Glycoside Hydrolase Family 4

Activities in Familymaltose-6-phosphate glucosidase (EC 3.2.1.122); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); 6-phospho-β-glucosidase (EC 3.2.1.86); α-glucuronidase (EC 3.2.1.139); α-galacturonase (EC 3.2.1.67); palatinase (EC 3.2.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNot known
NoteThe enzymes in this family display an unusual mechanism involving NAD+.
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (7580); Uniprot accession (703); PDB accession (11); 3D entries (7); cryst (0)
All (7346) Archaea (38) Bacteria (7307) unclassified (1) Structure (7) Characterized (27)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-galactosidase (MelA;BH2228) (Mel4A) 3.2.1.22 Bacillus halodurans C-125 BAB05947.1
NP_243094.1
Q9KAQ9  
 α-galactosidase (MelA;BmelA) 3.2.1.22 Bacillus megaterium IAM 13418 AGG11047.1    
 6-P-α-glucosidase (GlvA;Glv-1;GlgG;BSU08180) 3.2.1.122 Bacillus subtilis subsp. subtilis str. 168 BAA09103.1
AIY92109.1
AQR80772.1
AQR84985.1
CAB12647.1
NP_388699.1
P54716 1NRH[X]
1U8X[X]
 6-P-β-glucosidase (CelF;CelD;LicH;BSU38560) 3.2.1.86 Bacillus subtilis subsp. subtilis str. 168 CAA90288.1
AIY95172.1
AQR83897.1
AQR88112.1
CAB15882.1
NP_391735.1
P46320  
 α-galactosidase (MelA;BSU30300) 3.2.1.22 Bacillus subtilis subsp. subtilis str. 168 AAC00383.1
AIY94353.1
AQR83056.1
AQR87271.1
CAB15008.1
NP_390908.1
O34645  
 α-galacturonidase (LplD;BSU07130) 3.2.1.67 Bacillus subtilis subsp. subtilis str. 168 CAB12532.1
AAA22577.1
AIY92004.1
AQR80669.1
AQR84882.1
NP_388594.1
P39130 3FEF[A,B,C,D]
 α-galactosidase (MelA) 3.2.1.22 Citrobacter freundii M4 BAB20428.1
BAA96419.1
Q9F1K2
Q9KWG7
 
 6-phospho-α-glucosidase (MalH;GlvA;CAC0533) 3.2.1.122 Clostridium acetobutylicum ATCC 824 AAK78512.1
AAK69556.1
NP_347172.1
Q97LM4  
 6-phospho-α-glucosidase (Pagl;CAC3426) 3.2.1.122 Clostridium acetobutylicum ATCC 824 AAK81356.1
NP_350016.1
Q97DP6  
 α-galactosidase (AgaA;EfmE980_0223) 3.2.1.22 Enterococcus faecium E980 EFF38781.1 D4QHF3  
 α-glucosidase (PalH) 3.2.1.20 Erwinia rhapontici DSM 4484 AAK28734.1
CAC69278.1
Q9AI65  
 6-P-β-glucosidase (ChbF;ECs2440) 3.2.1.86 Escherichia coli O157:H7 str. Sakai BAB35863.1
NP_310467.1
Q8XE05  
 6-P-β-glucosidase (CelF) 3.2.1.86 Escherichia coli str. K-12 substr. MG1655 AAC74804.1
AAA23550.1
AIZ91164.1
ALI40497.1
AMC94710.1
BAA15523.1
CAA37073.1
CAA47257.1
NP_416248.1
P17411  
 α-galactosidase A (MelA;b4119) 3.2.1.22 Escherichia coli str. K-12 substr. MG1655 AAA97019.1
AAA24149.1
AAC77080.1
AIZ93112.1
ALI38224.1
AMC96976.1
CAA28581.1
NP_418543.1
P06720  
 6-P-α-glucosidase (MalH) 3.2.1.122 Fusobacterium mortiferum AAB63015.1 O06901  
 6-P-β-glucosidase (LicH;Gan4C) 3.2.1.86 Geobacillus stearothermophilus T-1 AHL67642.1 P84135 1S6Y[A]
5C3M[A,B,C,D]
 6-phospho-α-glucosidase (AglB) 3.2.1.122 Klebsiella pneumoniae ATCC 23357 AAK01457.1 G0GQ39
Q9AGA6
 
 6-P-α-glucosidase (SimA;Pagl;LSEI_0369) 3.2.1.122 Lactobacillus paracasei ATCC 334 ABJ69228.1 Q03C44  
 palatinase 3.2.1.- Protaminobacter rubrum AAE36426.1
AAY69571.1
   
 α-galactosidase (MelA;STM4298) 3.2.1.22 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL23122.1
CAA44010.1
P30877  
 SMb21643 (AgaL2) 3.2.1.22 Sinorhizobium meliloti 1021 CAC49962.1
NP_438102.1
Q92TF8  
 α-galactosidase (MelA;AgaL1;SMb21648) 3.2.1.22 Sinorhizobium meliloti 1021 CAC49967.1
NP_438107.1
Q9X4Y0  
 α-glucosidase (AglA;TM1834) 3.2.1.20 Thermotoga maritima MSB8 AAD36897.1
AGL50767.1
AHD18275.1
AKE29584.1
CAA04524.1
NP_229631.1
O33830 1OBB[A,B]
 α-glucuronidase (Agu;TM0434) (Agu4A) 3.2.1.139 Thermotoga maritima MSB8 AAD35519.1
AGL49356.1
AHD17808.1
AKE28228.1
NP_228244.1
Q9WYR5  
 α-glucuronidase (TM0752) (Agu4B) 3.2.1.139 Thermotoga maritima MSB8 AAD35834.1
AGL49678.1
AHD17493.1
AKE28533.1
NP_228561.1
Q9WZL1 1VJT[A]
 6-P-β-glucosidase (BglT;TM1281) 3.2.1.86 Thermotoga maritima MSB8 AAD36356.1
AGL50210.1
AHD18814.1
AKE29055.1
NP_229086.1
G4FE67
Q9X108
1UP4[A,B,C,D,E,F,G,H]
1UP6[A,B,C,D,E,F,G,H]
1UP7[A,B,C,D,E,F,G,H]
 α-glucosidase (AglA) 3.2.1.20 Thermotoga neapolitana CAA08868.1 O86960  
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