| Activities in Family | L-rhamnose-α-1,4-D-glucuronate lyase (EC 4.2.2.28); |
|---|---|
| Mechanism | b-elimination |
| 3D Structure Status | 7-fold β-propeller |
| Note | Formerly known as glycoside hydrolase family GH145 (Munoz-Munoz et al., PMID=28396425); subsequently reclassified as PL42 based on the publications of Kondo T et al. JBC 2021 (PMID=34303708) and Munoz-Munoz et al., mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25. |
| External resources | CAZypedia; |
| Statistics | GenBank accession (990); Uniprot accession (5); PDB accession (11); 3D entries (5); cryst (0) |