GlycosylTransferase Family 47

Activities in FamilyUDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC; UDP-Xyl: xylan β-1,4-xylosyltransferase (EC 2.4.2.-); α-1,3-L-arabinofuranosyltransferase (EC 2.4.2.-); arabinan α-1,5-L-arabinofuranosyltransferase (EC 2.4.2.-); glucomannan β-1,2-galactosyltransferase (EC 2.4.1.-); pectin β-1,4-glucuronyltransferase (EC 2.4.1.-); xylogalacturonan β-1,3-xylosyltransferase (EC; xyloglucan β-1,2-galactosyltransferase (EC 2.4.1.-).
Mechanism Inverting
3D Structure StatusGT-B
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase.
External resourcesGlymap;
Statistics GenBank accession (2388); Uniprot accession (43); PDB accession (16); 3D entries (3); cryst (0)

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