Glycoside Hydrolase Family 4

Activities in Familymaltose-6-phosphate glucosidase (EC 3.2.1.122); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); 6-phospho-β-glucosidase (EC 3.2.1.86); α-glucuronidase (EC 3.2.1.139); α-galacturonase (EC 3.2.1.67); palatinase (EC 3.2.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNot known
NoteThe enzymes in this family display an unusual mechanism involving NAD+.
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (7868); Uniprot accession (703); PDB accession (11); 3D entries (7); cryst (0)
All (7634) Archaea (38) Bacteria (7595) unclassified (1) Structure (7) Characterized (27)
| 1 | ... | 67 | 68 | 69 | 70 | 71 | 72 | 73 | 74 | 75 | 76 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 A7K99_04360   Tatumella citrea ATCC 39140 ARU97135.1    
 A7K98_04360   Tatumella citrea DSM 13699 ARU93097.1    
 TepiRe1_2361 (LicH)   Tepidanaerobacter acetatoxydans Re1 CCP27199.1    
 TepRe1_2193   Tepidanaerobacter acetatoxydans Re1 AEE92315.1    
 GZ22_00740   Terribacillus aidingensis MP602 AIF65323.1    
 GZ22_02375   Terribacillus aidingensis MP602 AIF65606.1    
 GZ22_03550   Terribacillus aidingensis MP602 AIF65809.1    
 GZ22_11110   Terribacillus aidingensis MP602 AIF67141.1    
 GZ22_12030   Terribacillus aidingensis MP602 AIF67298.1    
 AciPR4_1233   Terriglobus saanensis SP1PR4 ADV82058.1 E1N1P0  
 BW733_13230   Tessaracoccus flavescens SST-39T AQP51639.1    
 RPIT_03270   Tessaracoccus flavus RP1T AQP43955.1    
 BW730_09760   Tessaracoccus sp. NSG39 AQP47732.1    
 BKM78_12285   Tessaracoccus sp. T2.5-30 AQX16596.1    
 AC806_04455   Tetragenococcus halophilus MJ4 AOF49996.1    
 AC806_02740   Tetragenococcus halophilus MJ4 AOF49970.1    
 TEH_12420   Tetragenococcus halophilus NBRC 12172 BAK94569.1    
 TEH_20950 + TEH_20940   Tetragenococcus halophilus NBRC 12172 BAK95421.1
BAK95422.1
   
 Thebr_1991   Thermoanaerobacter brockii subsp. finnii Ako-1 ADV80510.1 C5U9F4  
 Thit_0297   Thermoanaerobacter italicus Ab9 ADD01615.1 D3T6K2  
 Thit_1733   Thermoanaerobacter italicus Ab9 ADD02978.1 D3T426  
 Tmath_0373   Thermoanaerobacter mathranii subsp. mathranii str. A3 ADH60150.1 D7AS06  
 Teth39_1944   Thermoanaerobacter pseudethanolicus ATCC 33223 ABY95575.1 B0KCW8  
 Thet_0441   Thermoanaerobacter sp. X513 ADN54093.1 E1SXA4  
 Thet_0308   Thermoanaerobacter sp. X513 ADN53969.1 E1SWR0  
 Teth514_0266   Thermoanaerobacter sp. X514 ABY91583.1 B0K275  
 Teth514_0394   Thermoanaerobacter sp. X514 ABY91706.1 B0K334  
 Thewi_0366 (probable fragment)   Thermoanaerobacter wiegelii Rt8.B1 AEM77856.1    
 Tsac_0110   Thermoanaerobacterium saccharolyticum JW/SL-YS485 AFK85146.1    
 Tsac_0200   Thermoanaerobacterium saccharolyticum JW/SL-YS485 AFK85236.1 I3VRU1  
 SAMN05660242_0957   Thermoanaerobacterium sp. RBIITD SNX53414.1    
 SAMN05660242_0849   Thermoanaerobacterium sp. RBIITD SNX53322.1    
 SAMN05660242_0937   Thermoanaerobacterium sp. RBIITD SNX53397.1    
 Tthe_2351   Thermoanaerobacterium thermosaccharolyticum DSM 571 ADL69819.1 D9TS96  
 Tthe_2397   Thermoanaerobacterium thermosaccharolyticum DSM 571 ADL69862.1 D9TSK7  
 Tthe_2424   Thermoanaerobacterium thermosaccharolyticum DSM 571 ADL69889.1 D9TSN4  
 Thethe_02447   Thermoanaerobacterium thermosaccharolyticum M0795 AGB20015.1    
 Thethe_02403   Thermoanaerobacterium thermosaccharolyticum M0795 AGB19972.1    
 Thert_00931 (GluC)   Thermoanaerobacterium thermosaccharolyticum TG57 AST57057.1    
 Thert_01994 (GluE)   Thermoanaerobacterium thermosaccharolyticum TG57 AST57947.1    
 Theco_0425   Thermobacillus composti KWC4 AGA56646.1    
 Theco_0497   Thermobacillus composti KWC4 AGA56710.1    
 Theco_1506   Thermobacillus composti KWC4 AGA57655.1    
 Tter_2617   Thermobaculum terrenum ATCC BAA-798 ACZ43505.1 D1CID4  
 Tter_2132   Thermobaculum terrenum ATCC BAA-798 ACZ43033.1 D1CH12  
 Tter_0137   Thermobaculum terrenum ATCC BAA-798 ACZ41059.1 D1CDQ3  
 Tter_0216   Thermobaculum terrenum ATCC BAA-798 ACZ41138.1 D1CDY2  
 Tter_1959   Thermobaculum terrenum ATCC BAA-798 ACZ42865.1 D1CGJ4  
 Tfu_2768   Thermobifida fusca YX AAZ56801.1 Q47L71  
 Tcur_3858   Thermomonospora curvata DSM 43183 ACY99387.1 D1AD78  
 Toce_0345   Thermosediminibacter oceani DSM 16646 ADL07126.1 D9S0W2  
 Toce_1700   Thermosediminibacter oceani DSM 16646 ADL08436.1 D9RYL2  
 THA_1970   Thermosipho africanus TCF52B ACJ76391.1 B7IEG4  
 BW47_04125   Thermosipho melanesiensis 431 APT73768.1    
 Tmel_0765   Thermosipho melanesiensis BI429 ABR30628.1 A6LL27  
 α-glucosidase (AglA;TM1834) 3.2.1.20 Thermotoga maritima MSB8 AAD36897.1
AGL50767.1
AHD18275.1
AKE29584.1
CAA04524.1
NP_229631.1
O33830 1OBB[A,B]
 α-glucuronidase (Agu;TM0434) (Agu4A) 3.2.1.139 Thermotoga maritima MSB8 AAD35519.1
AGL49356.1
AHD17808.1
AKE28228.1
NP_228244.1
Q9WYR5  
 α-glucuronidase (TM0752) (Agu4B) 3.2.1.139 Thermotoga maritima MSB8 AAD35834.1
AGL49678.1
AHD17493.1
AKE28533.1
NP_228561.1
Q9WZL1 1VJT[A]
 TM1068   Thermotoga maritima MSB8 AAD36145.1
AGL49996.1
AHD19024.1
AKE28844.1
NP_228874.1
Q9S5X4  
 6-P-β-glucosidase (BglT;TM1281) 3.2.1.86 Thermotoga maritima MSB8 AAD36356.1
AGL50210.1
AHD18814.1
AKE29055.1
NP_229086.1
G4FE67
Q9X108
1UP4[A,B,C,D,E,F,G,H]
1UP6[A,B,C,D,E,F,G,H]
1UP7[A,B,C,D,E,F,G,H]
 THMB_0440   Thermotoga maritima Tma100 AKE30102.1    
 THMB_1878   Thermotoga maritima Tma100 AKE31455.1    
 THMB_1090   Thermotoga maritima Tma100 AKE30717.1    
 THMB_1306   Thermotoga maritima Tma100 AKE30927.1    
 THMB_0771   Thermotoga maritima Tma100 AKE30407.1    
 THMC_1090   Thermotoga maritima Tma200 AKE26979.1    
 THMC_0440   Thermotoga maritima Tma200 AKE26364.1    
 THMC_1306   Thermotoga maritima Tma200 AKE27190.1    
 THMC_0771   Thermotoga maritima Tma200 AKE26669.1    
 THMC_1878   Thermotoga maritima Tma200 AKE27709.1    
 Tnap_1513   Thermotoga naphthophila RKU-10 ADA67589.1 D2C4D5  
 Tnap_0577   Thermotoga naphthophila RKU-10 ADA66673.1 D2C6T7  
 Tnap_0550   Thermotoga naphthophila RKU-10 ADA66646.1 D2C6R0  
 α-glucosidase (AglA) 3.2.1.20 Thermotoga neapolitana CAA08868.1 O86960  
 CTN_1291   Thermotoga neapolitana DSM 4359 ACM23467.1 B9K934  
 CTN_1501   Thermotoga neapolitana DSM 4359 ACM23677.1 B9K9P4  
 CTN_0761   Thermotoga neapolitana DSM 4359 ACM22937.1 B9K7K4  
 CTN_1830 (Tn-Agl)   Thermotoga neapolitana DSM 4359 ACM24006.1 B9KAM3 3U95[A,B,C,D,E,F]
 Tpet_0177   Thermotoga petrophila RKU-1 ABQ46206.1 A5IJ33  
 Tpet_0970   Thermotoga petrophila RKU-1 ABQ46988.1 A5ILB5  
 Tpet_1490   Thermotoga petrophila RKU-1 ABQ47498.1 A5IMS5  
 Tpet_1676   Thermotoga petrophila RKU-1 ABQ47681.1 A5INA8  
 T2812B_00885   Thermotoga sp. 2812B AIY85728.1    
 T2812B_02570   Thermotoga sp. 2812B AIY86061.1    
 T2812B_04995   Thermotoga sp. 2812B AIY86542.1    
 T2812B_07635   Thermotoga sp. 2812B AIY87054.1    
 CELL2_00925   Thermotoga sp. Cell2 AIY87543.1    
 CELL2_05040   Thermotoga sp. Cell2 AIY88307.1    
 CELL2_08725   Thermotoga sp. Cell2 AIY88978.1    
 TRQ2_0175   Thermotoga sp. RQ2 ACB08536.1 B1L7V5  
 TRQ2_0505   Thermotoga sp. RQ2 ACB08861.1 B1L963  
 TRQ2_0988   Thermotoga sp. RQ2 ACB09338.1 B1LAJ0  
 TRQ2_1538   Thermotoga sp. RQ2 ACB09874.1 B1LC66  
 TRQ7_05235   Thermotoga sp. RQ7 AJG40857.1    
 TRQ7_08980   Thermotoga sp. RQ7 AJG41574.1    
 TRQ7_07930   Thermotoga sp. RQ7 AJG41370.1    
 TRQ7_02680   Thermotoga sp. RQ7 AJG40371.1    
 TRQ7_00895   Thermotoga sp. RQ7 AJG40029.1    
 Theos_2435   Thermus oshimai JL-2 AFV77412.1    
 Tola_2010   Tolumonas auensis DSM 9187 ACQ93609.1 C4L7J3  
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