Auxiliary Activity Family 17
Mechanism | peroxygenase |
Note | Family created after the characterization of Phytophthora infestans enzymes by Sabbadin et. al., (PMID:34385392). AA17 are copper-dependent lytic polysaccharide monooxygenases (LPMOs) found in oomycetes; binding and cleavage of homogalacturonan with oxidation of C-4 has been demonstrated for three AA17 LPMOs from Phytophtora infestans; oxidative polygalacturonase; C4-oxidative cleavage of polygalacturonic acid, generating a C4-ketone in a b-position relative to one carboxylic group, resulting in an unstable b-keto acid that undergoes spontaneous decarboxylation and tautomerization |
Statistics | GenBank accession (89); Uniprot accession (4); PDB accession (3); 3D entries (3); cryst (0) |
Activity Id | EC# | Activity Name | Residue -2 | Bond -1 | Residue -1 |
Reacting Bond | Residue +1 | Bond +1 | Residue +2 | Reactant |
O396 |
1.14.99.- |
lytic polygalacturonan acid monooxygenase / polygalacturonan acid oxidase (C4-dehydrogenating) |
aDGalpA |
1,4 |
aDGalpA |
1,4o |
aDGalpA |
1.4 |
aDGalpA |
H2O2 |
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