3 (Hyal3)   Rattus norvegicus BAD14370.1
AAH97259.1
Q76HM9  
 Unknown (protein for MGC:94293)   Rattus norvegicus AAH82016.1 Q66H49  
 Unknown (protein for MGC:108951)   Rattus norvegicus AAH91219.1 Q5BK36  
 2B1 antigen   Rattus norvegicus AAH81748.1
CAA62016.1
EDM15179.1
NP_446419.1
Q62803  
 hyaluronidase 2 (Hyal2) 3.2.1.35 Rattus norvegicus AAD01980.1
AAH62410.1
AAO49504.1
NP_742037.1
Q80ZC7
Q9Z2Q3
 
 venom hyaluronidase   Rhynchium brunneum ACC93934.1 B2MVK6  
 PH-20   Saguinus fuscicollis ACV60227.1    
 PH-20 (fragment)   Saguinus fuscicollis ABD94488.1 A4K508  
 posterior head protein 20, partial (Ph-20)   Saguinus oedipus AEX20362.1    
 PH-20   Saimiri sciureus ACV60226.1    
 PH-20 (fragment)   Saimiri sciureus ABD94487.1 A4K507  
 hyaluronidase-2 (Hyal2)   Salmo salar ACI32917.1 B5X0T6  
 hyaluronidase-2 (Hyal2)   Salmo salar ACI33835.1 B5X3F4  
 hyaluronidase-2 (Hyal2)   Salmo salar ACI33947.1
ACN10738.1
B5X3R6  
 PH-20   Semnopithecus entellus ACV60223.1    
 PH-20 (fragment)   Semnopithecus entellus ABD94491.1 A4K511  
 salivary hyaluronidase   Simulium guianense AEB96520.1    
 Hyal1 (fragment)   Sousa chinensis ADZ57823.1    
 Hyal1 (fragment)   Stenella attenuata ADZ57820.1    
 Hyal1 (fragment)   Stenella coeruleoalba ADZ57822.1    
 SRAE_2000096800   Strongyloides ratti ED321 Heterogonic CEF66298.1    
 SRAE_X000016600   Strongyloides ratti ED321 Heterogonic CEF70836.1    
 SRAE_2000275100   Strongyloides ratti ED321 Heterogonic CEF68093.1    
 SRAE_X000016700   Strongyloides ratti ED321 Heterogonic CEF70837.1    
 SRAE_X000016500 (fragment)   Strongyloides ratti ED321 Heterogonic CEF70835.1    
 sperm adhesion molecule 1 (SPAM-1)   Sus scrofa CAC83973.2 Q8MI02  
 hyaluronoglucosaminidase 3   Sus scrofa AAR91601.1
AAR33037.1
Q6RHW2  
 hyaluronoglucosaminidase 1   Sus scrofa AAR91599.1
ACH56985.1
ACH56986.1
Q6RHW4  
 hyaluronidase 2 (Hyal2)   Sus scrofa AAR91600.1
ACH56987.1
Q6RHW3  
 Hyal1 (fragment)   Sus scrofa AEB78447.1    
 hyaluronidase PH-20, partial   Symphalangus syndactylus AEH95769.1    
 hyaluronidase (HYA1;SfHya1) 3.2.1.35 Synanceia horrida AAO74499.1 Q801Z8  
 hyaluronidase (Hya1;SvHya1;Sv-Hya)   Synanceia verrucosa BAJ54082.1    
 hyaluronidase TY / allergen (Tab y 2)   Tabanus yao ADM18346.1 E0XKJ9  
 hyaluronidase 2 (Hyal-2;TsHyal-2) 3.2.1.35 Tityus serrulatus AHF72516.1 W0HFN9  
 hyaluronidase 1 (Hya;Hyal-1;TsHyal-1) (partial) 3.2.1.35 Tityus serrulatus AHF72517.1 P85841  
 Hyal1 (fragment)   Tursiops aduncus ADZ57821.1    
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