Glycoside Hydrolase Family 4

Known Activitiesmaltose-6-phosphate glucosidase (EC 3.2.1.122); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); 6-phospho-β-glucosidase (EC 3.2.1.86); α-glucuronidase (EC 3.2.1.139).
Mechanism Retaining
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNot known
NoteThe enzymes in this family display an unusual mechanism involving NAD+.
External resourcesCAZypedia; InterPro; PFAM; PRINTS;
Statistics GenBank accession (1201); Uniprot accession (680); PDB accession (10); 3D entries (7); cryst (0)
All (1084) Archaea (24) Bacteria (1060) Structure (7 ) Characterized (24)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 α-galactosidase (MelA;BH2228) (Mel4A) 3.2.1.22 Bacillus halodurans C-125 BAB05947.1
NP_243094.1
Q9KAQ9  
 6-P-α-glucosidase (GlvA;Glv-1;GlgG;BSU08180) 3.2.1.122 Bacillus subtilis subsp. subtilis str. 168 BAA09103.1
CAB12647.1
NP_388699.1
P54716 1NRH[X]
1U8X[X]
 6-P-β-glucosidase (CelF;CelD;LicH;BSU38560) 3.2.1.86 Bacillus subtilis subsp. subtilis str. 168 CAA90288.1
CAB15882.1
NP_391735.1
P46320  
 α-galactosidase (MelA;BSU30300) 3.2.1.22 Bacillus subtilis subsp. subtilis str. 168 AAC00383.1
CAB15008.1
NP_390908.1
O34645.1  
 α-galactosidase (MelA) 3.2.1.22 Citrobacter freundii M4 BAA96419.1
BAB20428.1
Q9F1K2
Q9KWG7
 
 6-P-α-glucosidase (MalH;GlvA;CAC0533) 3.2.1.122 Clostridium acetobutylicum ATCC 824 AAK69556.1
AAK78512.1
NP_347172.1
Q97LM4  
 6-phospho-α-glucosidase (Pagl;CAC3426) 3.2.1.122 Clostridium acetobutylicum ATCC 824 AAK81356.1
NP_350016.1
Q97DP6  
 α-galactosidase (AgaA;EfmE980_0223) 3.2.1.22 Enterococcus faecium E980 EFF38781.1 D4QHF3  
 α-glucosidase (PalH) 3.2.1.20 Erwinia rhapontici AAK28734.1
CAC69278.1
Q9AI65  
 6-P-β-glucosidase (CelF) 3.2.1.86 Escherichia coli K-12 MG1655 AAA23550.1
AAC74804.1
BAA15515.1
BAA15523.1
CAA37073.1
CAA47257.1
NP_416248.1
P17411.4  
 α-galactosidase A (MelA) 3.2.1.22 Escherichia coli K-12 MG1655 AAA24149.1
AAA97019.1
AAC77080.1
CAA28581.1
NP_418543.1
P06720.1  
 6-P-α-glucosidase (MalH) 3.2.1.122 Fusobacterium mortiferum AAB63015.1 O06901.1  
 6-P-β-glucosidase 3.2.1.86 Geobacillus stearothermophilus   P84135 1S6Y[A]
 6-phospho-α-glucosidase (AglB) 3.2.1.122 Klebsiella pneumoniae ATCC 23357 AAK01457.1 Q9AGA6  
 6-P-α-glucosidase (SimA;Pagl;LSEI_0369) 3.2.1.122 Lactobacillus casei ATCC 334 ABJ69228.1 Q03C44  
 palatinase 3.2.1.- Protaminobacter rubrum AAE36426.1
AAY69571.1
   
 α-galactosidase (MelA;STM4298) 3.2.1.22 Salmonella typhimurium LT2 SGSC 1412; ATCC 700720 AAL23122.1
CAA44010.1
P30877.2  
 SMb21643 (AgaL2) 3.2.1.22 Sinorhizobium meliloti 1021 CAC49962.1
NP_438102.1
Q92TF8  
 α-galactosidase (MelA;AgaL1;SMb21648) 3.2.1.22 Sinorhizobium meliloti 1021 CAC49967.1
NP_438107.1
Q9X4Y0  
 α-glucosidase (AglA;TM1834) 3.2.1.20 Thermotoga maritima MSB8 AAD36897.1
CAA04524.1
NP_229631.1
O33830.2 1OBB[A,B]
 α-glucuronidase (Agu;TM0434) (Agu4A) 3.2.1.139 Thermotoga maritima MSB8 AAD35519.1
NP_228244.1
Q9WYR5  
 α-glucuronidase (TM0752) (Agu4B) 3.2.1.139 Thermotoga maritima MSB8 AAD35834.1
NP_228561.1
Q9WZL1 1VJT[A]
 6-P-β-glucosidase (BglT;TM1281) 3.2.1.86 Thermotoga maritima MSB8 AAD36356.1
NP_229086.1
Q9X108 1UP4[A,B,C,D,E,F,G,H]
1UP6[A,B,C,D,E,F,G,H]
1UP7[A,B,C,D,E,F,G,H]
 α-glucosidase (AglA) 3.2.1.20 Thermotoga neapolitana CAA08868.1 O86960  

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2012-01-31 © Copyright 1998-2012
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