Glycoside Hydrolase Family 34

Activities in FamilyExo-α-sialidase (EC 3.2.1.18);
Mechanism Retaining e
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesCAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics GenBank accession (138704); Uniprot accession (46); PDB accession (247); 3D entries (57); cryst (0)
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 neuraminidase (NA) 3.2.1.18 H3N2 subtype A/Tanzania/205/2010 H3N2    
4GZP[A] <carb_like_G39>
2.30
4GZQ[A] α-D-Neup5Ac
2.20
4GZS[A,B,C,D] 2.35
4GZT[A,B,C,D] <carb_like_G39>
2.19
4GZW[A,B,C,D] α-D-Neup5Ac
α-D-Neup5Ac-(2-3)-β-D-Galp
α-D-Neup5Ac-(2-3)-β-D-Galp-(1-3)-β-D-GlcpNAc
α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-GlcpNAc
2.45
4GZX[A,B,C,D] α-D-Neup5Ac
α-D-Neup5Ac-(2-6)-β-D-Galp
2.45
8G30[C,F,I,L] 3.10
8G3M[A,D,G,H] 3.00
8G3N[A,D,G,J] 2.90
8G3Q[A,B,C,D] 2.30
8G3R[A,B,E,F] 2.30
4GZO[A] 2.60
 neuraminidase (A/Hunan/02650/2016 (H7N9)) 3.2.1.18 Influenza A virus    
6PZF[A,B] 2.80
6Q1Z[B] 3.45
6Q1Z[A] 3.45
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1)) AJM70556.1 A0A0C5BL75
5HUG[A] 1.85
 neuraminidase (NA)   Influenza A virus (A/Anhui/1-BALF_RG44/2013(H7N9)) AHZ60015.1  
6LXJ[A,B,C,D] 2.90
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Bayern/62/2009(H1N1)) ACT33096.1 C3W6G3
C6KQL9
5NZ4[A,B] <carb_like_G39>
1.36
 neuraminidase (NA)   Influenza A virus (A/Bilthoven/17938/1969(H3N2)) AFG98822.1  
7U4E[A,B,C,D] 1.54
 neuraminidase 3.2.1.18 Influenza A virus (A/Brevig Mission/1/1918(H1N1)) AAF77036.1 Q9IGQ6
3B7E[A,B] <carb_like_ZMR>
1.45
3BEQ[A,B] 1.64
3CYE[A,B] 1.65
6D96[A,B,C,D,E,F,G,H] 2.15
6LXI[A,B] 2.50
8E6J[A,D,G,J] 2.70
8E6K[A,D,G,J] 3.10
 neuraminidase (pdmNA;NA) 3.2.1.18 Influenza A virus (A/California/04/2009(H1N1)) ACP41107.1
ACP44158.1
AEE69012.1
AJI76397.1
A0A0C4ZKQ4
C3W5S3
C7FH46
F8UU09
3TI3[A,B] <carb_like_LNV>
1.80
3TI4[A,B] <carb_like_LVO>
1.60
3TI5[A,B] <carb_like_ZMR>
1.90
3TI6[A,B] <carb_like_G39>
1.69
4B7J[A] D-1-deoxy-GlcpNAc
<carb_like_G39>
2.42
4B7M[A,B] 2.50
4B7N[A] <carb_like_ZMR>
2.84
4B7Q[A,B,C,D] <carb_like_ZMR>
2.73
4B7R[A,B,C,D] D-1-deoxy-GlcpNAc
<carb_like_G39>
1.90
 neuraminidase   Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6)) ABB88155.1  
4QN4[A,B] 1.80
4QN6[A,B] <carb_like_LNV>
1.95
 neuraminidase (NA)   Influenza A virus (A/Czech Republic/2/2014(H1N1)) AHN96347.1  
6LXK[A,B,C,D] 3.61
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Alberta/60/1976(H12N5)) BAF43417.1
ACS94008.1
ACZ45127.1
AGB50974.1
A1ILL9
C6KJK4
3SAL[A,B] 1.50
3SAN[A,B] <carb_like_ZMR>
1.60
3TI8[A,B] <carb_like_LNV>
1.60
7E6Q[A,B] 2.20
 neuraminidase   Influenza A virus (A/duck/England/1/1956(H11N6)) AAO62063.1
ABI84548.1
ACS94007.1
BAF43436.1
 
1V0Z[A,B,C,D] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
1.84
1W1X[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
α-D-Neup5Ac
2.0
1W20[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
α-D-Neup5Ac
2.08
1W21[A,B,C,D] α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
α-D-Manp-(1-6)[α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
α-D-Neup5Ac
2.08
2CML[A,B,C,D] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
α-D-Manp-(1-6)-α-D-Manp-(1-6)-D-1-deoxy-Manp
<carb_like_ZMR>
2.15
6HG5[A,B,C,D] <carb_like_G39>
1.60
6HGB[A,B,C,D] 1.50
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) AAA16234.1 Q07599
Q0A480
2HT5[A] α-D-GlcpNAc
2.40
2HT7[A] <carb_like_G39>
2.60
2HT8[A] <carb_like_G39>
2.40
2HTQ[A] <carb_like_ZMR>
2.20
2HTR[A] <carb_like_DAN>
2.50
2HTU[A] <carb_like_BCZ>
2.20
3O9J[A] α-D-GlcpNAc
<carb_like_RP6>
2.00
3O9K[A] <carb_like_ETT>
2.49
4D8S[A] β-D-4-deoxy-GlcpANAc-(1-1)-<non_carb>
2.40
4GB1[A] 2.62
4KS1[A] β-D-GlcpNAc
2.20
4KS2[A] 2.60
4KS3[A] <carb_like_1SL>
2.60
4KS4[A] 2.50
4KS5[A] 2.70
4MJU[A] 2.35
4MJV[A] 2.65
 neuraminidase (NA)   Influenza A virus (A/environment/Shanghai/S1439/2013(H7N9)) AGR49712.1  
6PZW[A,B,C,D] 3.00
6PZY[A,B,E,F] 3.17
6PZZ[A,B,C,D] 3.60
6U02[A,B,E,J] 3.05
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/environment/Sichuan/NCLL1/2014(H5N6)) AIK26474.1 A0A0B4N5Z5
A0A0B4N5Z8
5HUM[A,B,C,D] 1.60
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8)) AJE30335.1 A0A0C4WVM3
5HUN[A] 2.30
 neuraminidase (NA)   Influenza A virus (A/Hangzhou/2/2013(H7N9)) AGK84858.1  
4MWJ[A] 1.80
4MWQ[A] <carb_like_G39>
2.00
4MWR[A] <carb_like_ZMR>
1.80
4MWU[A] <carb_like_LNV>
1.80
4MWV[A] <carb_like_BCZ>
2.00
 neuraminidase (NA)   Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8)) AFA51737.1  
4WA3[A] L-1-deoxy-Fucp
1.80
4WA4[A] <carb_like_G39>
1.95
4WA5[A] <carb_like_ZMR>
1.95
 neuraminidase 3.2.1.18 Influenza A virus (A/Japan/305/1957(H2N2)) ABI84962.1
ACU79962.1
ACV49603.1
C7RWN0
Q0A2X0
Q1K9Q1
6Q20[A] 2.45
 neuraminidase-like (N10;NA)   Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)) AFC35440.1  
4GDJ[A,B,C,D] 2.00
 neuraminidase-like (N10)   Influenza A virus (A/little yellow-shouldered bat/Guatemala/153/2009(H17N10)) AFC35420.1  
4FVK[A,B] 2.20
4GDI[A,B,C,D,E,F] 1.95
4GEZ[A,B,C,D,E,F,G,H,I,J, D-1-deoxy-GlcpNAc
L-1-deoxy-Fucp
2.50
 neuraminidase   Influenza A virus (A/mallard duck/ALB/60/1976(H12N5)) ABB19465.1  
4QN5[A,B] α-D-Neup5Ac
α-D-Neup5Ac-(2-6)-β-D-Galp
1.70
 neuraminidase   Influenza A virus (A/mallard/ALB/196/1996(H10N7)) ABB88014.1  
4QN3[A,B] 2.09
4QN7[A,B] <carb_like_G39>
2.30
 neuraminidase   Influenza A virus (A/Memphis/31/98(H3N2)) AAP23239.1  
2AEP[A] β-D-Glcp
2.10
2AEQ[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
3.00
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Mexico/24049/2009(H1N1)) AGR50232.1 C3W6G3
S5MC84
5NZE[A,B] <carb_like_G39>
1.69
5NZF[A,B,C,D] <carb_like_G39>
1.75
5NZN[A,B,C,D] <carb_like_G39>
1.73
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Mexico/24061/2009(H1N1)) AGR50353.1 D5KL82
S5N0T0
4QNP[A,B] 2.80
 neuraminidase (NA)   Influenza A virus (A/Mexico/4108/2009(H1N1)) ACQ99631.1  
3NSS[A,B] 1.90
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Michigan/45/2015(H1N1)) AMA11477.1
AMV49036.1
APB91428.1
APC60200.1
A0A0X9QTS2
A0A144YDY0
7S0I[A] 2.89
 neuraminidase   Influenza A virus (A/mink/Sweden/E12665/84(H10N4)) AAO62044.1  
2HTV[A,B] α-D-GlcpNAc
2.80
2HTW[A] <carb_like_DAN>
3.50
 neuraminidase (NA)   Influenza A virus (A/Minnesota/11/2010(H3N2)) AIE52540.1  
6N6B[A] 2.30
 neuraminidase   Influenza A virus (A/Moscow/10/1999(H3N2)) CAD29994.1
AAT08003.1
ABE73101.1
AFG72793.1
AFM72211.1
 
7U4F[A] 1.40
8DWB[A]
8EZ3[C] D-1-deoxy-Manp
2.50
8EZ7[C] D-1-deoxy-Manp
2.60
8EZ8[C] D-1-deoxy-Manp
2.78
 neuraminidase (NA)   Influenza A virus (A/New York/20342/2010(H3N2)) ADM07507.1  
6BR5[A] <non_carb>-(1-3)-β-L-2-deoxy-Glcp1SH3N4NAc-(1-1)-<non_carb>
2.04
6BR6[A] β-L-2-deoxy-Glcp1SH3N4NAc-(1-1)-<non_carb>
2.04
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2)) AJE30346.1 A0A0C4WXC5
5HUK[A,B,C,D] 2.45
 neuraminidase (NA)   Influenza A virus (A/reassortant/NYMC X-213(A/Puerto Rico/8/1934 x A/Indiana/10/2011)(H3N2)) AIE52647.1  
8GAT[A]
8GAU[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/RI/5+/1957(H2N2)) ABF82433.1
ABF82434.1
ABF82435.1
Q194S9
Q194T0
Q194T1
3TIA[A,B,C,D] <carb_like_LNV>
1.80
3TIB[A,B,C,D] <carb_like_LVO>
2.20
3TIC[A,B,C,D] <carb_like_ZMR>
1.89
4H52[A,B] α-L-Manp3F5Ac-(2-0)-TYR
1.80
4H53[A,B,C,D] α-D-Neup5Ac-(2-3)-β-D-Galp
β-D-Neup5Ac
1.50
4K1H[A,B] 1.80
4K1I[A,B] <carb_like_G39>
1.80
4K1J[A,B] <carb_like_G39>
2.20
4K1K[A,B] <carb_like_G39>
1.60
 neuraminidase (NA)   Influenza A virus (A/Shangdong/9/1993(H3N2)) ACL12132.1
AFH00288.1
 
7U4G[A] <carb_like_ZMR>
1.65
 neuraminidase (NA)   Influenza A virus (A/Shanghai/02/2013(H7N9)) AGL44440.1  
5L14[A] 1.90
5L15[A] <carb_like_G39>
2.40
5L17[A] <carb_like_ZMR>
2.40
5L18[A] α-D-Neup5Ac
1.80
6PZD[A] 1.12
6PZE[A] 2.30
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)) ABY40430.1 A9YN63
4HZV[A] 1.80
4HZW[A] <carb_like_LNV>
1.70
4HZX[A] <carb_like_G39>
2.20
4HZY[A] 1.60
4HZZ[A] <carb_like_G39>
1.60
4I00[A] <carb_like_ZMR>
1.60
 neuraminidase (NA)   Influenza A virus (A/Taiwan/S02076/2013(H7N9)) AGL95090.1  
4MWL[A] 1.80
4MWW[A] <carb_like_G39>
1.90
4MWX[A] <carb_like_ZMR>
1.80
4MWY[A] <carb_like_LNV>
1.80
4MX0[A] <carb_like_BCZ>
2.10
5E6L[A] 2.10
5JYY[A] 2.10
 neuraminidase 3.2.1.18 Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) AAA43353.1 P03472
P05803
1A14[N] 2.50
1BJI[A] D-1-deoxy-Manp
<carb_like_DPC>
2.00
1F8B[A] <carb_like_DAN>
1.80
1F8C[A] <carb_like_4AM>
1.70
1F8D[A] <carb_like_9AM>
1.40
1F8E[A] <carb_like_49A>
1.40
1INY[A] 2.40
1L7F[A] <carb_like_BCZ>
1.80
1L7G[A] <carb_like_BCZ>
1.85
1L7H[A] <carb_like_BCZ>
1.85
1MWE[A] α-D-Neup5Ac
1.70
1NCA[N] 2.50
1NCB[N] 2.50
1NCC[N] 2.50
1NCD[A] 2.90
1NMA[A] 3.00
1NMB[A] 2.20
1NMC[A,N] D-1-deoxy-Manp
2.50
1NNA[A] 2.50
1NNB[A] <carb_like_DAN>
2.80
1NNC[A] D-1-deoxy-Manp
<carb_like_ZMR>
1.80
1XOE[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
2.20
1XOG[A] D-1-deoxy-GlcpNAc
D-1-deoxy-Manp
α-D-Manp-(1-2)-α-D-Manp-(1-2)-α-D-Manp-(1-3)-β-D-Manp-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
2.80
2C4A[A] α-D-Neup5Ac
2.15
2C4L[A] α-D-Neup5Ac
2.15
2QWA[A] 1.70
2QWB[A] α-D-Neup5Ac
2.00
2QWC[A] <carb_like_DAN>
1.60
2QWD[A] <carb_like_4AM>
2.00
2QWE[A] <carb_like_GNA>
2.00
2QWF[A] <carb_like_G20>
1.90
2QWG[A] <carb_like_G28>
1.80
2QWH[A] <carb_like_G39>
1.80
2QWI[A] D-1-deoxy-Manp
<carb_like_G20>
2.00
2QWJ[A] <carb_like_G28>
2.00
2QWK[A] <carb_like_G39>
1.80
3NN9[A] 2.30
3W09[A] <non_carb>-(1-4)-α-L-Glcp3F4N5Ac-(2-0)-TYR
2.00
4DGR[A] α-D-Glcp
β-D-Glcp
1.55
4NN9[A] 2.30
4WEG[A] α-L-Manp3F5Ac-(2-0)-TYR
2.10
5NN9[A] 2.30
5W26[A] α-L-4-deoxy-Manp3F5Ac-(2-0)-TYR
1.90
5W2U[A] α-L-7-deoxy-Manp3F5Ac-(2-0)-TYR
2.00
5W2W[A] α-L-8-deoxy-Manp3F5Ac-(2-0)-TYR
1.85
5W2Y[A] α-L-9-deoxy-Altp3F5Ac-(2-0)-TYR
2.39
6CRD[A,B,C,D,E,F,G,H] 2.57
6D3B[A] 1.40
6HCX[A] <carb_like_ZMR>
1.30
6HEB[A] D-1,4-deoxy-Ribp
<carb_like_G39>
1.75
6MCX[A] 2.30
6NN9[A] 2.30
7NN9[A] 2.00
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Texas/17/2009(H1N1)) ACS72690.1 C3W6G3
C6KP13
6G01[A,B] 1.61
6G02[A,B] 1.84
6HP0[A,B,C,D] 1.88
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Texas/47/2009(H1N1)) ACV67206.1 C3W6G3
C9EKP8
5NWE[A,B,C,D] <carb_like_G39>
2.00
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Tokyo/3/1967(H2N2)) AAB05621.1
AAO46245.1
P06820
1ING[A] 2.40
1INH[A] 2.40
1INW[A] <carb_like_AXP>
2.40
1INX[A] 2.40
1IVC[A] 2.40
1IVD[A] 1.90
1IVE[A] 2.40
1IVF[A] <carb_like_DAN>
2.40
1IVG[A] 1.90
1NN2[A] D-1-deoxy-GlcpNAc
2.20
2BAT[A] α-D-Neup5Ac
2.00
 neuraminidase 3.2.1.18 Influenza A virus (A/Viet Nam/1203/2004(H5N1)) AAT73329.1
AAW80723.1
ABP52008.1
ADD97097.1
Q6DPL2
2HTY[A,B,C,D,E,F,G,H] α-D-GlcpNAc
β-D-GlcpNAc
2.50
2HU0[A,B,C,D,E,F,G,H] <carb_like_G39>
2.95
2HU4[A,B,C,D,E,F,G,H] <carb_like_G39>
2.50
3CKZ[A] <carb_like_ZMR>
1.90
3CL2[A,B,C,D,E,F,G,H] <carb_like_G39>
2.54
 neuraminidase 3.2.1.18 Influenza A virus (A/whale/Maine/1/1984(H13N9)) AAA43575.1 P05803
2B8H[A] 2.20
 neuraminidase (NA) 3.2.1.18 Influenza A virus A/California/04/2009 AYV61531.1
QEH91764.1
A0A2P1ADF9
C3W5S3
6Q23[A,B,C,D] 3.27
 neuraminidase (NA) 3.2.1.18 Influenza A virus A/California/7/2009 QFR38305.1 A0A2P1ADF9
7U2Q[A,B,C,D] 3.20
 neuraminidase (NA) 3.2.1.18 Influenza A virus A/Michigan/45/2015 QBL89780.1 A0A2R4G8D7
7U2T[A,B,C,D] 3.25
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) AAA43733.1
CAB71147.1
P27907
Q9IW64
1A4G[A,B] <carb_like_ZMR>
2.20
1A4Q[A,B] <carb_like_DPC>
1.90
1NSB[A,B] 2.20
1NSC[A,B] α-D-Neup5Ac
1.70
1NSD[A,B] <carb_like_DAN>
1.80
 neuraminidase (NA) 3.2.1.18 Influenza B virus (B/Brisbane/60/2008) ACN29379.1
ACN29381.1
ADN32819.1
AFH57913.1
C0LT34
4CPL[A,B] 2.00
4CPM[A,B] D-1-deoxy-GlcpNAc
<carb_like_G39>
2.75
4CPN[A,B] <carb_like_ZMR>
2.40
 neuraminidase   Influenza B virus (B/Perth/211/2001) ABA02232.1
ABA02233.1
 
3K36[A,B] 2.20
3K37[A,B] <carb_like_BCZ>
2.00
 neuraminidase 3.2.1.18 Influenza B virus B/Lee/1940 AAA43749.1
NP_056663.1
P03474
1B9S[A] D-1-deoxy-GlcpNAc
2.50
1INF[A] 2.40
1INV[A] 2.40
1IVB[A] 2.40
1VCJ[A] 2.40
 neuraminidase (NA) 3.2.1.18 Influenza B virus B/Lyon/CHU/15.216/2011    
4CPO[B] 2.20
4CPY[A,B] <carb_like_G39>
1.80
4CPZ[A,B,C,D,E,F,G,H] <carb_like_ZMR>
2.20
4CPO[A] 2.20
 neuraminidase (NA)   Influenza B virus B/Nicaragua/7919_09/2014 QCT23101.1  
6V4N[I,M,N,W] 2.50
6V4O[I,M,N,W] 2.80
 neuraminidase (fragment)   unidentified influenza virus (A/canine/IL/11613/2015 (H3N2))    
6N4D[B,C,D] 1.80
6N4D[A] 1.80
 NA   Wuhan asiatic toad influenza virus WHHM46916 AVM87633.1  
7CM1[A,B] <carb_like_G39>
2.14
7FGB[A,B] 2.00
7FGC[A,B] <carb_like_ZMR>
1.90
7FGD[A,B] <carb_like_G39>
2.10
7FGE[A,B,C,D,E,F,G,H] <carb_like_BCZ>
2.80
 neuraminidase 3.2.1.18 Wuhan spiny eel influenza virus WHQSR4065 AVM87625.1  
7XVR[A,B] 2.40
7XVU[A,B] <carb_like_G39>
1.60
7XVV[A,B] <carb_like_ZMR>
1.85
7XVW[A,B] <carb_like_BCZ>
1.94
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