GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8766); Uniprot accession (1210); PDB accession (41); 3D entries (9); cryst (0)
All (7156) Archaea (7) Bacteria (5752) Eukaryota (1256) Viruses (138) unclassified (3) Structure (9) Characterized (52)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Apre_0416   Anaerococcus prevotii DSM 20548 ACV28465.1 C7RG54
3TZT[A,B] 2.10
 UDP-Gal: α-1,4-galactosyltransferase (LgtC) 2.4.1.- Neisseria meningitidis 126E AAB48385.1 P96945
1G9R[A] 2.00
1GA8[A] β-D-4-deoxy-Glcp-(1-4)-β-D-Glcp
2.00
1SS9[A] 2.60
 cytosolic O-glycosyltransferase - binding subunit GtfB (Gtf2;GtfB)   Streptococcus gordonii M99 AAS86345.1 Q79T00
5E9T[B,D] 2.92
5E9U[B,D,F,H] β-D-GlcpNAc
3.84
 UDP-Gal: galactosyltransferase (GlyE;SP1766) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75841.1
NP_346201.1
Q97P76
5GVV[A,F] 1.95
5GVW[A,B,C,D] 2.40
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 glycogenin α-glucosyltransferase (Gyg-1;Uvt-5;CeGN;CELE_F56B6.4) 2.4.1.186 Caenorhabditis elegans Bristol N2 NP_741749.1
AAB04562.1
AAL11464.1
AAM69110.1
CCD64318.1
CCD64319.1
CCD64320.1
NP_508608.1
NP_508609.1
H2KYQ5
Q95Q50
4QLB[E,F,G,H] 2.60
 glycogenin (Gyg;Gyg1;GYG1) 2.4.1.186 Homo sapiens AAH00033.1
AAB00114.1
AAB09752.1
AAD31084.1
AAD52093.1
AAH31096.2
AAV20877.1
ACM81895.1
BAG35212.1
BAG61788.1
CAA56073.1
CAC22472.1
CAG38784.1
NP_004121.2
XP_051426.1
XP_051427.1
XP_051428.2
D3DNH1
D3DNH2
P46976
Q6FHZ1
3Q4S[A] 1.98
3QVB[A] 2.26
3RMV[A] 1.82
3RMW[A] 1.93
3T7M[A,B] 1.80
3T7N[A,B] 1.98
3T7O[A,B] α-D-Glcp
1.85
3U2T[A] 2.05
3U2U[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-0)-TYR
1.45
3U2V[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-0)-TYR
1.50
3U2W[A,B] α-D-Glcp
1.68
3U2X[A,B] D-1-deoxy-Glcp
1.77
 glycogenin 2 (Gyg2) 2.4.1.186 Homo sapiens AAB84377.1
AAB84374.1
AAB84375.1
AAB84376.1
AAB84378.1
AAB84379.1
AAF61855.1
AAH23152.1
BAF85185.1
BAG53568.1
NP_003909.1
XP_043483.1
O15488
4UEG[A,B] 1.93
 xyloside xylosyltransferase 1 (MGC:19367)   Mus musculus AAH31419.1
BAE32468.1
BAE38667.1
NP_941028.1
Q3U4G3
Q8K2I0
4WLG[B] 3.00
4WLM[A,B] 3.00
4WLZ[B] 3.03
4WM0[A] 2.37
4WMA[A] 1.62
4WMB[A] 2.05
4WMI[A] 1.87
4WMK[A] 2.08
4WN2[A] 1.95
4WNH[A] 1.95
 glycogenin (Gyg) 2.4.1.186 Oryctolagus cuniculus AAA31404.1 P13280
1LL0[A,B,C,D,E,F,G,H,I,J] 3.43
1LL2[A] 1.90
1LL3[A] 1.90
3USQ[A] 2.40
3USR[A] 2.10
3V8Y[A] 2.15
3V8Z[A] 2.20
3V90[A] 2.00
3V91[A] 2.00
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