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Glycoside Hydrolase Family 45

Mechanism Inverting e
3D Structure Status6-stranded β-barrel
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental).
Noteformerly known as cellulase family K; distantly related to plant expansins
External resourcesCAZypedia; Expansin; PROSITE;
Statistics GenBank accession (710); Uniprot accession (102); PDB accession (34); 3D entries (10); cryst (0)
Summary
Download GH45 (2549) Taxonomic display Structure (10) Characterized (97) Activities in Family (3)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 endo-β-1,4-glucanase B / 45A (CelB;EGB;CJA_0374) (Cel45A) 3.2.1.4 pubmed
 Cellvibrio japonicus Ueda107 ACE82688.1
CAA36844.1		 B3PI35
P18126		   1
 endo-β-1,4-glucanase (F45;Fisuc_1933;FSU_2443) 3.2.1.4 pubmed
 Fibrobacter succinogenes subsp. succinogenes S85 ACX75523.1
ADL26053.1		 C9RIQ2   1
 endoglucanase B (GnuB) 3.2.1.4 pubmed
 uncultured bacterium AAP49340.1 Q6XR86   1
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 cellulase (Eng-2;ArENG2) 3.2.1.4 pubmed
 Adineta ricciae AKC91346.1 A0A0E3Z7U1   1
 endo-β-1,4-glucanase (EG27I) 3.2.1.4 pubmed
 Ampullaria crossean ABR92637.1 A7KME9   2
 endo-β-1,4-glucanase (EG27II) 3.2.1.4 pubmed
 Ampullaria crossean ABR92638.1 A7KMF0 5XBU[A]
5XBX[A]
5XC4[A]
5XC8[A]
5XC9[A]
5XCA[A] 		2
 cellulase 45A (AmCel-45A) 3.2.1.4 pubmed
 Anoplophora chinensis AFN89565.1 K4GMG5   1
 endo-β-1,4-glucanase (GABY01019707.1;AgraGH45-1) 3.2.1.4 pubmed
 Anthonomus grandis       1
 cellulase 21K (AkEG21;AkEG22) 3.2.1.4 pubmed
 Aplysia kurodai BAP19116.1 A0A077JGH0   2
 cellulase I (Ag-EGaseI) 3.2.1.4 pubmed
 Apriona germarii AAN78326.1
AAU44973.1		 Q5XQD1
Q8I815		   1
 endoglucanase II (Ag-EGaseII) 3.2.1.4 pubmed
 Apriona germarii AAR22385.1 Q6SS52   1
 glycoside hydrolase family 45 (Gh45-1) 3.2.1.4 pubmed
 Apriona japonica AHI15752.1 X2D5K6   1
 glycoside hydrolase family 45 (Gh45-2) 3.2.1.4 pubmed
 Apriona japonica AHI15753.1 X2D6C4   1
 cellulase I (Bh-EGaseI) 3.2.1.4 pubmed
 Batocera horsfieldi AKH90729.1 A0A0F7NSK2   1
 endoglucanase (Eng2;Bx-eng-2) 3.2.1.4 pubmed
 Bursaphelenchus xylophilus KA4 BAD34544.1
BAD34547.1		 Q6BCL7   1
 endoglucanase (Eng3;Bx-Eng-3) 3.2.1.4 pubmed
 Bursaphelenchus xylophilus KA4 BAD34548.1
BAD34545.1		 Q6BCL3   1
 endoglucanase (Eng1;Bx-Eng-1) 3.2.1.4 pubmed
 Bursaphelenchus xylophilus KA4 BAD34546.1
AFD53037.1
AFD53038.1
AFD53040.1
AFD53041.1
AFD53042.1
AFD53045.1
AFD53047.1
AFD53048.1
AFD53049.1
AFD53052.1
AFD53053.1
AFD53054.1
AFD53058.1
AFD53061.1
AFD53062.1
BAD34543.1		 K4F7Y8
K4FA32
Q6BCM1
Q6BCN0		   1
 endo-β-1,4-glucanase; (gluco)mannanase (CTR3) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Chrysomela tremula QCF40862.1 A0A4D6Q5X5   1
 endo-β-1,4-glucanase; (gluco)mannanase (CTR1) 3.2.1.4 pubmed
 Chrysomela tremulae ADU33285.1 E7CIS3   1
 xyloglucan hydrolase; (gluco)mannanase (CTR2) 3.2.1.151
3.2.1.-		 pubmed
pubmed
 Chrysomela tremulae ADU33286.1 E7CIS4   1
 endoglucanase (EG5;EG V) (Cel45A) 3.2.1.4 pubmed
 Chrysosporium lucknowense C1 AAQ38150.1
ACH15008.1		     1
 endo-β-1,4-glucanase (CjCel45A) (Cel45A) 3.2.1.4 pubmed
 Corbicula japonica BAH23793.1 B9X0W0   2
 endo-β-1,4-glucanase 3.2.1.4 pubmed
 Crinipellis scabella AAY00851.1     1
 endo-β-1,4-glucanase (Cel;CaCel) 3.2.1.4 pubmed
 Cryptopygus antarcticus ACV50414.1
ACV50415.1		 D3GDK4 5H4U[A,B,C] 1
 xyloglucan hydrolase (DVI6) 3.2.1.151 pubmed
 Diabrotica virgifera virgifera QCF40872.1 A0A4D6Q5Y3   1
 xyloglucan hydrolase (DVI5) 3.2.1.151 pubmed
 Diabrotica virgifera virgifera QCF40871.1 A0A4D6Q4A9   1
 endo-β-1,4-glucanase (DVI2) 3.2.1.4 pubmed
 Diabrotica virgifera virgifera QCF40868.1 A0A4D6Q326   1
 endo-β-1,4-glucanase; (gluco)mannanase (DVI9) 3.2.1.- pubmed
 Diabrotica virgifera virgifera QCF40875.1 A0A4D6Q7U5   1
 endo-β-1,4-glucanase; (gluco)mannanase (DVI10) 3.2.1.- pubmed
 Diabrotica virgifera virgifera QCF40876.1 A0A4D6Q3T6   1
 endo-β-1,4-glucanase; (gluco)mannanase (DVI8) 3.2.1.- pubmed
 Diabrotica virgifera virgifera QCF40874.1 A0A4D6Q2Y3   1
 endo-β-1,4-glucanase; (gluco)mannanase (DVI11) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Diabrotica virgifera virgifera QCF40877.1 A0A4D6Q371   1
 endo-β-1,4-glucanase (DVI1;DvvENGaseI) 3.2.1.4 pubmed
 Diabrotica virgifera virgifera AFI56547.1 I1VZE8   1
 endoglucanase (FpCel45A) (Cel45A) 3.2.1.4 pubmed
 Fomitopsis palustris FFPRI 0507 BAI58030.1
AVV62522.1
BAI58029.1		 D2YZL5   3
 endo-β-1,4-glucanase (Gh45-2) 3.2.1.4 pubmed
 Gastrophysa viridula AZH23718.1 A0A3Q8M7I7   1
 xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (Gh45-1) 3.2.1.151 pubmed
 Gastrophysa viridula ADU33334.1 E7CIX2   1
 endo-β-1,4-glucanase (GtGH45; GLOTRDRAFT_59933) 3.2.1.4 pubmed
 Gloeophyllum trabeum ATCC 11539 EPQ56593.1 S7QB86 8BZQ[A] 3
 endo-β-1,4-glucanase (Egl3) 3.2.1.4 pubmed
 Humicola grisea var. thermoidea BAA74956.1
AAE55435.1
AAN19009.1		 O93782
P43316		 1HD5[A] 1
 endo-β-1,4-glucanase IV (Egl4;EGIV) 3.2.1.4 pubmed
 Humicola grisea var. thermoidea BAA74957.1 O93783   1
 endo-β-1,4-glucanase V (EGV; EG V; NCE5) (Cel45A) 3.2.1.4 pubmed
 Humicola insolens DSM 1800 CAB42307.1
AAE16508.1
AAN23440.1
AAO30277.1
AAO30279.1
AAX00991.1
AAY74558.1
ABA35703.1
ABN29330.1
CAA01574.1
CAA01681.1
CAA01683.1
CAA01696.1
CAA01698.1
CAJ21530.1		 P43316 2ENG[A]
3ENG[A]
4ENG[A] 		1
 endo-β-1,4-glucanase (PAS_chr4_0643) (Cel45A) 3.2.1.4 pubmed
 Komagataella phaffii GS115 CAY71902.1
AOA69625.1		 C4R8H7   1
 endo-β-1,4-glucanase (DIV10) 3.2.1.4 pubmed
 Leptinotarsa decemlineata QCF40865.1 A0A4D6Q7T7   1
 xyloglucan hydrolase (DIV11) 3.2.1.151 pubmed
 Leptinotarsa decemlineata QCF40866.1 A0A4D6Q3S7   1
 glucomannan endo-β-1,4-glucanase (LDE2) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Leptinotarsa decemlineata ADU33346.1 E7CIY4   1
 endo-β-1,4-glucanase; (gluco)mannanase (LDE3) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Leptinotarsa decemlineata ADU33347.1 E7CIY5   1
 endo-β-1,4-glucanase; xyloglucan hydrolase (LDE5) 3.2.1.4
3.2.1.151		 pubmed
pubmed
 Leptinotarsa decemlineata ADU33349.1 E7CIY7   1
 endo-β-1,4-glucanase (LDE6) 3.2.1.4 pubmed
 Leptinotarsa decemlineata ADU33350.1 E7CIY8   1
 endo-β-1,4-glucanase; (gluco)mannanase (LDE7) 3.2.1.- pubmed
 Leptinotarsa decemlineata ADU33351.1 E7CIY9   1
 endo-β-1,4-glucanase (Cel45A) 3.2.1.4 pubmed
 Macrophomina phaseolina AAY00850.1
CAL49897.1		     1
 endoglucanase (Fm1;HG 67-5) 3.2.1.4 pubmed
 Mastotermes darwiniensis hindgut symbiont sp. CAD39197.1 Q7YZU0   1
 endoglucanase (Fm3) 3.2.1.4 pubmed
 Mastotermes darwiniensis hindgut symbiont sp. CAD39199.1 Q7YZT8   1
 endoglucanase (Fm4) 3.2.1.4 pubmed
 Mastotermes darwiniensis hindgut symbiont sp. CAD39200.1 Q7YZT7   1
 endoglucanase (Fm2) 3.2.1.4 pubmed
 Mastotermes darwiniensis hindgut symbiont sp. CAD39198.1 Q7YZT9   1
 endo-β-1,4-glucanase (MaCel45A) (Cel45A) 3.2.1.4 doi
 Melanocarpus albomyces CAD56665.1
AAU96162.1
QCO31627.1		 Q8J0K8 1L8F[A]
1OA7[A]
1OA9[A] 		1
 endo-β-1,4-glucanase (Mce1) 3.2.1.4 pubmed
 Mucor circinelloides FERM P-17446 BAD95808.1
ABA29991.1
ACK18401.1		 Q53VB3   1
 endo-β-1,4-glucanase (Mce2) 3.2.1.4 pubmed
 Mucor circinelloides FERM P-17446 BAD95809.1
ABA29992.1
ACK18402.1		 Q53VB2   1
 endo-1,4-glucanase 1 (Egl1) 3.2.1.4 pubmed
 Mycosarcoma maydis AAB36147.1 P54424   1
 endoglucanase (Eg) 3.2.1.4 pubmed
 Mytilus edulis CAC59695.1
CAC59694.1		 P82186
Q95P02		 1WC2[A] 2
 endoglucanase (NcCel45A;NCU05121.1) (Cel45A) 3.2.1.4 pubmed
 Neurospora crassa OR74A CAD70529.1
EAA27871.1
XP_324478.1		 Q1K5M0
Q872Q1		 6MVI[A]
6MVJ[A] 		1
 endoglucanase V / 45A (EG V;PdCel45A) (Cel45A) 3.2.1.4 pubmed
 Penicillium decumbens 114-2 ACF33814.1 B5AKD1   2
 endo-β-1,4-glucanase (EG) 3.2.1.4 pubmed
 Phaedon cochleariae CAA76931.1 O97401   1
 endo-β-1,4-glucanase (PCO1) 3.2.1.4 pubmed
 Phaedon cochleariae CCJ09450.1 K4QDH6   1
 xyloglucan hydrolase (PCO7) 3.2.1.151 pubmed
 Phaedon cochleariae CCJ09455.1 K4QDH7   1
 endo-β-1,4-glucanase; (gluco)mannanase (PCO3) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Phaedon cochleariae CCJ09451.1 K4QDG4   1
 endo-β-1,4-glucanase; (gluco)mannanase (PCO4) 3.2.1.4
3.2.1.-		 pubmed
pubmed
 Phaedon cochleariae CCJ09452.1 K7DWA1   1
 endo-β-1,4-glucanase; (gluco)mannanase (PCO5) 3.2.1.- pubmed
 Phaedon cochleariae CCJ09453.1 K7DW99   1
 endo-β-1,4-glucanase; (gluco)mannanase (PCO6) 3.2.1.- pubmed
 Phaedon cochleariae CCJ09454.1 K7DWA7   1
 cellulase (Ghf45eg-1) (fragment) 3.2.1.4 pubmed
 Phaeosphaeria sp. LH21 AGU16531.1 T1WGL7   1
 cellulase (Ghf45eg-2) 3.2.1.4 pubmed
 Phaeosphaeria sp. LH21 AGU16532.1 T1WFT4   1
 endoglucanase V (EGV;PcCel45A) (Cel45A) 3.2.1.4 pubmed
 Phanerochaete chrysosporium K-3 BAG68300.1
AEK06231.1		 B3Y002
G0ZPJ6		 3X2G[A]
3X2H[A]
3X2I[A]
3X2J[A]
3X2K[A]
3X2L[A]
3X2M[A]
3X2N[A]
3X2O[A]
3X2P[A]
4ZM7[A]
5KJO[A]
5KJQ[A] 		3
 endo-β-1,4-glucanase (Pce1) 3.2.1.4 pubmed
 Phycomyces nitens FERM P-17447 BAD77808.1
ABA29993.1
ACK18403.1		 Q5R230   1
 endoglucanase 45A (Cel45A) 3.2.1.4 pubmed
 Piromyces sp. equi CAB92325.1 Q9P868   1
 endoglucanase (RsSym45eg1;RsSymEG2;SM2038B84) 3.2.1.4 pubmed
 Reticulitermes speratus hindgut protist 130484 BAA98041.1
BAF57324.1
BAG71490.1		 A4UWR4
Q9JH92		   1
 cellulose endo-β-1,4-glucosidase (RrCel45) 3.2.1.4 doi
 Rhizophlyctis rosea AWL24828.1 A0A2U8LMQ2   1
 endo-β-1,4-glucanase (Rce1;RCE I) 3.2.1.4 pubmed
 Rhizopus arrhizus FERM BP-6889 BAC53956.1
ABA29988.1
ACK18398.1		 Q8J1L2   1
 endo-β-1,4-glucanase (Rce2; RCE II) 3.2.1.4 pubmed
 Rhizopus arrhizus FERM BP-6889 BAC53987.1
ABA29990.1
ACK18400.1		 Q8J1L1   1
 endo-β-1,4-glucanase (Rce3; RCE III) 3.2.1.4 pubmed
 Rhizopus arrhizus FERM BP-6889 BAC53988.1
ABA29989.1
ACK18399.1		 Q8J1L0   1
 endo-β-1,4-glucanase (EG2) 3.2.1.4 pubmed
 Rhizopus reflexus TP-02 AFQ94052.1 J7K958   1
 cellulose endo-β-1,4-glucosidase (sscle_01g005720) 3.2.1.4 pubmed
 Sclerotinia sclerotiorum 1980 UF-70 APA05802.1 A0A1D9PTE7   1
 endoglucanase I (EgI) 3.2.1.4 pubmed
 Scopulariopsis brevicaulis TOF-1212   Q7M4T4   1
 endo-β-1,4-glucanase (SOR1) 3.2.1.4 pubmed
 Sitophilus oryzae ADU33246.1 E7CIN4   1
 endo-β-1,4-glucanase(SOR2) 3.2.1.4 pubmed
 Sitophilus oryzae ADU33247.1 E7CIN5   1
 xyloglucan hydrolase (SOR3) 3.2.1.151 pubmed
 Sitophilus oryzae ADU33248.1 E7CIN6   1
 xyloglucan hydrolase (SOR4) 3.2.1.151 pubmed
 Sitophilus oryzae ADU33249.1 E7CIN7   1
 xyloglucan hydrolase (SOR5) 3.2.1.151 pubmed
 Sitophilus oryzae ADU33250.1 E7CIN8   1
 endo-β-1,4-glucanase (Stce1) 3.2.1.4 pubmed
 Staphylotrichum coccosporum IFO 31817 BAG69187.1 B5BNY1   1
 endoglucanase (CBH I) 3.2.1.4 pubmed
 Syncephalastrum racemosum BCC18080 ABU49185.2 A7UGD9   1
 endo-β-1,4-glucanase (Cbh45-1) 3.2.1.4 pubmed
 Thermochaetoides thermophila CT2 AGY80100.1 V9PD44   1
 endo-β-1,4-glucanase (MtGH45; MYCTH_76901) 3.2.1.4 pubmed
 Thermothelomyces thermophilus ATCC 42464 AEO54078.1 G2Q0Y0   1
 endo-β-1,4-glucanase (THITE_2110957) 3.2.1.4 pubmed
 Thermothielavioides terrestris NRRL 8126 AEO64667.1 G2QVH7 5GLX[A]
5GLY[A]
5GM9[A] 		1
 β-1_4-endoglucanase (Cel45) 3.2.1.4 pubmed
 Thielavia arenaria XZ7 APQ40634.1 A0A2U7M673   1
 endoglucanase V (EGV) (Cel45A) 3.2.1.4 pubmed
 Trichoderma reesei CAA83846.1 P43317   2
 endoglucanase V (EGV) 3.2.1.4 pubmed
 Trichoderma viride AS 3.3711 AAQ21385.1 Q7Z7X0   2
 cellulose endo-β-1,4-glucosidase (NT0285A89) 3.2.1.4 pubmed
 uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57356.1 A4UWU6   1
 cellulose endo-β-1,4-glucosidase (SM2765A61) 3.2.1.4 pubmed
 uncultured symbiotic protist of Mastotermes darwiniensis BAF57450.1 A4UX40   1
 cellulose endo-β-1,4-glucosidase (SM2760A28) 3.2.1.4 pubmed
 uncultured symbiotic protist of Mastotermes darwiniensis BAF57443.1 A4UX33   1
 cellulose endo-β-1,4-glucosidase (SM2030A92) 3.2.1.4 pubmed
 uncultured symbiotic protist of Reticulitermes speratus BAF57323.1 A4UWR3   1
 cellulose endo-β-1,4-glucosidase (SM2042A70) 3.2.1.4 pubmed
 uncultured symbiotic protist of Reticulitermes speratus BAF57325.1 A4UWR5   1
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