Auxiliary Activity Family 17

Mechanism peroxygenase
NoteFamily created after the characterization of Phytophthora infestans enzymes by Sabbadin et. al., (PMID:34385392). AA17 are copper-dependent lytic polysaccharide monooxygenases (LPMOs) found in oomycetes; binding and cleavage of homogalacturonan with oxidation of C-4 has been demonstrated for three AA17 LPMOs from Phytophtora infestans; oxidative polygalacturonase; C4-oxidative cleavage of polygalacturonic acid, generating a C4-ketone in a b-position relative to one carboxylic group, resulting in an unstable b-keto acid that undergoes spontaneous decarboxylation and tautomerization
Statistics GenBank accession (89); Uniprot accession (6); PDB accession (3); 3D entries (3); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lytic polygalacturonic acid monooxygenase (PiAA17C; PITG_04949) 1.14.99.- Phytophthora infestans T30-4 EEY68486.1 D0N2F7
6Z5Y[A,B] 1.01
 lytic polygalacturonic acid monooxygenase 17B (PsAA17B; PHYSODRAFT_485524) 1.14.99.- Phytophthora sojae P6497 EGZ23520.1
XP_009518808.1
G4YSM7
8S71[A,B] 2.05
 lytic polygalacturonic acid monooxygenase 17A (PsAA17A; PHYSODRAFT_483955) 1.14.99.- Phytophthora sojae P6497 EGZ23516.1 G4YSM3
8S6S[A,B] 1.79
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