Polysaccharide Lyase Family 24

Activities in FamilyGlucuronic ulvan lyase (EC 4.2.2.-);
Iduronic ulvan lyase (EC 4.2.2.-);
Mechanism b-elimination
3D Structure Status7-bladed β-propeller
NoteFamily created after Kopel et al. (2016) J. Biol. Chem., 291, 5871-5878 [PMID=26763234]. Ulvan lyases cleave the bond between 3-sulfated rhamnose (Rha3S) linked to either D-glucuronic acid (GlcA) or L-iduronic acid (IduA) in the marine polysaccharide ulvan. Members of this family are known to specifically cleave the b(1,4) glycosidic bond between GlcUA and R3S residues by b-elimination.
Statistics GenBank accession (62); Uniprot accession (6); PDB accession (6); 3D entries (2); cryst (0)

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