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Glycoside Hydrolase Family 5 / Subf 2

Activities in Sub FamilyChitosanase (EC 3.2.1.132);
Endo-β-1,4-glucanase (EC 3.2.1.4);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (10); Uniprot accession (147); PDB accession (47); 3D entries (17); cryst (0)
Summary
Download GH5_2 (2298) Taxonomic display Structure (17) Characterized (129)
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Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 glycoside hydrolase family 5 subfamily 2   Acanthocinus aedilis UNG40277.1     2
 glycoside hydrolase family 5 subfamily 2   Acanthocinus aedilis UNG40275.1     2
 glycoside hydrolase family 5 subfamily 2   Acanthocinus aedilis UNG40273.1     2
 glycoside hydrolase family 5 subfamily 2   Acanthocinus aedilis UNG40276.1     2
 glycoside hydrolase family 5 subfamily 2   Acanthocinus aedilis UNG40274.1     2
 I4U23_022449   Adineta vaga UJR19320.1     2
 glycoside hydrolase family 5 subfamily 2   Agapanthia villosoviridescens UNG40288.1     2
 glycoside hydrolase family 5 subfamily 2   Agapanthia villosoviridescens UNG40284.1     2
 glycoside hydrolase family 5 subfamily 2   Agapanthia villosoviridescens UNG40287.1     2
 glycoside hydrolase family 5 subfamily 2   Agapanthia villosoviridescens UNG40286.1     2
 glycoside hydrolase family 5 subfamily 2   Agapanthia villosoviridescens UNG40285.1     2
 247468   Anaeromyces robustus v1.0 (Anasp1)       2
 glycoside hydrolase family 5 subfamily 2   Anisarthron barbipes UNG40280.1     2
 glycoside hydrolase family 5 subfamily 2   Anisarthron barbipes UNG40278.1     2
 glycoside hydrolase family 5 subfamily 2   Anisarthron barbipes UNG40279.1     2
 glycoside hydrolase family 5 subfamily 2   Anisarthron barbipes UNG40283.1     2
 glycoside hydrolase family 5 subfamily 2   Anisarthron barbipes UNG40281.1     2
 glycoside hydrolase family 5 subfamily 2   Anisarthron barbipes UNG40282.1     2
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 Anoplophora chinensis AFN89566.1 K4GMM5   2
 cellulase (Eng)   Aphelenchoides besseyi AIK28470.2
AIK28470.1		     2
 cellulase (Eng-1)   Aphelenchoides fragariae AFD33558.1     2
 β-1,4-endoglucanase / cellulase (Eng-1;Afr-ENG-1) (fragment)   Aphelenchoides fragariae AFD33557.1     2
 Eng-3 (fragment)   Aphelenchoides fragariae AFI63769.1     2
 endo-β-1,4-glucanase (Aα-Eng-1)   Aphelenchus avenae BAI44493.1
BAI44494.1		     2
 endo-β-1,4-glucanase (Aα-Eng-2)   Aphelenchus avenae BAI44495.1
BAI44496.1		     2
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 Apriona germarii AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 Apriona japonica AHI15751.1 X2D6U4   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-5)   Apriona japonica AHI15750.1     2
 endo-?-1,4-xylanase (AJAGH5_2-1) 3.2.1.8 Apriona japonica AHI15746.1 X2D6U2   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-2)   Apriona japonica AHI15747.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-3)   Apriona japonica AHI15748.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-4)   Apriona japonica AHI15749.1     2
 50264   Caecomyces churrovis (Caecom1)       2
 442420   Caecomyces churrovis (Caecom1)       2
 526445   Caecomyces churrovis (Caecom1)       2
 576045   Caecomyces churrovis (Caecom1)       2
 ORF   Coptotermes formosanus AGM32066.1     2
 ORF (fragment)   Coptotermes formosanus AGM32347.1     2
 ORF (fragment)   Coptotermes formosanus AGM33006.1     2
 endoglucanase (Eng1;Dα-Eng1)   Ditylenchus africanus ABY52965.1     2
 endo-β-1,4-glucanase (Eng-1B)   Ditylenchus destructor ACJ60676.1     2
 endo-β-1,4-glucanase (Eng-2)   Ditylenchus destructor ACP20205.1     2
 endo-β-1,4-glucanase (Eng-1A)   Ditylenchus destructor ADW77528.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40299.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40296.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40294.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40293.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40298.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40297.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40295.1     2
 glycoside hydrolase family 5 subfamily 2   Exocentrus adspersus UNG40292.1     2
 glycoside hydrolase family 5 subfamily 2   Gaurotes virginea UNG40291.1     2
 glycoside hydrolase family 5 subfamily 2   Gaurotes virginea UNG40289.1     2
 glycoside hydrolase family 5 subfamily 2   Gaurotes virginea UNG40290.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27800.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27801.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27802.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27803.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27804.1     2
 endo-β-1,4-glucanase (Eng-3)   Globodera rostochiensis AHW98762.1     2
 endo-β-1,4-glucanase (Eng1)   Globodera rostochiensis AHW98760.1     2
 endo-β-1,4-glucanase (Eng-2)   Globodera rostochiensis AHW98761.1     2
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1		 Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1		 Q8MM50   2
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1		 O16028
Q7KQF7		   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1		 O44078
O77094		   2
 endo-β-1,4-glucanase 2 (Eng2)   Globodera tabacum solanacearum AAD56393.1     2
 endo-β-1,4-glucanase 1 (Eng1)   Globodera tabacum solanacearum AAD56392.1     2
 ORF   Heterodera avenae AVA09688.1     2
 endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a) 3.2.1.4 Heterodera avenae ACO55952.1
AFQ55438.1
AGH32769.1		 D5FQ93
M4QVR5		   2
 endo-β-1,4-glucanase 2 (Eng2)   Heterodera avenae AFQ55680.1
AFQ55681.1		     2
 endo-β-1,4-glucanase 3 (Eng3)   Heterodera avenae AFQ55682.1
AFQ55683.1		     2
 β-1,4-endoglucanase-1 (fragment)   Heterodera cruciferae AJE31858.1     2
 endoglucanase 4 (Eng4;Eng-4)   Heterodera glycines AAK85303.1
AAP88024.1		     2
 cellulase (Eng6;Eng-6;G26D05)   Heterodera glycines AAM50039.1
AAO25506.1		     2
 cellulase (Eng5;Eng-5)   Heterodera glycines AAN32884.1
AAP97436.1		     2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1		 O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1		 O18454
O61595		   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1		 O77449   2
 endoglucanase   Heterodera glycines QLK97578.1     2
 β-1,4-endoglucanase (EnG)   Heterodera glycines AYC07648.1     2
 β-1,4-endoglucanase (EnG)   Heterodera glycines AYC07647.1     2
 β-1,4-endoglucanase-2 precursor (Eng2)   Heterodera koreana 01 ART34946.1     2
 endo-β-1,4-glucanase 1 (Eng1;Hssp19)   Heterodera schachtii CAC12958.1     2
 endo-β-1,4-glucanase 2 (Eng2;Hssp19)   Heterodera schachtii CAC12959.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27797.1
AER27799.1		     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27798.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27793.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27794.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27795.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27796.1     2
 β-1,4-endoglucanase   Hirschmanniella mucronata QBO95451.1     2
 ORF (fragment)   Koerneria sudhausi SB413 ADY92762.1     2
 3966   Labyrinthula sp. SR_Ha_C (LabyHa_1)       2
 4693   Labyrinthula sp. SR_Ha_C (LabyHa_1)       2
 1810   Labyrinthula sp. SR_Ha_C (LabyHa_1)       2
 glycoside hydrolase family 5 subfamily 2   Leptura aurulenta UNG40301.1     2
 glycoside hydrolase family 5 subfamily 2   Leptura aurulenta UNG40303.1     2
 glycoside hydrolase family 5 subfamily 2   Leptura aurulenta UNG40300.1     2
 glycoside hydrolase family 5 subfamily 2   Leptura aurulenta UNG40304.1     2
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