Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 β-1,4-endoglucanase (fragment)   Pratylenchus neglectus AER27770.1
AJF21509.1
    2
 endo-β-1,4-glucanase (Pp-Eng-1)   Pratylenchus penetrans BAB68522.1 Q95YN1   2
 endo-β-1,4-glucanase (Pp-Eng-2)   Pratylenchus penetrans BAB68523.1 Q95YN0   2
 β-1,4-endoglucanase (fragment)   Pratylenchus penetrans AER27771.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus penetrans AER27772.1
AJF21506.1
AJF21507.1
AJF21508.1
    2
 β-1,4-endoglucanase (fragment)   Pratylenchus penetrans AER27773.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus penetrans AER27774.1     2
 β-1,4-endoglucanase, partial (fragment)   Pratylenchus penetrans AJF21510.1     2
 β-1,4-endoglucanase, partial (fragment)   Pratylenchus penetrans AJF21511.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus pratensis AER27775.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus pratensis AER27776.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus pratensis AER27777.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus pratensis AER27778.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus pratensis AER27779.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus pratensis AER27780.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus thornei AER27781.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus thornei AER27782.1     2
 β-1,4-endoglucanase, partial (fragment)   Pratylenchus thornei AJF21504.1     2
 β-1,4-endoglucanase, partial (fragment)   Pratylenchus thornei AJF21505.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus vulnus AER27783.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus vulnus AER27784.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus vulnus AER27785.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus vulnus AER27787.1     2
 β-1,4-endoglucanase (fragment)   Pratylenchus vulnus AER27790.1     2
 endo-β-1,4-glucanase (Eng-2)   Pratylenchus vulnus CDM79919.1
AER27791.1
CDM79920.1
    2
 endo-β-1,4-glucanase (Eng-1)   Pratylenchus vulnus CDM79917.1
AER27786.1
AER27789.1
AER27792.1
CDM79918.1
    2
 β-1,4-endoglucanase (fragment)   Pratylenchus vulnus AER27788.1     2
 Eng-5 (fragment)   Pratylenchus vulnus CDM79921.1     2
 endoglucanase / cellulase (PhEG) 3.2.1.4 Psacothea hilaris BAB86867.1 Q8T890   2
 endo-β-1,4-glucanase (Eng1A;Rs-Eng1A)   Radopholus similis ABV54446.1 B2XBK6   2
 endo-β-1,4-glucanase (Eng1;Eng1B;Rs-Eng1B)   Radopholus similis ABV54447.1
ACB38289.1
B2XBK7   2
 endo-β-1,4-glucanase (Eng2;Rs-Eng2)   Radopholus similis ABV54448.1 B2XBK8   2
 endo-β-1,4-glucanase (Eng3;Rs-Eng3)   Radopholus similis ABV54449.1
AKF02781.1
B2XBK9   2
 endo-β-1,4-glucanase (Eng-1)   Rotylenchulus reniformis ADM72857.1 E1B292   2
 cellulase (CFP-EG1) 3.2.1.4 Spirotrichonympha leidyi BAD90558.1 Q5DWF1   2
 SM2735A02   uncultured symbiotic protist of Cryptocercus punctulatus BAF57456.1 A4UX46   2
 SM2736A91   uncultured symbiotic protist of Cryptocercus punctulatus BAF57457.1 A4UX47   2
 SM2736B44   uncultured symbiotic protist of Cryptocercus punctulatus BAF57458.1 A4UX48   2
 SM2738A77   uncultured symbiotic protist of Cryptocercus punctulatus BAF57459.1 A4UX49   2
 SM2739A08   uncultured symbiotic protist of Cryptocercus punctulatus BAF57460.1 A4UX50   2
 NT0283A83   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57327.1 A4UWR7   2
 NT0285A72   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57328.1 A4UWR8   2
 NT0285A74   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57329.1 A4UWR9   2
 NT0285B14   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57330.1 A4UWS0   2
 NT0287A37;NT0290A76;NT0290B18;NT0290B53   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57332.1
BAF57336.1
BAF57338.1
BAF57339.1
A4UWS2   2
 NT0288A58   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57334.1 A4UWS4   2
 NT0291B62;NT0290A90;NT0291A24   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57341.1
BAF57337.1
BAF57340.1
A4UWT1   2
 SM2760A61   uncultured symbiotic protist of Mastotermes darwiniensis BAF57413.1 A4UX03   2
 SM2632A46;SM2637A04   uncultured symbiotic protist of Neotermes koshunensis BAF57361.1
BAF57367.1
A4UWV1   2
 SM2632B73;SM2637B70;SM2649A06;SM2649A59;SM2649B23   uncultured symbiotic protist of Neotermes koshunensis BAF57363.1
BAF57368.1
BAF57369.1
BAF57370.1
BAF57373.1
A4UWV3   2
 SM2636B47   uncultured symbiotic protist of Neotermes koshunensis BAF57366.1 A4UWV6   2
 SM2040A25   uncultured symbiotic protist of Reticulitermes speratus BAF57290.1 A4UWN0   2
 SM2041A23   uncultured symbiotic protist of Reticulitermes speratus BAF57292.1 A4UWN2   2
 SM2041A77 (fragment)   uncultured symbiotic protist of Reticulitermes speratus BAF57293.1 A4UWN3   2
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