| Activities in Family | heparan β-glucuronyltransferase (EC 2.4.1.225); xyloglucan β-galactosyltransferase (EC 2.4.1.-); heparan synthase (EC 2.4.1.-); arabinan α-L-arabinosyltransferase (EC 2.4.2.-). |
|---|---|
| Mechanism | Inverting |
| Note | The long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase. |
| External resources | Glymap; |
| Statistics | GenBank accession (1151); Uniprot accession (236); |
| Eukaryota | ||||||
| Protein Name | EC# | Organism | GenBank | Uniprot | PDB/3D | |
| UDP-Xyl: xylogalacturonan β-1,3-xylosyltransferase (Xgd1;AtXGD1;At5g33290) | 2.4.2.- | Arabidopsis thaliana | NP_198314.2 AAK83577.1 AAL62020.1 AED93892.1 AHL38602.1 |
Q94AA9 | ||
| At2g35100 (probable UDP-β-L-Ara: arabinan α-1,5-L-arabinosyltransferase;ARAD1;AtARAD1) | 2.4.2.- | Arabidopsis thaliana | AAC61825.1 AAT71926.1 AAU94417.1 AEC09064.1 AHL38814.1 BAF00874.1 NP_181055.1 |
O82181 Q6DBG8 |
||
| At5g62220 (GT18) | 2.4.1.- | Arabidopsis thaliana | BAA97186.1 AED97582.1 AHL38570.1 NP_201028.1 |
Q9LVB4 | ||
| xyloglucan β-1,2-galactosyltransferase (Mur3;AtMUR3;Kam1;At2g20370) | 2.4.1.- | Arabidopsis thaliana | AAO39815.1 AAD21751.1 AAZ23926.1 AEC06999.1 AHL38848.1 BAE98519.1 BAH19963.1 NP_179627.2 |
Q7XJ98 Q7XJ98 |
||
| β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) | 2.4.1.224 2.4.1.225 |
Bos taurus | AAC35386.1 AAI26571.1 NP_803462.1 |
O77783 | ||
| β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) | 2.4.1.224 2.4.1.225 |
Cricetulus griseus | AAF71276.1 | Q9JK82 | ||
| heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) | 2.4.1.224 2.4.1.225 |
Drosophila melanogaster | AAD34749.1 AAF57601.1 BAB89399.1 NP_523790.1 |
Q9XZ08 | ||
| UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) | 2.4.1.224 2.4.1.225 |
Homo sapiens | AAB07008.1 AAB62718.1 AAC50764.1 AAC51219.1 AAH10058.1 AAH68545.1 BAH12417.1 NP_000392.1 |
B2R5Z6 Q93063 |
||
| UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) | 2.4.1.224 2.4.1.225 |
Homo sapiens | AAB62283.1 AAC51154.1 AAH01174.1 ACS08204.1 ADI56520.1 AGT15863.1 BAG35949.1 NP_000118.1 |
B2R7V2 Q16394 |
||
| exostosin-like 3 (Extl3;Extr1) | 2.4.1.223 2.4.1.225 |
Homo sapiens | AAC39598.1 AAB67602.1 AAD01877.1 AAD42041.1 AAH06363.1 AAP36017.1 AAW12588.1 AAW12589.1 ACW32787.1 BAA24080.1 BAA25445.2 BAA25445.3 NP_001431.1 |
D3DST8 O43909 Q53XT3 |
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| exostosin-like 1 (Extl1) | 2.4.1.224 | Homo sapiens | AAC51141.1 AAD02840.1 AAF73172.1 AAH65528.1 CAI17130.1 NP_004446.1 |
Q92935 | ||
| α-1,4-N-acetylglucosaminyltransferase-I/II / exostosin-like 3 (Extl3) | 2.4.1.224 | Mus musculus | AAD42040.1 AAH65073.1 AAW12587.1 BAE23506.1 NP_061258.2 |
Q9WVL6 | ||
| pectin β-glucuronyltransferase (NpGUT1) (fragment) | 2.4.1.- | Nicotiana plumbaginifolia | BAC20928.1 | Q8GSQ4 | ||
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