| Activities in Family | L-rhamnose-α-1,4-D-glucuronate lyase (EC 4.2.2.28); |
|---|---|
| Mechanism | b-elimination |
| 3D Structure Status | 7-fold β-propeller |
| Note | Formerly known as glycoside hydrolase family GH145 (Munoz-Munoz et al., PMID=28396425); subsequently reclassified as PL42 based on the publications of Kondo T et al. JBC 2021 (PMID=34303708) and Munoz-Munoz et al., mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25. |
| External resources | CAZypedia; |
| Statistics | GenBank accession (766); Uniprot accession (5); PDB accession (11); 3D entries (5); cryst (0) |
| Bacteria | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| L-Rhα-a-1,4-GlcA α-L-rhamnohydrolase (BACCELL_00856) | 4.2.2.28 | pubmed |
Bacteroides cellulosilyticus DSM 14838 | EEF91490.1 | E2N9B1 | 5MVH[A] | |
| L-Rhα-a-1,4-GlcA α-L-rhamnohydrolase / exo-acting α-L-rhamnosidase (BT3686; BT_3686) | 4.2.2.28 | pubmed |
Bacteroides thetaiotaomicron VPI-5482 | AAO78791.1 | Q8A1H5 | 5MUK[A] 5MUL[A] |
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| Eukaryota | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| L-rhamnose-α-1,4-D-glucuronate lyase (Forham1) | 4.2.2.28 | pubmed |
Fusarium oxysporum 12S | BCT36655.1 | A0A8D5PZ14 | 7ESK[A] 7ESL[A] 7ESM[A] 7ESN[A] 7YQS[A] 8I4D[A] |
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