GlycosylTransferase Family 8

Activities in FamilyHexosyltransferases (EC 2.4.1.-);
UDP-Gal α-galactosyltransferase (EC 2.4.1.-);
UDP-Gal:glucoside α-1,3-galactosyltransferase (EC 2.4.1.-);
UDP-Glc: LOS α-1,3-glucosyltransferase (EC 2.4.1.-);
UDP-GlcA: inositol phosphorylceramide α-glucuronosyltransferase (EC 2.4.1.-);
UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-);
UDP-GlcNAc: α-N-acetylglucosaminyltransferase (EC 2.4.1.-);
α-1,3-galactosyltransferase (EC 2.4.1.-);
α-glucosyltransferase (EC 2.4.1.-);
β-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-);
Chiro-inositol 1-α-galactosyltransferase / fagopyritol synthase (EC 2.4.1.-);
Homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.-);
UDP-Gal: myo-inositol 3-α-galactosyltransferase (EC;
[retaining] glycogenin α-glucosyltransferase (EC;
LPS 3-α-galactosyltransferase (EC;
UDP-Glc: LPS α-glucosyltransferase (EC;
UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (EC 2.4.2.-);
[inverting] UDP-Xyl: protein O-β-xylosyltransferase (EC 2.4.2.-);
[retaining] UDP-Xyl: aDXylp-1,3-aDGlcp-O-Ser α-1,3-xylosyltransferase (EC;
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (24449); Uniprot accession (109); PDB accession (63); 3D entries (12); cryst (0)

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