Activities in Family	Hexosyltransferases (EC 2.4.1.-); UDP-Gal α-galactosyltransferase (EC 2.4.1.-); UDP-Gal:glucoside α-1,3-galactosyltransferase (EC 2.4.1.-); UDP-Glc: LOS α-1,3-glucosyltransferase (EC 2.4.1.-); UDP-GlcA: inositol phosphorylceramide α-glucuronosyltransferase (EC 2.4.1.-); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-); UDP-GlcNAc: α-N-acetylglucosaminyltransferase (EC 2.4.1.-); α-1,3-galactosyltransferase (EC 2.4.1.-); α-glucosyltransferase (EC 2.4.1.-); β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-); Chiro-inositol 1-α-galactosyltransferase / fagopyritol synthase (EC 2.4.1.-); Homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.-); UDP-Gal: myo-inositol 3-α-galactosyltransferase (EC 2.4.1.123); [retaining] glycogenin α-glucosyltransferase (EC 2.4.1.186); LPS 3-α-galactosyltransferase (EC 2.4.1.44); UDP-Glc: LPS α-glucosyltransferase (EC 2.4.1.58); UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (EC 2.4.2.-); [inverting] UDP-Xyl: protein O-β-xylosyltransferase (EC 2.4.2.-); [retaining] UDP-Xyl: aDXylp-1,3-aDGlcp-O-Ser α-1,3-xylosyltransferase (EC 2.4.2.62);
Mechanism	Retaining
3D Structure Status	GT-A
Note	Distant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resources	Glymap; HOMSTRAD;
Commercial Enzyme Provider(s)	CHEMILY;
Statistics	GenBank accession (24224); Uniprot accession (107); PDB accession (63); 3D entries (12); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Apre_0416		Anaerococcus prevotii DSM 20548	ACV28465.1		3TZT[A,B] 2.10
bimodular LPS [galactan I] α-1,3-galactopyranosyltransferase / β-1,3-galactofuranosyltransferase (WbbM;RfbC)	2.4.1.-	Klebsiella pneumoniae 01:K20 / 889/50	AAC98416.1	Q48484	6U4B[A] 2.10
UDP-Gal: α-1,4-galactosyltransferase (LgtC)	2.4.1.-	Neisseria meningitidis 126E	AAB48385.1	P96945 Q93EK7	1G9R[A] 2.00 1GA8[A] β-D-4-deoxy-Glcp-(1-4)-β-D-Glcp 2.00 1SS9[A] 2.60
cytosolic O-glycosyltransferase - binding subunit GtfB (Gtf2;GtfB)		Streptococcus gordonii M99	AAS86345.1		5E9T[B,D] 2.92 5E9U[B,D,F,H] β-D-GlcpNAc 3.84
UDP-Gal: galactosyltransferase (GlyE;SP1766)	2.4.1.-	Streptococcus pneumoniae TIGR4	AAK75841.1 NP_346201.1	A0A0H2URJ6 Q97P76	5GVV[A,F] 1.95 5GVW[A,B,C,D] 2.40
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
glycogenin α-glucosyltransferase (Gyg-1;Uvt-5;CeGN;CELE_F56B6.4)	2.4.1.186	Caenorhabditis elegans Bristol N2	NP_741749.1 AAB04562.1 AAL11464.1 AAM69110.1 CCD64318.1 CCD64319.1 CCD64320.1 NP_508608.1 NP_508609.1	H2KYQ5 Q95Q50	4QLB[E,F,G,H] 2.60
UDP-Gal: glucoside α-1,3-galactosyltransferase (Gat1; PuGat1)	2.4.1.-	Globisporangium ultimum DAOM BR144		K3WC47	6MW8[A] 1.76 6MW5[A] 2.10
glycogenin (Gyg;Gyg1;GYG1)	2.4.1.186	Homo sapiens	AAH00033.1 AAB00114.1 AAB09752.1 AAD31084.1 AAD52093.1 AAH31096.2 AAV20877.1 ACM81895.1 BAG35212.1 BAG61788.1 CAA56073.1 CAC22472.1 CAG38784.1 NP_004121.2 XP_051426.1 XP_051427.1 XP_051428.2	B2R5R5 B4DSX6 D3DNH1 D3DNH2 P46976 Q6FHZ1 Q8N5Y3	3Q4S[A] 1.98 3QVB[A] 2.26 3RMV[A] 1.82 3RMW[A] 1.93 3T7M[A,B] 1.80 3T7N[A,B] 1.98 3T7O[A,B] α-D-Glcp 1.85 3U2T[A] 2.05 3U2U[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-0)-TYR 1.45 3U2V[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-0)-TYR 1.50 3U2W[A,B] α-D-Glcp 1.68 3U2X[A,B] D-1-deoxy-Glcp 1.77 6EQJ[A] 2.18 6EQL[A,B] 2.38 7Q0B[E,F,G,H] 3.00 7Q0S[E,F,G,H] P-(0-6)-α-L-Manp 4.00 7Q12[B,C,D,E] P-(0-6)-α-L-Manp 3.70 7Q13[B,C,D,E] P-(0-6)-α-L-Manp α-D-Glcp 3.00 7ZBN[C,D,G,H] 2.62 8CVX[B,C,D,E] P-(0-6)-α-D-Glcp 3.50 8CVY[B,D,F] 3.60 8CVZ[A,F,G,H,I,J] 3.52
glycogenin 2 (Gyg2)	2.4.1.186	Homo sapiens	AAB84377.1 AAB84374.1 AAB84375.1 AAB84376.1 AAB84378.1 AAB84379.1 AAF61855.1 AAH23152.1 BAF85185.1 BAG53568.1 NP_003909.1 XP_043483.1	A8K8Y1 B3KUV6 O15488	4UEG[A,B] 1.93
bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1)	2.4.2.-	Homo sapiens	CAA07571.1 AAI17426.1 AAI26405.1 ACM81049.1 ACM83412.1 AHW56517.1 AHW56672.1 AHW56712.1 AHW56713.1 BAA25535.2 BAA25535.3 BAH11875.1 BAH12135.1 BAH13559.1 CAB62965.1 CAG30396.1 CAI17890.1 CAI17950.1 CAI18754.1 CAI18769.1 CAI18772.1 CAI18784.1 CAI18785.1 CAI18788.1 CAQ06854.1 CAQ06855.1 CAQ06856.1 CAQ08276.1 CAQ08280.1 CAQ08281.1 CAQ08796.1 CAQ08800.1 CAQ08801.1 CAQ09323.1 CAQ09433.1 CAQ09434.1 CAQ09435.1 CAQ09639.1 CAQ09894.1 CAQ09895.1 CAQ09896.1 CAQ10763.1 CAQ11002.1 CAX14873.1 CAX14874.1 CAX14935.1 CAX14936.1 CAX15214.1 CAX15215.1 NP_004728.1 NP_598397.1	B0QY09 B0QY11 B7Z2I9 B7Z399 B7Z7C3 B7ZB84 B7ZB85 O95461 X5D9N1 X5DR28 X5DRG1 X5DRJ7	7UI6[A,B] 3.70 7UI7[A,B] 3.40 7ZVJ[A,B] 2.61
UDP-Xyl: xyloside α-1,3-xylosyltransferase 1 (XXYLT1; MGC:19367)	2.4.2.62	Mus musculus	AAH31419.1 BAE32468.1 BAE38667.1 NP_941028.1	Q3U4G3	4WLG[B] 3.00 4WLM[A,B] 3.00 4WLZ[B] 3.03 4WM0[A] 2.37 4WMA[A] 1.62 4WMB[A] 2.05 4WMI[A] 1.87 4WMK[A] 2.08 4WN2[A] 1.95 4WNH[A] 1.95
glycogenin (Gyg)	2.4.1.186	Oryctolagus cuniculus	AAA31404.1	P13280	1LL0[A,B,C,D,E,F,G,H,I,J] 3.43 1LL2[A] 1.90 1LL3[A] 1.90 1ZCT[A,B] 2.60 1ZCU[A] 2.00 1ZCV[A] 1.98 1ZCY[A] 1.99 1ZDF[A] 2.45 1ZDG[A] 2.30 3USQ[A] 2.40 3USR[A] 2.10 3V8Y[A] 2.15 3V8Z[A] 2.20 3V90[A] 2.00 3V91[A] 2.00
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