| Activities in Family | Glucomannan β-1,2-galactosyltransferase (EC 2.4.1.-); Pectin β-1,4-glucuronyltransferase (EC 2.4.1.-); Xyloglucan β-1,2-galactosyltransferase (EC 2.4.1.-); Xyloglucan β-1,2-galacturonyltransferase (EC 2.4.1.-); UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225); UDP-Xyl: xylan β-1,4-xylosyltransferase (EC 2.4.2.-); α-1,3-L-arabinofuranosyltransferase (EC 2.4.2.-); Arabinan α-1,5-L-arabinofuranosyltransferase (EC 2.4.2.-); Xylogalacturonan β-1,3-xylosyltransferase (EC 2.4.2.41); |
|---|---|
| Mechanism | Inverting |
| 3D Structure Status | GT-B |
| Note | The long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase. |
| External resources | Glymap; |
| Statistics | GenBank accession (2520); Uniprot accession (43); PDB accession (16); 3D entries (3); cryst (0) |
| Eukaryota | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| UDP-Xyl: xylogalacturonan β-1,3-xylosyltransferase (Xgd1;AtXGD1;At5g33290) | 2.4.2.41 | pubmed |
Arabidopsis thaliana | NP_198314.2 AAK83577.1 AAL62020.1 AED93892.1 AHL38602.1 |
Q94AA9 W8PUC9 |
||
| arabinan α-1,5-L-arabinosyltransferase (At2g35100;ARAD1;AtARAD1) | 2.4.2.- | pubmed |
Arabidopsis thaliana | AAC61825.1 AAT71926.1 AAU94417.1 AEC09064.1 AHL38814.1 BAF00874.1 NP_181055.1 |
O82181 Q6DBG8 |
||
| UDP-Xyl: xylan β-1,4-xylosyltransferase (At1g27440;Irx10;AtGUT2) | 2.4.2.- | pubmed |
Arabidopsis thaliana | AAF99743.1 AAY25465.1 ABF58973.1 AEE30830.1 AHL38922.1 NP_174064.1 |
A0A178WC87 Q9FZJ1 |
||
| UDP-Xyl: xylan β-1,4-xylosyltransferase (AT5g61840;AtGUT1;Irx10-L) | 2.4.2.- | pubmed |
Arabidopsis thaliana | AAL47406.1 AAL06841.1 AAM64940.1 AED97524.1 AHL38571.1 BAB10084.1 BAC20929.1 BAD94554.1 NP_568941.1 |
A0A178UAL2 Q56ZI9 Q940Q8 |
||
| xyloglucan β-1,2-galactosyltransferase (At5g62220;AtGT18) | 2.4.1.- | pubmed |
Arabidopsis thaliana | BAA97186.1 AED97582.1 AHL38570.1 NP_201028.1 |
A0A654GD91 F4K6F1 Q9LVB4 |
||
| xyloglucan β-1,2-galacturonyltransferase (At1g63450;GT16) | 2.4.1.- | Arabidopsis thaliana | NP_176534.1 AEE34101.1 AHL38894.1 |
A0A178W9N1 Q9SH31 |
|||
| glucomannan β-1,2-galactosyltransferase (At4g13990;GT14) | 2.4.1.- | pubmed |
Arabidopsis thaliana | AAP04155.1 AEE83357.1 AHL38700.1 ANM67227.1 CAB10178.1 CAB78441.1 NP_193135.1 |
Q84R16 | ||
| xyloglucan β-1,2-galactosyltransferase (Mur3;AtMUR3;Kam1;At2g20370) | 2.4.1.- | Arabidopsis thaliana | AAO39815.1 AAD21751.1 AAZ23926.1 AEC06999.1 AHL38848.1 BAE98519.1 BAH19963.1 NP_179627.2 |
A0A5S9WZW3 B9DGU6 Q7XJ98 Q7XJ98 |
|||
| extensin-β-L-arabinoside α-L-arabinosyltranferase (ExAD; At3g57630) | 2.4.2.- | Arabidopsis thaliana | AAS49056.1 AAT06446.1 AEE79680.1 AEE79681.1 AHL38724.1 ANM65828.1 BAE98560.1 CAB41192.1 NP_191322.1 |
A0A654FIP1 Q0WWD8 Q6NKR6 Q9SVX7 |
|||
| β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (exostosin-2) (Ext2) | 2.4.1.225 | Bos taurus | AAC35386.1 AAI26571.1 NP_803462.1 |
A0JN91 O77783 |
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| β-glucuronyltransferase / α-N-acetylglucosaminyltransferase (Ext1) | 2.4.1.225 | Cricetulus griseus | AAF71276.1 | Q9JK82 | |||
| heparan sulfate α-1,4-N-acetylglucosaminyltransferase-I/II (CG15110;Dext3;botv) | 2.4.1.225 | Drosophila melanogaster | AAD34749.1 AAF57601.1 BAB89399.1 NP_523790.1 |
Q9XZ08 | |||
| UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2) | 2.4.1.225 | Homo sapiens | AAB07008.1 AAB62718.1 AAC50764.1 AAC51219.1 AAH10058.1 AAH68545.1 BAH12417.1 NP_000392.1 |
B2R5Z6 B7Z431 Q6NUL1 Q93063 |
7SCH[B] 7SCJ[B] 7SCK[B] 7UQX[B] 7UQY[B] 7ZAY[B] |
||
| UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1) | 2.4.1.225 | Homo sapiens | AAB62283.1 AAC51154.1 AAH01174.1 ACS08204.1 ADI56520.1 AGT15863.1 BAG35949.1 NP_000118.1 |
B2R7V2 D7RTA7 Q16394 |
7SCH[A] 7SCJ[A] 7SCK[A] 7UQX[A] 7UQY[A] 7ZAY[A] |
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| exostosin-like 3 (Extl3;Extr1) | 2.4.1.225 | Homo sapiens | AAC39598.1 AAB67602.1 AAD01877.1 AAD42041.1 AAH06363.1 AAP36017.1 AAW12588.1 AAW12589.1 ACW32787.1 ADO22448.1 BAA24080.1 BAA25445.2 BAA25445.3 NP_001431.1 |
A0A384NPY9 B4DG91 D3DST8 O43909 Q53XT3 |
7AU2[A,B] 7AUA[A,B] 8OG1[A] 8OG4[A,B] |
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| pectin β-glucuronyltransferase (NpGUT1) (fragment) | 2.4.1.- | pubmed |
Nicotiana plumbaginifolia | BAC20928.1 | Q8GSQ4 | ||
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