Glycoside Hydrolase Family 4

Activities in Family6-P-α-glucosidase (EC 3.2.1.122);
α-glucuronidase (EC 3.2.1.139);
α-glucosidase (EC 3.2.1.20);
β-glucosidase (EC 3.2.1.21);
α-galactosidase (EC 3.2.1.22);
Galacturonan α-1,4-galacturonidase (EC 3.2.1.67);
6-P-β-glucosidase (EC 3.2.1.86);
Mechanism Other a,e
3D Structure StatusRossmann fold
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNot known
NoteThe enzymes in this family display an unusual mechanism involving NAD+.
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (28198); Uniprot accession (30); PDB accession (21); 3D entries (10); cryst (0)
| 1 | ... | 115 | 116 | 117 | 118 | 119 | 120 | 121 | 122 | 123 | ... | 278 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 IC807_12170   Geobacillus zalihae SURF-189 QNU17189.1    
 V5H98_09635   Georgenia sp. M64 WWO76044.1    
 V5H98_04900   Georgenia sp. M64 WWO79549.1    
 MF406_06435   Georgenia sp. TF02-10 UNX55863.1    
 FE251_10065   Georgenia wutianyii Z294 QDB79681.1    
 FE374_05870   Georgenia yuyongxinii Z443 QDC24215.1    
 RAM21_07255   Gilliamella apicola ESL0178 WLS90475.1    
 GAPWK_1507   Gilliamella apicola wkB1 AHN26082.1    
 F1C58_00290   Glaciihabitans sp. INWT7 QNE45521.1    
 F1C58_05285   Glaciihabitans sp. INWT7 QNE46380.1    
 CJ185_000140   Gleimia europaea UMB0652 WIK62757.1    
 CJ187_001225   Gleimia hominis UMB0859 WIK64716.1    
 CYJ72_010350   Globicatella sanguinis UMB0514 WIK66302.1    
 Q3C38_10350   Globicatella sanguinis UMB2445 WKT55707.1    
 LB888_01315   Globicatella sp. PHS-GS-PNBC-21-1553 WPC08916.1    
 GCM10025732_34530 (fragment)   Glycomyces mayteni JCM 16217 BFF25488.1    
 GCM10025732_34540 (fragment)   Glycomyces mayteni JCM 16217 BFF25489.1    
 MY490_02900   Gottfriedia acidiceleris LH14 UPM54837.1    
 MY490_01795   Gottfriedia acidiceleris LH14 UPM54634.1    
 MY490_03005   Gottfriedia acidiceleris LH14 UPM54857.1    
 MY490_20110   Gottfriedia acidiceleris LH14 UPM54019.1    
 MUN88_11375   Gracilibacillus caseinilyticus SSWR10-1 UOQ46704.1    
 MUN88_11355   Gracilibacillus caseinilyticus SSWR10-1 UOQ46700.1    
 MUN88_08805   Gracilibacillus caseinilyticus SSWR10-1 UOQ50138.1    
 MUN88_00915   Gracilibacillus caseinilyticus SSWR10-1 UOQ48755.1    
 MUN87_19045   Gracilibacillus salinarum SSPM10-3 UOQ84729.1    
 MUN87_07485   Gracilibacillus salinarum SSPM10-3 UOQ86721.1    
 MUN87_13330   Gracilibacillus salinarum SSPM10-3 UOQ83736.1    
 MUN87_10065   Gracilibacillus salinarum SSPM10-3 UOQ87196.1    
 MUN87_07465   Gracilibacillus salinarum SSPM10-3 UOQ86717.1    
 GI584_21445 (MelA)   Gracilibacillus salitolerans SCU50 QGH36455.1    
 GI584_17920 (MelA)   Gracilibacillus salitolerans SCU50 QGH35814.1    
 YC6258_03469   Gynuella sunshinyii YC6258 AJQ95505.1    
 R2S03_17175   Hafnia alvei 2023JQ-00054 WOO49179.1    
 R2S03_03560   Hafnia alvei 2023JQ-00054 WOO50275.1    
 R2S03_19870   Hafnia alvei 2023JQ-00054 WOO49690.1    
 RIN66_20360   Hafnia alvei 3.8.4 WNN52369.1    
 RIN66_19410   Hafnia alvei 3.8.4 WNN52190.1    
 RIN66_16060   Hafnia alvei 3.8.4 WNN51568.1    
 HBA19_19715   Hafnia alvei A23BA QIP57715.1    
 HBA19_20660   Hafnia alvei A23BA QIP57892.1    
 HBA19_16325   Hafnia alvei A23BA QIP57087.1    
 CD201_15475   Hafnia alvei CBA7135 AWV45877.1    
 CD201_18725   Hafnia alvei CBA7135 AWV46473.1    
 CD201_19680   Hafnia alvei CBA7135 AWV46649.1    
 AT03_20490   Hafnia alvei FB1 AIU74547.1    
 AT03_21385   Hafnia alvei FB1 AIU74707.1    
 AT03_17015   Hafnia alvei FB1 AIU73926.1    
 I6H95_19465   Hafnia alvei FDAARGOS_1038 QQE43083.1    
 I6H95_20515   Hafnia alvei FDAARGOS_1038 QQE43277.1    
 AL518_06055   Hafnia alvei FDAARGOS_158 AMH17612.1    
 AL518_06955   Hafnia alvei FDAARGOS_158 AMH17771.1    
 U0008_20985   Hafnia alvei HAMBI_1279 WQD25225.1    
 U0008_20030   Hafnia alvei HAMBI_1279 WQD25046.1    
 U0008_16445   Hafnia alvei HAMBI_1279 WQD24384.1    
 A6V27_11740   Hafnia alvei HUMV-5920 ANC40981.1    
 A6V27_07565   Hafnia alvei HUMV-5920 ANC40224.1    
 EYZ02_15995   Hafnia alvei PCM_1220 QBJ34285.1    
 EYZ02_19230   Hafnia alvei PCM_1220 QBJ35396.1    
 EYZ02_20225   Hafnia alvei PCM_1220 QBJ35060.1    
 K9N75_19350   Hafnia paralvei AVS0177 UBM40468.1    
 K9N75_20255   Hafnia paralvei AVS0177 UBM40638.1    
 BH0183 (LicH)   Halalkalibacterium halodurans C-125 BAB03902.1
NP_241049.1
   
 α-galactosidase (MelA;BH2228) (Mel4A) 3.2.1.22 Halalkalibacterium halodurans C-125 BAB05947.1
NP_243094.1
Q9KAQ9  
 BH0912   Halalkalibacterium halodurans C-125 BAB04631.1
NP_241778.1
   
 Halsa_0144   Halanaerobium hydrogeniformans ADQ13634.1    
 HLVA_21520   Haliovirga abyssi IC12 BDU51583.1    
 MUO15_18595   Halobacillus amylolyticus SSHM10-5 UOR11565.1    
 MUO15_18370   Halobacillus amylolyticus SSHM10-5 UOR11525.1    
 HBHAL_1471   Halobacillus halophilus DSM 2266 CCG43843.1    
 CEH05_02515   Halobacillus halophilus HL2HP6 ASF38036.1    
 HM131_01955   Halobacillus mangrovi KTB 131 ARI75663.1    
 P9989_16565   Halobacillus naozhouensis KCTC 13234 WFT73968.1    
 P9989_20320   Halobacillus naozhouensis KCTC 13234 WFT74664.1    
 P9989_16155   Halobacillus naozhouensis KCTC 13234 WFT73889.1    
 MUO14_10570   Halobacillus shinanisalinarum SSTM10-2 UOQ95326.1    
 MUO14_06210   Halobacillus shinanisalinarum SSTM10-2 UOQ94543.1    
 MUO14_06440   Halobacillus shinanisalinarum SSTM10-2 UOQ94585.1    
 MUO14_05995   Halobacillus shinanisalinarum SSTM10-2 UOQ94503.1    
 QRD89_03615   Halobacillus sp. ACCC02827 WJE16456.1    
 Halha_1131   Halobacteroides halobius DSM 5150 AGB41080.1    
 Halha_2519   Halobacteroides halobius DSM 5150 AGB42393.1    
 Halha_2533   Halobacteroides halobius DSM 5150 AGB42407.1    
 P8S53_04305   Halomonas sp. M1 WFE75642.1    
 Hore_23300   Halothermothrix orenii H 168 ACL71075.1    
 R3I40_09195   Helcobacillus massiliensis UMB10441 WOO92582.1    
 HIF96_00020   Helcococcus kunzii H10 QZO76447.1    
 HIF96_02970   Helcococcus kunzii H10 QZO76998.1    
 HIF96_05570   Helcococcus kunzii H10 QZO75753.1    
 GUI37_00020   Helcococcus kunzii H13 QUY63979.1    
 GUI37_03310   Helcococcus kunzii H13 QUY64585.1    
 GUI37_05735   Helcococcus kunzii H13 QUY65044.1    
 SCB71_16850 (MelA)   Herbiconiux sp. KACC 21604 WPO85873.1    
 SCB71_16820 (MelA)   Herbiconiux sp. KACC 21604 WPO85867.1    
 L3i23_09550   Herbiconiux sp. L3-i23 BDI22179.1    
 HL652_14775 (MelA)   Herbiconiux sp. SALV-R1 QJU54759.1    
 HL652_14805 (MelA)   Herbiconiux sp. SALV-R1 QJU54764.1    
 SD1D_0702 (MelA)   Herbinix luporum SD1D CUH92250.1    
 KIY57_14780 (fragment)   Heyndrickxia coagulans 13002 WNE61142.1    
 L3V65_02480   Heyndrickxia coagulans 19-1-JSRL-34-1 UJZ87915.1    
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