Activities in Family	Glucomannan β-1,2-galactosyltransferase (EC 2.4.1.-); Pectin β-1,4-glucuronyltransferase (EC 2.4.1.-); Xyloglucan β-1,2-galactosyltransferase (EC 2.4.1.-); Xyloglucan β-1,2-galacturonyltransferase (EC 2.4.1.-); UDP-GlcA: N-acetylglucosaminyl-proteoglycan β-1,4-glucuronosyltransferase (EC 2.4.1.225); UDP-Xyl: xylan β-1,4-xylosyltransferase (EC 2.4.2.-); α-1,3-L-arabinofuranosyltransferase (EC 2.4.2.-); Arabinan α-1,5-L-arabinofuranosyltransferase (EC 2.4.2.-); Xylogalacturonan β-1,3-xylosyltransferase (EC 2.4.2.41);
Mechanism	Inverting
3D Structure Status	GT-B
Note	The long animal heparan synthases are made of two domains. The N-terminal domain, which adds b-1,4-GlcA residues, belongs to family GT47 while the C-terminal domain, which adds a-1,4-GlcNAc residues, belongs to family GT64. The plant homologs, which have a single domain, display various specificities ranging from xyloglucan b-galactosyltransferase to a pectin b-glucuronyltransferase and arabinan a-L-arabinosyltransferase.
External resources	Glymap;
Statistics	GenBank accession (2718); Uniprot accession (43); PDB accession (16); 3D entries (3); cryst (0)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-2;Ext2)	2.4.1.225	Homo sapiens	AAB07008.1 AAB62718.1 AAC50764.1 AAC51219.1 AAH10058.1 AAH68545.1 BAH12417.1 NP_000392.1	B2R5Z6 B7Z431 Q6NUL1 Q93063	7SCH[B] 3.10 7SCJ[B] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc 3.40 7SCK[B] β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc 2.80 7UQX[B] 3.30 7UQY[B] 3.00 7ZAY[B] 2.80
UDP-GlcUA:β-glucuronyltransferase / UDP-GlcNAc: α-N-acetylglucosaminyltransferase (exostosin-1;Ext1)	2.4.1.225	Homo sapiens	AAB62283.1 AAC51154.1 AAH01174.1 ACS08204.1 ADI56520.1 AGT15863.1 BAG35949.1 NP_000118.1	B2R7V2 D7RTA7 Q16394	7SCH[A] 3.10 7SCJ[A] α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc 3.40 7SCK[A] β-D-GlcpA-(1-4)-α-D-GlcpNAc-(1-4)-β-D-GlcpA-(1-4)-α-D-GlcpNAc 2.80 7UQX[A] 3.30 7UQY[A] 3.00 7ZAY[A] 2.80
exostosin-like 3 (Extl3;Extr1)	2.4.1.225	Homo sapiens	AAC39598.1 AAB67602.1 AAD01877.1 AAD42041.1 AAH06363.1 AAP36017.1 AAW12588.1 AAW12589.1 ACW32787.1 ADO22448.1 BAA24080.1 BAA25445.2 BAA25445.3 NP_001431.1	A0A384NPY9 B4DG91 D3DST8 O43909 Q53XT3	7AU2[A,B] 2.43 7AUA[A,B] 2.93 8OG1[A] 1.58 8OG4[A,B] 2.10
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