Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (139011); Uniprot accession (46); PDB accession (250); 3D entries (58); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)		Influenza A virus A/Michigan/20/2022	UXG50454.1
neuraminidase (NA)		Influenza A virus A/Michigan/20/2022	UYL68063.1
neuraminidase (NA)		Influenza A virus A/Michigan/200/2019	QCW11663.1
neuraminidase (NA)		Influenza A virus A/Michigan/201/2019	QCW11674.1
neuraminidase (NA)		Influenza A virus A/Michigan/202/2019	QCW14838.1 QDX13084.1
neuraminidase (NA)		Influenza A virus A/Michigan/203/2019	QCW14850.1 QDX13096.1
neuraminidase (NA)		Influenza A virus A/Michigan/204/2019	QCW11685.1
neuraminidase (NA)		Influenza A virus A/Michigan/21/2018	AVP04120.1
neuraminidase (NA)		Influenza A virus A/Michigan/21/2021	ULE39352.1
neuraminidase (NA)		Influenza A virus A/Michigan/21/2021	UYL82506.1
neuraminidase (NA)		Influenza A virus A/Michigan/21/2021	UYN13177.1
neuraminidase (NA)		Influenza A virus A/Michigan/21/2022	UXG49915.1
neuraminidase (NA)		Influenza A virus A/Michigan/21/2022	UYL68075.1
neuraminidase (NA)		Influenza A virus A/Michigan/22/2018	AXA18887.1
neuraminidase (NA)		Influenza A virus A/Michigan/22/2021	ULE39364.1
neuraminidase (NA)		Influenza A virus A/Michigan/22/2021	UYL82518.1
neuraminidase (NA)		Influenza A virus A/Michigan/22/2021	UYN13189.1
neuraminidase (NA)		Influenza A virus A/Michigan/22/2022	UXG51089.1
neuraminidase (NA)		Influenza A virus A/Michigan/22/2022	UYL68094.1
neuraminidase (NA)		Influenza A virus A/Michigan/23/2018	AXA18899.1
neuraminidase (NA)		Influenza A virus A/Michigan/23/2021	UZO40675.1
neuraminidase (NA)		Influenza A virus A/Michigan/23/2021	UZO40663.1
neuraminidase (NA)		Influenza A virus A/Michigan/23/2022	USW62258.1
neuraminidase (NA)		Influenza A virus A/Michigan/23/2022	UXG50466.1
neuraminidase (NA)		Influenza A virus A/Michigan/24/2018	AVR41094.1
neuraminidase (NA)		Influenza A virus A/Michigan/24/2021	UZO40699.1
neuraminidase (NA)		Influenza A virus A/Michigan/24/2021	UZO40687.1
neuraminidase (NA)		Influenza A virus A/Michigan/24/2022	USW62270.1
neuraminidase (NA)		Influenza A virus A/Michigan/24/2022	UYL67559.1
neuraminidase (NA)		Influenza A virus A/Michigan/25/2018	AVR42473.1
neuraminidase (NA)		Influenza A virus A/Michigan/25/2021	UZO40711.1
neuraminidase (NA)		Influenza A virus A/Michigan/25/2021	UZO40723.1
neuraminidase (NA)		Influenza A virus A/Michigan/25/2022	USW62282.1
neuraminidase (NA)		Influenza A virus A/Michigan/25/2022	UXG50478.1
neuraminidase (NA)		Influenza A virus A/Michigan/26/2018	AVR42485.1
neuraminidase (NA)		Influenza A virus A/Michigan/26/2021	UZO40747.1
neuraminidase (NA)		Influenza A virus A/Michigan/26/2021	UZO40735.1
neuraminidase (NA)		Influenza A virus A/Michigan/26/2022	UTR03247.1
neuraminidase (NA)		Influenza A virus A/Michigan/26/2022	UUV82029.1
neuraminidase (NA)		Influenza A virus A/Michigan/27/2018	AVR41112.1
neuraminidase (NA)		Influenza A virus A/Michigan/27/2021	UZO40759.1
neuraminidase (NA)		Influenza A virus A/Michigan/27/2021	UZO40771.1
neuraminidase (NA)		Influenza A virus A/Michigan/27/2022	UTR03259.1
neuraminidase (NA)		Influenza A virus A/Michigan/27/2022	UUV82041.1
neuraminidase (NA)		Influenza A virus A/Michigan/272/2017	AYF59508.1
neuraminidase (NA)		Influenza A virus A/Michigan/274/2019	QDE07202.1 QEI02439.1
neuraminidase (NA)		Influenza A virus A/Michigan/275/2019	QDE05724.1
neuraminidase (NA)		Influenza A virus A/Michigan/276/2019	QDE05739.1
neuraminidase (NA)		Influenza A virus A/Michigan/277/2019	QDE05745.1
neuraminidase (NA)		Influenza A virus A/Michigan/278/2019	QDE06284.1 QEI01965.1
neuraminidase (NA)		Influenza A virus A/Michigan/279/2019	QDE07214.1 QED94944.1
neuraminidase (NA)		Influenza A virus A/Michigan/28/2018	AXA18918.1
neuraminidase (NA)		Influenza A virus A/Michigan/28/2019	QBY33617.1
neuraminidase (NA)		Influenza A virus A/Michigan/28/2021	UZO40795.1
neuraminidase (NA)		Influenza A virus A/Michigan/28/2021	UZO40783.1
neuraminidase (NA)		Influenza A virus A/Michigan/28/2022	UTR03271.1
neuraminidase (NA)		Influenza A virus A/Michigan/28/2022	UUV80664.1
neuraminidase (NA)		Influenza A virus A/Michigan/280/2019	QDE05757.1
neuraminidase (NA)		Influenza A virus A/Michigan/281/2019	QDE07226.1 QEI02451.1
neuraminidase (NA)		Influenza A virus A/Michigan/282/2019	QDQ44973.1
neuraminidase (NA)		Influenza A virus A/Michigan/283/2019	QDJ94797.1
neuraminidase (NA)		Influenza A virus A/Michigan/284/2019	QDQ44985.1
neuraminidase (NA)		Influenza A virus A/Michigan/285/2019	QDJ94808.1
neuraminidase (NA)		Influenza A virus A/Michigan/286/2019	QDQ44997.1
neuraminidase (NA)		Influenza A virus A/Michigan/287/2019	QDQ45009.1
neuraminidase (NA)		Influenza A virus A/Michigan/29/2018	AXA18930.1
neuraminidase (NA)		Influenza A virus A/Michigan/29/2019	QBY34116.1
neuraminidase (NA)		Influenza A virus A/Michigan/29/2022	UTR03295.1
neuraminidase (NA)		Influenza A virus A/Michigan/29/2022	UTR03283.1
neuraminidase (NA)		Influenza A virus A/Michigan/30/2018	AVX28945.1
neuraminidase (NA)		Influenza A virus A/Michigan/30/2019	QBY32924.1 QCW14855.1
neuraminidase (NA)		Influenza A virus A/Michigan/30/2022	UTR03307.1
neuraminidase (NA)		Influenza A virus A/Michigan/30/2022	UTR03319.1
neuraminidase (NA)		Influenza A virus A/Michigan/301/2017	AVG71649.1
neuraminidase (NA)		Influenza A virus A/Michigan/302/2017	AVH77559.1
neuraminidase (NA)		Influenza A virus A/Michigan/303/2017	AVG71661.1
neuraminidase (NA)		Influenza A virus A/Michigan/304/2017	AVH77570.1
neuraminidase (NA)		Influenza A virus A/Michigan/305/2017	AVG71673.1
neuraminidase (NA)		Influenza A virus A/Michigan/306/2017	AVG71685.1
neuraminidase (NA)		Influenza A virus A/Michigan/307/2017	AVH77581.1
neuraminidase (NA)		Influenza A virus A/Michigan/308/2017	AVG71697.1
neuraminidase (NA)		Influenza A virus A/Michigan/309/2017	AVG71709.1
neuraminidase (NA)		Influenza A virus A/Michigan/309/2017	AVP04151.1
neuraminidase (NA)		Influenza A virus A/Michigan/31/2018	AVX28956.1
neuraminidase (NA)		Influenza A virus A/Michigan/31/2019	QBY32936.1 QCW14867.1
neuraminidase (NA)		Influenza A virus A/Michigan/31/2022	UTR03331.1
neuraminidase (NA)		Influenza A virus A/Michigan/31/2022	UTR03343.1
neuraminidase (NA)		Influenza A virus A/Michigan/32/2019	QBY34117.1
neuraminidase (NA)		Influenza A virus A/Michigan/32/2022	UUV89804.1
neuraminidase (NA)		Influenza A virus A/Michigan/32/2022	UUV82053.1
neuraminidase (NA)		Influenza A virus A/Michigan/324/2017	AVP04156.1
neuraminidase (NA)		Influenza A virus A/Michigan/33/2019	QBY32948.1 QCW14879.1
neuraminidase (NA)		Influenza A virus A/Michigan/33/2022	UUV89816.1
neuraminidase (NA)		Influenza A virus A/Michigan/33/2022	UUV82065.1
neuraminidase (NA)		Influenza A virus A/Michigan/33/2023	WJN09730.1
neuraminidase (NA)		Influenza A virus A/Michigan/33/2023	WJN09718.1
neuraminidase (NA)		Influenza A virus A/Michigan/34/2019	QCG84802.1 QCW14893.1
neuraminidase (NA)		Influenza A virus A/Michigan/34/2022	UUV89828.1
neuraminidase (NA)		Influenza A virus A/Michigan/34/2022	UUV82077.1
neuraminidase (NA)		Influenza A virus A/Michigan/35/2019	QCG83139.1
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