| Activities in Family | α-glucuronyltransferase (EC 2.4.1.-); |
|---|---|
| Mechanism | Inverting |
| 3D Structure Status | GT-A (AlphaFold) |
| Note | The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49. |
| External resources | CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap; |
| Statistics | GenBank accession (570); Uniprot accession (14); PDB accession (3); 3D entries (1); cryst (0) |
| Eukaryota | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1) | 2.4.1.- | pubmed |
Homo sapiens | CAA07571.1 AAI17426.1 AAI26405.1 ACM81049.1 AHW56517.1 BAA25535.2 BAA25535.3 BAH11875.1 BAH12135.1 BAH13559.1 CAB62946.1 CAG30396.1 CAI17890.1 CAI17950.1 CAI18754.1 CAI18769.1 CAI18772.1 CAI18784.1 CAI18785.1 CAI18788.1 CAQ06854.1 CAQ06856.1 CAQ08281.1 CAQ08801.1 CAQ09323.1 CAQ09434.1 CAQ09435.1 CAQ09895.1 CAQ09896.1 CAQ10763.1 CAQ11002.1 CAX14873.1 CAX14874.1 CAX15214.1 CAX15215.1 NP_004728.1 NP_598397.1 |
B7Z2I9 B7Z399 B7Z7C3 O95461 X5DR28 |
7UI6[A,B] 7UI7[A,B] 7ZVJ[A,B] |
|
| bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE2) | 2.4.1.- | Homo sapiens | BAC04675.1 AAH37291.1 ABE14687.1 BAC03909.1 BAG51581.1 NP_689525.2 |
B3KP69 Q8N3Y3 Q8N8Y6 Q8NAK3 |
|||
| Top | |||||||