Auxiliary Activity Family 17

Mechanism peroxygenase
NoteFamily created after the characterization of Phytophthora infestans enzymes by Sabbadin et. al., (PMID:34385392). AA17 are copper-dependent lytic polysaccharide monooxygenases (LPMOs) found in oomycetes; binding and cleavage of homogalacturonan with oxidation of C-4 has been demonstrated for three AA17 LPMOs from Phytophtora infestans; oxidative polygalacturonase; C4-oxidative cleavage of polygalacturonic acid, generating a C4-ketone in a b-position relative to one carboxylic group, resulting in an unstable b-keto acid that undergoes spontaneous decarboxylation and tautomerization
Statistics GenBank accession (88); Uniprot accession (4); PDB accession (1); 3D entries (1); cryst (0)
Activity IdEC#Activity NameResidue -2Bond -1Residue -1 Reacting BondResidue +1Bond +1Residue +2Reactant
O396 1.14.99.- lytic polygalacturonan acid monooxygenase / polygalacturonan acid oxidase (C4-dehydrogenating) aDGalpA 1,4 aDGalpA 1,4o aDGalpA 1.4 aDGalpA H2O2
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