GlycosylTransferase Family 49

Activities in Familyβ-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-).
Mechanism Inverting
3D Structure StatusGT-A (AlphaFold)
NoteThe animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesCFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics GenBank accession (408); Uniprot accession (14);
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1) 2.4.1.-   Homo sapiens CAA07571.1
AAI17426.1
AAI26405.1
ACM81049.1
AHW56517.1
BAA25535.2
BAA25535.3
BAH11875.1
BAH12135.1
BAH13559.1
CAB62946.1
CAG30396.1
CAI17890.1
CAI17950.1
CAI18754.1
CAI18769.1
CAI18772.1
CAI18784.1
CAI18785.1
CAI18788.1
CAQ06854.1
CAQ06856.1
CAQ08281.1
CAQ08801.1
CAQ09323.1
CAQ09434.1
CAQ09435.1
CAQ09895.1
CAQ09896.1
CAQ10763.1
CAQ11002.1
CAX14873.1
CAX14874.1
CAX15214.1
CAX15215.1
NP_004728.1
NP_598397.1
B7Z2I9
B7Z399
B7Z7C3
O95461
X5DR28
 
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE2) 2.4.1.-   Homo sapiens BAC04675.1
AAH37291.1
ABE14687.1
BAC03909.1
BAG51581.1
NP_689525.2
B3KP69
Q8N3Y3
Q8N8Y6
Q8NAK3
 
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