Activities in Family	lipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-); UDP-Gal:glucoside α-1,3-galactosyltransferase (EC 2.4.1.-)
Mechanism	Retaining
3D Structure Status	GT-A
Note	Distant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resources	Glymap; HOMSTRAD;
Commercial Enzyme Provider(s)	CHEMILY;
Statistics	GenBank accession (19951); Uniprot accession (102); PDB accession (52); 3D entries (11); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
Apre_0416		Anaerococcus prevotii DSM 20548	ACV28465.1		3TZT[A,B] 2.10
bimodular LPS [galactan I] α-1,3-galactopyranosyltransferase / β-1,3-galactofuranosyltransferase (WbbM;RfbC)	2.4.1.-	Klebsiella pneumoniae 01:K20 / 889/50	AAC98416.1	Q48484	6U4B[A] 2.10
UDP-Gal: α-1,4-galactosyltransferase (LgtC)	2.4.1.-	Neisseria meningitidis 126E	AAB48385.1	P96945 Q93EK7	1G9R[A] 2.00 1GA8[A] β-D-4-deoxy-Glcp-(1-4)-β-D-Glcp 2.00 1SS9[A] 2.60
cytosolic O-glycosyltransferase - binding subunit GtfB (Gtf2;GtfB)		Streptococcus gordonii M99	AAS86345.1		5E9T[B,D] 2.92 5E9U[B,D,F,H] β-D-GlcpNAc 3.84
UDP-Gal: galactosyltransferase (GlyE;SP1766)	2.4.1.-	Streptococcus pneumoniae TIGR4	AAK75841.1 NP_346201.1	A0A0H2URJ6 Q97P76	5GVV[A,F] 1.95 5GVW[A,B,C,D] 2.40
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
glycogenin α-glucosyltransferase (Gyg-1;Uvt-5;CeGN;CELE_F56B6.4)	2.4.1.186	Caenorhabditis elegans Bristol N2	NP_741749.1 AAB04562.1 AAL11464.1 AAM69110.1 CCD64318.1 CCD64319.1 CCD64320.1 NP_508608.1 NP_508609.1	H2KYQ5 Q95Q50	4QLB[E,F,G,H] 2.60
UDP-Gal:glucoside α-1,3-galactosyltransferase	2.4.1.-	Globisporangium ultimum DAOM BR144		K3WC47	6MW8[A] 1.76 6MW5[A] 2.10
glycogenin (Gyg;Gyg1;GYG1)	2.4.1.186	Homo sapiens	AAH00033.1 AAB00114.1 AAB09752.1 AAD31084.1 AAD52093.1 AAH31096.2 AAV20877.1 ACM81895.1 BAG35212.1 BAG61788.1 CAA56073.1 CAC22472.1 CAG38784.1 NP_004121.2 XP_051426.1 XP_051427.1 XP_051428.2	B2R5R5 B4DSX6 D3DNH1 D3DNH2 P46976 Q6FHZ1 Q8N5Y3	3Q4S[A] 1.98 3QVB[A] 2.26 3RMV[A] 1.82 3RMW[A] 1.93 3T7M[A,B] 1.80 3T7N[A,B] 1.98 3T7O[A,B] α-D-Glcp 1.85 3U2T[A] 2.05 3U2U[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-0)-TYR 1.45 3U2V[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-0)-TYR 1.50 3U2W[A,B] α-D-Glcp 1.68 3U2X[A,B] D-1-deoxy-Glcp 1.77 6EQJ[A] 2.18 6EQL[A,B] 2.38
glycogenin 2 (Gyg2)	2.4.1.186	Homo sapiens	AAB84377.1 AAB84374.1 AAB84375.1 AAB84376.1 AAB84378.1 AAB84379.1 AAF61855.1 AAH23152.1 BAF85185.1 BAG53568.1 NP_003909.1 XP_043483.1	A8K8Y1 B3KUV6 O15488	4UEG[A,B] 1.93
xyloside xylosyltransferase 1 (MGC:19367)		Mus musculus	AAH31419.1 BAE32468.1 BAE38667.1 NP_941028.1		4WLG[B] 3.00 4WLM[A,B] 3.00 4WLZ[B] 3.03 4WM0[A] 2.37 4WMA[A] 1.62 4WMB[A] 2.05 4WMI[A] 1.87 4WMK[A] 2.08 4WN2[A] 1.95 4WNH[A] 1.95
glycogenin (Gyg)	2.4.1.186	Oryctolagus cuniculus	AAA31404.1	P13280	1LL0[A,B,C,D,E,F,G,H,I,J] 3.43 1LL2[A] 1.90 1LL3[A] 1.90 1ZCT[A,B] 2.60 1ZCU[A] 2.00 1ZCV[A] 1.98 1ZCY[A] 1.99 1ZDF[A] 2.45 1ZDG[A] 2.30 3USQ[A] 2.40 3USR[A] 2.10 3V8Y[A] 2.15 3V8Z[A] 2.20 3V90[A] 2.00 3V91[A] 2.00
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