Polysaccharide Lyase Family 42

Activities in FamilyL-rhamnose-α-1,4-D-glucuronate lyase (EC 4.2.2.-); L-Rhα-α-1,4-GlcA α-L-rhamnohydrolase (EC 3.2.1.-)
Mechanism b-elimination
3D Structure Status7-fold β-propeller
NoteFormerly known as glycoside hydrolase family GH145 (Munoz-Munoz et al., PMID=28396425); subsequently reclassified as PL42 based on the publications of Kondo T et al. JBC 2021 (PMID=34303708) and Munoz-Munoz et al., mBio 2021 (PMID=34340552) showing lyase activity on aLRha-1,4-aDGlcA. Several members of the family show hydrolase activity catalyzed by a non-invariant active site on the posterior side of the b-propeller structure while the lyase active site on the anterior surface is well conserved and shows similarities to PL24 and PL25.
External resourcesCAZypedia;
Statistics GenBank accession (426); Uniprot accession (4); PDB accession (9); 3D entries (5); cryst (0)


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