GlycosylTransferase Family 49

Activities in Familyβ-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-).
Mechanism Inverting
NoteThe animal LARGE bifunctional glycosyltransferases are made of two domains. The N-terminal domain, which adds a-1,3-xyl residues, belongs to family GT8 while the C-terminal domain, which adds b-1,3-GlcA residues, belongs to family GT49.
External resourcesCFG(Glycosphingolipid); CFG(N-linked); CFG(Terminal); Glymap;
Statistics GenBank accession (286); Uniprot accession (86);
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACCB07638 (fragment)   Apis cerana AEY60191.1    
 ORF   Ascaris suum ADY42842.1    
 ORF (fragment)   Ascaris suum ADY44727.1    
 ORF (fragment)   Ascaris suum ADY47199.1    
 Bathy10g03960   Bathycoccus prasinos RCC1105 CCO18391.1    
 B3GNT6   Bos taurus AAX08785.1
AAI05207.1
AAX46482.1
Q5EA01  
 K08H2.9   Caenorhabditis elegans Bristol N2 CAE17897.1 Q7YWW9  
 F01D4.9   Caenorhabditis elegans Bristol N2 CAE17756.1 Q7YTQ3  
 F21H7.10   Caenorhabditis elegans Bristol N2 CAB07595.1
CAB07674.1
NP_507102.1
G5EGF3
O18090
 
 F22F7.6   Caenorhabditis elegans Bristol N2 AAF99911.2
AAF99911.1
CCD67445.1
CCH63850.1
NP_503575.1
Q9GZF1  
 C18G1.3   Caenorhabditis elegans Bristol N2 AAC17758.1
AAC17758.2
ADA77626.1
ADA77627.1
ADI32797.1
CCD65233.1
CCD65234.1
CCD65236.1
NP_504280.1
D6VP98
H2KYW9
O61921
 
 F56H6.6   Caenorhabditis elegans Bristol N2 CAB04495.1
NP_493107.1
O45584  
 C54C8.2   Caenorhabditis elegans Bristol N2 CAB05464.2
CAB05464.1
NP_493157.1
O02230  
 T15D6.4   Caenorhabditis elegans Bristol N2 CAB05626.1
CAB05626.2
NP_493133.1
O02320  
 K09C8.4 (Lge-1)   Caenorhabditis elegans Bristol N2 CAA91997.3
CAA91997.2
CAA91997.4
NP_509833.1
Q21389  
 ORF   Callorhinchus milii AFO95554.1    
 CYME_CMM115C   Cyanidioschyzon merolae strain 10D BAM80985.1    
 Gyltl1b   Danio rerio AAU12252.1
AAI62103.1
CAK04442.1
CAK04901.1
B3DFN1
Q66PG1
 
 glycosyltransferase-like 1A   Danio rerio AAU12251.1
AAI62096.1
B3DFM4
Q66PG2
 
 β-1,3-N-acetylglycosaminyltransferase 1   Danio rerio AGD94656.1 L7YAI7  
 dd_03030   Dictyostelium discoideum AX4 AAM33211.1
AAO51855.1
Q86IZ0  
 CG9171-like protein (fragment)   Drosophila americana ABS88391.1
ABS88392.1
ABS88393.1
ABS88394.1
ABS88395.1
ABS88396.1
ABS88397.1
ABS88398.1
ABS88399.1
ABS88400.1
ABS88401.1
ABS88402.1
ABS88403.1
ABS88404.1
ABS88405.1
ABS88406.1
ABS88407.1
ABS88408.1
ABS88409.1
ABS88410.1
ABS88411.1
ABS88412.1
ABS88413.1
ABS88414.1
ABS88415.1
ABS88416.1
ABS88417.1
ABS88418.1
ABS88419.1
ABS88420.1
ABS88421.1
ABS88422.1
ABS88423.1
ABS88424.1
ABS88425.1
A7UH18  
 Dbus_chr2Rg2240   Drosophila busckii ALC42661.1    
 Dbus_chr2Lg886   Drosophila busckii ALC38801.1    
 Dbus_chr2Lg388 (fragment)   Drosophila busckii ALC38303.1    
 Dbus_chr2Lg1033   Drosophila busckii ALC38948.1    
 Dbus_chr2Lg880 (fragment)   Drosophila busckii ALC38795.1    
 RE56074p (CG11149)   Drosophila melanogaster AAL49129.1
AAF52281.1
AAN10553.1
ABI34186.1
ACZ94180.1
AGB92638.1
NP_608952.2
NP_723110.1
Q8SYJ5
Q9VMN1
 
 CG15483   Drosophila melanogaster ACJ23454.1
AAF53224.1
AAS15697.1
NP_609592.1
B6IDY0
Q9VK55
 
 CG9171   Drosophila melanogaster AAN10556.1
AAF52288.2
AAN71464.1
ACZ94182.1
AGB92641.1
AGB92642.1
NP_608958.2
NP_723117.1
Q7JRE1
Q9VMM5
 
 CG3253   Drosophila melanogaster AAF47166.1
AAK77266.1
AFH08241.1
NP_611886.1
Q9W1A7  
 glycosyltransferase-like 1A   Gallus gallus AAU12250.1 Q66PG3  
 Gyltl1b   Gallus gallus AAU12249.1 Q66PG4  
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE; Large1) 2.4.1.-
2.4.2.-
Homo sapiens CAA07571.1
AAI17426.1
AAI26405.1
ACM81049.1
AHW56517.1
BAA25535.2
BAA25535.3
BAH11875.1
BAH12135.1
BAH13559.1
CAB62946.1
CAG30396.1
CAI17890.1
CAI17950.1
CAI18754.1
CAI18769.1
CAI18772.1
CAI18784.1
CAI18785.1
CAI18788.1
CAQ06854.1
CAQ06856.1
CAQ08281.1
CAQ08801.1
CAQ09323.1
CAQ09434.1
CAQ09435.1
CAQ09895.1
CAQ09896.1
CAQ10763.1
CAQ11002.1
CAX14873.1
CAX14874.1
CAX15214.1
CAX15215.1
NP_004728.1
NP_598397.1
O95461  
 β-1,3-N-acetylglucosaminyltransferase 1 (B3gnt1) 2.4.1.- Homo sapiens AAC39538.1
AAH21965.1
AAY46155.1
ABX94893.1
BAG52119.1
BAG57146.1
BAG57791.1
NP_006867.1
O43505  
 bifunctional α-1,3-xylosyltransferase / β-1,3-glucuronyltransferase (LARGE2) 2.4.1.-
2.4.2.-
Homo sapiens BAC04675.1
AAH37291.1
ABE14687.1
BAC03909.1
BAG51581.1
NP_689525.2
Q8N3Y3
Q8N8Y6
Q8NAK3
 
 ORF (fragment)   Hottentotta judaicus ADY39562.1    
 ORF (fragment)   Hottentotta judaicus ADY39571.1    
 ORF (fragment)   Hymenochirus curtipes AEQ18068.1    
 ORF (Gyltl1B)   Ictalurus punctatus AHH39116.1    
 ORF LARGE   Ictalurus punctatus AHH40413.1    
 ls5930a1_00002   Leucosporidium scottii CRX78931.1    
 ls5930a1_00002   Leucosporidium scottii CRX78931.1    
 LRAMOSA06373   Lichtheimia ramosa CDS14203.1    
 LRAMOSA06585   Lichtheimia ramosa CDS14416.1    
 LRAMOSA08720   Lichtheimia ramosa CDS06192.1    
 LRAMOSA08745   Lichtheimia ramosa CDS06217.1    
 LRAMOSA08817   Lichtheimia ramosa CDS06289.1    
 LRAMOSA01423   Lichtheimia ramosa CDS07474.1    
 LRAMOSA01970   Lichtheimia ramosa CDS08021.1    
 LRAMOSA02561   Lichtheimia ramosa CDS09884.1    
 LRAMOSA02792   Lichtheimia ramosa CDS10115.1    
 LRAMOSA04124   Lichtheimia ramosa CDS11928.1    
 LRAMOSA02958   Lichtheimia ramosa CDS10282.1    
 ORF   Macaca fascicularis BAE01692.1
BAE87809.1
Q4R5D3  
 N-acetyllactosaminide β-1,3-N-acetylglucosaminyltransferase (B3gnt1)   Macaca mulatta AFE66075.1
AFH29116.1
AFI35343.1
   
 ORF   Macaca mulatta AFE80844.1    
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96176.1 D9IFZ6  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96177.1 D9IFZ7  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96178.1 D9IFZ8  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96179.1 D9IFZ9  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96180.1 D9IG00  
 LARGE-2 (fragment)   Mastomys erythroleucus ADI96181.1 D9IG01  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96195.1 D9IG15  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96196.1 D9IG16  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96197.1 D9IG17  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96198.1 D9IG18  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96199.1 D9IG19  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96200.1 D9IG20  
 LARGE-1 (fragment)   Mastomys erythroleucus ADI96201.1 D9IG21  
 LARGE-2 (fragment)   Mastomys kollmannspergeri ADI96166.1 D9IFY6  
 LARGE-2 (fragment)   Mastomys kollmannspergeri ADI96167.1 D9IFY7  
 LARGE-2 (fragment)   Mastomys kollmannspergeri ADI96168.1 D9IFY8  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96184.1 D9IG04  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96186.1 D9IG06  
 LARGE-1 (fragment)   Mastomys kollmannspergeri ADI96187.1 D9IG07  
 LARGE-2 (fragment)   Mastomys natalensis ADI96169.1 D9IFY9  
 LARGE-2 (fragment)   Mastomys natalensis ADI96170.1 D9IFZ0  
 LARGE-2 (fragment)   Mastomys natalensis ADI96171.1 D9IFZ1  
 LARGE-2 (fragment)   Mastomys natalensis ADI96172.1 D9IFZ2  
 LARGE-2 (fragment)   Mastomys natalensis ADI96173.1 D9IFZ3  
 LARGE-2 (fragment)   Mastomys natalensis ADI96174.1 D9IFZ4  
 LARGE-2 (fragment)   Mastomys natalensis ADI96175.1 D9IFZ5  
 LARGE-1 (fragment)   Mastomys natalensis ADI96188.1 D9IG08  
 LARGE-1 (fragment)   Mastomys natalensis ADI96189.1 D9IG09  
 LARGE-1 (fragment)   Mastomys natalensis ADI96191.1 D9IG11  
 LARGE-1 (fragment)   Mastomys natalensis ADI96192.1 D9IG12  
 LARGE-1 (fragment)   Mastomys natalensis ADI96193.1 D9IG13  
 LARGE-1 (fragment)   Mastomys natalensis ADI96194.1 D9IG14  
 LARGE (MKIAA0609)   Mus musculus AAI00400.1
AAH61506.1
AAI25488.1
AAI25490.1
ADI96202.1
BAC65610.1
CAA06945.1
Q059X9
Q80TW0
Q9Z1M7
 
 ORF   Mus musculus AAU95213.1
AAH33922.1
AAH96655.1
AAI16716.1
AAU95214.1
ADI96182.1
BAC36913.1
BAD90366.1
CAM20617.1
CAM20618.1
CAM20619.1
CAM20620.1
NP_766258.1
A2AHG8
Q5XPT3
Q8BJZ8
Q8K253
 
 1500032M01Rik   Mus musculus C57BL/6J BAC34203.1
AAH02191.1
AAH69927.1
BAC39041.1
BAE34720.1
NP_780592.1
Q8BWP8
Q8BWP8
 
 ORF   Musca domestica ALHF AFP62402.1    
 ORF (fragment)   Mustela putorius furo AER99534.1    
 ORF (fragment)   Mustela putorius furo AES00982.1    
 ORF   Mustela putorius furo AES10900.1    
 NGATSA_2018100 (fragment)   Nannochloropsis gaditana CCMP526 AFJ68883.1    
 ORF   Pan troglodytes BAK63035.1    
 ORF (fragment)   Pan troglodytes BAK63167.1    
 PHATR_46672   Phaeodactylum tricornutum CCAP 1055/1 ACI65301.1 B5Y3E7  
 DKFZp459K1316   Pongo abelii CAH93244.1 Q5R4S2  
 DKFZp459G0120 (fragment)   Pongo abelii CAI29669.1 Q5NVJ4  
 LARGE-2 (fragment)   Rattus losea ADI96183.1 D9IG03  
 LARGE-1 (fragment)   Rattus losea ADI96203.1 D9IG23  
 ORF   Rattus norvegicus AAH61762.1
NP_954538.1
Q6P7A1  
 RHTO0S_04e01684g   Rhodotorula toruloides CECT1137 CDR39118.1    
 RHTO0S_08e04566g   Rhodotorula toruloides CECT1137 CDR43695.1    
 Smp_146640 (fragment)   Schistosoma mansoni CAZ32100.1 C4Q9F1  
 PIIN_04436   Serendipita indica DSM 11827 CCA70499.1    
 SRAE_2000492600   Strongyloides ratti ED321 Heterogonic CEF70293.1    
 SRAE_2000268800   Strongyloides ratti ED321 Heterogonic CEF68027.1    
 SRAE_2000303300   Strongyloides ratti ED321 Heterogonic CEF68376.1    
 SRAE_X000141700   Strongyloides ratti ED321 Heterogonic CEF59671.1    
 SRAE_2000402400   Strongyloides ratti ED321 Heterogonic CEF69375.1    
 SRAE_2000492700   Strongyloides ratti ED321 Heterogonic CEF70294.1    
 SRAE_1000063100   Strongyloides ratti ED321 Heterogonic CEF62358.1    
 SRAE_2000346100   Strongyloides ratti ED321 Heterogonic CEF68806.1    
 SRAE_2000112600   Strongyloides ratti ED321 Heterogonic CEF66458.1    
 SRAE_1000187000   Strongyloides ratti ED321 Heterogonic CEF63610.1    
 SRAE_2000510500 (fragment)   Strongyloides ratti ED321 Heterogonic CEF70474.1    
 SRAE_2000170200   Strongyloides ratti ED321 Heterogonic CEF67037.1    
 SRAE_1000026200   Strongyloides ratti ED321 Heterogonic CEF61986.1    
 SRAE_X000177100 (fragment)   Strongyloides ratti ED321 Heterogonic CEF60031.1    
 UDP-GlcNAc: β-Gal β-1,3-N-acetylglucosaminyltransferase 1 (B3GnT1)   Sus scrofa AFR42416.1    
 InvC   Volvox carteri f. nagariensis BAH03159.1 B6ZKF6  
 ORF   Xenopus laevis AAH60410.1
AAI08591.1
Q6PA90  
 Unknown (protein for MGC:122763)   Xenopus tropicalis AAI36205.1 A4IIY7  
 Unknown (protein for IMAGE:7546851) (IMAGE:7546851)   Xenopus tropicalis AAI67687.1 B3DM36  
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