Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1020); Uniprot accession (275); PDB accession (40); 3D entries (13); cryst (0)
All (905) Bacteria (737) Eukaryota (154) unclassified (14) Structure (13) Characterized (119)
| 1 | 2 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1
O16028
Q7KQF7
  2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1
O44078
O77094
  2
 endoglucanase 4 (Eng4;Eng-4) 3.2.1.4 Heterodera glycines AAK85303.1
AAP88024.1
Q7YZF3
Q95UR3
  2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1
O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1
O18454   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 Heterodera glycines AAC33848.1
AAC33860.1
O77449   2
 endo-β-1,4-glucanase 1 (Eng-1) 3.2.1.4 Meloidogyne incognita AAD45868.1 Q9UA57   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21881.1 Q9BJZ2   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
 endoglucanase / cellulase (PhEG) 3.2.1.4 Psacothea hilaris BAB86867.1 Q8T890   2
 cellulase (CFP-EG1) 3.2.1.4 Spirotrichonympha leidyi BAD90558.1 Q5DWF1   2
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endo-β-1,4-glucanase (G10-10) 3.2.1.4 uncultured organism ACY24859.1 D8VN74   2
 multimodular β-glucanase 3.2.1.- uncultured organism ADD61840.1 D9ZET6   2
 SARM_0026 / 457020_01700 / TW-40 3.2.1.4 uncultured organism ADX05697.1     2
 SARM_0013 / 3932955_213080 / TW-1 3.2.1.4 uncultured organism ADX05684.1     2
 SARM_0016 /3953955_160820 / TW-27 (fragment) 3.2.1.- uncultured organism ADX05687.1     2
 endoglucanase (RR.13;RR.13-2) 3.2.1.- unidentified microorganism CAJ19149.1 Q2YI54   2
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