Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (239); Uniprot accession (52); PDB accession (58); 3D entries (17); cryst (0)

Archaea
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
β-glucuronidase (GusB;Ssol98_010100007956)	3.2.1.31	pubmed	Saccharolobus solfataricus 98/2	AET42956.1	G8GCV1		3
Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
β-glucuronidase (Gus)	3.2.1.31	pubmed	Arthrobacter sp. RP10	AAV91790.1	Q5MJX7		3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Arthrobacter sp. RP40.7	AAV91792.1	Q5MJX5		3
β-glucuronidase (BifdGUS; UidA; HMPREF0168_2111)	3.2.1.31	pubmed	Bifidobacterium dentium ATCC 27679	WP_003843201.1	E0QAF3	5Z1B[A,B,C,D]	3
β-glucuronidase (BdGUS; BifdGUS; LacZ1; BDP_2112)	3.2.1.31	pubmed	Bifidobacterium dentium Bd1	ADB10673.1		6LD0[A,B,C,D] 6LD6[A,B,C,D] 6LDB[A,B,C,D] 6LDC[A,B,C,D] 6LDD[A,B,C,D]	3
β-glucuronidase (BglR; CPGUS; CPE0147)	3.2.1.31	pubmed	Clostridium perfringens str. 13	BAB79853.1 CAD12654.1 NP_561063.1 WP_003467686.1	Q8VNV4 Q8XP19	4JKM[A,B] 6CXS[A,B]	3
β-glucuronidase (UidA)	3.2.1.31	pubmed	Clostridium sp. Marseille-P299	WP_066714276.1			3
β-glucuronidase (DtGlcA; DICTH_1429)	3.2.1.31	pubmed	Dictyoglomus thermophilum H-6-12	ACI18585.1	B5YFE0	6XXW[A]	3
β-galacturonidase (EtGalAse)	3.2.1.-	pubmed	Eisenbergiella tayi	WP_069152983.1	A0A1E3AEY6	6NCW[A,B,C,D] 6NCX[A,B,C,D]	3
β-glucuronidase (EcGUS; UidA; GusA; GurA; b1617)	3.2.1.31	pubmed	Escherichia coli str. K-12 substr. MG1655	AAC74689.1 AAA68923.1 AAB30197.1 AAR75623.1 ABE20937.1 ACR88323.1 AIZ91278.1 ALI40610.1 AMC98822.1 AUG16387.1 AVI56132.1 AYG19328.1 CAJ55495.1 CAJ55496.1 CAJ55497.1 CAJ55498.1 CAJ55499.1 CAJ55500.1 NP_416134.1 WP_001551153.1	A0A0D8WFE1 A0A1X3I6P5 A0A7Z1D535 A9DEX9 A9DEY7 A9DEZ1 A9DEZ6 A9DF00 A9DF05 P05804 U4Q148	3K46[A,B] 3K4A[A,B] 3K4D[A,B] 3LPF[A,B] 3LPG[A,B] 4JHZ[A,B] 5CZK[A,B] 6LEG[A,B,C,D] 6LEJ[A,B] 6LEL[A,B] 6LEM[A,B] 7PR6[A,B] 8OHX[A,B]	3
β-glucuronidase (CG447_12395)	3.2.1.31	pubmed	Faecalibacterium prausnitzii A2165	ATP00638.1 EEU97254.1	C7H4D2	6ED2[A]	3
β-glucuronidase (C4Q21_10165)	3.2.1.31	pubmed	Faecalibacterium prausnitzii APC918/95b	AXB29257.1	A0A3F3JX71	6U7I[A,B,C,D]	3
β-galacturonidase (FcGalAse; BHW29_02690)	3.2.1.-	pubmed	Faecalibacterium sp. CAG:74_58_120	OLA24209.1	A0A1Q6Q230		3
β-glucuronidase (EeGUS; EUBELI_20590)	3.2.1.31	pubmed	Lachnospira eligens ATCC 27750	ACR73734.1	A0A174ZZA3 C4Z6Z2	6BJQ[A] 6BJW[A] 6BO6[A] 6D4O[A] 8GEN[A] 8GEO[A] 8GEQ[A] 8GER[A] 8UGT[A]	3
β-glucuronidase (HMPREF0539_0313; UidA)	3.2.1.31	pubmed	Lacticaseibacillus rhamnosus LMS2-1	EEN81625.1	A0A2A5L2J1 C2JTS9	6ECA[A,B]	3
β-glucuronidase (GusA; LgGUS)	3.2.1.31	pubmed	Lactobacillus gasseri ADH	AAK07836.1 AAS22718.1	Q9AHJ8		3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Levilactobacillus brevis RO1	ACU21612.1	D2DMF3		3
β-glucuronidase (RgGUS; UidA)	3.2.1.31	pubmed	Mediterraneibacter gnavus E1	AAQ76046.1	A0A2N5PVZ8 Q6W7J7	5Z18[A,B,C,D,E,F] 5Z19[A,B,C,D,E,F] 6EC6[A,B] 6JZ1[A,B] 6JZ2[A,B] 6JZ3[A,B] 6JZ4[A,B] 6JZ5[A,B] 6JZ6[A,B] 6JZ7[A,B] 6JZ8[A,B]	3
β-glucuronidase (PBOR_13360)	3.2.1.31	doi	Paenibacillus borealis DSM 13188	AIQ57810.1	A0A089LCJ8		3
β-glucuronidase (ERS852391_01800; Uida_2)	3.2.1.31	pubmed	Roseburia hominis 2789STDY5608834	CUO31707.1			3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Staphylococcus sp. RLH1	AAK29422.1 AAR75615.1 AAR75620.1 AAR75621.1 ABP04762.1	Q9AFA2		3
β-glucuronidase (SAG0698)	3.2.1.31	pubmed	Streptococcus agalactiae 2603V/R	AAM99585.1 NP_687713.1 Q8E0N2		4JKK[A] 4JKL[A,B]	3
β-glucuronidase (Gus;TmGUS;TM1062;Tmari_1066)	3.2.1.31	pubmed	Thermotoga maritima MSB8	AAD36143.1 AAR75619.1 AAR75627.1 AGL49990.1 AHD19030.1 AKE28838.1 NP_228868.1	Q9X0F2 R4NQD9		3
β-glucuronidase (TlGUSL1)	3.2.1.31	pubmed	Treponema lecithinolyticum		A0AA82WPE8	8DHW[A,B] 8E72[A,B] 8DHV[A,B]	3
β-glucuronidase (uidA_2)	3.2.1.31	pubmed	uncultured Clostridium sp.		A0A1C5YG41	6U7J[A,B,C,D]	3
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
glycyrrhizin β-glucuronidase (PGUS; GUS)	3.2.1.31	doi	Aspergillus oryzae Li-3 / Penicillium purpurogenum Li-3	ABU68712.1	A7XS03	5C70[A,B] 5C71[A,B,C,D]	3
glycyrrhizin β-glucuronidase (AtGUS)	3.2.1.128	pubmed	Aspergillus terreus Li-20	AEP39213.1	G4XPL5		3
glycyrrhizin β-glucuronidase (AuGUS)	3.2.1.128	pubmed	Aspergillus ustus Li-62	AEK69352.1	G1FNU5		3
β-glucuronidase (GusB)	3.2.1.31	pubmed	Canis lupus familiaris	AAC48809.1	O18835		3
glycyrrhizin β-glucuronidase (cg-GUS)	3.2.1.128	pubmed	Chaetomium globosum DX-THS3	QIM55348.1	A0A6G8IQN4		3
β-glucuronidase (GusB)	3.2.1.31	pubmed	Felis catus	AAD01498.1 AAD01499.1	O97524		3
β-glucuronidase b (HsGUS; GusB; GUSB)	3.2.1.31	pubmed	Homo sapiens	AAA52561.1 AAH14142.1 AAQ96851.1 AAR75622.1 ABH92596.1 ACH09936.1 ACM86199.1 BAD97126.1 BAG35619.1 BAG61991.1 BAG64768.1 CAC41170.1 NP_000172.1 NP_000172.2 SJX44098.1	B2R6X2 B4DTH9 P08236	1BHG[A,B] 3HN3[A,B,D,E]	3
β-glucuronidase (GusB;Gus-S)	3.2.1.31	pubmed	Mus musculus	AAA37696.1 AAA37697.1 AAA63307.1 AAA63308.1 AAA63309.1 AAA98623.1 AAH71226.1 AAQ41980.1 BAE23021.1 BAE29265.1 BAE34865.1 BAE35155.1 BAE35384.1 BAE36917.1 CAC41171.1 NP_034498.1	P12265 Q3TW82		3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Penicillium canescens DSM1215	AAV91787.1	Q5MJY0		3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Penicillium canescens RPK	AAV91785.1	Q5MJY2		3
β-glucuronidase (GusB;Gus)	3.2.1.31	pubmed	Rattus norvegicus	AAA41228.1 AAP86274.1 CAA68705.1 NP_058711.1	P06760 Q7TPJ3		3
β-glucuronidase (Gus)	3.2.1.31	pubmed	Scopulariopsis sp. RP38.3	AAV91788.1	Q5MJX9		3
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