GlycosylTransferase Family 49

Activities in Family	α-glucuronyltransferase (EC 2.4.1.-);
Mechanism	Inverting
3D Structure Status	GT-A (AlphaFold)
Note	The animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resources	CFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics	GenBank accession (603); Uniprot accession (14); PDB accession (3); 3D entries (1); cryst (0)

Summary

Download GT49 (1436) Taxonomic display Structure (1) Characterized (2)

Eukaryota

Protein Name

EC#

Organism

GenBank

Uniprot

PDB/3D

Carbohydrate Ligands

Resolution (Å)

bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1)

2.4.1.-

Homo sapiens

CAA07571.1
AAI17426.1
AAI26405.1
ACM81049.1
AHW56517.1
BAA25535.2
BAA25535.3
BAH11875.1
BAH12135.1
BAH13559.1
CAB62946.1
CAG30396.1
CAI17890.1
CAI17950.1
CAI18754.1
CAI18769.1
CAI18772.1
CAI18784.1
CAI18785.1
CAI18788.1
CAQ06854.1
CAQ06856.1
CAQ08281.1
CAQ08801.1
CAQ09323.1
CAQ09434.1
CAQ09435.1
CAQ09895.1
CAQ09896.1
CAQ10763.1
CAQ11002.1
CAX14873.1
CAX14874.1
CAX15214.1
CAX15215.1
NP_004728.1
NP_598397.1

B7Z2I9
B7Z399
B7Z7C3
O95461
X5DR28

7UI6[A,B]		3.70
7UI7[A,B]		3.40
7ZVJ[A,B]		2.61

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