Glycoside Hydrolase Family 5 / Subf 2

Activities in Sub Family	Chitosanase (EC 3.2.1.132); Endo-β-1,4-glucanase (EC 3.2.1.4); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (10); Uniprot accession (147); PDB accession (47); 3D entries (17); cryst (0)

Summary

Download GH5_2 (2269) Taxonomic display Structure (17) Characterized (129)

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Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
endoglucanase (C1A2)	3.2.1.4	pubmed	uncultured bacterium	BAO65795.1			2
cellulase (C2A3)	3.2.1.4	pubmed	uncultured bacterium	BAO65801.1			2
endo-β-1,4-glucanase (Cel5A) (Cel5A)	3.2.1.4	pubmed	Vibrio xiamenensis G21	ADJ93836.1	D8V609		2
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
cellulase / exo-β-glucanase 5B (AmCel-5B)	3.2.1.4	pubmed	Anoplophora chinensis	AFN89566.1	K4GMM5		2
endoglucanase III (Ag-EGaseIII)	3.2.1.4	pubmed	Apriona germarii	AAX18655.1	Q5DIE3		2
glycoside hydrolase family 5 subfamily 2 (Gh5-6)	3.2.1.4	pubmed	Apriona japonica	AHI15751.1	X2D6U4		2
endo-?-1,4-xylanase (AJAGH5_2-1)	3.2.1.8	pubmed	Apriona japonica	AHI15746.1	X2D6U2		2
β-1,4-endoglucanase (Eng-3)	3.2.1.4	pubmed	Globodera rostochiensis RO-1	AAN03645.1 AAN03646.1	Q8MM42		2
β-1,4-endoglucanase (Eng-4)	3.2.1.4	pubmed	Globodera rostochiensis RO-1	AAN03647.1 AAN03648.1	Q8MM50		2
endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1)	3.2.1.4	pubmed	Globodera rostochiensis RO-1	AAC63988.1 AAC48325.1	O16028 Q7KQF7		2
endoglucanase 2 (Eng2;Eng-2)	3.2.1.4	pubmed	Globodera rostochiensis RO-1	AAC48341.1 AAC63989.1	O44078 O77094		2
endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a)	3.2.1.4	doi	Heterodera avenae	ACO55952.1 AFQ55438.1 AGH32769.1	D5FQ93 M4QVR5		2
endoglucanase 1 (Eng1;Eng-1)	3.2.1.4	pubmed	Heterodera glycines	AAC15707.1 AAC48327.1 CAB42450.1 CAB59144.1	O18453		2
endoglucanase 2 (Eng2;Eng-2)	3.2.1.4	pubmed	Heterodera glycines	AAC48326.1 AAC15708.1 CAB42449.1 CAB59143.1	O18454 O61595		2
endoglucanase 3 (Eng3;Eng-3)	3.2.1.4	pubmed	Heterodera glycines	AAC33848.1 AAC33860.1	O77449		2
endo-β-1,4-glucanase 1 (Eng-1)	3.2.1.4	pubmed	Meloidogyne incognita	AAD45868.1	Q9UA57		2
β-1,4-endoglucanase (Eng-2)	3.2.1.4	pubmed	Meloidogyne incognita	AAK21883.2	Q9BJZ0		2
endo-β-1,4-glucanase (Eng-1A;Mi-eng-1)	3.2.1.4	pubmed	Meloidogyne incognita	AAK21882.1	Q9BJZ1		2
β-1,4-endoglucanase (Eng-2)	3.2.1.4	pubmed	Meloidogyne incognita	AAK21881.1	Q9BJZ2		2
endo-β-1,4-glucanase (CelA)	3.2.1.4	pubmed	Orpinomyces joyonii 19-2	AAC49731.1	P87211		2
endoglucanase / cellulase (PhEG)	3.2.1.4	pubmed	Psacothea hilaris	BAB86867.1	Q8T890		2
cellulase (CFP-EG1)	3.2.1.4	pubmed	Spirotrichonympha leidyi	BAD90558.1	Q5DWF1		2
NT0285A72	3.2.1.4	pubmed	uncultured symbiotic protist of Hodotermopsis sjoestedti	BAF57328.1	A4UWR8		2
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
ancestral endocellulase Cel5A (LFCA_EG)	3.2.1.4	doi	synthetic construct			6GJF[B,C,D,E,F] 6GJF[A]	2
endo-β-1,4-glucanase (cel36)	3.2.1.4	pubmed	uncultured microorganism	AOA60287.1			2
endo-β-1,4-glucanase (G10-10)	3.2.1.4	pubmed	uncultured organism	ACY24859.1	D8VN74		2
SARM_0026 / 457020_01700 / TW-40	3.2.1.4	pubmed	uncultured organism	ADX05697.1	E9NSK2	5UHX[A] 5WH8[A]	2
SARM_0013 / 3932955_213080 / TW-1	3.2.1.4	pubmed	uncultured organism	ADX05684.1	E9NSI9		2
endoglucanase (RR.13;RR.13-2)	3.2.1.73	pubmed	unidentified microorganism	CAJ19149.1	Q2YI54		2
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