Glycoside Hydrolase Family 73

Activities in FamilyPeptidoglycan endo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-);
Mannosyl-glycoprotein endo-β-N-acetylglucosaminidase (EC 3.2.1.96);
Mechanism Unknown e
3D Structure Statuslysozyme fold
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
NoteThe 3-D structure of Sphingomonas sp. strain A1 FlgJ protein of this family has recently been solved (Hashimotoa et al., BBRC 2009); there is only one, unconfirmed, report of b-1,4-N-acetylmuramoylhydrolase (EC 3.2.1.17) activity
External resourcesCAZypedia;
Statistics GenBank accession (39697); Uniprot accession (32); PDB accession (25); 3D entries (14); cryst (0)
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Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Alsa1_CDS0005   Staphylococcus phage Alsa_1 WNM50355.1    
 Alsa2_CDS0243   Staphylococcus phage Alsa_2 WNM50857.1    
 Alsa3_CDS0033   Staphylococcus phage Alsa_3 WNM50902.1    
 Alsa4_CDS0023   Staphylococcus phage Alsa_4 WNM51153.1    
 lysin   Staphylococcus phage ASZ22RN WCS65176.1    
 CHAP-domain tail tip cell wall hydrolase   Staphylococcus phage B166 AKC04670.1    
 CHAP-domain tail tip cell wall hydrolase   Staphylococcus phage B236 AKC04737.1    
 glucosaminidase domain-containing protein   Staphylococcus phage BUCT556 QSM00659.1    
 bifunctional autolysin Atl/N-acetylmuramoyl-L-alanine amidase/endo-β-N-acetylglucosaminidase   Staphylococcus phage CNPx AMM44586.1    
 DSP07_11   Staphylococcus phage DSP07 QWT56478.1    
 Henu2_gp6   Staphylococcus phage Henu2 QAU03478.1    
 ABLNHBOO_00006   Staphylococcus phage Henu2 UYF04898.1    
 Hesat_gp64   Staphylococcus phage Hesat WAX23184.1    
 HSA84_gp024   Staphylococcus phage HSA84 AUG85752.1    
 bifunctional autolysin   Staphylococcus phage IME1318_01 ARM67814.1    
 endo-β-N-acetylglucosaminidase   Staphylococcus phage IME1323_01 ARM67883.1    
 N-acetylmuramoyl-L-alanine amidase   Staphylococcus phage IME1348_01 ARM68072.1    
 glucosaminidase domain-containing protein   Staphylococcus phage IME1364_02 QPN96379.1    
 endo-β-N-acetylglucosaminidase   Staphylococcus phage IME1365_01 ARM68527.1    
 lysin   Staphylococcus phage J1 WNT48934.1    
 lysin   Staphylococcus phage J2 WNT49003.1    
 lysin   Staphylococcus phage J4 WNT49064.1    
 Koombakaat1_00163   Staphylococcus phage Koomba-kaat_1 UXE02953.1    
 ORF   Staphylococcus phage KSAP11 BBM81471.1    
 ORF   Staphylococcus phage KSAP7 BBM81284.1    
 ORF   Staphylococcus phage L-m44 WHM49636.1    
 UVUMRFZT_CDS0194   Staphylococcus phage LJLAME001 WXX03111.1    
 Lorac_024   Staphylococcus phage Lorac AXC42915.1    
 LSA2308_00106   Staphylococcus phage LSA2308 QQO38126.1    
 LSA2311_orf00096   Staphylococcus phage LSA2311 USZ62904.1    
 mphiCDS_0009   Staphylococcus phage mosaic phi11 WYN33682.1    
 MRS_104   Staphylococcus phage MR003 phiMR003 BBI90221.1    
 N-acetylglucosaminidase   Staphylococcus phage MSP1 WJZ70322.1    
 PBSA08_072   Staphylococcus phage PBSA08 WCO82427.1    
 ph24   Staphylococcus phage PH15 ABI21813.1    
 ORF5   Staphylococcus phage phi 53 AAM49609.1    
 SEP1_028   Staphylococcus phage phiIBB-SEP1 AGR48156.1    
 phiJB_ORF66 (LyS)   Staphylococcus phage phiJB ALA12220.1    
 RNIID_1630   Staphylococcus phage phiRNIID BEU75375.1    
  bifunctional autolysin Atl N-acetylmuramoyl-L-alanine amidase endo-β-N-acetylglucosaminidase   Staphylococcus phage phiSP119-3 AZB66874.1    
  bifunctional autolysin Atl N-acetylmuramoyl-L-alanine amidase endo-β-N-acetylglucosaminidase   Staphylococcus phage phiSP44-1 Staphylococcus pseudintermedius 14-29-44 AZB66677.1    
 PM56_096   Staphylococcus phage PM56 QVD57641.1    
 PM93_107   Staphylococcus phage PM93 QVD58534.1    
 lysin   Staphylococcus phage PMBT9 QQV87981.1    
 qdsa001_102   Staphylococcus phage qdsa001 ARQ95858.1    
 Romulus_096   Staphylococcus phage Romulus QVD58928.1    
 ORF004   Staphylococcus phage ROSA AAX91500.1    
 lysin N-acetylmuramoyl-L-alanine amidase   Staphylococcus phage Rosita WVR18230.1    
 CoNPh38_CDS0173   Staphylococcus phage S-CoN_Ph38 WNM56049.1    
 SA12_046   Staphylococcus phage SA12 AGO49863.1    
 SA13_57   Staphylococcus phage SA13 AFO71508.1    
 lysin   Staphylococcus phage SA75 QIA28752.1    
 SA97_032   Staphylococcus phage SA97 AHZ95690.1    
 SAC_139   Staphylococcus phage SAC WJZ48770.1    
 ORF   Staphylococcus phage SAP13_TA-2022 UUV45448.1    
 ORF   Staphylococcus phage SAP1_TA-2022 UUV45184.1    
 ORF   Staphylococcus phage SAP2_TA-2022 UUV45252.1    
 SAP33_00001   Staphylococcus phage SAP33 QDH45449.1    
 SAP3_41   Staphylococcus phage SAP3_TA-2022 QMP81550.1    
 ORF   Staphylococcus phage SAP3_TA-2022 UUV45319.1    
 SAP40_00063   Staphylococcus phage SAP40 QDH45575.1    
 ORF   Staphylococcus phage SAP6 WAW12175.1    
 glucosaminidase domain-containing protein   Staphylococcus phage SAP71 WRO06533.1    
 ORF   Staphylococcus phage SAP8_TA-2022 UUV45381.1    
 ORF   Staphylococcus phage SAPYZU_15 QXV86307.1    
 CPT_Sebago_008   Staphylococcus phage Sebago QBQ72244.1    
 bifunctional autolysin   Staphylococcus phage SN10 ASU01339.1    
 bifunctional autolysin   Staphylococcus phage SN11 ASU01269.1    
 bifunctional autolysin   Staphylococcus phage SN13 ASU01198.1    
 bifunctional autolysin   Staphylococcus phage SN8 ASU01407.1    
 ORF_13   Staphylococcus phage SP120 BBJ33950.1    
 SP197g_44   Staphylococcus phage SP197 BBJ34051.1    
 SP276g_08   Staphylococcus phage SP276 BBJ34085.1    
 SP5_059   Staphylococcus phage SP5 AFQ96867.1    
 SP6_0055   Staphylococcus phage SP6 AFQ96926.1    
 SpT152_065 (AtL)   Staphylococcus phage SpT152 APD19880.1    
 SpT252_008 (AtL)   Staphylococcus phage SpT252 APD19891.1    
 SpT5_008 (AtL)   Staphylococcus phage SpT5 APD19756.1    
 SSP49_111   Staphylococcus phage SSP49 WBF47936.1    
 SAP1_059   Staphylococcus phage StAP1 APC42924.1    
 ORF   Staphylococcus phage StAP1 WAW11960.1    
 Stau2_41   Staphylococcus phage Stau2 AKA61292.1    
 StauST398-1_0010   Staphylococcus phage StauST398-1 AFN39879.1    
 StauST398-3_0063   Staphylococcus phage StauST398-3 AFN39863.1    
 StauST398-5_0057   Staphylococcus phage StauST398-5 AGR46344.1    
 peptidoglycan hydrolase   Staphylococcus phage StB12 AFD22279.1    
 peptidoglycan hydrolase   Staphylococcus phage StB27 AFD22208.1    
 cell wall hydrolase   Staphylococcus phage TEM123 AFI61617.1    
 cell wall hydrolase   Staphylococcus phage TEM126 ADV76510.1    
 CLI63_00044   Staphylococcus phage UPMK_2 AUM57565.1    
 RP15_gp030   Staphylococcus phage vB_Sau-RP15 QYC52003.1    
 ORF   Staphylococcus phage vB_SauH_DELF3 BCK59783.1    
 SPJ221_96   Staphylococcus phage vB_SauH_SPJ2 WEW53645.1    
 tail lysin   Staphylococcus phage vB_SauM-HM01 UGL60720.1    
 ORF   Staphylococcus phage vB_SauM-V1SA19 UVD42513.1    
 ORF   Staphylococcus phage vB_SauM-V1SA20 UVT34949.1    
 ORF   Staphylococcus phage vB_SauM-V1SA22 UVD42606.1    
 Remus_033   Staphylococcus phage vB_SauM_Remus AFV80921.1    
 Romulus_033   Staphylococcus phage vB_SauM_Romulus AFV81095.1    
 VL10_ORF107   Staphylococcus phage vB_SauM_VL10 WAX23298.1    
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