| Mechanism | Retaining e |
|---|---|
| Clan | GH-C |
| 3D Structure Status | β-jelly roll |
| Catalytic Nucleophile/Base | Glu (experimental) |
| Catalytic Proton Donor | Glu (experimental) |
| Note | formerly known as cellulase family H. |
| External resources | CAZypedia; HOMSTRAD; |
| Commercial Enzyme Provider(s) | MEGAZYME; |
| Statistics | GenBank accession (3411); Uniprot accession (94); PDB accession (61); 3D entries (23); cryst (1) |
| Archaea | ||||||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | ||||
| cellulase (TCel6;Cmaq_1621) | 3.2.1.4 | pubmed |
Caldivirga maquilingensis IC-167 | ABW02444.1 AEG76945.1 |
A8M9X3 | |||||
| endo-β-1,4-glucanase A (EglA; EGPf; TCel1; PF0854) (Cel12) | 3.2.1.4 | pubmed |
Pyrococcus furiosus DSM 3638 | AAL80978.1 AAD54602.1 AAE50601.1 AAM56799.1 AAW12536.1 ABJ38334.1 ACM94275.1 ACW20099.1 AEG76943.1 NP_578583.1 |
E7FHY8 Q9V2T0 |
3VGI[A] 3WQ0[A] 3WQ1[A] 3WQ7[A,B] 3WR0[A] 3WT3[A,B] 3WXP[A] 3WY6[A] |
||||
| endo-β-1,4-glucanase (SsGluC) | 3.2.1.4 | pubmed |
Saccharolobus shibatae B12 | CZS63539.1 | A0A1B5G0A1 | |||||
| cellulase (CelB;SSO2534) | 3.2.1.4 | pubmed |
Saccharolobus solfataricus P2 | CAC24331.1 AAK42663.1 NP_343873.1 |
Q97VS7 | |||||
| endoglucanase (SSO1354) | 3.2.1.4 | pubmed |
Saccharolobus solfataricus P2 | AAK41590.1 NP_342800.1 |
Q97YG7 | |||||
| multidomain glycosidase (MDG; ADU37_CDS22600) | 3.2.1.4 | pubmed pubmed |
Thermococcus sp. 2319x1 | ALV63957.1 | A0A0U3SGP7 | |||||
| multidomain glycosidase (MDG; ADU37_CDS22600) | 3.2.1.4 | pubmed pubmed |
Thermococcus sp. 2319x1 | ALV63957.1 | A0A0U3SGP7 | 7S8K[A,B] | ||||
| Bacteria | ||||||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | ||||
| endoglucanase (GuxA; Acel_0615) (Cel6A-Cel12A) | 3.2.1.4 | doi |
Acidothermus cellulolyticus 11B | ABK52388.1 | A0LSH8 | 7MKR[A] 7MKS[A] |
||||
| cellulase (Cel12;AcCel12B;Acel_0619) (Cel12B) | 3.2.1.4 | pubmed |
Acidothermus cellulolyticus 11B | ABK52392.1 | A0LSI2 | |||||
| endo-β-1,4-glucanase / xyloglucanase (XG12;BLi03304;BL02586) (Cel12A) | 3.2.1.4 3.2.1.151 |
pubmed pubmed |
Bacillus licheniformis DSM 13 = ATCC 14580 | AAU42138.1 AAU24774.1 |
Q65FM6 Q7X4S4 |
2JEM[A,B] 2JEN[A] |
||||
| endo-β-1,4-glucanase (Cel12A) (Cel12A) | 3.2.1.4 | pubmed |
Bacillus licheniformis GXN151 | AAP44491.1 | Q7X4S4 | |||||
| multifunctional glycoside hydrolase (Cdan_2053; SOJ16_001858) | 3.2.1.73 | doi |
Caldicellulosiruptor danielii | WP_045175321.1 WPX08008.1 |
||||||
| multifunctional glycoside hydrolase (Cmor_0543; OTK00_002183) | 3.2.1.73 | doi |
Caldicellulosiruptor morganii DSM 8990 | WAM33661.1 WP_082054593.1 |
||||||
| Rv1090 (Cel12) (fragment) | 3.2.1.4 | pubmed |
Mycobacterium tuberculosis H37Rv | CAA17206.1 AFN48988.1 CCP43843.1 NP_215606.1 |
O53438 | |||||
| endo-1,4-glucanase S | 3.2.1.4 | pubmed |
Pectobacterium carotovorum SCC3193 | AAA24817.1 AAR63651.1 AAR67704.1 ABJ29235.1 ACP76254.1 |
P16630 | |||||
| endo-1,4-glucanase B (CelB) | 3.2.1.4 | pubmed |
Pectobacterium carotovorum subsp. carotovorum LY34 | AAC02965.2 | O31030 | |||||
| endo-β-1,4-glucanase (CMCase; W5S_2949) | 3.2.1.4 | doi |
Pectobacterium sp. SCC3193 | AFI91032.1 | P16630 | |||||
| cellulase A (CelA) (Cel12A) | 3.2.1.4 | pubmed |
Rhodothermus marinus ITI378 | AAB65594.1 AAR63650.1 AAR67703.1 ABJ29234.1 ACP76253.1 |
O33897 | 1H0B[A,B] 2BW8[A,B] 2BWA[A,B] 2BWC[A,B] 3B7M[A,B,C,D] |
||||
| xyloglucanase / type III effector (NopAA; GunA) | 3.2.1.151 | pubmed |
Sinorhizobium fredii USDA257 | AGH09926.1 | A0A0T6ZV48 M4PUR5 |
6SDU[A,B,C,D] | ||||
| cellulose endo-β-1,4-glucosidase (STHERM_c20650) | 3.2.1.4 | pubmed |
Spirochaeta thermophila DSM 6192 | ADN02999.1 | E0RQU3 | |||||
| endo-β-1,4-glucanase (CelA2;Cel2) | 3.2.1.4 | pubmed |
Streptomyces halstedii JM8 | AAC45429.1 | O08468 | |||||
| endo-β-1,4-glucanase (CelB;CelB2;EGI) | 3.2.1.4 | pubmed |
Streptomyces lividans 1326 | AAB71950.1 AAR63649.1 AAR67702.1 ABH87634.1 ABJ29233.1 ACP76252.1 |
Q54331 | 1NLR[A] 2NLR[A] |
||||
| endo-β-1,4-glucanase S (EglS) | 3.2.1.4 | pubmed |
Streptomyces rochei A2 | CAA52139.1 | Q59963 | |||||
| cellulase 12A (Cel12A) | 3.2.1.4 | pubmed |
Streptomyces sp. 11AG8 | AAF91283.1 AAE59731.1 AAQ25310.1 AAQ31830.1 AAR63648.1 AAR67701.1 ACP76251.1 |
Q9KIH1 | 1OA4[A] | ||||
| endo-β-1,4-glucanase (Cel;CelStrep) | 3.2.1.4 | pubmed |
Streptomyces sp. G12 | CCI74016.1 | I7L8N7 | |||||
| endo-β-1,4-glucanase S1 (CelS1) | 3.2.1.4 | doi |
Streptomyces viridosporus T7A | AAD25090.1 | Q9X602 | |||||
| endo-β-1,4-glucanase (Cel) | 3.2.1.4 | URL |
Streptomyces xylophagus KX6 | ACN56471.1 | D2D3J0 | |||||
| endo-β-1,4-glucanase A (CelA;TmCel12A;TM1524;TM_1524;Tmari_1532) (Cel12A) | 3.2.1.4 | pubmed |
Thermotoga maritima MSB8 | AGL50456.1 AAD36591.1 AHD18579.1 AKE29285.1 CAA93273.1 NP_229324.1 |
G4FFR2 Q60032 Q9S5X8 |
3AMH[A,B] 3AMM[A,B] 3AMN[A,B] 3AMP[A,B] 3AMQ[A,B,C,D] 3O7O[A,B] 3VHN[A,B,C,D,E,F,G,H] 3VHO[A,B] 3VHP[A,B] |
||||
| endo-β-1,4-glucanase B (CelB;TM1525) (Cel12B) | 3.2.1.4 | pubmed |
Thermotoga maritima MSB8 | AAD36592.1 AGL50457.1 AHD18578.1 AKE29286.1 CAA93274.1 NP_229325.1 |
G4FFR3 Q60033 Q7DF96 |
|||||
| endo-β-1,4-glucanase A (CelA) | 3.2.1.4 | pubmed |
Thermotoga neapolitana | AAC95059.1 CAB06783.1 |
O08428 P96491 |
|||||
| endo-β-1,4-glucanase B (CelB) | 3.2.1.4 | pubmed |
Thermotoga neapolitana | AAC95060.1 CAB06782.1 |
P96492 Q798L1 |
|||||
| cellulase (TCel2;Tpet_1267) | 3.2.1.4 | pubmed |
Thermotoga petrophila RKU-1 | ABQ47281.1 | A5IM58 | |||||
| cellulase (TCel5;Tpet_1268) | 3.2.1.4 | pubmed |
Thermotoga petrophila RKU-1 | ABQ47282.1 | A5IM59 | |||||
| endoglucanase (RSC-EG1) | 3.2.1.4 | pubmed |
uncultured bacterium | AFD36891.1 | H9BVK4 | |||||
| cellulase (Lc-CelA) | 3.2.1.4 | pubmed |
uncultured bacterium | AHL27894.1 | W8PWF3 | 3WX5[A,B] | ||||
| Eukaryota | ||||||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | ||||
| endo-β-1,4-glucanase 1 (Cmc1;Cmc-1;FI CM-cellulase;FI-CMCase) | 3.2.1.4 | pubmed |
Aspergillus aculeatus F-50 | BAA00435.1 AAR63632.1 AAR67685.1 ABJ29216.1 ACP76235.1 CAA36757.1 |
P22669 | 5GM3[A,B] 5GM4[A,B,C,D,E,F,G] 5GM5[A,B,C,D,E,F,G] |
||||
| endo-β-1,4-glucanase (xyloglucan-specific) (XEG1) | 3.2.1.151 | pubmed |
Aspergillus aculeatus KSM 510 | AAD02275.1 | O94218 | 3VL8[A] 3VL9[A,B] 3VLB[B,D] |
||||
| xyloglucanase (GH12B; Xgh12B; AsCeGH12B) | 3.2.1.151 | pubmed |
Aspergillus cervinus VKPM F-612 | AWN00461.1 | A0A2U8UBT0 | |||||
| endo-β-1,4-glucanase (GH12A; Bgh12A; AsCeGH12A) | 3.2.1.4 | pubmed |
Aspergillus cervinus VKPM F-612 | AYM46706.1 | A0A3G2C3I4 | |||||
| endo-xyloglucanase (XegA;AclaXegA;ACLA_029940) | 3.2.1.151 | pubmed |
Aspergillus clavatus NRRL 1 | EAW08261.1 | A1CRJ0 | |||||
| endoglucanase (AfCel12A;Afu7g06150;AFUA_7G06150) (Cel12A) | 3.2.1.4 3.2.1.151 |
pubmed pubmed |
Aspergillus fumigatus Af293 | EAL86857.1 | Q4WGT4 | |||||
| endoglucanase (Cel12B) | 3.2.1.4 | pubmed |
Aspergillus kawachii IFO 4308 | AAM77715.1 AAR63634.1 AAR67687.1 ABJ29218.1 ACP76237.1 |
Q8NJY2 | |||||
| endo-β-1,4-glucanase (CekA) | 3.2.1.4 | pubmed |
Aspergillus kawachii IFO 4308 | AAR63633.1 AAR67686.1 ABJ29217.1 ACP76236.1 BAA02297.1 |
Q12679 | |||||
| endo-β-1,4-glucanase (xyloglucan-specific) (AN0452.2) | 3.2.1.151 | pubmed |
Aspergillus nidulans FGSC A4 | EAA66551.1 ABF50842.1 |
Q5BG78 | |||||
| endo-β-1,4-glucanase (EglA; AnEglA) | 3.2.1.4 | pubmed |
Aspergillus niger CBS 120.49 / N400 | AAE60101.1 AAE84291.1 CAA03652.1 CAA03657.1 CAA11964.1 CAG17891.1 |
O74705 | 1KS4[A] 1KS5[A] |
||||
| endo-β-1,4-glucanase (EglA;An14g02760) | 3.2.1.4 | pubmed |
Aspergillus niger CBS 513.88 | CAK46524.1 | A2R322 | |||||
| endoglucanase | 3.2.1.4 | pubmed |
Aspergillus niger HO | AIX97359.1 | O74705 | |||||
| xyloglucan-specific endo-β-1,4-glucanase (Xeg12A) | 3.2.1.151 | pubmed |
Aspergillus niger N402 | ABF46829.1 | A1XP58 | |||||
| endoglucanase A (EglA) (partial) | 3.2.1.4 | pubmed |
Aspergillus niger VTCC F-021 / VTCC-F021 | ADD12042.1 | D3YC02 | |||||
| xyloglucan-specific endo-β-1,4-glucanase (XegA) | 3.2.1.151 | pubmed |
Aspergillus niveus PR-2 | AEV23011.1 | H6TQN1 | 4NPR[A,B] | ||||
| endo-β-1,4-glucanase (CelA) | 3.2.1.4 | pubmed |
Aspergillus oryzae KBN616 | BAA22588.1 AAR63635.1 AAR67688.1 ABJ29219.1 ACP76238.1 |
O13454 | |||||
| xyloglucan-specific endo-β-1,4-glucanase (Xeg12A; AO090003000905) (Xeg12A) | 3.2.1.151 | pubmed |
Aspergillus oryzae RIB40 | BAE58022.1 | Q2UK93 | |||||
| endo-β-1,4-glucanase (CelA;AO090026000102) | 3.2.1.4 | pubmed |
Aspergillus oryzae RIB40 | BAE59597.1 | Q2UFR8 | |||||
| endoglucanase (EglD;AtEglD;AtGH12;ATEG_09894) | 3.2.1.4 | pubmed |
Aspergillus terreus NIH2624 | EAU30085.1 XP_001218516.1 |
Q0C8U0 | cryst | ||||
| endo-β-1,4-glucanase (AuCel12A) (Cel12A) | 3.2.1.4 | pubmed |
Aspergillus usamii E001 | AEL12376.1 | G1ETN1 | |||||
| mixed β-1,3-1,4-glucanase (Mlg2) | 3.2.1.4 3.2.1.73 |
pubmed pubmed |
Bipolaris zeicola | AAF65311.1 | Q9P8N6 | |||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Chaetomium brasiliense CBS 140.50 | AAM77701.1 AAR63638.1 AAR67691.1 ABJ29222.1 ACP76241.1 |
Q8NJZ6 | |||||
| endo-β-1,3-1,4-glucanase (CtGlu12) | 3.2.1.73 | pubmed |
Chaetomium sp. CQ31 | A0A915Q9D1 | 7EE2[A] 7EEE[A] 7EEJ[A] |
|||||
| endoglucanase (EG3; EG III) | 3.2.1.4 | pubmed |
Chrysosporium lucknowense | AAQ38148.1 ACH15006.1 |
||||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Clonostachys rosea 1003 | AAM77706.1 | Q8NJZ1 | |||||
| endoglucanase (Cel12B) | 3.2.1.4 | pubmed |
Clonostachys rosea 1003 | AAM77707.1 AAR63643.1 AAR67696.1 ABJ29227.1 ACP76246.1 |
Q8NJZ0 | |||||
| endoglucanase (Cel12C) | 3.2.1.4 | pubmed |
Clonostachys rosea 1003 | AAM77708.1 AAR63644.1 AAR67697.1 ABJ29228.1 ACP76247.1 |
Q8NJY9 | |||||
| endoglucanase (Cel12D) | 3.2.1.4 | pubmed |
Clonostachys rosea 1003 | AAM77709.1 AAR63645.1 AAR67698.1 ABJ29229.1 ACP76248.1 |
Q8NJY8 | |||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Emericella desertorum CBS 653.73 | AAM77702.1 AAR63647.1 AAR67700.1 ABJ29231.1 ACP76250.1 |
Q8NJZ5 | |||||
| endoglucanase II (EG-II;Eg2;EG35) (Cel12) | 3.2.1.4 | pubmed |
Fomitopsis palustris FFPRI 0507 | BAF49602.1 | A4PID1 | |||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Fusarium equiseti CBS 185.34 | AAM77703.1 AAR63639.1 AAR67692.1 ABJ29223.1 ACP76242.1 |
Q8NJZ4 | |||||
| xyloglucanase (fg05851;FGSG_05851) (6993) | 3.2.1.151 | pubmed |
Fusarium graminearum PH-1 | XP_386027.1 | ||||||
| broad specificity endo-β-glucanase (fg11037;FGSG_11037) (7138) | 3.2.1.4 | pubmed |
Fusarium graminearum PH-1 | XP_391213.1 | ||||||
| broad specificity endo-β-glucanase (FGRAMPH1_01T25915; fg07892;FGSG_07892) (7048) | 3.2.1.4 | pubmed |
Fusarium graminearum PH-1 | SCB65334.1 XP_388068.1 |
I1RUJ7 | |||||
| broad specificity endo-β-glucanase (fgd146-200;FGSG_16349) (7213) | 3.2.1.4 | pubmed |
Fusarium graminearum PH-1 | XP_383205.1 | ||||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Fusarium striatum CBS 203.32 | AAM77704.1 AAR63640.1 AAR67693.1 ABJ29224.1 ACP76243.1 |
Q8NJZ3 | |||||
| endoglucanase (Cel12B) | 3.2.1.4 | pubmed |
Fusarium striatum CBS 203.32 | AAM77705.1 AAR63641.1 AAR67694.1 ABJ29225.1 ACP76244.1 |
Q8NJZ2 | |||||
| endo-β-1,4-glucanase (Cel12g;GtCel12A) (Cel12A) | 3.2.1.4 | pubmed |
Gloeophyllum trabeum ATCC 11539 | AEJ35167.1 AEM23897.1 |
F8T946 P84196 |
|||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Humicola grisea ATCC 22081 | AAM77714.2 AAR63636.1 AAR63637.1 AAR67689.1 AAR67690.1 ABJ29220.1 ABJ29221.1 ACP76239.1 ACP76240.1 |
Q8NJY3 | 1OLR[A] 1UU4[A] 1UU5[A] 1UU6[A] 1W2U[A] |
||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Hypocrea schweinitzii ATCC 66965 | AAM77711.1 AAE59776.1 AAN19481.1 AAO95540.1 AAQ42102.1 AAR63631.1 AAR67684.1 ABJ29215.1 ACP76234.1 |
Q8NJY6 | 1OA3[A,B,C,D] | ||||
| endoglucanase (PDE_06439) (Cel12A) | 3.2.1.4 | pubmed |
Penicillium oxalicum 114-2 | EPS31484.1 | S7ZMB4 | |||||
| acid-stable endoxyloglucanase / xyloglucan-specific endo-β-1,4-glucanase (PoXeg12A) (Xeg12A) | 3.2.1.151 | pubmed |
Penicillium oxalicum HP7-1 | AJA40324.1 | A0A0A7RRF2 | |||||
| endoglucanase 28 (Cel12A) | 3.2.1.4 | pubmed |
Phanerochaete chrysosporium K3 | AAU12276.1 | Q66NB6 | |||||
| xyloglucan-specific endoglucanase (EGL12-G;XEG1;PsXEG1;Ps109681;PHYSODRAFT_559651) (Cel12G) | 3.2.1.151 | pubmed |
Phytophthora sojae | ABB22029.1 EGZ16757.1 |
G4ZHR2 Q30BZ2 |
7DRB[A,C] 7DRC[A] 7W3V[A] |
||||
| endoglucanase (Cel3A;CMCase3a;CMCase IIIa) | 3.2.1.4 | doi |
Polyporus arcularius 69B-8 | BAD98315.1 | Q50LE3 | |||||
| endo-β-1,4-glucanase (PpCel12A) (partial) (Cel12A) | 3.2.1.4 | pubmed |
Postia placenta Mad-698-R | ADH51731.1 | D7REW4 | |||||
| endo-β-1,3-1,4-glucanase (MoCel12A;MG00677.4) (Cel12A) | 3.2.1.73 | pubmed |
Pyricularia oryzae 70-15 | XP_368567.1 | G4NAZ1 | |||||
| endo-xyloglucanase (MoCel12C;MG10972.4) (Cel12C) | 3.2.1.151 | pubmed |
Pyricularia oryzae 70-15 | XP_361895.1 | G4NBX2 | |||||
| endo-β-1,3-1,4-glucanase (MoCel12B;MG08537.4) (Cel12B) | 3.2.1.73 | pubmed |
Pyricularia oryzae 70-15 | XP_362900.1 | G4N5V2 | |||||
| xyloglucanase B (RmXEG12B) (Xeg12B) | 3.2.1.151 | pubmed |
Rhizomucor miehei CAU432 | AGC24033.1 | M9PK16 | |||||
| xyloglucanase A (RmXEG12A) (Xeg12A) | 3.2.1.151 | pubmed |
Rhizomucor miehei CAU432 | AGC24032.1 | M9PJT0 | |||||
| β-glucanase (lichenase-like) (Cel12A) | 3.2.1.4 | pubmed |
Stachybotrys chartarum CECT 20565 / Stachybotrys atra BP-A | CAL48345.1 | Q08HM8 | |||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Stachybotrys echinatus CBS 304.54 | AAM77710.1 AAR63646.1 AAR67699.1 ABJ29230.1 ACP76249.1 |
Q8NJY7 | |||||
| endoglucanase 1 (Eg1; EG1) | 3.2.1.4 | doi |
Talaromyces amestolkiae CIB | ATY39123.1 | A0A2H4R494 | |||||
| endo-β-1,4-glucanase 3 / III (Egl3;EG3;EGIII;ThEG3;ThEGIII) (Cel12A) | 3.2.1.4 | pubmed |
Trichoderma harzianum IOC-3844 | AFK32784.1 | I3RY46 | 4H7M[A,B] | ||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Trichoderma koningii ATCC 2613 | AAM77712.1 | Q8NJY5 | |||||
| endo-β-1,4-glucanase III (Egl3;EGIII;EG III;EG3;TrCel12A) (Cel12A) | 3.2.1.4 | pubmed |
Trichoderma reesei QM9414 | AAE59774.1 AAE59775.1 AAN19479.1 AAN19480.1 AAO95538.1 AAO95539.1 AAQ24888.1 AAQ42100.1 AAQ42101.1 AAR60524.1 AAR63629.1 AAR63630.1 AAR67682.1 AAR67683.1 ABE22099.1 ABJ29213.1 ABJ29214.1 ABV71388.1 ACP76232.1 ACP76233.1 BAA20140.1 |
O00095 | 1H8V[A,B,C,D,E,F] 1OA2[A,B,C,D,E,F] 1OLQ[A,B] |
||||
| endoglucanase (Cel12A) | 3.2.1.4 | pubmed |
Trichoderma viride ATCC 26802 | AAM77713.1 | Q8NJY4 | |||||
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