Activities in Family	maltose-6-phosphate glucosidase (EC 3.2.1.122); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); 6-phospho-β-glucosidase (EC 3.2.1.86); α-glucuronidase (EC 3.2.1.139); α-galacturonase (EC 3.2.1.67); palatinase (EC 3.2.1.-)
Mechanism	Other a,e
3D Structure Status	Rossmann fold
Catalytic Nucleophile/Base	Not applicable
Catalytic Proton Donor	Not known
Note	The enzymes in this family display an unusual mechanism involving NAD+.
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (25890); Uniprot accession (30); PDB accession (21); 3D entries (10); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
6-P-α-glucosidase (GlvA;Glv-1;GlgG;BSU08180)	3.2.1.122	Bacillus subtilis subsp. subtilis str. 168	BAA09103.1 AIY92109.1 AQR80772.1 AQR84985.1 CAB12647.1 NP_388699.1	A0A6M4JJN1 P54716	1NRH[X] P-(0-6)-β-D-Glcp 2.05 1U8X[X] P-(0-6)-β-D-Glcp 2.05
α-galacturonidase (LplD;BSU07130)	3.2.1.67	Bacillus subtilis subsp. subtilis str. 168	CAB12532.1 AAA22577.1 AIY92004.1 AQR80669.1 AQR84882.1 NP_388594.1	A0A6M4JJD7 P39130	3FEF[A,B,C,D] 2.20
6-P-β-glucosidase (LicH;Gan4C)		Geobacillus stearothermophilus T-1	AHL67642.1		1S6Y[A] 2.31 5C3M[A,B,C,D] 3.06
6-phospho-α-glucosidase (AglB; KPN2242_23510)	3.2.1.122	Klebsiella pneumoniae KCTC 2242	AEK00576.1 AAK01457.1	G0GQ39 Q9AGA6	6DUX[A,B] 2.25 6DVV[A,B] 2.25
ORF		Merdibacter massiliensis			6VC6[A] P-(0-6)-α-D-Glcp 2.13
α-glucosidase (AglA;TM1834)	3.2.1.20	Thermotoga maritima MSB8	AAD36897.1 AGL50767.1 AHD18275.1 AKE29584.1 CAA04524.1 NP_229631.1	O33830 R4P2C3	1OBB[A,B] α-D-Glcp-(1-4)-α-D-Glcp 1.90
α-glucuronidase (TM0752) (Agu4B)	3.2.1.139	Thermotoga maritima MSB8	AAD35834.1 AGL49678.1 AHD17493.1 AKE28533.1 NP_228561.1	Q9WZL1 R4P1E7	1VJT[A] <carb_like_NAD> 2.50 6KCX[A] 1.93 7BR4[A] <carb_like_NAD> 1.95 7BRF[A] 2.15 7CTD[A] 2.15 7CTL[A] 1.97 7CTM[A] β-D-GlcpA 1.85
6-P-β-glucosidase (BglT;TM1281)	3.2.1.86	Thermotoga maritima MSB8	AAD36356.1 AGL50210.1 AHD18814.1 AKE29055.1 NP_229086.1	G4FE67 Q9X108	1UP4[A,B,C,D,E,F,G,H] 2.85 1UP6[A,B,C,D,E,F,G,H] P-(0-6)-β-D-Glcp 2.55 1UP7[A,B,C,D,E,F,G,H] P-(0-6)-β-D-Glcp 2.4
CTN_1830 (Tn-Agl)		Thermotoga neapolitana DSM 4359	ACM24006.1		3U95[A,B,C,D,E,F] 2.00
unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
ORF		metagenomes			6WBT[A,B,C,D] P-(0-6)-α-D-Glcp 2.52
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