Glycoside Hydrolase Family 34

Activities in Familysialidase or neuraminidase (EC 3.2.1.18)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD; ProteinSpotlight;
Statistics GenBank accession (84532); Uniprot accession (20285); PDB accession (180); 3D entries (35); cryst (0)
All (80551) Viruses (80547) unclassified (4) Structure (35) Characterized (36)
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/American green-winged teal/Washington/195750/2014(H5N1)) AJM70556.1   5HUG[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/Brevig Mission/1/1918(H1N1)) AAF77036.1 Q9IGQ6 3B7E[A,B]
3BEQ[A,B]
3CYE[A,B]
 neuraminidase (pdmNA;NA) 3.2.1.18 Influenza A virus (A/California/04/2009(H1N1)) ACP41107.1
ACP44158.1
AEE69012.1
AJI76397.1
C3W5S3 3TI3[A,B]
3TI4[A,B]
3TI5[A,B]
3TI6[A,B]
4B7J[A]
4B7M[A,B]
4B7N[A]
4B7Q[A,B,C,D]
4B7R[A,B,C,D]
 neuraminidase (AvNA) 3.2.1.18 Influenza A virus (A/Cambodia/JP52a/2005(H5N1)) ABO10176.1 A3RMH0  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Alberta/60/1976(H12N5)) BAF43417.1
ACS94008.1
ACZ45127.1
AGB50974.1
A1ILL9 3SAL[A,B]
3SAN[A,B]
3TI8[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) ABI84504.1
ACA04739.1
ACZ45137.1
AGB50887.1
Q0A480  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) (A/DUCK/UKRAINE/1/63) AAA16234.1 Q07599 2HT5[A]
2HT7[A]
2HT8[A]
2HTQ[A]
2HTR[A]
2HTU[A]
3O9J[A]
3O9K[A]
4D8S[A]
4GB1[A]
4KS1[A]
4KS2[A]
4KS3[A]
4KS4[A]
4KS5[A]
4MJU[A]
4MJV[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/environment/Sichuan/NCLL1/2014(H5N6)) AIK26474.1   5HUM[A,B,C,D]
 neuraminidase 3.2.1.18 Influenza A virus (A/Fiji/15899/83(H1N1)) (A/FIJI/15899/83(H3N2)) CAA07348.1 Q9WA95  
 neuraminidase (HumNA;NA) 3.2.1.18 Influenza A virus (A/Gansu/Chenguan/1129/2007(H1N1)) ACF33772.1 B5AYA6  
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/gyrfalcon/Washington/41088-6/2014(H5N8)) AJE30335.1   5HUN[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Mexico/24061/2009(H1N1)) AGR50353.1   4QNP[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/mink/Sweden/E12665/84(H10N4)) AAO62044.1 Q6XV46 2HTV[A,B]
2HTW[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2)) AJE30346.1   5HUK[A,B,C,D]
 neuraminidase (fragment) 3.2.1.18 Influenza A virus (A/Puerto Rico/8/1934(Cambridge)(H1N1)) (A/PUERTO RICO/8/34 A/PR/8/34) AAA43412.1
NP_040981.1
P03468  
 neuraminidase 3.2.1.18 Influenza A virus (A/RI/5+/1957(H2N2)) ABF82433.1
ABF82434.1
ABF82435.1
Q194T1 3TIA[A,B,C,D]
3TIB[A,B,C,D]
3TIC[A,B,C,D]
4H52[A,B]
4H53[A,B,C,D]
4K1H[A,B]
4K1I[A,B]
4K1J[A,B]
4K1K[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)) ABY40430.1 A9YN63 4HZV[A]
4HZW[A]
4HZX[A]
4HZY[A]
4HZZ[A]
4I00[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) (A/TERN/AUSTRALIA/G70C/75) AAA43353.1 P03472 1A14[N]
1BJI[A]
1F8B[A]
1F8C[A]
1F8D[A]
1F8E[A]
1INY[A]
1L7F[A]
1L7G[A]
1L7H[A]
1MWE[A]
1NCA[N]
1NCB[N]
1NCC[N]
1NMC[A,N]
1NNA[A]
1NNB[A]
1NNC[A]
1XOE[A]
1XOG[A]
2C4A[A]
2C4L[A]
2QWA[A]
2QWB[A]
2QWC[A]
2QWD[A]
2QWE[A]
2QWF[A]
2QWG[A]
2QWH[A]
2QWI[A]
2QWJ[A]
2QWK[A]
3NN9[A]
3W09[A]
4DGR[A]
4NN9[A]
4WEG[A]
5NN9[A]
6NN9[A]
7NN9[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Tokyo/3/1967(H2N2)) AAB05621.1
AAO46245.1
P06820 1ING[A]
1INH[A]
1INW[A]
1INX[A]
1IVC[A]
1IVD[A]
1IVE[A]
1IVF[A]
1IVG[A]
1NN2[A]
2BAT[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/Victoria/3/1975(H3N2)) (X-47) AAB03361.1
AFM71970.1
P03482  
 neuraminidase 3.2.1.18 Influenza A virus (A/Viet Nam/1203/2004(H5N1)) AAT73329.1
AAW80723.1
ABP52008.1
ADD97097.1
Q6DPL2 2HTY[A,B,C,D,E,F,G,H]
2HU0[A,B,C,D,E,F,G,H]
2HU4[A,B,C,D,E,F,G,H]
3CKZ[A]
3CL2[A,B,C,D,E,F,G,H]
 neuraminidase 3.2.1.18 Influenza A virus (A/whale/Maine/1/1984(H13N9)) (A/WHALE/MAINE/1/84) (H1N9) AAA43575.1 P05803 1NCD[N]
1NMA[N]
1NMB[N]
2B8H[A]
 neuraminidase (fragment) 3.2.1.18 Influenza A virus (A/Wilson-Smith/1933(H1N1)) (A/WSN/33) AAA43397.1 P03470  
 neuraminidase 3.2.1.18 Influenza B virus AAA43749.1
NP_056663.1
P03474 1B9S[A]
1INF[A]
1INV[A]
1IVB[A]
1NSB[A]
1NSC[A]
1NSD[A]
1VCJ[A]
 neuraminidase 3.2.1.18 Influenza B virus AAA43729.1 P16191  
 neuraminidase 3.2.1.18 Influenza B virus AAA43731.1
AAA43737.1
P16193  
 neuraminidase 3.2.1.18 Influenza B virus AAA43735.1 P16195  
 neuraminidase 3.2.1.18 Influenza B virus AAA43741.1 P16201  
 neuraminidase 3.2.1.18 Influenza B virus AAA43743.1 P16203  
 neuraminidase 3.2.1.18 Influenza B virus AAA43745.1 P16205  
 neuraminidase 3.2.1.18 Influenza B virus AAA43747.1 P16207  
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) AAA43733.1 P27907 1A4G[A,B]
1A4Q[A,B]
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) CAB71147.1 Q9IW64  
 neuraminidase (NA) 3.2.1.18 Influenza B virus (B/Brisbane/60/2008) ACN29379.1
ACN29381.1
ADN32819.1
AFH57913.1
C0LT34 4CPL[A,B]
4CPM[A,B]
4CPN[A,B]
 neuraminidase 3.2.1.18 Influenza B virus (B/Nashville/6/89) AAA43739.1
AAD42327.2
P16199
Q9WPR0
 
 neuraminidase (NA) (partial) 3.2.1.18 Influenza B virus B/Lyon/CHU/15.216/2011     4CPO[B]
4CPY[A,B]
4CPZ[A,B,C,D,E,F,G,H]
4CPO[A]
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