Glycoside Hydrolase Family 97

Activities in Familyglucoamylase (EC 3.2.1.3); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22)
Mechanism inverting and retain
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu for inverting members; Asp for retaining members
Catalytic Proton DonorGlu
NoteCreated based on a paper by Hughes et al. (2003) Oral Microbiol Immunol. 18:309-312 (PMID: 12930523); *Mechanistic and structural elucidation by Gloster et al. (2008) Chem. Biol., Oct 8 (PMID:18848471); the inverting a-glucosidases (EC 3.2.1.20) could be renamed glucoamylases (EC 3.2.1.3 according to Kitamura et al. (2008) J. Biol. Chem., Nov 3 (PMID:18981178)
External resourcesCAZypedia;
Statistics GenBank accession (1052); Uniprot accession (166); PDB accession (12); 3D entries (3); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-galactosidase (BtGH97b;BT1871;BT_1871) 3.2.1.22 Bacteroides thetaiotaomicron VPI-5482 AAO76978.1
NP_810784.1
Q8A6L0 3A24[A,B]
5E1Q[A,B]
 α-mannan α-galactosidase (BT2620) 3.2.1.22 Bacteroides thetaiotaomicron VPI-5482 AAO77727.1
NP_811533.1
Q8A4H9  
 α-D-galactosidase (BT3664) 3.2.1.22 Bacteroides thetaiotaomicron VPI-5482 AAO78769.1
NP_812575.1
Q8A1J7  
 bifunctional β-L-arabinopyranosidase/α-D-galactosidase (BT3661) 3.2.1.22
3.2.1.88
Bacteroides thetaiotaomicron VPI-5482 AAO78766.1
NP_812572.1
Q8A1K0  
 α-glucosidase / glucoamylase (SusB;BtGH97a;BT3703;BT_3703) 3.2.1.3 Bacteroides thetaiotaomicron VPI-5482 AAC44671.1
AAO78808.1
NP_812614.1
G8JZS4
P71094
2D73[A,B]
2JKA[A,B]
2JKE[A,B]
2JKP[A,B]
2ZQ0[A,B]
3WFA[A,B]
 α-glucoside hydrolase (PspAG97A) (Ag97A) 3.2.1.- Pseudoalteromonas sp. K8 AMB20699.1   5HQ4[A]
5HQA[A]
5HQB[A]
5HQC[A]
 α-glucosidase (SusB;Aglu;BFO_2272) 3.2.1.20 Tannerella forsythia 92A2 ATCC 43037 AEW20125.1
AAO33827.1
Q84FT4  
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