Glycoside Hydrolase Family 34

Activities in Familysialidase or neuraminidase (EC 3.2.1.18)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD; ProteinSpotlight;
Statistics GenBank accession (84532); Uniprot accession (20285); PDB accession (180); 3D entries (35); cryst (0)
All (80551) Viruses (80547) unclassified (4) Structure (35) Characterized (36)
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 neuraminidase (NA) (fragment)   H3N2 subtype A/Tanzania/205/2010 H3N2    
4GZP[A] <carb_like_G39>
2.30
4GZQ[A] α-D-Neup5Ac
2.20
4GZS[A,B,C,D] 2.35
4GZT[A,B,C,D] <carb_like_G39>
2.19
4GZW[A,B,C,D] α-D-Neup5Ac
α-D-Neup5Ac-(2-3)-β-D-Galp
α-D-Neup5Ac-(2-3)-β-D-Galp-(1-3)-β-D-GlcpNAc
α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-GlcpNAc
2.45
4GZX[A,B,C,D] α-D-Neup5Ac
α-D-Neup5Ac-(2-6)-β-D-Galp
2.45
4GZO[A] 2.60
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1)) AJM70556.1  
5HUG[A] 1.85
 neuraminidase 3.2.1.18 Influenza A virus (A/Brevig Mission/1/1918(H1N1)) AAF77036.1 Q9IGQ6
3B7E[A,B] <carb_like_ZMR>
1.45
3BEQ[A,B] 1.64
3CYE[A,B] 1.65
 neuraminidase (pdmNA;NA) 3.2.1.18 Influenza A virus (A/California/04/2009(H1N1)) ACP41107.1
ACP44158.1
AEE69012.1
AJI76397.1
C3W5S3
3TI3[A,B] <carb_like_LNV>
1.80
3TI4[A,B] <carb_like_LVO>
1.60
3TI5[A,B] <carb_like_ZMR>
1.90
3TI6[A,B] <carb_like_G39>
1.69
4B7J[A] D-1-deoxy-GlcpNAc
<carb_like_G39>
2.42
4B7M[A,B] 2.50
4B7N[A] <carb_like_ZMR>
2.84
4B7Q[A,B,C,D] <carb_like_ZMR>
2.73
4B7R[A,B,C,D] D-1-deoxy-GlcpNAc
<carb_like_G39>
1.90
 neuraminidase   Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6)) ABB88155.1 Q2FCL6
4QN4[A,B] 1.80
4QN6[A,B] <carb_like_LNV>
1.95
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Alberta/60/1976(H12N5)) BAF43417.1
ACS94008.1
ACZ45127.1
AGB50974.1
A1ILL9
3SAL[A,B] 1.50
3SAN[A,B] <carb_like_ZMR>
1.60
3TI8[A,B] <carb_like_LNV>
1.60
 neuraminidase   Influenza A virus (A/duck/England/1/1956(H11N6)) AAO62063.1
ABI84548.1
ACS94007.1
BAF43436.1
Q6XV27
1V0Z[A,B,C,D] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
1.84
1W1X[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
α-D-Neup5Ac
2.0
1W20[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
α-D-Neup5Ac
2.08
1W21[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
α-D-Neup5Ac
2.08
2CML[A,B,C,D] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
α-D-Manp-(1-6)-α-D-Manp-(1-6)-D-1-deoxy-Manp
<carb_like_ZMR>
2.15
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) (A/DUCK/UKRAINE/1/63) AAA16234.1 Q07599
2HT5[A] α-D-GlcpNAc
2.40
2HT7[A] <carb_like_G39>
2.60
2HT8[A] <carb_like_G39>
2.40
2HTQ[A] <carb_like_ZMR>
2.20
2HTR[A] <carb_like_DAN>
2.50
2HTU[A] <carb_like_BCZ>
2.20
3O9J[A] α-D-GlcpNAc
<carb_like_RP6>
2.00
3O9K[A] <carb_like_ETT>
2.49
4D8S[A] β-D-4-deoxy-GlcpANAc-(1-1)-<non_carb>
2.40
4GB1[A] 2.62
4KS1[A] β-D-GlcpNAc
2.20
4KS2[A] 2.60
4KS3[A] <carb_like_1SL>
2.60
4KS4[A] 2.50
4KS5[A] 2.70
4MJU[A] 2.35
4MJV[A] 2.65
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/environment/Sichuan/NCLL1/2014(H5N6)) AIK26474.1  
5HUM[A,B,C,D] 1.60
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8)) AJE30335.1  
5HUN[A] 2.30
 neuraminidase (NA)   Influenza A virus (A/Hangzhou/2/2013(H7N9)) AGK84858.1  
4MWJ[A] 1.80
4MWQ[A] <carb_like_G39>
2.00
4MWR[A] <carb_like_ZMR>
1.80
4MWU[A] <carb_like_LNV>
1.80
4MWV[A] <carb_like_BCZ>
2.00
 neuraminidase (NA)   Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8)) AFA51737.1  
4WA3[A] L-1-deoxy-Fucp
1.80
4WA4[A] <carb_like_G39>
1.95
4WA5[A] <carb_like_ZMR>
1.95
 neuraminidase-like (N10;NA)   Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)) AFC35440.1  
4GDJ[A,B,C,D] 2.00
 neuraminidase-like (N10)   Influenza A virus (A/little yellow-shouldered bat/Guatemala/153/2009(H17N10)) AFC35420.1  
4FVK[A,B] 2.20
4GDI[A,B,C,D,E,F] 1.95
4GEZ[A,B,C,D,E,F,G,H,I,J, D-1-deoxy-GlcpNAc
L-1-deoxy-Fucp
2.50
 neuraminidase   Influenza A virus (A/mallard duck/ALB/60/1976(H12N5)) ABB19465.1 Q20UH7
4QN5[A,B] α-D-Neup5Ac
α-D-Neup5Ac-(2-6)-β-D-Galp
1.70
 neuraminidase   Influenza A virus (A/mallard/ALB/196/1996(H10N7)) ABB88014.1 Q20R18
4QN3[A,B] 2.09
4QN7[A,B] <carb_like_G39>
2.30
 neuraminidase   Influenza A virus (A/Memphis/31/98(H3N2)) AAP23239.1 Q80DL0
2AEP[A] β-D-Glcp
2.10
2AEQ[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
3.00
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Mexico/24061/2009(H1N1)) AGR50353.1  
4QNP[A,B] 2.80
 neuraminidase (NA)   Influenza A virus (A/Mexico/4108/2009(H1N1)) ACQ99631.1 C4RSU7
3NSS[A,B] 1.90
 neuraminidase 3.2.1.18 Influenza A virus (A/mink/Sweden/E12665/84(H10N4)) AAO62044.1 Q6XV46
2HTV[A,B] α-D-GlcpNAc
2.80
2HTW[A] <carb_like_DAN>
3.50
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2)) AJE30346.1  
5HUK[A,B,C,D] 2.45
 neuraminidase 3.2.1.18 Influenza A virus (A/RI/5+/1957(H2N2)) ABF82433.1
ABF82434.1
ABF82435.1
Q194T1
3TIA[A,B,C,D] <carb_like_LNV>
1.80
3TIB[A,B,C,D] <carb_like_LVO>
2.20
3TIC[A,B,C,D] <carb_like_ZMR>
1.89
4H52[A,B] α-L-Manp3F5Ac-(2-0)-TYR
1.80
4H53[A,B,C,D] α-D-Neup5Ac-(2-3)-β-D-Galp
β-D-Neup5Ac
1.50
4K1H[A,B] 1.80
4K1I[A,B] <carb_like_G39>
1.80
4K1J[A,B] <carb_like_G39>
2.20
4K1K[A,B] <carb_like_G39>
1.60
 neuraminidase (NA)   Influenza A virus (A/Shanghai/02/2013(H7N9)) AGL44440.1  
5L14[A] 1.90
5L15[A] <carb_like_G39>
2.40
5L17[A] <carb_like_ZMR>
2.40
5L18[A] α-D-Neup5Ac
1.80
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)) ABY40430.1 A9YN63
4HZV[A] 1.80
4HZW[A] <carb_like_LNV>
1.70
4HZX[A] <carb_like_G39>
2.20
4HZY[A] 1.60
4HZZ[A] <carb_like_G39>
1.60
4I00[A] <carb_like_ZMR>
1.60
 neuraminidase (NA)   Influenza A virus (A/Taiwan/S02076/2013(H7N9)) AGL95090.1  
4MWL[A] 1.80
4MWW[A] <carb_like_G39>
1.90
4MWX[A] <carb_like_ZMR>
1.80
4MWY[A] <carb_like_LNV>
1.80
4MX0[A] <carb_like_BCZ>
2.10
5E6L[A] 2.10
5JYY[A] 2.10
 neuraminidase 3.2.1.18 Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) (A/TERN/AUSTRALIA/G70C/75) AAA43353.1 P03472
1A14[N] 2.50
1BJI[A] D-1-deoxy-Manp
<carb_like_DPC>
2.00
1F8B[A] <carb_like_DAN>
1.80
1F8C[A] <carb_like_4AM>
1.70
1F8D[A] <carb_like_9AM>
1.40
1F8E[A] <carb_like_49A>
1.40
1INY[A] 2.40
1L7F[A] <carb_like_BCZ>
1.80
1L7G[A] <carb_like_BCZ>
1.85
1L7H[A] <carb_like_BCZ>
1.85
1MWE[A] α-D-Neup5Ac
1.70
1NCA[N] 2.50
1NCB[N] 2.50
1NCC[N] 2.50
1NMC[A,N] D-1-deoxy-Manp
2.50
1NNA[A] 2.50
1NNB[A] <carb_like_DAN>
2.80
1NNC[A] D-1-deoxy-Manp
<carb_like_ZMR>
1.80
1XOE[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
2.20
1XOG[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
α-D-Manp-(1-2)-α-D-Manp-(1-2)-α-D-Manp-(1-3)-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
2.80
2C4A[A] α-D-Neup5Ac
2.15
2C4L[A] α-D-Neup5Ac
2.15
2QWA[A] 1.70
2QWB[A] α-D-Neup5Ac
2.00
2QWC[A] <carb_like_DAN>
1.60
2QWD[A] <carb_like_4AM>
2.00
2QWE[A] <carb_like_GNA>
2.00
2QWF[A] <carb_like_G20>
1.90
2QWG[A] <carb_like_G28>
1.80
2QWH[A] <carb_like_G39>
1.80
2QWI[A] D-1-deoxy-Manp
<carb_like_G20>
2.00
2QWJ[A] <carb_like_G28>
2.00
2QWK[A] <carb_like_G39>
1.80
3NN9[A] 2.30
3W09[A] <non_carb>-(1-4)-α-L-Glcp3F4N5Ac-(2-0)-TYR
2.00
4DGR[A] α-D-Glcp
β-D-Glcp
1.55
4NN9[A] 2.30
4WEG[A] α-L-Manp3F5Ac-(2-0)-TYR
2.10
5NN9[A] 2.30
6NN9[A] 2.30
7NN9[A] 2.00
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Tokyo/3/1967(H2N2)) AAB05621.1
AAO46245.1
P06820
1ING[A] 2.40
1INH[A] 2.40
1INW[A] <carb_like_AXP>
2.40
1INX[A] 2.40
1IVC[A] 2.40
1IVD[A] 1.90
1IVE[A] 2.40
1IVF[A] <carb_like_DAN>
2.40
1IVG[A] 1.90
1NN2[A] D-1-deoxy-GlcpNAc
2.20
2BAT[A] α-D-Neup5Ac
2.00
 neuraminidase 3.2.1.18 Influenza A virus (A/Viet Nam/1203/2004(H5N1)) AAT73329.1
AAW80723.1
ABP52008.1
ADD97097.1
Q6DPL2
2HTY[A,B,C,D,E,F,G,H] α-D-GlcpNAc
β-D-GlcpNAc
2.50
2HU0[A,B,C,D,E,F,G,H] <carb_like_G39>
2.95
2HU4[A,B,C,D,E,F,G,H] <carb_like_G39>
2.50
3CKZ[A] <carb_like_ZMR>
1.90
3CL2[A,B,C,D,E,F,G,H] <carb_like_G39>
2.54
 neuraminidase 3.2.1.18 Influenza A virus (A/whale/Maine/1/1984(H13N9)) (A/WHALE/MAINE/1/84) (H1N9) AAA43575.1 P05803
1NCD[N] 2.90
1NMA[N] 3.00
1NMB[N] 2.20
2B8H[A] 2.20
 neuraminidase-like (NAL) (partial)   Influenza A virus A/flat-faced bat/Peru/033/2010 (H18N11) BAX00602.1
BAX00603.1
BAX00607.1
BAX00608.1
BAX00609.1
 
4K3Y[A,B,C,D] 2.68
4MC7[B,C,D] 2.99
4MC7[A] 2.99
 neuraminidase 3.2.1.18 Influenza B virus AAA43749.1
NP_056663.1
P03474
1B9S[A] D-1-deoxy-GlcpNAc
2.50
1INF[A] 2.40
1INV[A] 2.40
1IVB[A] 2.40
1NSB[A] 2.20
1NSC[A] α-D-Neup5Ac
1.70
1NSD[A] <carb_like_DAN>
1.80
1VCJ[A] 2.40
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) AAA43733.1 P27907
1A4G[A,B] <carb_like_ZMR>
2.20
1A4Q[A,B] <carb_like_DPC>
1.90
 neuraminidase (NA) 3.2.1.18 Influenza B virus (B/Brisbane/60/2008) ACN29379.1
ACN29381.1
ADN32819.1
AFH57913.1
C0LT34
4CPL[A,B] 2.00
4CPM[A,B] D-1-deoxy-GlcpNAc
<carb_like_G39>
2.75
4CPN[A,B] <carb_like_ZMR>
2.40
 neuraminidase   Influenza B virus (B/Perth/211/2001) ABA02232.1
ABA02233.1
Q3S341
3K36[A,B] 2.20
3K37[A,B] <carb_like_BCZ>
2.00
 neuraminidase (NA) (partial) 3.2.1.18 Influenza B virus B/Lyon/CHU/15.216/2011    
4CPO[B] 2.20
4CPY[A,B] <carb_like_G39>
1.80
4CPZ[A,B,C,D,E,F,G,H] <carb_like_ZMR>
2.20
4CPO[A] 2.20
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