Glycoside Hydrolase Family 34

Activities in Familysialidase or neuraminidase (EC 3.2.1.18)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD; ProteinSpotlight;
Statistics GenBank accession (92799); Uniprot accession (20285); PDB accession (195); 3D entries (39); cryst (0)
All (87819) Viruses (87815) unclassified (4) Structure (39) Characterized (39)
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1)) AJM70556.1   5HUG[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Bayern/62/2009(H1N1)) ACT33096.1 C6KQL9 5NZ4[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/Brevig Mission/1/1918(H1N1)) AAF77036.1 Q9IGQ6 3B7E[A,B]
3BEQ[A,B]
3CYE[A,B]
 neuraminidase (pdmNA;NA) 3.2.1.18 Influenza A virus (A/California/04/2009(H1N1)) ACP41107.1
ACP44158.1
AEE69012.1
AJI76397.1
C3W5S3 3TI3[A,B]
3TI4[A,B]
3TI5[A,B]
3TI6[A,B]
4B7J[A]
4B7M[A,B]
4B7N[A]
4B7Q[A,B,C,D]
4B7R[A,B,C,D]
 neuraminidase (AvNA) 3.2.1.18 Influenza A virus (A/Cambodia/JP52a/2005(H5N1)) ABO10176.1 A3RMH0  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Alberta/60/1976(H12N5)) BAF43417.1
ACS94008.1
ACZ45127.1
AGB50974.1
A1ILL9 3SAL[A,B]
3SAN[A,B]
3TI8[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) ABI84504.1
ACA04739.1
ACZ45137.1
AGB50887.1
Q0A480  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) (A/DUCK/UKRAINE/1/63) AAA16234.1 Q07599 2HT5[A]
2HT7[A]
2HT8[A]
2HTQ[A]
2HTR[A]
2HTU[A]
3O9J[A]
3O9K[A]
4D8S[A]
4GB1[A]
4KS1[A]
4KS2[A]
4KS3[A]
4KS4[A]
4KS5[A]
4MJU[A]
4MJV[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/environment/Sichuan/NCLL1/2014(H5N6)) AIK26474.1   5HUM[A,B,C,D]
 neuraminidase 3.2.1.18 Influenza A virus (A/Fiji/15899/83(H1N1)) (A/FIJI/15899/83(H3N2)) CAA07348.1 Q9WA95  
 neuraminidase (HumNA;NA) 3.2.1.18 Influenza A virus (A/Gansu/Chenguan/1129/2007(H1N1)) ACF33772.1 B5AYA6  
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8)) AJE30335.1   5HUN[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Mexico/24049/2009(H1N1)) AGR50232.1   5NZE[A,B]
5NZF[A,B,C,D]
5NZN[A,B,C,D]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Mexico/24061/2009(H1N1)) AGR50353.1   4QNP[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/mink/Sweden/E12665/84(H10N4)) AAO62044.1 Q6XV46 2HTV[A,B]
2HTW[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2)) AJE30346.1   5HUK[A,B,C,D]
 neuraminidase (fragment) 3.2.1.18 Influenza A virus (A/Puerto Rico/8/1934(Cambridge)(H1N1)) (A/PUERTO RICO/8/34 A/PR/8/34) AAA43412.1
NP_040981.1
P03468  
 neuraminidase 3.2.1.18 Influenza A virus (A/RI/5+/1957(H2N2)) ABF82433.1
ABF82434.1
ABF82435.1
Q194T1 3TIA[A,B,C,D]
3TIB[A,B,C,D]
3TIC[A,B,C,D]
4H52[A,B]
4H53[A,B,C,D]
4K1H[A,B]
4K1I[A,B]
4K1J[A,B]
4K1K[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)) ABY40430.1 A9YN63 4HZV[A]
4HZW[A]
4HZX[A]
4HZY[A]
4HZZ[A]
4I00[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) (A/TERN/AUSTRALIA/G70C/75) AAA43353.1 P03472 1A14[N]
1BJI[A]
1F8B[A]
1F8C[A]
1F8D[A]
1F8E[A]
1INY[A]
1L7F[A]
1L7G[A]
1L7H[A]
1MWE[A]
1NCA[N]
1NCB[N]
1NCC[N]
1NMC[A,N]
1NNA[A]
1NNB[A]
1NNC[A]
1XOE[A]
1XOG[A]
2C4A[A]
2C4L[A]
2QWA[A]
2QWB[A]
2QWC[A]
2QWD[A]
2QWE[A]
2QWF[A]
2QWG[A]
2QWH[A]
2QWI[A]
2QWJ[A]
2QWK[A]
3NN9[A]
3W09[A]
4DGR[A]
4NN9[A]
4WEG[A]
5NN9[A]
5W26[A]
5W2U[A]
5W2W[A]
5W2Y[A]
6HCX[A]
6HEB[A]
6NN9[A]
7NN9[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Texas/47/2009(H1N1)) ACV67206.1 C9EKP8 5NWE[A,B,C,D]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Tokyo/3/1967(H2N2)) AAB05621.1
AAO46245.1
P06820 1ING[A]
1INH[A]
1INW[A]
1INX[A]
1IVC[A]
1IVD[A]
1IVE[A]
1IVF[A]
1IVG[A]
1NN2[A]
2BAT[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/Victoria/3/1975(H3N2)) (X-47) AAB03361.1
AFM71970.1
P03482  
 neuraminidase 3.2.1.18 Influenza A virus (A/Viet Nam/1203/2004(H5N1)) AAT73329.1
AAW80723.1
ABP52008.1
ADD97097.1
Q6DPL2 2HTY[A,B,C,D,E,F,G,H]
2HU0[A,B,C,D,E,F,G,H]
2HU4[A,B,C,D,E,F,G,H]
3CKZ[A]
3CL2[A,B,C,D,E,F,G,H]
 neuraminidase 3.2.1.18 Influenza A virus (A/whale/Maine/1/1984(H13N9)) (A/WHALE/MAINE/1/84) (H1N9) AAA43575.1 P05803 1NCD[N]
1NMA[N]
1NMB[N]
2B8H[A]
 neuraminidase (fragment) 3.2.1.18 Influenza A virus (A/Wilson-Smith/1933(H1N1)) (A/WSN/33) AAA43397.1 P03470  
 neuraminidase 3.2.1.18 Influenza B virus AAA43749.1
AUR34031.1
AUR34033.1
AUR34035.1
AUR34037.1
AUR34039.1
AUR34041.1
AUR34043.1
AUR34045.1
AUR34047.1
AUR34049.1
AUR34051.1
AUR34053.1
AUR34055.1
AUS93079.1
AUS93090.1
AUS93100.1
AUS93111.1
AUS93144.1
AUS93166.1
AUS93186.1
AUS93265.1
AUS93274.1
AUS93299.1
AUS93375.1
AVA07002.1
AVA07013.1
AVA07024.1
AVA07035.1
AVA07046.1
AVA07057.1
AVA07068.1
AVA07079.1
AVA07090.1
AVA07101.1
AVA07112.1
AVA07123.1
AVA07134.1
AVA07145.1
AVA07156.1
AVA09764.1
AVA16217.1
AVA16240.1
AVA16251.1
AVA16262.1
AVA16273.1
AVA17046.1
AVA17057.1
AVA17068.1
AVA17079.1
AVA17090.1
AVA17101.1
AVA17112.1
AVA17123.1
AVA17330.1
AVA18105.1
AVA31319.1
AVA31601.1
AVA32010.1
AVA32116.1
AVI14959.1
AVI14981.1
AVP04610.1
AVP04637.1
AVP04703.1
AVP04714.1
AVP04725.1
AVP04797.1
AVP04846.1
AVP04879.1
AVP04907.1
AVP04931.1
AVP04945.1
AVP04956.1
AVP04991.1
AVP05055.1
AVP05066.1
AVP05165.1
AVP05341.1
AVP05406.1
AVP05457.1
AVP05539.1
AVP05561.1
AVP05592.1
AVP05605.1
AVP05737.1
AVP05759.1
AVP05803.1
AVP05847.1
AVP05869.1
AVP05880.1
AVP05935.1
AVP05957.1
AVP06058.1
AVP06078.1
AVP06110.1
AVP06188.1
AVR49381.1
AVR49393.1
AVR49404.1
AVR49415.1
AVR49514.1
AVR49547.1
AVR49559.1
AVR49589.1
AVR49635.1
AVR49646.1
AVR49679.1
AVR49701.1
AVR49751.1
AVR49815.1
AVR50051.1
AVR50084.1
AVR50150.1
AVR50204.1
AVR50238.1
AVR50392.1
AVR50403.1
AVR50425.1
AVR51637.1
AVR51646.1
AVR51657.1
AVR51690.1
AVR51723.1
AVR51777.1
AVR51789.1
AVR51800.1
AVR51811.1
AVR51844.1
AVR51855.1
AVR51877.1
AVR51888.1
AVR51899.1
AVR51976.1
AVR51987.1
AVR52020.1
AVR52053.1
AVR52229.1
AVR52262.1
AVR52284.1
AVR52306.1
AVR52339.1
AVR52405.1
AVR52493.1
AVR52504.1
AVR52548.1
AVT55956.1
AVT55958.1
AVX28259.1
AWB13970.1
AWB13981.1
AWB13992.1
AWB14003.1
AWB14069.1
AWB14080.1
AWB14102.1
AWB14146.1
AWC05888.1
AWC05899.1
AWC05954.1
AWC06020.1
AWC06031.1
AWC06053.1
AWC06141.1
AWC06152.1
AWC06174.1
AWC06185.1
AWC06218.1
AWC06229.1
AWC06295.1
AWC06328.1
AWC06339.1
AWC06350.1
AWC06361.1
AWC06372.1
AWC06383.1
AWC06416.1
AWC06487.1
AWC06509.1
AWC06526.1
AWC06570.1
AWC06581.1
AWC06592.1
AWC06636.1
AWI66455.1
AWI66457.1
AWI66459.1
AWI66461.1
AWI66463.1
AWI66465.1
AWI66467.1
AWI66469.1
AWI66471.1
AWI66473.1
AWI66475.1
AWI66477.1
AWI66479.1
AWI66481.1
AWI66483.1
AWK60240.1
AWK60242.1
AWK60244.1
AWK60246.1
AWK60248.1
AWK60250.1
AWK60252.1
AWK60254.1
AWK60256.1
AWK60258.1
AWK60260.1
AWK60262.1
AWK60264.1
AWK60266.1
AWK60268.1
AWK60270.1
AWK60272.1
AWK96660.1
AWK96701.1
AWK96733.1
AWK
P03474 1B9S[A]
1INF[A]
1INV[A]
1IVB[A]
1NSB[A]
1NSC[A]
1NSD[A]
1VCJ[A]
 neuraminidase 3.2.1.18 Influenza B virus AAA43729.1 P16191  
 neuraminidase 3.2.1.18 Influenza B virus AAA43731.1
AAA43737.1
P16193  
 neuraminidase 3.2.1.18 Influenza B virus AAA43735.1 P16195  
 neuraminidase 3.2.1.18 Influenza B virus AAA43741.1 P16201  
 neuraminidase 3.2.1.18 Influenza B virus AAA43743.1 P16203  
 neuraminidase 3.2.1.18 Influenza B virus AAA43745.1 P16205  
 neuraminidase 3.2.1.18 Influenza B virus AAA43747.1 P16207  
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) AAA43733.1 P27907 1A4G[A,B]
1A4Q[A,B]
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) CAB71147.1 Q9IW64  
 neuraminidase (NA) 3.2.1.18 Influenza B virus (B/Brisbane/60/2008) ACN29379.1
ACN29381.1
ADN32819.1
AFH57913.1
C0LT34 4CPL[A,B]
4CPM[A,B]
4CPN[A,B]
 neuraminidase 3.2.1.18 Influenza B virus (B/Nashville/6/89) AAA43739.1
AAD42327.2
P16199
Q9WPR0
 
 neuraminidase (NA) (partial) 3.2.1.18 Influenza B virus B/Lyon/CHU/15.216/2011     4CPO[B]
4CPY[A,B]
4CPZ[A,B,C,D,E,F,G,H]
4CPO[A]
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