Polysaccharide Lyase Family 42

Activities in FamilyL-rhamnose-α-1,4-D-glucuronate lyase (EC;
Mechanism b-elimination
3D Structure Status7-fold β-propeller
NoteFormerly known as glycoside hydrolase family GH145 (Munoz-Munoz et al., PMID=28396425); subsequently reclassified as PL42 based on the publications of Kondo T et al. JBC 2021 (PMID=34303708) and Munoz-Munoz et al., mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25.
External resourcesCAZypedia;
Statistics GenBank accession (789); Uniprot accession (5); PDB accession (11); 3D entries (5); cryst (0)

Last update: 2024-07-09 © Copyright 1998-2024
AFMB - CNRS - Université d'Aix-Marseille