GlycosylTransferase Family 8

Activities in Familylipopolysaccharide α-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide α-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-α-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan α-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan α-glucuronyltransferase (EC 2.4.1.-)
Mechanism Retaining
3D Structure StatusGT-A
NoteDistant similarity to family GT24; The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-Xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesGlymap; HOMSTRAD;
Commercial Enzyme Provider(s)CHEMILY;
Statistics GenBank accession (8766); Uniprot accession (1210); PDB accession (41); 3D entries (9); cryst (0)
All (7156) Archaea (7) Bacteria (5752) Eukaryota (1256) Viruses (138) unclassified (3) Structure (9) Characterized (52)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-1,3-glucosyltransferase (WaaO) 2.4.1.58 Escherichia coli F470 AAC69676.1 Q9ZIS5  
 UDP-Glc:(glucosyl) LPS α-1,2-glucosyltransferase (WaaR) 2.4.1.58 Escherichia coli F632 AAC69652.1 O68204  
 UDP-Glc: (galactosyl) LPS α-1,2-glucosyltransferase (WaaJ) 2.4.1.58 Escherichia coli F653 AAC69663.2
AAC69663.1
Q9ZIT6  
 UDP-Glc:(galactosyl)lipopolysaccharide α-1,2-glucosyltransferase (WaaJ; EDL933_4888) 2.4.1.58 Escherichia coli O157:H7 str. EDL933 AAG58771.1
AIG71029.1
NP_290207.1
   
 UDP-Glc:(galactosyl)lipopolysaccharide α-1,2-glucosyltransferase (WaaJ;ECs4502) 2.4.1.58 Escherichia coli O157:H7 str. Sakai BAB37925.1
NP_312529.1
Q8XDC2  
 UDP-Glc:(galactosyl) LPS α-1,2-glucosyltransferase (WaaJ;RfaJ;b3626) 2.4.1.58 Escherichia coli str. K-12 substr. MG1655 AAC76650.1
AAA24087.1
AAB18603.1
AIZ93573.1
ALI38685.1
AMC96514.1
NP_418083.1
P27129  
 LPS α-1,3-glucosyltransferase (RfaI;WaaO;b3627) 2.4.1.- Escherichia coli str. K-12 substr. MG1655 AAC76651.1
AAA24086.1
AAB18604.1
AIZ93572.1
ALI38684.1
AMC96515.1
NP_418084.1
P27128  
 a-(1,2/4)-glucosyltransferase (Rfaj;HP1416) 2.4.1.- Helicobacter pylori 26695 AAD08459.1
AFV42637.1
NP_208207.1
O25962  
 α-1,6-glucosyltransferase (RfaJ;HP0159) 2.4.1.- Helicobacter pylori 26695 AAD07221.1
AFV41380.1
NP_206958.1
O24967  
 β-1,3-N-acetyl-glucosaminyltransferase (jhp1032) 2.4.1.- Helicobacter pylori J99 AAD06608.1
AKE82422.1
NP_223749.1
Q9ZKA7  
 LPS [galactan I] α-1,3-galactopyranosyltransferase (WbbM;RfbC) 2.4.1.- Klebsiella pneumoniae 01:K20 / 889/50 AAC98416.1 Q48484  
 α-galactosyltransferase (LgtC) 2.4.1.- Neisseria gonorrhoeae F62 AAA68011.1
AAV26681.1
Q50948  
 UDP-Gal: α-1,4-galactosyltransferase (LgtC) 2.4.1.- Neisseria meningitidis 126E AAB48385.1 P96945 1G9R[A]
1GA8[A]
1SS9[A]
 LPS α-1,2-glucosyltransferase (RfaJ) 2.4.1.58 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAC16411.1
AAL22576.1
CAA37842.1
P19817  
 LPS α-1,3-galactosyltransferase RfaI 2.4.1.44 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL22577.1
AAC16412.1
CAA37841.1
P19816  
 glycosyltransferase (Gtf2;Spaf_1924) 2.4.1.- Streptococcus parasanguinis FW213 ABL74005.1
AFJ26866.1
A1C3M0  
 UDP-Gal: α-Glc-PP-lipid α-1,3-galactosyltransferase (WciN) 2.4.1.44 Streptococcus pneumoniae 6B AEO88441.1    
 dual-specificity glycosyltransferase (GlyA;SP1771) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75845.1
AAE55314.1
AAQ38130.1
AAY71776.1
NP_346205.1
Q97P72  
 glycosyltransferase (GlyB;SP1770) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75844.1
NP_346204.1
Q97P73  
 bifunctional UDP-Glc/UDP-Gal: glucosyltransferase-galactosyltransferase (GlyD;SP1767) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75842.1
NP_346202.1
Q97P75  
 UDP-Gal: galactosyltransferase (GlyE;SP1766) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75841.1
NP_346201.1
Q97P76 5GVV[A,F]
5GVW[A,B,C,D]
 UDP-Gal: galactosyltransferase (GlyF;SP1765) 2.4.1.- Streptococcus pneumoniae TIGR4 AAK75840.1
ABA35790.1
NP_346200.1
Q97P77  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Inositol 1-α-galactosyltransferase 1 (galactinol synthase 1) (GolS-1) 2.4.1.123 Ajuga reptans CAB51533.1 Q9XGN4  
 UDP-GlcA: inositol phosphorylceramide α-glucuronosyltransferase (IPUT1;At5g18480) 2.4.1.- Arabidopsis thaliana NP_197349.1
AAL58891.1
AAN28860.1
AED92569.1
AHL38620.1
BAC43531.1
Q8GWB7
Q8W118
 
 homogalacturonan α-1,4-galacturonosyltransferase (LGT1;JS36;Gaut1;AtGAUT1;At3g61130/T20K12.30) 2.4.1.- Arabidopsis thaliana CAB71043.1
AAK62572.1
AAN18196.1
ABD14404.1
AEE80159.1
AHL38722.1
CAB91508.1
NP_191672.1
Q94BZ8
Q9LE59
 
 UDP-GlcA: xylan α-glucuronyltransferase (Gux2;At4g33330) 2.4.1.- Arabidopsis thaliana BAC43192.1
AAO64859.1
AEE86207.1
AEE86208.1
AHL38665.1
ANM66118.1
ANM66119.1
ANM66120.1
BAD43609.1
BAD43764.1
CAB38791.1
CAB80050.1
CAD89087.1
NP_195059.1
Q8GWW4
Q9SZB0
 
 UDP-GlcA: xylan α-glucuronyltransferase (Gux1;PGSIP1;At3g18660) 2.4.1.- Arabidopsis thaliana BAB01792.1
AAL07212.1
AAN13228.1
AAU93699.1
AEE76127.1
AEE76128.1
AEE76129.1
AHL38759.1
CAD89083.1
CAH56865.1
NP_188496.1
NP_566615.1
Q940B5
Q9LSB1
 
 inositol 1-α-galactosyltransferase (GS) 2.4.1.123 Brassica napus AAD26116.1
ABC15006.1
ACJ15472.1
ADG03603.1
Q9XEJ7  
 glycogenin α-glucosyltransferase (Gyg-1;Uvt-5;CeGN;CELE_F56B6.4) 2.4.1.186 Caenorhabditis elegans Bristol N2 NP_741749.1
AAB04562.1
AAL11464.1
AAM69110.1
CCD64318.1
CCD64319.1
CCD64320.1
NP_508608.1
NP_508609.1
H2KYQ5
Q95Q50
4QLB[E,F,G,H]
 fagopyritol synthase 1 (FeGolS-1) (fagopyritol B1 synthase) 2.4.1.- Fagopyrum esculentum AAM96870.1 Q7XZ05  
 fagopyritol synthase 2 (FeGolS-2) (fagopyritol A1/B1 synthase) 2.4.1.- Fagopyrum esculentum AAM96868.1 Q7XZ07  
 galactinol synthase (GmGolS) 2.4.1.123 Glycine max AAM96867.1 Q7XZ08  
 UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (GXYLT2;GLT8D4;FLJ10539) 2.4.2.- Homo sapiens NP_001073862.1
AAI27734.1
CAK32330.1
XP_059527.1
A0PJZ3  
 glycogenin (Gyg;Gyg1;GYG1) 2.4.1.186 Homo sapiens AAH00033.1
AAB00114.1
AAB09752.1
AAD31084.1
AAD52093.1
AAH31096.2
AAV20877.1
ACM81895.1
BAG35212.1
BAG61788.1
CAA56073.1
CAC22472.1
CAG38784.1
NP_004121.2
XP_051426.1
XP_051427.1
XP_051428.2
D3DNH1
D3DNH2
P46976
Q6FHZ1
3Q4S[A]
3QVB[A]
3RMV[A]
3RMW[A]
3T7M[A,B]
3T7N[A,B]
3T7O[A,B]
3U2T[A]
3U2U[A,B]
3U2V[A,B]
3U2W[A,B]
3U2X[A,B]
 glycogenin 2 (Gyg2) 2.4.1.186 Homo sapiens AAB84377.1
AAB84374.1
AAB84375.1
AAB84376.1
AAB84378.1
AAB84379.1
AAF61855.1
AAH23152.1
BAF85185.1
BAG53568.1
NP_003909.1
XP_043483.1
O15488 4UEG[A,B]
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1) 2.4.1.-
2.4.2.-
Homo sapiens CAA07571.1
AAI17426.1
AAI26405.1
ACM81049.1
ACM83412.1
AHW56517.1
AHW56672.1
AHW56712.1
AHW56713.1
BAA25535.2
BAA25535.3
BAH11875.1
BAH12135.1
BAH13559.1
CAB62965.1
CAG30396.1
CAI17890.1
CAI17950.1
CAI18754.1
CAI18769.1
CAI18772.1
CAI18784.1
CAI18785.1
CAI18788.1
CAQ06854.1
CAQ06855.1
CAQ06856.1
CAQ08276.1
CAQ08280.1
CAQ08281.1
CAQ08796.1
CAQ08800.1
CAQ08801.1
CAQ09323.1
CAQ09433.1
CAQ09434.1
CAQ09435.1
CAQ09639.1
CAQ09894.1
CAQ09895.1
CAQ09896.1
CAQ10763.1
CAQ11002.1
CAX14873.1
CAX14874.1
CAX14935.1
CAX14936.1
CAX15214.1
CAX15215.1
NP_004728.1
NP_598397.1
O95461  
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE2) 2.4.1.-
2.4.2.-
Homo sapiens BAC04675.1
AAH37291.1
ABE14687.1
BAC03909.1
BAG51581.1
NP_689525.2
Q8N3Y3
Q8N8Y6
Q8NAK3
 
 UDP-Xyl: β-glucoside α-1,3-xylosyltransferase (GXYLT1;GLT8D3) 2.4.2.- Homo sapiens XP_290597.4
AAH15597.2
AAH30023.1
AAH39145.1
BAG54154.1
XP_058509.1
XP_062319.1
XP_290597.3
B3KWJ2
Q4G148
Q8IXV1
 
 galactinol synthase (CorF) 2.4.1.123 Medicago sativa AAM97493.1 Q84MZ5  
 Glycogenin-1 (Gyg;Gyg1) 2.4.1.186 Mus musculus AAH29903.1
AAD48901.1
BAE35197.1
NP_038783.1
Q3TWR9
Q9R062
 
 glycogenin (GNN;NCU06698.1;7F4.180) 2.4.1.186 Neurospora crassa OR74A CAD70922.1
AAS68518.1
CAY34861.1
XP_326984.1
Q1K740
Q871S1
 
 glycogenin (Gyg) 2.4.1.186 Oryctolagus cuniculus AAA31404.1 P13280 1LL0[A,B,C,D,E,F,G,H,I,J]
1LL2[A]
1LL3[A]
3USQ[A]
3USR[A]
3V8Y[A]
3V8Z[A]
3V90[A]
3V91[A]
 glycogenin (Gyg1) 2.4.1.186 Rattus norvegicus AAH70944.1
AAB53334.1
AAB81219.1
NP_112305.1
O08730  
 glycogenin (Glg1;YKR058w) 2.4.1.186 Saccharomyces cerevisiae S288c AAA91646.1
CAA82136.1
CAY34851.1
NP_012984.1
P36143  
 glycogenin (Glg2;YJL137c;J0663 2.4.1.186 Saccharomyces cerevisiae S288c AAA91644.1
AAV20191.1
CAA60818.1
CAA89432.1
CAY34850.1
NP_012398.1
P47011  
 UDP-GlcNAc: α-N-acetylglucosaminyltransferase (Gnt1;Yor320c) 2.4.1.- Saccharomyces cerevisiae S288c CAA62175.1
CAA99640.1
NP_014965.1
Q12096  
 α-1,3-galactosyltransferase (Gct1;Otg1;SPAC5H10.12c) 2.4.1.- Schizosaccharomyces pombe 972h- CAA89962.1
NP_592825.1
Q09680  
 α-1,3-galactosyltransferase (Gct2;Otg2;SPBC4C3.08) 2.4.1.- Schizosaccharomyces pombe 972h- CAA16830.1
NP_596297.1
O43061  
 α-1,3-galactosyltransferase (Gct3;Otg3;SPBC4C3.09) 2.4.1.- Schizosaccharomyces pombe 972h- CAA16831.1
NP_596296.1
O43062  
 galactinol synthase (GolS-1) 2.4.1.123 Solanum lycopersicum AAL26804.1
AAO72744.1
Q947G8  
 galactinol synthase 2 (ZmGolS2) 2.4.1.123 Zea mays AAQ07249.1 Q5DVS6  
 galactinol synthase 1 (ZmGolS1) 2.4.1.123 Zea mays AAQ07248.1 Q5DVS7  
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