GlycosylTransferase Family 47

Activities in Familyheparan β-glucuronyltransferase (EC 2.4.1.225); xyloglucan β-galactosyltransferase (EC 2.4.1.-); heparan synthase (EC 2.4.1.-); arabinan α-L-arabinosyltransferase (EC 2.4.2.-).
Mechanism Inverting
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase.
External resourcesGlymap;
Statistics GenBank accession (1008); Uniprot accession (236);
All (462) Bacteria (3) Eukaryota (457) Viruses (2) Characterized (13)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 UDP-Xyl: xylogalacturonan β-1,3-xylosyltransferase (Xgd1;AtXGD1;At5g33290) 2.4.2.- Arabidopsis thaliana NP_198314.2
AAK83577.1
AAL62020.1
AED93892.1
AHL38602.1
Q94AA9  
 At2g35100 (probable UDP-β-L-Ara: arabinan α-1,5-L-arabinosyltransferase;ARAD1;AtARAD1) 2.4.2.- Arabidopsis thaliana AAC61825.1
AAT71926.1
AAU94417.1
AEC09064.1
AHL38814.1
BAF00874.1
NP_181055.1
O82181
Q6DBG8
 
 At5g62220 (GT18) 2.4.1.- Arabidopsis thaliana BAA97186.1
AED97582.1
AHL38570.1
NP_201028.1
Q9LVB4  
 xyloglucan β-1,2-galactosyltransferase (Mur3;AtMUR3;Kam1;At2g20370) 2.4.1.- Arabidopsis thaliana AAO39815.1
AAD21751.1
AAZ23926.1
AEC06999.1
AHL38848.1
BAE98519.1
BAH19963.1
NP_179627.2
Q7XJ98
Q7XJ98
 
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) 2.4.1.224
2.4.1.225
Bos taurus AAC35386.1
AAI26571.1
NP_803462.1
O77783  
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.224
2.4.1.225
Cricetulus griseus AAF71276.1 Q9JK82  
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.224
2.4.1.225
Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1
Q9XZ08  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.224
2.4.1.225
Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
BAH12417.1
NP_000392.1
B2R5Z6
Q93063
 
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.224
2.4.1.225
Homo sapiens AAB62283.1
AAC51154.1
AAH01174.1
ACS08204.1
ADI56520.1
AGT15863.1
BAG35949.1
NP_000118.1
B2R7V2
Q16394
 
 exostosin-like 3 (Extl3;Extr1) 2.4.1.223
2.4.1.225
Homo sapiens AAC39598.1
AAB67602.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12589.1
ACW32787.1
BAA24080.1
BAA25445.2
BAA25445.3
NP_001431.1
D3DST8
O43909
Q53XT3
 
 exostosin-like 1 (Extl1) 2.4.1.224 Homo sapiens AAC51141.1
AAD02840.1
AAF73172.1
AAH65528.1
CAI17130.1
NP_004446.1
Q92935  
 α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) 2.4.1.224 Mus musculus AAD42040.1
AAH65073.1
AAW12587.1
BAE23506.1
NP_061258.2
Q9WVL6  
 pectin β-glucuronyltransferase (NpGUT1) (fragment) 2.4.1.- Nicotiana plumbaginifolia BAC20928.1 Q8GSQ4  
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