Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (239); Uniprot accession (52); PDB accession (58); 3D entries (17); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
β-glucuronidase (BifdGUS; UidA; HMPREF0168_2111)	3.2.1.31	Bifidobacterium dentium ATCC 27679	WP_003843201.1	E0QAF3	5Z1B[A,B,C,D] β-D-GlcpA-(1-1)-<non_carb> β-D-GlcpA-(1-2)-unknown 1.45	3
β-glucuronidase (BdGUS; BifdGUS; LacZ1; BDP_2112)	3.2.1.31	Bifidobacterium dentium Bd1	ADB10673.1		6LD0[A,B,C,D] 1.90 6LD6[A,B,C,D] 2.20 6LDB[A,B,C,D] 1.65 6LDC[A,B,C,D] 2.18 6LDD[A,B,C,D] 2.21	3
β-glucuronidase (BglR; CPGUS; CPE0147)	3.2.1.31	Clostridium perfringens str. 13	BAB79853.1 CAD12654.1 NP_561063.1 WP_003467686.1	Q8VNV4 Q8XP19	4JKM[A,B] 2.26 6CXS[A,B] 2.80	3
β-glucuronidase (DtGlcA; DICTH_1429)	3.2.1.31	Dictyoglomus thermophilum H-6-12	ACI18585.1	B5YFE0	6XXW[A] 1.85	3
β-galacturonidase (EtGalAse)	3.2.1.-	Eisenbergiella tayi	WP_069152983.1	A0A1E3AEY6	6NCW[A,B,C,D] 2.10 6NCX[A,B,C,D] α-D-GalpA 2.25	3
β-glucuronidase (EcGUS; UidA; GusA; GurA; b1617)	3.2.1.31	Escherichia coli str. K-12 substr. MG1655	AAC74689.1 AAA68923.1 AAB30197.1 AAR75623.1 ABE20937.1 ACR88323.1 AIZ91278.1 ALI40610.1 AMC98822.1 AUG16387.1 AVI56132.1 AYG19328.1 CAJ55495.1 CAJ55496.1 CAJ55497.1 CAJ55498.1 CAJ55499.1 CAJ55500.1 NP_416134.1 WP_001551153.1	A0A0D8WFE1 A0A1X3I6P5 A0A7Z1D535 A9DEX9 A9DEY7 A9DEZ1 A9DEZ6 A9DF00 A9DF05 P05804 U4Q148	3K46[A,B] 2.50 3K4A[A,B] 2.90 3K4D[A,B] <carb_like_EVA> 2.39 3LPF[A,B] 2.26 3LPG[A,B] 2.42 4JHZ[A,B] 2.83 5CZK[A,B] 2.39 6LEG[A,B,C,D] 2.60 6LEJ[A,B] 2.62 6LEL[A,B] 2.50 6LEM[A,B] 3.19 7PR6[A,B] 8OHX[A,B]	3
b glucuronidase (FpGUS; Fp2-L1)		Faecalibacterium prausnitzii			7KGY[A,B,C,D] 2.20	3
β-glucuronidase (CG447_12395)	3.2.1.31	Faecalibacterium prausnitzii A2165	ATP00638.1 EEU97254.1	C7H4D2	6ED2[A] 2.30	3
β-glucuronidase (C4Q21_10165)	3.2.1.31	Faecalibacterium prausnitzii APC918/95b	AXB29257.1	A0A3F3JX71	6U7I[A,B,C,D] 2.70	3
β-glucuronidase (EeGUS; EUBELI_20590)	3.2.1.31	Lachnospira eligens ATCC 27750	ACR73734.1	A0A174ZZA3 C4Z6Z2	6BJQ[A] β-D-GlcpA 2.70 6BJW[A] 3.00 6BO6[A] 2.80 6D4O[A] 2.90 8GEN[A] 2.94 8GEO[A] D-1-deoxy-GlcpA 2.89 8GEQ[A] D-1-deoxy-GlcpA 2.75 8GER[A] 2.40 8UGT[A] 2.65	3
β-glucuronidase (HMPREF0539_0313; UidA)	3.2.1.31	Lacticaseibacillus rhamnosus LMS2-1	EEN81625.1	A0A2A5L2J1 C2JTS9	6ECA[A,B] 2.85	3
β-glucuronidase (RgGUS; UidA)	3.2.1.31	Mediterraneibacter gnavus E1	AAQ76046.1	A0A2N5PVZ8 Q6W7J7	5Z18[A,B,C,D,E,F] 2.50 5Z19[A,B,C,D,E,F] 2.50 6EC6[A,B] 2.85 6JZ1[A,B] 1.73 6JZ2[A,B] 1.29 6JZ3[A,B] 1.50 6JZ4[A,B] <carb_like_EVA> 1.71 6JZ5[A,B] β-D-GlcpA 1.58 6JZ6[A,B] 1.61 6JZ7[A,B] 1.45 6JZ8[A,B] β-D-GlcpA 1.58	3
β-glucuronidase (SAG0698)	3.2.1.31	Streptococcus agalactiae 2603V/R	AAM99585.1 NP_687713.1 Q8E0N2		4JKK[A] 2.59 4JKL[A,B] 2.29	3
β-glucuronidase (TlGUSL1)	3.2.1.31	Treponema lecithinolyticum		A0AA82WPE8	8DHW[A,B] 1.75 8E72[A,B] 1.95 8DHV[A,B] 1.60	3
β-glucuronidase (uidA_2)	3.2.1.31	uncultured Clostridium sp.		A0A1C5YG41	6U7J[A,B,C,D] 2.20	3
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
glycyrrhizin β-glucuronidase (PGUS; GUS)	3.2.1.31	Aspergillus oryzae Li-3 / Penicillium purpurogenum Li-3	ABU68712.1	A7XS03	5C70[A,B] 3.10 5C71[A,B,C,D] α-D-GlcpA-(1-1)-<non_carb> 2.62	3
β-glucuronidase b (HsGUS; GusB; GUSB)	3.2.1.31	Homo sapiens	AAA52561.1 AAH14142.1 AAQ96851.1 AAR75622.1 ABH92596.1 ACH09936.1 ACM86199.1 BAD97126.1 BAG35619.1 BAG61991.1 BAG64768.1 CAC41170.1 NP_000172.1 NP_000172.2 SJX44098.1	B2R6X2 B4DTH9 P08236	1BHG[A,B] 2.53 3HN3[A,B,D,E] β-D-Manp 1.70	3
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