GlycosylTransferase Family 47

Activities in Familyheparan β-glucuronyltransferase (EC 2.4.1.225); xyloglucan β-galactosyltransferase (EC 2.4.1.-); heparan synthase (EC 2.4.1.-); arabinan α-L-arabinosyltransferase (EC 2.4.2.-).
Mechanism Inverting
NoteThe long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase.
External resourcesGlymap;
Statistics GenBank accession (1965); Uniprot accession (31); PDB accession (2); 3D entries (1); cryst (0)
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 xyloglucan β-1,2-galactosyltransferase (Mur3;AtMUR3;Kam1;At2g20370) 2.4.1.-   Arabidopsis thaliana AAO39815.1
AAD21751.1
AAZ23926.1
AEC06999.1
AHL38848.1
BAE98519.1
BAH19963.1
NP_179627.2
A0A5S9WZW3
B9DGU6
Q7XJ98
Q7XJ98
 
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) 2.4.1.225   Bos taurus AAC35386.1
AAI26571.1
NP_803462.1
A0JN91
O77783
 
 β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) 2.4.1.225   Cricetulus griseus AAF71276.1 Q9JK82  
 heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) 2.4.1.225   Drosophila melanogaster AAD34749.1
AAF57601.1
BAB89399.1
NP_523790.1
Q9XZ08  
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) 2.4.1.225   Homo sapiens AAB07008.1
AAB62718.1
AAC50764.1
AAC51219.1
AAH10058.1
AAH68545.1
BAH12417.1
NP_000392.1
B2R5Z6
B7Z431
Q6NUL1
Q93063
 
 UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) 2.4.1.225   Homo sapiens AAB62283.1
AAC51154.1
AAH01174.1
ACS08204.1
ADI56520.1
AGT15863.1
BAG35949.1
NP_000118.1
B2R7V2
D7RTA7
Q16394
 
 exostosin-like 3 (Extl3;Extr1) 2.4.1.225   Homo sapiens AAC39598.1
AAB67602.1
AAD01877.1
AAD42041.1
AAH06363.1
AAP36017.1
AAW12588.1
AAW12589.1
ACW32787.1
ADO22448.1
BAA24080.1
BAA25445.2
BAA25445.3
NP_001431.1
A0A384NPY9
B4DG91
D3DST8
O43909
Q53XT3
7AU2[A,B]
7AUA[A,B]
 pectin β-glucuronyltransferase (NpGUT1) (fragment) 2.4.1.-   Nicotiana plumbaginifolia BAC20928.1 Q8GSQ4  
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