Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (139783); Uniprot accession (49); PDB accession (251); 3D entries (58); cryst (0)

Viruses
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)	3.2.1.18	pubmed	H3N2 subtype A/Tanzania/205/2010 H3N2		K7N5N3 K7N5N8	4GZP[A] 4GZQ[A] 4GZS[A,B,C,D] 4GZT[A,B,C,D] 4GZW[A,B,C,D] 4GZX[A,B,C,D] 8G30[C,F,I,L] 8G3M[A,D,G,H] 8G3N[A,D,G,J] 8G3Q[A,B,C,D] 8G3R[A,B,E,F] 4GZO[A]
neuraminidase (A/Hunan/02650/2016 (H7N9))	3.2.1.18	pubmed	Influenza A virus			6PZF[A,B] 6Q1Z[B] 6Q1Z[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1))	AJM70556.1	A0A0C5BL75	5HUG[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Bayern/62/2009(H1N1))	ACT33096.1	C3W6G3 C6KQL9	5NZ4[A,B]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/Brevig Mission/1/1918(H1N1))	AAF77036.1	Q9IGQ6	3B7E[A,B] 3BEQ[A,B] 3CYE[A,B] 6D96[A,B,C,D,E,F,G,H] 6LXI[A,B] 8E6J[A,D,G,J] 8E6K[A,D,G,J]
neuraminidase (pdmNA;NA)	3.2.1.18	pubmed	Influenza A virus (A/California/04/2009(H1N1))	ACP41107.1 ACP44158.1 AEE69012.1 AJI76397.1	A0A0C4ZKQ4 C3W5S3 C7FH46 F8UU09	3TI3[A,B] 3TI4[A,B] 3TI5[A,B] 3TI6[A,B] 4B7J[A] 4B7M[A,B] 4B7N[A] 4B7Q[A,B,C,D] 4B7R[A,B,C,D]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/duck/Alberta/60/1976(H12N5))	BAF43417.1 ACS94008.1 ACZ45127.1 AGB50974.1	A1ILL9 C6KJK4	3SAL[A,B] 3SAN[A,B] 3TI8[A,B] 7E6Q[A,B]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/duck/Ukraine/1/1963(H3N8))	AAA16234.1	Q07599 Q0A480	2HT5[A] 2HT7[A] 2HT8[A] 2HTQ[A] 2HTR[A] 2HTU[A] 3O9J[A] 3O9K[A] 4D8S[A] 4GB1[A] 4KS1[A] 4KS2[A] 4KS3[A] 4KS4[A] 4KS5[A] 4MJU[A] 4MJV[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/environment/Sichuan/NCLL1/2014(H5N6))	AIK26474.1	A0A0B4N5Z5 A0A0B4N5Z8	5HUM[A,B,C,D]
neuraminidase (HumNA;NA)	3.2.1.18	pubmed	Influenza A virus (A/Gansu/Chenguan/1129/2007(H1N1))	ACF33772.1	B5AYA6
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8))	AJE30335.1	A0A0C4WVM3	5HUN[A]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/Japan/305/1957(H2N2))	ABI84962.1 ACU79962.1 ACV49603.1	C7RWN0 Q0A2X0 Q1K9Q1	6Q20[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Mexico/24049/2009(H1N1))	AGR50232.1	C3W6G3 S5MC84	5NZE[A,B] 5NZF[A,B,C,D] 5NZN[A,B,C,D]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Mexico/24061/2009(H1N1))	AGR50353.1	D5KL82 S5N0T0	4QNP[A,B]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Michigan/45/2015(H1N1))	AMA11477.1 AMV49036.1 APB91428.1 APC60200.1	A0A0X9QTS2 A0A144YDY0	7S0I[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2))	AJE30346.1	A0A0C4WXC5	5HUK[A,B,C,D]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/RI/5+/1957(H2N2))	ABF82433.1 ABF82434.1 ABF82435.1	Q194S9 Q194T0 Q194T1	3TIA[A,B,C,D] 3TIB[A,B,C,D] 3TIC[A,B,C,D] 4H52[A,B] 4H53[A,B,C,D] 4K1H[A,B] 4K1I[A,B] 4K1J[A,B] 4K1K[A,B]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/swine/Missouri/2124514/2006(H2N3))	ABY40430.1	A9YN63	4HZV[A] 4HZW[A] 4HZX[A] 4HZY[A] 4HZZ[A] 4I00[A]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/tern/Australia/G70C/1975(H11N9))	AAA43353.1	P03472 P05803	1A14[N] 1BJI[A] 1F8B[A] 1F8C[A] 1F8D[A] 1F8E[A] 1INY[A] 1L7F[A] 1L7G[A] 1L7H[A] 1MWE[A] 1NCA[N] 1NCB[N] 1NCC[N] 1NCD[A] 1NMA[A] 1NMB[A] 1NMC[A,N] 1NNA[A] 1NNB[A] 1NNC[A] 1XOE[A] 1XOG[A] 2C4A[A] 2C4L[A] 2QWA[A] 2QWB[A] 2QWC[A] 2QWD[A] 2QWE[A] 2QWF[A] 2QWG[A] 2QWH[A] 2QWI[A] 2QWJ[A] 2QWK[A] 3NN9[A] 3W09[A] 4DGR[A] 4NN9[A] 4WEG[A] 5NN9[A] 5W26[A] 5W2U[A] 5W2W[A] 5W2Y[A] 6CRD[A,B,C,D,E,F,G,H] 6D3B[A] 6HCX[A] 6HEB[A] 6MCX[A] 6NN9[A] 7NN9[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Texas/17/2009(H1N1))	ACS72690.1	C3W6G3 C6KP13	6G01[A,B] 6G02[A,B] 6HP0[A,B,C,D]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus (A/Texas/47/2009(H1N1))	ACV67206.1	C3W6G3 C9EKP8	5NWE[A,B,C,D]
neuraminidase (NA)	3.2.1.18		Influenza A virus (A/Tokyo/3/1967(H2N2))	AAB05621.1 AAO46245.1	P06820	1ING[A] 1INH[A] 1INW[A] 1INX[A] 1IVC[A] 1IVD[A] 1IVE[A] 1IVF[A] 1IVG[A] 1NN2[A] 2BAT[A]
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/Victoria/3/1975(H3N2)) (X-47)	AAB03361.1 AFM71970.1	I6S5E0 P03482
neuraminidase	3.2.1.18	pubmed	Influenza A virus (A/Viet Nam/1203/2004(H5N1))	AAT73329.1 AAW80723.1 ABP52008.1 ADD97097.1	Q6DPL2	2HTY[A,B,C,D,E,F,G,H] 2HU0[A,B,C,D,E,F,G,H] 2HU4[A,B,C,D,E,F,G,H] 3CKZ[A] 3CL2[A,B,C,D,E,F,G,H]
neuraminidase	3.2.1.18		Influenza A virus (A/whale/Maine/1/1984(H13N9))	AAA43575.1	P05803	2B8H[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus A/California/04/2009	AYV61531.1 QEH91764.1	A0A2P1ADF9 C3W5S3	6Q23[A,B,C,D]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus A/California/7/2009	QFR38305.1	A0A2P1ADF9 C7FH46	7U2Q[A,B,C,D]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza A virus A/Michigan/45/2015	QBL89780.1	A0A2R4G8D7 C7FH46	7U2T[A,B,C,D]
neuraminidase	3.2.1.18	pubmed	Influenza B virus (B/BEIJING/1/87)	AAA43733.1 CAB71147.1	P27907 Q9IW64	1A4G[A,B] 1A4Q[A,B] 1NSB[A,B] 1NSC[A,B] 1NSD[A,B]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza B virus (B/Brisbane/60/2008)	ACN29379.1 ACN29381.1 ADN32819.1 AFH57913.1	C0LT34	4CPL[A,B] 4CPM[A,B] 4CPN[A,B]
neuraminidase	3.2.1.18	pubmed	Influenza B virus (B/Nashville/6/89)	AAA43739.1 AAD42327.2	P16199 Q9WPR0
neuraminidase	3.2.1.18	pubmed	Influenza B virus B/Lee/1940	AAA43749.1 NP_056663.1 WHU32586.1 WHU32809.1 WHU32853.1 WHU32951.1 WHU33007.1 WHU33563.1	P03474	1B9S[A] 1INF[A] 1INV[A] 1IVB[A] 1VCJ[A]
neuraminidase (NA)	3.2.1.18	pubmed	Influenza B virus B/Lyon/CHU/15.216/2011			4CPO[B] 4CPY[A,B] 4CPZ[A,B,C,D,E,F,G,H] 4CPO[A]
neuraminidase	3.2.1.18	pubmed	Wuhan spiny eel influenza virus WHQSR4065	AVM87625.1	A0A2P1GNP4	7XVR[A,B] 7XVU[A,B] 7XVV[A,B] 7XVW[A,B]
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