Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 cellulase / exo-β-glucanase 5B (AmCel-5B) 3.2.1.4 Anoplophora chinensis AFN89566.1     2
 cellulase (Eng)   Aphelenchoides besseyi AIK28470.2
AIK28470.1
    2
 cellulase (Eng-1)   Aphelenchoides fragariae AFD33558.1     2
 β-1,4-endoglucanase / cellulase (Eng-1;Afr-ENG-1) (fragment)   Aphelenchoides fragariae AFD33557.1     2
 Eng-3 (fragment)   Aphelenchoides fragariae AFI63769.1     2
 endo-β-1,4-glucanase (Aα-Eng-1)   Aphelenchus avenae BAI44493.1
BAI44494.1
C9K4V2   2
 endo-β-1,4-glucanase (Aα-Eng-2)   Aphelenchus avenae BAI44495.1
BAI44496.1
C9K4V4   2
 endoglucanase III (Ag-EGaseIII) 3.2.1.4 Apriona germari AAX18655.1 Q5DIE3   2
 glycoside hydrolase family 5 subfamily 2 (Gh5-6) 3.2.1.4 Apriona japonica AHI15751.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-5)   Apriona japonica AHI15750.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-1)   Apriona japonica AHI15746.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-2)   Apriona japonica AHI15747.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-3)   Apriona japonica AHI15748.1     2
 glycoside hydrolase family 5 subfamily 2 (Gh5-4)   Apriona japonica AHI15749.1     2
 ORF   Coptotermes formosanus AGM32066.1     2
 ORF (fragment)   Coptotermes formosanus AGM32347.1     2
 ORF (fragment)   Coptotermes formosanus AGM33006.1     2
 endoglucanase (Eng1;Dα-Eng1) 3.2.1.4 Ditylenchus africanus ABY52965.1 B6CI25   2
 endo-β-1,4-glucanase (Eng-1B)   Ditylenchus destructor ACJ60676.1 D1FVA4   2
 endo-β-1,4-glucanase (Eng-2)   Ditylenchus destructor ACP20205.1 D6BL58   2
 endo-β-1,4-glucanase (Eng-1A)   Ditylenchus destructor ADW77528.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27800.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27801.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27802.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27803.1     2
 β-1,4-endoglucanase (fragment)   Globodera pallida AER27804.1     2
 endo-β-1,4-glucanase (Eng-3)   Globodera rostochiensis AHW98762.1     2
 endo-β-1,4-glucanase (Eng1)   Globodera rostochiensis AHW98760.1     2
 endo-β-1,4-glucanase (Eng-2)   Globodera rostochiensis AHW98761.1     2
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1
Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1
Q8MM50   2
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1
O16028
Q7KQF7
  2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1
O44078
O77094
  2
 endo-β-1,4-glucanase 2 (Eng2)   Globodera tabacum solanacearum AAD56393.1 Q9U6M4   2
 endo-β-1,4-glucanase 1 (Eng1)   Globodera tabacum solanacearum AAD56392.1 Q9U6M5   2
 endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a)   Heterodera avenae ACO55952.1
AFQ55438.1
AGH32769.1
D5FQ93   2
 endo-β-1,4-glucanase 2 (Eng2)   Heterodera avenae AFQ55680.1
AFQ55681.1
    2
 endo-β-1,4-glucanase 3 (Eng3)   Heterodera avenae AFQ55682.1
AFQ55683.1
    2
 β-1,4-endoglucanase-1 (fragment)   Heterodera cruciferae AJE31858.1     2
 endoglucanase 4 (Eng4;Eng-4) 3.2.1.4 Heterodera glycines AAK85303.1
AAP88024.1
Q7YZF3
Q95UR3
  2
 cellulase (Eng6;Eng-6;G26D05)   Heterodera glycines AAM50039.1
AAO25506.1
Q86DQ0   2
 cellulase (Eng5;Eng-5)   Heterodera glycines AAN32884.1
AAP97436.1
Q8ITJ4   2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1
O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1
O18454   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1
O77449   2
 β-1,4-endoglucanase-2 precursor (Eng2)   Heterodera koreana 01 ART34946.1     2
 endo-β-1,4-glucanase 1 (Eng1;Hssp19) (partial)   Heterodera schachtii CAC12958.1 Q9GRU6   2
 endo-β-1,4-glucanase 2 (Eng2;Hssp19)   Heterodera schachtii CAC12959.1 Q9GRU5   2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27797.1
AER27799.1
    2
 β-1,4-endoglucanase (fragment)   Hirschmanniella gracilis AER27798.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27793.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27794.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27795.1     2
 β-1,4-endoglucanase (fragment)   Hirschmanniella loofi AER27796.1     2
 ORF (fragment)   Koerneria sudhausi SB413 ADY92762.1     2
 Mard-eng-1 (fragment)   Meloidogyne ardenensis AER27760.1     2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne arenaria AHX24636.1     2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne arenaria AAK21893.1 Q9BJY3   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne arenaria AAK21892.1 Q9BJY4   2
 β-1,4-endoglucanase (fragment)   Meloidogyne artiellia AER27761.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne chitwoodi AER27805.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne chitwoodi AER27807.1     2
 endo-β-1,4-glucanase   Meloidogyne chitwoodi Mc-eng-2 AER27806.1     2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne hapla AHX24637.1     2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne hapla AAK21891.1
AAS48572.1
Q9BJY5   2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne hispanica AHX24640.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne ichinohei AER27762.1     2
 β-1,4-endoglucanase (fragment)   Meloidogyne ichinohei AER27763.1     2
 endo-β-1,4-glucanase 1 (Eng-1) 3.2.1.4 Meloidogyne incognita AAD45868.1 Q9UA57   2
 cellulase (Eng4)   Meloidogyne incognita AAR37375.1 Q5QJ65   2
 cellulase (Eng3;Eng-1)   Meloidogyne incognita AAR37374.1
AHX24639.1
Q5QJ66   2
 β-1,4-endoglucanase Eng-1vi (fragment)   Meloidogyne incognita AAK21890.1 Q9BH59   2
 β-1,4-endoglucanase Eng-1v (fragment)   Meloidogyne incognita AAK21889.1 Q9BJY6   2
 β-1,4-endoglucanase Eng-1iv (fragment)   Meloidogyne incognita AAK21888.1 Q9BH59   2
 β-1,4-endoglucanase Eng-1iii (fragment)   Meloidogyne incognita AAK21887.1 Q9BH59   2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne incognita AAK21886.1 Q9BJY7   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne incognita AAK21885.1 Q9BJY8   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21881.1 Q9BJZ2   2
 β-1,4-endoglucanase-1, partial (Eng-1) (fragment)   Meloidogyne javanica AHX24638.1     2
 β-1,4-endoglucanase Eng-1ii (fragment)   Meloidogyne javanica AAK21895.1 Q9BJY1   2
 β-1,4-endoglucanase Eng-1i (fragment)   Meloidogyne javanica AAK21894.1 Q9BJY2   2
 cellulase (Eng-3)   Meloidogyne javanica HYN CAJ77137.1
ACA66271.1
A2VA30   2
 cellulase 5 (Cgh5A)   Mesosa myops AMA76414.1     2
 cellulase 5 (Cgh5D)   Mesosa myops AMA76418.1     2
 cellulase 5 (Cgh5F)   Mesosa myops AMA76419.1     2
 cellulase 5, partial (Cgh5E)   Mesosa myops AMA76417.1     2
 cellulase 5 (Cgh5B)   Mesosa myops AMA76415.1     2
 cellulase 5 (Cgh5C)   Mesosa myops AMA76416.1     2
 endo-β-1,4-glucanase I (EGaseI)   Oncideres albomarginata chamela ADI24131.1 D7P694   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
 endoglucanase (Eng1;Pc-ENG1)   Pratylenchus coffeae ABX79356.1 B6CH67   2
 β-1,4-endoglucanase (fragment)   Pratylenchus convallariae AER27764.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus crenatus AER27765.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus crenatus AER27766.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus crenatus AER27767.1     2
 endo-β-1,4-glucanase (Eng;Pg-ENG)   Pratylenchus goodeyi AJD14760.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus neglectus AER27768.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus neglectus AER27769.1     2
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