Glycoside Hydrolase Family 4

Activities in Familymaltose-6-phosphate glucosidase (EC 3.2.1.122); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); 6-phospho-β-glucosidase (EC 3.2.1.86); α-glucuronidase (EC 3.2.1.139); α-galacturonase (EC 3.2.1.67); palatinase (EC 3.2.1.-)
Mechanism Retaining
3D Structure StatusRossmann fold
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNot known
NoteThe enzymes in this family display an unusual mechanism involving NAD+.
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (23145); Uniprot accession (30); PDB accession (21); 3D entries (10); cryst (0)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 6-P-α-glucosidase (GlvA;Glv-1;GlgG;BSU08180) 3.2.1.122 Bacillus subtilis subsp. subtilis str. 168 BAA09103.1
AIY92109.1
AQR80772.1
AQR84985.1
CAB12647.1
NP_388699.1
A0A6M4JJN1
P54716
1NRH[X] P-(0-6)-β-D-Glcp
2.05
1U8X[X] P-(0-6)-β-D-Glcp
2.05
 α-galacturonidase (LplD;BSU07130) 3.2.1.67 Bacillus subtilis subsp. subtilis str. 168 CAB12532.1
AAA22577.1
AIY92004.1
AQR80669.1
AQR84882.1
NP_388594.1
A0A6M4JJD7
P39130
3FEF[A,B,C,D] 2.20
 6-P-β-glucosidase (LicH;Gan4C)   Geobacillus stearothermophilus T-1 AHL67642.1  
1S6Y[A] 2.31
5C3M[A,B,C,D] 3.06
 6-phospho-α-glucosidase (AglB; KPN2242_23510) 3.2.1.122 Klebsiella pneumoniae KCTC 2242 AEK00576.1
AAK01457.1
G0GQ39
Q9AGA6
6DUX[A,B] 2.25
6DVV[A,B] 2.25
 ORF   Merdibacter massiliensis    
6VC6[A] P-(0-6)-α-D-Glcp
2.13
 α-glucosidase (AglA;TM1834) 3.2.1.20 Thermotoga maritima MSB8 AAD36897.1
AGL50767.1
AHD18275.1
AKE29584.1
CAA04524.1
NP_229631.1
O33830
R4P2C3
1OBB[A,B] α-D-Glcp-(1-4)-α-D-Glcp
1.90
 α-glucuronidase (TM0752) (Agu4B) 3.2.1.139 Thermotoga maritima MSB8 AAD35834.1
AGL49678.1
AHD17493.1
AKE28533.1
NP_228561.1
Q9WZL1
R4P1E7
1VJT[A] <carb_like_NAD>
2.50
6KCX[A] 1.93
7BR4[A] <carb_like_NAD>
1.95
7BRF[A] 2.15
7CTD[A] 2.15
7CTL[A] 1.97
7CTM[A] β-D-GlcpA
1.85
 6-P-β-glucosidase (BglT;TM1281) 3.2.1.86 Thermotoga maritima MSB8 AAD36356.1
AGL50210.1
AHD18814.1
AKE29055.1
NP_229086.1
G4FE67
Q9X108
1UP4[A,B,C,D,E,F,G,H] 2.85
1UP6[A,B,C,D,E,F,G,H] P-(0-6)-β-D-Glcp
2.55
1UP7[A,B,C,D,E,F,G,H] P-(0-6)-β-D-Glcp
2.4
 CTN_1830 (Tn-Agl)   Thermotoga neapolitana DSM 4359 ACM24006.1  
3U95[A,B,C,D,E,F] 2.00
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 ORF   metagenomes    
6WBT[A] P-(0-6)-α-D-Glcp
2.52
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