Activities in Family	Peptidoglycan endo-β-1,4-N-acetylglucosaminidase (EC 3.2.1.-); Mannosyl-glycoprotein endo-β-N-acetylglucosaminidase (EC 3.2.1.96);
Mechanism	Unknown e
3D Structure Status	lysozyme fold
Catalytic Nucleophile/Base	Not known
Catalytic Proton Donor	Glu
Note	The 3-D structure of Sphingomonas sp. strain A1 FlgJ protein of this family has recently been solved (Hashimotoa et al., BBRC 2009); there is only one, unconfirmed, report of b-1,4-N-acetylmuramoylhydrolase (EC 3.2.1.17) activity
External resources	CAZypedia;
Statistics	GenBank accession (40403); Uniprot accession (32); PDB accession (27); 3D entries (15); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
ERS445050_00844 (Ykfc_1)	3.2.1.-	Clostridioides difficile NCTC13307	CKG89751.1		8YXK[A,B] 1.87
peptidoglycan hydrolase with β-N-acetylglucosaminidase specificity / autolysin (Acp;CPE1231)	3.2.1.-	Clostridium perfringens str. 13	BAB80937.1 ADA00360.1 NP_562147.1	D2KAF8 Q8XL11	5AZM[A] 1.75 5WQW[A] 1.76 8YXN[A,B] 1.60
LNB41_02895		Enterococcus faecalis Fac74	UER80703.1		7QFU[A] 1.45
A4V06_04040		Enterococcus faecalis KB1	ANU72273.1 ASU26966.1 QQR11538.1		7QFU[A] 1.45
peptidoglycan hydrolase / N-acetylglucosaminidase (Auto;Lmo1076)	3.2.1.96	Listeria monocytogenes EGD-e	NP_464601.1 CAC99154.1	Q8Y842	3FI7[A] 2.35
flagellum-specific muramidase / peptidoglycan hydrolase (FlgJ;StFlgJ;STM1182)	3.2.1.-	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	AAL20112.1 AAA27070.1 NP_460153.1	P15931	5DN4[A] 1.80 5DN5[A,B,C] 2.15
peptidoglycan hydrolase (FlgJ;SPH1045)	3.2.1.-	Sphingomonas sp. A1	BAH11452.1	B7XH69	2ZYC[A] 1.74 3K3T[A] 1.75 3VWO[A] 1.80
SAB1633c		Staphylococcus aureus RF122	CAI81322.1		6U0O[B] 2.60
SAV1052 autolysin	3.2.1.-	Staphylococcus aureus subsp. aureus Mu50	BAB57214.2 BAB45607.1 CAD98826.1	Q931U5 Q931U5	6FXO[A] 2.28
SAV1775		Staphylococcus aureus subsp. aureus Mu50	BAB57937.1 BAB46695.1 NP_372299.1		6FXP[A,B] 2.03
SAV2307		Staphylococcus aureus subsp. aureus Mu50	BAB58469.1 BAB44551.1 NP_372831.1		4PI7[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc 1.60 4PI8[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc 1.39 4PI9[A] <non_carb>-(1-3)-β-D-GlcpNAc 1.48 4PIA[A] 1.47
SAOUHSC_02979		Staphylococcus aureus subsp. aureus NCTC 8325	ABD31967.1		5T1Q[A,B,C,D] 2.15
peptidoglycan endo-β-N-acetylglucosaminidase (LytB)	3.2.1.-	Streptococcus pneumoniae R6	AAK99671.1 AAW08925.1 CAA09078.1 CAA09078.2 NP_358461.1	P59205 P59206	7PJ3[A] 7PJ4[A] 7PJ5[A] 7PJ6[A] 7PL3[A] 1.78 7POD[A] β-D-GlcpNAc-(1-4)[<non_carb>-(1-3)]-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)[<C3O2>-(1-3)]-β-D-GlcpNAc-(1-1)-methyl 1.50
endo-β-N-acetylglucosaminidase (LytB;SP0965)	3.2.1.-	Streptococcus pneumoniae TIGR4	AAK75086.1 AAQ38107.1 AAY71753.1 ABA35746.1 ABA35884.1 NP_345446.1	P59205	4Q2W[A] 1.65
β-N-acetylglucosaminidase (TM0633)	3.2.1.-	Thermotoga maritima MSB8	AAD35717.1 AGL49559.1 AHD17612.1 AKE28421.1 NP_228442.1	Q9WZA1 R4NYQ2	4QDN[A] 1.70
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