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Glycoside Hydrolase Family 15

Mechanism Inverting a
ClanGH-L
3D Structure Status( α / α ) 6 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteAlthough historically composed of anomeric-inverting glucosidases, a retaining mechanism has been molecularly revealed for transglucosylating dextran dextranases [PMID=40749827]. Although the catalytic machinery is similar for both enzyme categories, the rearrangement of the spatial position of one of the catalytic glutamates governs the reaction mechanism and outcome.
External resourcesCAZypedia; Glucoamylase Page; PROSITE;
Statistics GenBank accession (18843); Uniprot accession (84); PDB accession (30); 3D entries (11); cryst (1)
Summary
Download GH15 (22105) Taxonomic display Structure (11 - 1 cryst) Characterized (85) Activities in Family (5)
Archaea
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 glucoamylase (MGA; MJ1610) 3.2.1.3 pubmed
 Methanocaldococcus jannaschii DSM 2661 AAB99630.1
NP_248620.1		 Q59005  
 glucoamylase (PTO1492) 3.2.1.3 doi
 Picrophilus torridus DSM 9790 AAT44077.1 Q6KYX5  
 glucoamylase (Ssg; Sso0990) 3.2.1.3 pubmed
 Saccharolobus solfataricus P2 AAK41262.1
NP_342472.1		 Q97ZD0  
 glucoamylase (Gaa; Saci_1198) 3.2.1.3 pubmed
 Sulfolobus acidocaldarius DSM 639 AAY80545.1 Q4J9I5  
 trehalase (SaTreH1; Saci_1816) 3.2.1.28 pubmed
 Sulfolobus acidocaldarius DSM 639 AAY81122.1 Q4J7W0  
 trehalase (SaTreH1; SA1816; Saci1816) 3.2.1.28 pubmed
 Sulfolobus acidocaldarius NBRC 15157 BBA94969.1 A0A2Z5U3T3  
 trehalase (SaTreH2; SA1250; Saci1250) 3.2.1.28 pubmed
 Sulfolobus acidocaldarius NBRC 15157 BBA94968.1 A0A0U2VTJ8  
 glucoamylase (STGA; ST0815) 3.2.1.3 URL
 Sulfurisphaera tokodaii str. 7 BAB65828.1
BAK54392.1
NP_376719.1		 F9VN95
Q973T2		  
 trehalase (Ta0286) 3.2.1.28 pubmed
 Thermoplasma acidophilum 122-1B2 BAR87974.1 A0A0G4DCS1  
 glucoamylase (TaGA;Ta0342) 3.2.1.3 pubmed
 Thermoplasma acidophilum DSM 1728 CAC11486.1
NP_393821.1		 Q9HL88  
 trehalase (TVG1381191; TVN1315) 3.2.1.28 pubmed
 Thermoplasma volcanium GSS1 NP_111834.1
BAB60480.1
BAR87973.1		 A0A0G4DBK0
Q978S7		  
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 glucodextranase (G1d) 3.2.1.70 pubmed
 Arthrobacter globiformis I42 BAA90671.1
BAB20416.1		 Q9LBQ9 1UG9[A]
1ULV[A]
 glucodextranase (Gld) 3.2.1.70 pubmed
 Arthrobacter globiformis T-3044 BAA13597.1 P70745  
 glucoamylase (GA; TtcGA; TTE1813) 3.2.1.3 pubmed
 Caldanaerobacter subterraneus subsp. tengcongensis MB4 AAM25005.1
NP_623401.1		 Q8R917  
 glucoamylase (GA;CcGA;CauloGA;MalS;Cc2282) 3.2.1.3 pubmed
 Caulobacter vibrioides CB15 AAK24253.1
BAO51876.1
NP_421085.1		 Q9A613
W8VKE3		  
 glucoamylase (CGA) 3.2.1.3 pubmed
 Clostridium sp. G0005 BAA02251.1 P29761  
 glucoamylase 3.2.1.3 doi
 Clostridium thermoamylolyticum ATCC 29251 BAC80264.2 Q765N4  
 glucoamylase (GlucaM) 3.2.1.3 pubmed
 Corallococcus coralloides EGB AKM12417.1 A0A0H3WKG6  
 dextran dextrinase (DDase; DDext; DDin) (extracellular;intracellular) 3.2.1.3
2.4.1.2		 doi
pubmed
 Gluconobacter oxydans ATCC 11894 BAS29771.1 A0A0M5MSC0 9JU0[A,B,C,D]
 isomaltose glucohydrolase (IGHase; Kfla_1896) 3.2.1.205 pubmed
 Kribbella flavida DSM 17836 ADB30990.1 D2PPM8 5Z3A[A]
5Z3B[A]
5Z3C[A]
5Z3D[A]
5Z3E[A]
5Z3F[A]
7C24[A]
7C25[A]
7C26[A]
7C27[A]
 glucoamylase (GamA; LegY; lpp0489) 3.2.1.3 pubmed
 Legionella pneumophila str. Paris CAH11637.1 Q5X7W6  
 trehalase (MtreH) 3.2.1.28 pubmed
 Microvirga sp. MC18 UHN91757.1    
 α,α-trehalase (MSMEG_4535;MSMEG4528) 3.2.1.28 pubmed
 Mycolicibacterium smegmatis MC2 155 ABK72415.1
AFP40876.1
AIU09606.1		 A0R0W9  
 glucoamylase (SdGA; GlyNAX; Sde_0600) 3.2.1.3 pubmed
 Saccharophagus degradans 2-40 ABD79864.1 Q21N65  
 glucoamylase (VldI) 3.2.1.3 pubmed
 Streptomyces hygroscopicus subsp. limoneus KCCM 11405 ABC67273.1 Q15JF7  
 α-glucan-4(6)-α-glucosyltransferase (Td46GT; U473_02335) 2.4.1.2 pubmed
 Tepidibacillus decaturensis Z9 KXG42991.1
WP_068722961.1		    
 glucoamylase (TGA) 3.2.1.3 pubmed
 Thermoactinomyces vulgaris R-47 BAA97041.1
BAB40639.1		 Q9KWR2 cryst
 glucoamylase (TeGA) 3.2.1.3 pubmed
 Thermoanaerobacter ethanolicus WP_003871318.1
EGD50618.1		    
 cycloisomaltooligosaccharide glucanotransferase + isomaltooligosaccharide 6-α-glucosyltransferase (TtCITase) 2.4.1.2 doi
 Thermoanaerobacter thermocopriae WP_028992696.1    
 glucoamylase (Ga1) 3.2.1.3 doi
 Thermoanaerobacterium thermosaccharolyticum ATCC 7956 AAC24003.1
ABJ38330.1
ACW20095.1		 O85672 1LF6[A]
1LF9[A]
 trehalase (Vtre15; AX767_03780) 3.2.1.28 pubmed
 Variovorax sp. PAMC 28711 AMM23567.1    
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 glucoamylase G2 3.2.1.3 pubmed
 Agroathelia rolfsii AHU9627 BAA08436.1
ABL22841.1
CAI45339.1
CAI45340.1
CAI45341.1
CAI45342.1
CAI45344.1
CAI45345.1
CAT03378.1
CAY05381.1		 Q12596  
 glucoamylase P (GamP; GA-P) 3.2.1.3 pubmed
 Amorphotheca resinae ATCC 20495 CAA47945.1
CAA48243.1
CAY05396.1		 Q03045 6FHW[A,B]
 glucoamylase (GaA;Arx) 3.2.1.3 pubmed
 Arxula adeninivorans CAA86997.1 P42042  
 glucoamylase (GA I) 3.2.1.3 pubmed
 Aspergillus awamori KT-11 BAD06004.1
CAY05390.1		 Q76L97  
 glucoamylase G1 (GlaA) 3.2.1.3 pubmed
 Aspergillus awamori NRRL 3112 AAB59296.1
AAB59297.1
AEI58995.1		 F8U3V1
P04064
P69327		  
 glucoamylase (Gla) 3.2.1.3 pubmed
 Aspergillus awamori X-100 AAB02927.1
CAY05380.1		 Q12537 1AGM[A]
1DOG[A]
1GAH[A]
1GAI[A]
1GLM[A]
3GLY[A]
 glucoamylase (GlaAb; AbraCBS73388_002164) 3.2.1.3 doi
 Aspergillus brasiliensis CBS 733.88 GKZ26209.1 A0A9W6DQU1  
 glucoamylase (GA1) 3.2.1.3 pubmed
 Aspergillus flavus NSH9 ANA09033.1 A0A166HLT6  
 glucoamylase (GA2) 3.2.1.3 pubmed
 Aspergillus flavus NSH9 ARF07718.1 A0A1W5T6Y9  
 glucoamylase (RSGA; AfuGA ; AFUB_017770) 3.2.1.3 doi
 Aspergillus fumigatus A1163 EDP53734.1 B0XSV7  
 glucoamylase (AfGA; Afu2g00690; AFUA_2G00690) 3.2.1.3 pubmed
 Aspergillus fumigatus Af293 EAL87168.1 Q4WIT7  
 glucoamylase (GAI) (Man8A) 3.2.1.3 pubmed
 Aspergillus luchuensis (formerly Aspergillus awamori var. kawachi) BAA00331.1 P23176  
 glucoamylase (GlaA; AG; An03g06550) 3.2.1.3 doi
 Aspergillus niger CBS 513.88 CAK38411.1
AAE51533.1
AAP60775.1
AAQ77828.1
AAR61399.1
AAT67041.1
ABH92240.1
ABH92241.1
ABL16522.1
ABL22839.1
ACJ91357.1
ACP59407.1
ADX86749.1
AEE60909.1
CAA25219.1
CAA25303.1
CAA25304.1
CAC22383.1
CAC28418.1
CAX21649.1
CAY05387.1		 A2QHE1
F1DHX7
P69328
Q6DNH5		 3EQA[A]
6FRV[A]
 glucoamylase (GlaB) 3.2.1.3 pubmed
 Aspergillus oryzae O-1013 BAA25205.1
CAY05377.1		 O59846  
 glucoamylase (GlaB;AO090003000321) 3.2.1.3 pubmed
 Aspergillus oryzae RIB40 BAE57516.1 Q2ULP9  
 glucoamylase (GlaA; AO090010000746) 3.2.1.3 pubmed
 Aspergillus oryzae RIB40 BAA00841.1
AAB20818.1
ABA62323.1
BAA01540.1
BAE66563.1
CAY05395.1		 P36914  
 glucoamylase (Gla) 3.2.1.3 pubmed
 Aspergillus shirousami BAA01254.1
ABJ38329.1
ACW20094.1		 P22832  
 glucan 1,4-α-glucosidase (AtriGA15A) 3.2.1.3 pubmed
 Aspergillus tritici WZ99 AQX36340.1 A0A1S6XZP1  
 glucoamylase (GlaA) 3.2.1.3 pubmed
 Aspergillus tubingensis T8.4 AAS91802.1
ACC16345.1
ACC34982.1		    
 glucoamylase (APGA1) (extracellular) 3.2.1.3 URL
 Aureobasidium pullulans NRRL Y-12974 / NRRL 12974 ADN65120.1
ADN65121.1		 E2GDF4  
 glucoamylase (Gla15; GLA15) 3.2.1.3 pubmed
 Bispora sp. MEY-1 / CGMCC 2500 AIQ80993.1 A0A0A7DMD1  
 glucoamylase (Gla1;HfGla1) 3.2.1.3 pubmed
 Cyberlindnera fabianii J640 BAJ21225.1 E1CJT1  
 glucoamylase (GlA) 3.2.1.3 pubmed
 Fomitopsis palustris FFPRI 0507 BAE47183.1 Q33CE4  
 glucoamylase 3.2.1.3 pubmed
 Fusarium venenatum A3/5 AAP00500.1
AAM17546.1
AAS37043.1		    
 glucoamylase (Gla1) 3.2.1.3 doi
 Humicola grisea var. thermoidea NRLL 15219 AAA33386.1
ACC34981.1
CAY05382.1		 Q12623  
 glucoamylase (GLA) 3.2.1.3 pubmed
 Lentinula edodes L54 AAF75523.1 Q9P4C5  
 glucoamylase (Glα-1;NCU01517.1;B5O22.70) 3.2.1.3 pubmed
 Neurospora crassa OR74A CAB91426.1
AAE15056.1
AAE15057.1
CAA47707.1
XP_327956.1		 P14804  
 glucoamylase (PDE_09417) (Amy15A) 3.2.1.3 pubmed
 Penicillium oxalicum 114-2 EPS34453.1 S8B6D7  
 glucoamylase (PoGA;PDE_05527) 3.2.1.3 pubmed
 Penicillium oxalicum 114-2 EPS30575.1 S7ZIW0 6FHV[A]
 glucoamylase (PoGA15A) 3.2.1.3 pubmed
 Penicillium oxalicum GXU20 AOS89805.1 A0A1D8DGR2  
 glucoamylase (Amy15) 3.2.1.3 doi
 Penicillium oxalicum HP7-1 AVQ10352.1 A0A1D8DGR2  
 glucoamylase (Sga1; ScSGA1; MGG_01096; MG01096.4) (vacuolar) 3.2.1.3 pubmed
 Pyricularia oryzae 70-15 XP_368148.1
CAY05367.1
EAA49438.1		 G4NCF7  
 glucoamylase (GA) 3.2.1.3 pubmed
 Rasamsonia emersonii CAC28076.1
AAR61398.1
AAR61400.1
ABH92236.1
ABH92239.1
ABH92242.1
ABL22840.1
CAY05394.1		 Q9C1V4  
 glucoamylase (Gla; RpGla) 3.2.1.3 pubmed
 Rhizomucor pusillus GX-3 AGJ52080.1 M9TM63  
 glucoamylase (RaGa) 3.2.1.3 pubmed
 Rhizopus arrhizus 3.2893 ABI75077.1 Q09GR5  
 glucoamylase (AmyB) 3.2.1.3 pubmed
 Rhizopus arrhizus NBRC 4785 BAH09873.1 B7XC01  
 glucoamylase 3.2.1.3 doi
 Rhizopus arrhizus SAM0034 BAA00033.1
AAQ18643.1
ABJ38331.1
ACW20096.1		 P07683
Q7Z7X9		  
 glucoamylase (AmyC; RO3G_00127.1) (fragment) 3.2.1.3 pubmed
 Rhizopus delemar RA 99-880 EIE75423.1 I1BGU3  
 glucoamylase (AmyD; RO3G_06101.1) 3.2.1.3 pubmed
 Rhizopus delemar RA 99-880 EIE81396.1 I1BYW6  
 glucoamylase (Sga1;Sga;YIL099W) 3.2.1.3 pubmed
 Saccharomyces cerevisiae S288c CAA86282.1
AAA35042.1
CAA32071.1
CAY05366.1
NP_012167.1		 P08019
P08019		  
 glucoamylase S1 (STA1;DEX2;MAL5) (frameshift) 3.2.1.3 pubmed
 Saccharomyces cerevisiae var. diastaticus CAA26487.1
CAY05400.1		 P04065  
 glucoamylase S2 (STA2) (frameshift) 3.2.1.3 pubmed
 Saccharomyces cerevisiae var. diastaticus AAA20560.1
AAA35107.1
CAY05401.1		 P29760  
 glucoamylase (Glu;Glu1) 3.2.1.3 pubmed
 Saccharomycopsis fibuligera HUT 7212 AAA34649.1
AAA83997.1
CAY05397.1		 P08017 1AYX[A]
2F6D[A]
2FBA[A]
 glucoamylase (Glu 0111;Glm) 3.2.1.3 pubmed
 Saccharomycopsis fibuligera IFO 0111 CAC83969.1
CAY05393.1		 Q8TFE5  
 glucoamylase (Gla;Gla1) 3.2.1.3 pubmed
 Saccharomycopsis fibuligera KZ CAA41120.1
CAY05399.1		 P26989  
 glucoamylase (GlaA) 3.2.1.3 pubmed
 Talaromyces pinophilus CF-2612 BAN67899.1 S6BPF5  
 glucoamylase (Gla1; GlA; Gla) 3.2.1.3 pubmed
 Talaromyces verruculosus B1-537 APM84499.1 A0A1L5IUR2  
 glucoamylase (GLA; TtGA) 3.2.1.3 pubmed
 Thermochaetoides thermophila CT2 ABD96025.1 Q0H9W2  
 glucoamylase (Gla) 3.2.1.3 URL
 Thermomyces lanuginosus A236 ABQ23180.1 A5HNU1  
 glucoamylase (Gla1) 3.2.1.3 pubmed
 Thermomyces lanuginosus ATCC 200065 AAX49506.1
CAY05385.1		 Q58HN1  
 glucoamylase (MtGla;Gla1;MYCTH_72393) 3.2.1.3 pubmed
 Thermothelomyces thermophilus ATCC 42464 AEO61583.1 G2QPS0  
 glucoamylase (GlaA) 3.2.1.3 pubmed
 Thielavia terrestris ATCC20627 AAE85601.1    
 glucoamylase (GA; TGA; TrGA) 3.2.1.3 pubmed
 Trichoderma reesei AAB34091.1
ACP59416.1		   2VN4[A]
2VN7[A]
 glucoamylase (Glu1;TmGlu1) 3.2.1.3 doi
 Tricholoma matsutake NBRC 30773 BAL43555.1 H1AAU7  
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