Glycoside Hydrolase Family 97

Activities in Familyglucoamylase (EC 3.2.1.3); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22)
Mechanism inverting and retain
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu for inverting members; Asp for retaining members
Catalytic Proton DonorGlu
NoteCreated based on a paper by Hughes et al. (2003) Oral Microbiol Immunol. 18:309-312 (PMID: 12930523); *Mechanistic and structural elucidation by Gloster et al. (2008) Chem. Biol., Oct 8 (PMID:18848471); the inverting a-glucosidases (EC 3.2.1.20) could be renamed glucoamylases (EC 3.2.1.3 according to Kitamura et al. (2008) J. Biol. Chem., Nov 3 (PMID:18981178)
External resourcesCAZypedia;
Statistics GenBank accession (1008); Uniprot accession (166); PDB accession (12); 3D entries (3); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-galactosidase (BtGH97b;BT1871;BT_1871) 3.2.1.22 Bacteroides thetaiotaomicron VPI-5482 AAO76978.1
NP_810784.1
Q8A6L0
3A24[A,B] 2.30
5E1Q[A,B] 1.94
 α-glucosidase / glucoamylase (SusB;BtGH97a;BT3703;BT_3703) 3.2.1.3 Bacteroides thetaiotaomicron VPI-5482 AAC44671.1
AAO78808.1
NP_812614.1
G8JZS4
P71094
2D73[A,B] 1.60
2JKA[A,B] 1.90
2JKE[A,B] <carb_like_NOJ>
1.7
2JKP[A,B] <carb_like_CTS>
1.99
2ZQ0[A,B] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.60
3WFA[A,B] 2.00
 α-glucoside hydrolase (PspAG97A) (Ag97A) 3.2.1.- Pseudoalteromonas sp. K8 AMB20699.1  
5HQ4[A] 1.93
5HQA[A] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.75
5HQB[A] α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
1.80
5HQC[A] 2.00
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