Glycoside Hydrolase Family 33

Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (12431); Uniprot accession (131); PDB accession (195); 3D entries (34); cryst (0)

Summary

Download GH33 (12538) Taxonomic display Structure (34) Characterized (98) Activities in Family (5)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
sialidase (NanH)	3.2.1.18	pubmed	Actinomyces viscosus T14V	AAA21932.1	Q44562
exo-α-sialidase / neuraminidase (AmGH33A; Amuc_0625; Am0707)	3.2.1.18	pubmed	Akkermansia muciniphila ATCC BAA-835	ACD04462.1 QTD81261.1	B2UPI5
exo-α-sialidase / neuraminidase (AmGH33B; Amuc_1835; Am2085)	3.2.1.18	pubmed	Akkermansia muciniphila ATCC BAA-835	ACD05653.1 QTD80356.1	B2UN42
sialidase (Hz136)	3.2.1.18	pubmed	Alistipes sp.			6MNJ[B] 6MNJ[A]
sialidase (NanH; BF1806)	3.2.1.18	pubmed	Bacteroides fragilis NCTC 9343	CAH07505.1 WP_010992682.1	Q5LEE6
sialidase (BF1729)	3.2.1.18	pubmed	Bacteroides fragilis YCH46	BAA05853.1 AAA22912.1 BAC56895.1 BAC56895.2 BAD48476.1	P31206 P31206
bimodular α-1,5-rhamnosidase / α-2,3-KDO-hydrolase (cleaves α-L-Rhap-1,5-D-Kdo) (BT1013)	3.2.1.124	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO76120.1 NP_809926.1	Q8A904
sialidase (BtsA;BTSA;BT0455)	3.2.1.18	pubmed	Bacteroides thetaiotaomicron VPI-5482	AAO75562.1 NP_809368.1 WP_008766031.1	C6IEX0 Q8AAK9	4BBW[A]
exo-α-sialidase (SiaBb2;BBP_0054)	3.2.1.18	pubmed	Bifidobacterium bifidum JCM 1254	BAK26854.1	F5HN10
α-2,6- / α-2,3-sialidase (NanH1;Blon_0646)	3.2.1.18	pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ51753.1	B7GPM3
α-2,6- / α-2,3-sialidase (NanH2;Blon_2348)	3.2.1.18	pubmed	Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088	ACJ53406.1	B7GNQ0
sialidase (SiaC;CAPCAMM2a;Ccan_04790)	3.2.1.18	pubmed	Capnocytophaga canimorsus Cc5	AEK22601.1 ACA13563.1	B5SV83 F9YS48
sialidase (NanA)	3.2.1.18	pubmed	Clostridium chauvoei JF4135	CAR82361.1	E1UGY4
sialidase 1 'small'	3.2.1.18	pubmed	Clostridium perfringens A99	CAA68780.1	P10481
exo-α-sialidase 'large' (NanH)	3.2.1.18	pubmed	Clostridium perfringens A99	CAA60796.1	Q59310
sialidase 2 (NanH)	3.2.1.18	pubmed	Clostridium perfringens ATCC 10543	CAA50436.1	Q59311
sialidase NanI (CpNanI;CPF_0721)	3.2.1.18	pubmed	Clostridium perfringens ATCC 13124	ABG83208.1	A0A0H2YQR1 Q0TT67	4L2E[A] 5TSP[A,B] 8U2A[A] 8U5O[A]
α-2,3-sialidase NanH (CPF_0985)	3.2.1.18	pubmed	Clostridium perfringens ATCC 13124	ABG84018.1		8UB5[A] 8UL7[A] 8ULE[A] 8UM0[A]
sialidase NanJ (CPF_0532)	3.2.1.18	pubmed	Clostridium perfringens ATCC 13124	ABG84247.1		8URL[A] 8UVV[A] 9C20[A]
exo-α-sialidase (NanI;CPSA;CPE0725)	3.2.1.18	pubmed	Clostridium perfringens str. 13	BAB80431.1 NP_561641.1	Q59310 Q8XMG4	2BF6[A] 2VK5[A] 2VK6[A] 2VK7[A,B] 8U2A[A] 8U5O[A]
sialidase	3.2.1.18	doi	Clostridium septicum NC0054714	CAA44916.1	P29767
sialidase (NanH;SiaH)	3.2.1.18	pubmed	Clostridium tertium	CAA69951.1	P77848
trans-sialidase (NanH;NanA)	2.4.1.-	pubmed	Corynebacterium diphtheriae KCTC 3075	ACS34893.1	C6JSW6
sialidase (PaNA; PPA1560)	3.2.1.18	pubmed	Cutibacterium acnes KPA171202	AAT83304.1	A0A8B2VIR8 Q6A7G1	7LBU[A] 7LBV[A]
sialidase (NanA)	3.2.1.18	pubmed	Edwardsiella tarda TX01	AFP73415.1	J7GU76
lipid A Kdo hydrolase (KdhA;FTL_0465)	3.2.1.124	pubmed	Francisella tularensis subsp. holarctica LVS	CAJ78905.1 AJI59416.1	Q2A4W5
lipid A Kdo hydrolase (KdoH1) (sialidase-like subunit)	3.2.1.124	pubmed	Francisella tularensis subsp. novicida U112	ADR71924.1 ABK89391.1 AJI60298.1	A0Q576
lipid A Kdo hydrolase (KdhA;FTT_0399c)	3.2.1.124	pubmed	Francisella tularensis subsp. tularensis SCHU S4	CAG45032.1	Q5NHP8
lipid A Kdo hydrolase (KdhA;HP0580;HP_0580)	3.2.1.124	pubmed	Helicobacter pylori 26695	AAD07646.1 NP_207375.1	O25303
lipid A Kdo hydrolase (KdhA;lpg2939)	3.2.1.124	pubmed	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	AAU28985.1 AGH52162.1	Q5ZRE3
anhydrosialidase (RgNanH;HMPREF1201_01421) (intramolecular)	4.2.2.15	pubmed	Mediterraneibacter gnavus	ETD19277.1	A0A829NK98 A7B557	4X47[A] 4X49[A] 4X4A[A] 4X6K[A]
sialidase (NedA)	3.2.1.18	pubmed	Micromonospora viridifaciens	BAA00852.1 AAQ70871.1	Q02834	1EUR[A] 1EUS[A] 1EUT[A] 1EUU[A] 1W8N[A] 1W8O[A] 1WCQ[A,B,C] 2BER[A] 2BQ9[A,B,C] 2BZD[A,B,C] 4J9T[A]
sialidase M (Siα-AU;AuSia;AUSA)	3.2.1.18	pubmed	Paenarthrobacter ureafaciens IFO 12140 / ATCC 7562	BAD66680.2 AAX22758.1	Q5W7Q2
sialidase	3.2.1.18	doi	Paraclostridium sordellii G12	AAA23280.1 AAB38297.1	P15698 P94675
sialidase	3.2.1.18	pubmed	Paraclostridium sordellii G39	AAB38298.1	P94676
sialidase	3.2.1.18	pubmed	Paraclostridium sordellii G5	AAB38296.1	P94674
sialidase (NanH)	3.2.1.18	pubmed	Pasteurella multocida 86-1913	AAG35310.1	Q9EZV6
sialidase (NanB)	3.2.1.18	pubmed	Pasteurella multocida 86-1913	AAG35309.1	Q9EZV7
sialidase (PGN_1608)	3.2.1.18	pubmed	Porphyromonas gingivalis ATCC 33277	BAG34127.1 AUR49244.1	B2RL82
sialidase (CF002_1468;NedA)	3.2.1.18	pubmed	Porphyromonas gingivalis TDC 60	AUR47485.1		8GN6[A,B,C]
sialidase (PG0352)	3.2.1.18	pubmed	Porphyromonas gingivalis W83	AAQ65563.1 NP_904664.1	Q7MX62	8FEB[A] 8T1Y[A] 8T1Z[A] 8T24[A] 8T26[A] 8T27[A]
sialidase (NanH; STSA)	3.2.1.18	pubmed	Salmonella enterica LT2	AMG28514.2	A0A3F3BHS6 P29768	1DIL[A] 1DIM[A] 2SIL[A] 2SIM[A] 3SIL[A] 6TRG[XXX] 6TVI[AAA] 7AEY[AAA] 7AF2[AAA]
sialidase	3.2.1.18	pubmed	Streptococcus intermedius ATCC 27335	BAJ15290.1	E0CZJ4
sialidase A (NanA)	3.2.1.18	pubmed	Streptococcus pneumoniae 6	CAA51473.1 ACJ76903.1	B8XTT3 P62575 Q59959	5KKY[A,B] 7A54[A,B] 7A5X[A,B]
sialidase B (NanB)	3.2.1.18	pubmed pubmed	Streptococcus pneumoniae 6	AAC44396.1 AAW08718.1	Q54727
sialidase B (NanB)	3.2.1.18	pubmed pubmed	Streptococcus pneumoniae 6	AAC44396.1	Q54727
sialidase (NanC;SPCG_0853)	3.2.1.18	pubmed pubmed	Streptococcus pneumoniae CGSP14	ACB90105.1	B2IP34
sialidase (NanC;SPCG_0853)	3.2.1.18	pubmed pubmed	Streptococcus pneumoniae CGSP14	ACB90105.1	B2IP34
sialidase (NanA;SPD_1504)	3.2.1.18	pubmed	Streptococcus pneumoniae D39	ABJ55437.1	A0A0H2ZQ85 Q04J78
neuraminidase (NanC)	3.2.1.18	pubmed pubmed	Streptococcus pneumoniae G54	ACF56230.1	A0A0B7LH44 A0A0H2UQE4 A0A182DW00 B5E561	4YW0[A,B] 4YW1[A,B] 4YW2[A,B] 4YW3[A,B] 4YW4[A,B] 4YW5[A,B] 4YZ1[A,B] 4YZ2[A,B] 4YZ3[A,B] 4YZ4[A,B] 4YZ5[A,B] 5F9T[A,B]
neuraminidase (NanC)	3.2.1.18	pubmed pubmed	Streptococcus pneumoniae G54	ACF56230.1	A0A0B7LH44 A0A0H2UQE4 A0A182DW00 B5E561	4YW0[A,B] 4YW1[A,B] 4YW2[A,B] 4YW3[A,B] 4YW4[A,B] 4YW5[A,B] 4YZ1[A,B] 4YZ2[A,B] 4YZ3[A,B] 4YZ4[A,B] 4YZ5[A,B] 5F9T[A,B]
intramolecular trans-sialidase B (NanB;SP_1687)	4.2.2.15	pubmed pubmed	Streptococcus pneumoniae TIGR4	AAK75766.1 NP_346126.1	Q54727	2JKB[A] 2VW0[A] 2VW1[A] 2VW2[A] 4FOQ[A] 4FOV[A] 4FOW[A] 4FOY[A] 4FP2[A] 4FP3[A] 4FPC[A] 4FPE[A] 4FPF[A] 4FPG[A] 4FPH[A] 4FPJ[A] 4FPK[A] 4FPL[A] 4FPO[B] 4FPY[A] 4FQ4[A] 4XE9[A] 4XHB[A] 4XHX[A] 4XIK[A] 4XIL[A] 4XIO[A] 4XJ8[A] 4XJ9[A] 4XJA[A] 4XJU[A] 4XJW[A] 4XJZ[A] 4XMA[A] 4XMI[A] 4XOG[A] 4XYX[A]
intramolecular trans-sialidase B (NanB;SP_1687)	4.2.2.15	pubmed pubmed	Streptococcus pneumoniae TIGR4	AAK75766.1 NP_346126.1	Q54727	2JKB[A] 2VW0[A] 2VW1[A] 2VW2[A] 4FOQ[A] 4FOV[A] 4FOW[A] 4FOY[A] 4FP2[A] 4FP3[A] 4FPC[A] 4FPE[A] 4FPF[A] 4FPG[A] 4FPH[A] 4FPJ[A] 4FPK[A] 4FPL[A] 4FPO[B] 4FPY[A] 4FQ4[A] 4XE9[A] 4XHB[A] 4XHX[A] 4XIK[A] 4XIL[A] 4XIO[A] 4XJ8[A] 4XJ9[A] 4XJA[A] 4XJU[A] 4XJW[A] 4XJZ[A] 4XMA[A] 4XMI[A] 4XOG[A] 4XYX[A]
neuraminidase (NanA;SpneT_02001817)	3.2.1.18	pubmed	Streptococcus pneumoniae TIGR4	ZP_01407762.1		2YA4[A,B] 2YA5[A,B] 2YA6[A,B] 2YA7[A,B,C,D] 2YA8[A,B]
sialidase (NanH;TF0036; BFO_2207)	3.2.1.18	pubmed	Tannerella forsythia 92A2	AEW22573.1	G8UIQ1	7QXO[A,B] 7QY8[A,B] 7QY9[A,B] 7QYJ[A,B] 7QYP[A,B] 7QZ3[A,B]
exo-neuraminidase (TdNeu;TDE0471)	3.2.1.18	pubmed	Treponema denticola ATCC 35405	AAS10966.1 NP_971085.1	Q73QH2
sialidase (NanH)	3.2.1.18	pubmed	Trueperella pyogenes	AAK15462.1	Q9AHP2
sialidase / neuraminidase (NanH;VcNA;VCSA)	3.2.1.18	pubmed pubmed	Vibrio cholerae 569B 395	AAA27546.1	A5F7A4 P0C6E9 P37060	1KIT[A] 1W0O[A] 1W0P[A] 6EKS[A] 6EKU[A]
sialidase / neuraminidase (NanH;VcNA;VCSA)	3.2.1.18	pubmed pubmed	Vibrio cholerae 569B 395	AAA27546.1	A5F7A4 P0C6E9 P37060	1KIT[A] 1W0O[A] 1W0P[A] 6EKS[A] 6EKU[A]
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
2-keto-3-deoxynononic acid sialidase (KDNase;AfKDNase;Afu4g13800;AFUA_4G13800) (6407)	3.2.1.18 3.2.1.-	pubmed pubmed	Aspergillus fumigatus Af293	EAL89414.2	Q4WQS0	2XCY[A,B] 2XZI[A,B] 2XZJ[A,B] 2XZK[A,B] 4M4N[A,B] 4M4U[A,B] 4M4V[A,B]
KDNase (ATEG_04964)	3.2.1.-	doi	Aspergillus terreus NIH2624	Q0CMX0		7P1B[A] 7P1D[A] 7P1E[A] 7P1F[A,B] 7P1O[A,B]
ganglioside sialidase (Neu3)	3.2.1.18	pubmed	Bos taurus	BAA75071.1 AAE69071.1 NP_776547.1	O97859
sialidase	3.2.1.18	pubmed	Cricetulus griseus	AAA19746.1	Q64393
sialidase (Neu3.2)	3.2.1.18	pubmed	Danio rerio	AAH77080.1 AAH96984.1 AAI52169.1 ABO30983.1	A7MCG3 A7TUD4 Q4V9A4 Q6DEM9
sialidase (Neu4)	3.2.1.18	pubmed	Danio rerio	AAH95117.1 AAI65570.1 ABO45315.1	Q503Z4
sialidase (Neu3.3)	3.2.1.18	pubmed	Danio rerio	AAI25932.1 AAI16604.1 AAI64496.1 ABO30989.1 ABO30991.1	A0JMM3 B8LF84 Q1JPT6
sialidase (Neu3.1)	3.2.1.18	pubmed	Danio rerio	AAI27593.1 ABO30984.1	A0PJS4 A7TUD5
ganglioside sialidase (Neu3)	3.2.1.18	pubmed	Homo sapiens	ACM83942.1 AAE69072.1 AAI36398.1 AAI44060.1 BAA82611.1 BAF83131.1 BAG51074.1 BAG64566.1 CAB96131.1 CAE90379.1 NP_006647.2 XP_035091.1	A0A024R5N6 B4E0V4 Q9UQ49
sialidase (Neu2) (cytosolic)	3.2.1.18	pubmed	Homo sapiens	CAB41449.1 AAH69151.1 AAI07054.1 AAY24360.1 NP_005374.1	Q9Y3R4	1SNT[A] 1SO7[A] 1VCU[A,B] 2F0Z[A] 2F10[A] 2F11[A] 2F12[A] 2F13[A] 2F24[A] 2F25[A,B] 2F26[A] 2F27[A,B] 2F28[A] 2F29[A,B] 4NC5[A] 4NCS[A]
lysosomal sialidase (Neu1;Neu-1;NanH;G9)	3.2.1.18	pubmed	Homo sapiens	AAB96774.1 AAD09239.1 AAD21814.1 AAH00722.1 AAH11900.1 AAP35870.1 ACM80442.1 ACM85519.1 AQY76954.1 AQY76955.1 BAB63297.1 BAD92248.1 BAF83655.1 CAA55356.1 CAG32998.1 CAG46714.1 CAI17742.1 CAI18221.1 CAI41850.1 CAM26147.1 CAQ08322.1 CAQ09153.1 CAQ09305.1 CAQ09512.1 NP_000425.1	A0A1U9X836 A8K4K1 Q59GU8 Q5JQI0 Q6IBT5 Q99519
sialidase (Neu4;LOC129807) (long-form mitochondria;short-form ER)	3.2.1.18	pubmed	Homo sapiens	AAH12899.2 AAH63465.1 AAI05975.1 AAI17215.1 AAP34475.1 AAX82022.1 ABA66598.1 BAF82110.1 BAF82765.1 BAG52266.1 BAH12778.1 BAH13385.1 CAC81904.1 NP_542779.2	A8K056 A8K211 B3KR54 B7Z542 Q3KR05 Q8WWR8
intramolecular trans-sialidase L (MDSA)	4.2.2.15	pubmed pubmed	Macrobdella decora	AAC47263.1	Q27701	1SLI[A] 1SLL[A] 2SLI[A] 3SLI[A] 4SLI[A]
intramolecular trans-sialidase L (MDSA)	4.2.2.15	pubmed pubmed	Macrobdella decora	AAC47263.1	Q27701	1SLI[A] 1SLL[A] 2SLI[A] 3SLI[A] 4SLI[A]
sialidase (Neu1;Neu-1;G9) (lysosomal)	3.2.1.18	pubmed	Mus musculus	AAC84167.1 AAC53536.1 AAH04666.1 BAE26586.1 CAA72215.1 CAD91185.1 NP_035023.2	O35657 Q3UL64 Q7TSW3	8DU5[A,B]
cytosolic sialidase	3.2.1.18	pubmed	Mus musculus	BAB39152.1 AAH26408.1 AAI05658.1 AAI05659.1 AAI05660.1 AAI05662.1 ACM77811.1 BAA92867.1 BAE26342.1 NP_056565.1	C0KJU9 Q0VGI4 Q3ULV6 Q8R0U7 Q9JMH3
sialidase (Neu3)	3.2.1.18	pubmed	Mus musculus	BAA92868.1 AAI16893.1 AAI16925.1 BAC34251.1 BAE22130.1 NP_057929.1	Q543I9 Q9JMH7
sialidase 3a (Neu3A)	3.2.1.18	pubmed	Oryzias latipes Hd-rR	BAL03608.1	G3XKV6
sialidase 3b (Neu3B)	3.2.1.18	pubmed	Oryzias latipes Hd-rR	BAL03609.1	G3XKV7
sialidase 4 (Neu4)	3.2.1.18	pubmed	Oryzias latipes Hd-rR	BAM74165.1	H2LPW5
sialidase	3.2.1.18	pubmed	Rattus norvegicus	BAA03805.1 AAH91154.1 BAA09169.1 NP_058826.1	A0A0G2JZS7 Q5BK97 Q64627
KDNase	3.2.1.-	doi	Trichophyton rubrum CMCC(F)T1i	OAL63013.1	A0A178EUH2	7P1Q[A] 7P1R[A,B,C,D] 7P1S[A,B,C,D] 7P1U[A,B] 7P1V[A,B,C,D]
2,3-trans-sialidase (TbSA C2;Tb927.8.7350)	2.4.1.-	pubmed	Trypanosoma brucei brucei TREU927	AAX69221.1	Q57YT7
trans-sialidase (Ts1e-1;TconTS1) (fragment)	2.4.1.-	pubmed	Trypanosoma congolense	CCD30512.1 CAD59552.1 CAH04004.1	G0WJG7 Q7YZT3
trans-sialidase (Ts1B) (fragment)	2.4.1.-	pubmed	Trypanosoma congolense	CCD30509.1	G0WJG4
trans-sialidase	2.4.1.-	pubmed	Trypanosoma cruzi	AAO30669.1 AAT21541.1 ABH92705.1 BAA09334.1	Q26964
trans-sialidase (TcTS)	2.4.1.-	pubmed	Trypanosoma cruzi	AAA66352.1 AAO30670.1 AAT21542.1	Q26966	1MR5[A] 1MS0[A,B] 1MS1[A,B] 1MS3[A,B] 1MS4[A,B] 1MS5[A,B] 1MS8[A,B] 1MS9[A,B] 1S0I[A] 1S0J[A] 1S0K[A] 2AH2[A] 3B69[A] 3OPZ[A,B,C,M] 3PJQ[A]
sialidase 85-1.1	3.2.1.18	pubmed	Trypanosoma cruzi CL	AAA30245.1	P18269
sialidase SA85-1.2	3.2.1.18	pubmed	Trypanosoma cruzi CL	AAA30246.1	Q03625
trans-sialidase (TcTS;Tc00.1047053509495.30)	2.4.1.-	pubmed	Trypanosoma cruzi CL Brener	EAN85580.1	Q4CZ79
trans-sialidase (TcTS-12)	2.4.1.-	pubmed	Trypanosoma cruzi CL BRENER	ACF17926.1	B3VSM4
trans-sialidase (TcTS-15)	2.4.1.-	pubmed	Trypanosoma cruzi CL BRENER	ACF17927.1	B3VSM5
trans-sialidase (TcTS-24)	2.4.1.-	pubmed	Trypanosoma cruzi CL BRENER	ACF17928.1	B3VSM6
trans-sialidase (TcTS-46)	2.4.1.-	pubmed	Trypanosoma cruzi CL BRENER	ACF17929.1	B3VSM7
trans-sialidase (TcTS-49)	2.4.1.-	pubmed	Trypanosoma cruzi CL BRENER	ACF17930.1	B3VSM8
trans-sialidase	2.4.1.-	pubmed	Trypanosoma cruzi TULAHUEN	AAA99444.1	Q26969
trans-sialidase (TCTS)	2.4.1.-	pubmed	Trypanosoma cruzi Y-STRAIN	CAC34453.1 ABH92692.1	Q9BHJ5
sialidase (TeSA)	3.2.1.18	pubmed	Trypanosoma evansi	ACM43506.1	B9VS11
sialidase (TrSA)	3.2.1.18	pubmed	Trypanosoma rangeli	AAC95493.1 AAC95494.1 AAC95495.1	O44049 Q7JNE5 Q7JNE6	1MZ5[A] 1MZ6[A] 1N1S[A] 1N1T[A] 1N1V[A] 1N1Y[A] 1WCS[A] 2A75[A] 2AGS[A] 2FHR[A]
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