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Glycoside Hydrolase Family 34

Known Activitiessialidase or neuraminidase (EC 3.2.1.18)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD; InterPro; PFAM; ProteinSpotlight;
Statistics GenBank accession (27547); Uniprot accession (20295); PDB accession (101); 3D entries (16); cryst (0)
Summary
All (27966) Viruses (27966) Structure (16 ) Characterized (122)
Viruses
Protein Name EC#OrganismGenBankUniprotPDB/3D
 neuraminidase 3.2.1.18 Influenza A virus (A/Aquatic bird/Hong Kong/M603/98(H11N1)) VIRUS (A/AQUATIC BIRD/HONG KONG/M603/97 (H5N1)) AAF02314.1 Q9PZM6  
 neuraminidase 3.2.1.18 Influenza A virus (A/Bangkok/1/1979(H3N2)) (A/BANGKOK/1/79) AAA43386.1 P06818.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Brevig Mission/1/1918(H1N1)) AAF77036.1 Q9IGQ6 3B7E[A,B]
3BEQ[A,B]
3CYE[A,B]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/California/04/2009(H1N1)) ACP41107.1
ACP44158.1
AEE69012.1		 C3W5S3 3TI3[A,B]
3TI4[A,B]
3TI5[A,B]
3TI6[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Beijing/1/94(H9N2)) AAD49008.1 Q9Q0T7  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/739/94(H9N2)) AAD49007.1 Q9Q0T8  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/FY20/99(H9N2)) AAG48215.1 Q9DRI3  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/G23/97(H9N2)) AAD49002.1 Q9Q0U3  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/G9/97(H9N2)) AAD49001.1 Q9Q0U4  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/KC12/99(H9N2)) AAG48216.1 Q9DRI2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/NT16/99(H9N2)) AAG48212.1 Q9DRI6  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Hong Kong/SF2/99(H9N2)) AAG48218.1 Q9DRI0  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chicken/Korea/38349-p96323/96(H9N2)) AAD49010.1 Q9PZF9  
 neuraminidase subtype 2 3.2.1.18 Influenza A virus (A/Chicken/Korea/MS96/96(H9N2)) AAF70404.1 Q9J458  
 neuraminidase 3.2.1.18 Influenza A virus (A/chicken/Pakistan/2/99(H9N2)) CAC19695.1 Q9DID8  
 neuraminidase 3.2.1.18 Influenza A virus (A/chicken/Pennsylvania/1370/1983(H5N2)) AAA43424.1 D1LQE0
P09573.2		  
 neuraminidase 3.2.1.18 Influenza A virus (A/chicken/Pennsylvania/8125/1983(H5N2)) AAA43423.1 P09574.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/chicken/Taiwan/7-5/99(H6N1)) AAF17620.1 Q9PZD6  
 neuraminidase 3.2.1.18 Influenza A virus (A/Chile/1/1983(H1N1)) AAA96671.1
CAA33354.1		 P11485.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Cor/16/1974(H7N7)) AAA43093.1 P08327.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Alberta/60/1976(H12N5)) ACS94008.1
ACZ45127.1
BAF43417.1		 A1ILL9 3SAL[A,B]
3SAN[A,B]
3TI8[A,B]
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Burjatia/652/1988(H3N8)) (A/DUCK/BURJATIA/652/88) AAA43365.1 Q07570  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Chabarovsk/1610/1972 (H3N8)) (A/DUCK/CHABAROVSK/1610.72) AAA43367.1 Q07571  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Hokkaido/8/1980(H3N8)) AAA43372.1 Q07572  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Hong Kong/Y280/97(H9N2)) AAD49004.1 Q9Q0U1  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Hong Kong/Y439/97(H9N2)) AAD49005.1 Q9Q0U0  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Memphis/928/1974(H3N8)) (A/DUCK/MEMPHIS/928/74) AAA43404.1 Q07573  
 neuraminidase 3.2.1.18 Influenza A virus (A/Duck/Ohio/118C/93 (H1N1)) AAF77041.1 Q9IGQ2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Duck/Ohio/175/86 (H1N1)) AAF77038.1 Q9IGQ5  
 neuraminidase 3.2.1.18 Influenza A virus (A/Duck/Ohio/194/86 (H1N1)) AAF77040.1
ABL67124.1		 Q9IGQ3  
 neuraminidase 3.2.1.18 Influenza A virus (A/Duck/Ohio/30/86 (H1N1)) AAF77039.1 Q9IGQ4  
 neuraminidase 3.2.1.18 Influenza A virus (A/duck/Ukraine/1/1963(H3N8)) (A/DUCK/UKRAINE/1/63) AAA16234.1 Q07599 2HT5[A]
2HT7[A]
2HT8[A]
2HTQ[A]
2HTR[A]
2HTU[A]
3O9J[A]
3O9K[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/England/939/1969(H3N2) x A/Puerto_Rico/8/1934(H3N2)) (A/ENGLAND/939/69(H3N2) X A/PUERTO_RICO/8/34(H3N2)) CAA07347.1 Q9YQQ6  
 neuraminidase 1 3.2.1.18 Influenza A virus (A/environment/Hong Kong/437-10/99 (H5N1)) AAG01226.1 Q9EA48  
 neuraminidase 1 3.2.1.18 Influenza A virus (A/environment/Hong Kong/437-4/99 (H5N1)) AAG01196.1 Q9EA68  
 neuraminidase 3.2.1.18 Influenza A virus (A/environment/Hong Kong/437-6/99 (H5N1)) AAG01206.1 Q9EA61  
 neuraminidase 1 3.2.1.18 Influenza A virus (A/environment/Hong Kong/437-8/99 (H5N1)) AAG01216.1 Q77NF0
Q9EA53		  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Alaska/1/1991(H3N8)) (A/EQUINE/ALASKA/1/91) AAA43354.1 Q07575  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Algiers/1972(H3N8)) (A/EQUINE/ALGIERS/72) AAA43355.1 Q07576  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Jilin/1/1989(H3N8)) AAA43374.1 Q07578  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Kentucky/1/1981(H3N8)) AAA43245.1 P08326.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Miami/1/1963(H3N8)) (A/EQUINE/MIAMI/1/63) AAA43409.1 B0KVU4
Q07579		  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/New Market/1979(H3N3)) (A/EQUINE/NEW MARKET/79) AAA43427.1 Q07580  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Sao Paulo/6/1969(H3N8)) (A/EQUINE/SAO PAULO/6/69) AAA43429.1 Q07581  
 neuraminidase 3.2.1.18 Influenza A virus (A/equine/Tennessee/5/1986(H3N8)) (A/EQUINE/TENNESSEE/5/86) AAA43430.1 B0VWW4
Q07582		  
 neuraminidase 3.2.1.18 Influenza A Virus (A/Fiji/15899/83(H1N1)) (A/FIJI/15899/83(H3N2)) CAA07348.1 Q9WA95  
 neuraminidase 3.2.1.18 Influenza A virus (A/Fort Monmouth/1/1947-mouse adapted(H1N1)) AAF77037.1
CAB40419.1		 Q8JSD9  
 neuraminidase 3.2.1.18 Influenza A virus (A/fowl/Weybridge(H7N7)) AAA43425.1 P18881.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) AAD51926.1 Q9Q0U7  
 neuraminidase 3.2.1.18 Influenza A virus (A/guinea fowl/New York/4-3587/1984(H3N8)) (A/GUINEA FOWL/NEW YORK/4-3587/84) AAA43428.1 Q07574  
 neuraminidase 3.2.1.18 Influenza A virus (A/herring gull/DE/677/1988(H2N8)) (A/HERRING GULL/DE/677/88) AAA43368.1 Q07577  
 neuraminidase 3.2.1.18 Influenza A virus (A/Hong Kong/1074/99(H9N2)) CAB95858.1 Q9ICY3  
 neuraminidase subtype 1 3.2.1.18 Influenza A virus (A/Hong Kong/481/97(H5N1)) AAF74321.1 Q9IP58  
 neuraminidase subtype 1 3.2.1.18 Influenza A virus (A/Hong Kong/482/97(H5N1)) AAF74322.1 Q9IP57  
 neuraminidase subtype 1 3.2.1.18 Influenza A virus (A/Hong Kong/483/1997(H5N1)) AAF74323.1
ACZ45116.1		 Q9IP56  
 neuraminidase subtype 1 3.2.1.18 Influenza A virus (A/Hong Kong/485/97(H5N1)) AAF74324.1 Q9IP55  
 neuraminidase subtype 1 3.2.1.18 Influenza A virus (A/Hong Kong/486/97(H5N1)) AAF74325.1 Q9IP54  
 neuraminidase 3.2.1.18 Influenza A virus (A/Kiev/59/1979(H1N1)) (A/KIEV/59/79) AAA43435.1 P31348.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Leningrad/1954/1(H1N1)) AAA43797.1 P31349.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/mallard/Alberta/35/1976(H1N1)) AAF77042.1
ABB20505.1		 Q9IGQ1  
 neuraminidase 3.2.1.18 Influenza A virus (A/mallard/Edmonton/220/1990(H3N8)) (A/MALLARD/EDMONTON/220/90) AAA43369.1 Q07583  
 neuraminidase 3.2.1.18 Influenza A virus (A/mink/Sweden/E12665/84(H10N4)) AAO62044.1 Q6XV46 2HTV[A,B]
2HTW[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/parrot/Ulster/73(H7N1)) (A/PARROT/ULSTER/73) AAA43377.1 P06819.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/pheasant/Hong Kong/SSP11/99(H9N2)) AAG48214.1 Q9DRI4  
 neuraminidase 3.2.1.18 Influenza A virus (A/Pigeon/Hong Kong/FY6/99(H9N2)) AAG48211.1 Q9DRI7  
 neuraminidase 3.2.1.18 Influenza A virus (A/Pigeon/Hong Kong/Y233/97(H9N2)) AAD49003.1 Q9Q0U2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Puerto Rico/8/1934(Cambridge)(H1N1)) (A/PUERTO RICO/8/34 A/PR/8/34) AAA43412.1
NP_040981.1		 P03468  
 neuraminidase 3.2.1.18 Influenza A virus (A/Quail/Hong Kong/A17/99(H9N2)) AAG48210.1 Q9DRI8  
 neuraminidase 3.2.1.18 Influenza A virus (A/Quail/Hong Kong/AF157/92(H9N2)) VIRUS (A/QUAIL/HONG KONG/AF157/93(H9N2)) AAD49009.1 Q9PZG0  
 neuraminidase 3.2.1.18 Influenza A virus (A/Quail/Hong Kong/G1/97 (H9N2)) AAD49006.1 Q9Q0T9  
 neuraminidase 3.2.1.18 Influenza A virus (A/Quail/Hong Kong/NT28/99(H9N2)) AAG48217.1 Q9DRI1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Quail/Hong Kong/SSP10/99(H9N2)) AAG48213.1 Q9DRI5  
 neuraminidase 3.2.1.18 Influenza A virus (A/quail/Italy/1117/1965(H10N8)) (A/QUAIL/ITALY/1117/65) AAA43373.1 Q07584  
 neuraminidase 3.2.1.18 Influenza A virus (A/RI/5+/1957(H2N2)) ABF82433.1
ABF82434.1
ABF82435.1		 Q194T1 3TIA[A,B,C,D]
3TIB[A,B,C,D]
3TIC[A,B,C,D]
 neuraminidase 3.2.1.18 Influenza A virus (A/RI/5-/1957(H2N2)) (A/RI/5-/57 (H2N2)) AAA43413.1 P03484.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/shearwater/Australia/1/1972(H6N5)) (A/SHEARWATER/72) AAA43672.1 P03478.2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Silky Chicken/Hong Kong/SF44/99(H9N2)) AAG48219.1 Q9DRH9  
 neuraminidase 3.2.1.18 Influenza A virus (A/sw/Kanagawa/2/1978(H1N2)) (SW/KANAGAWA/2/78) BAA00619.1 Q09106  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Colorado/1/1977(H3N2)) AAG01743.1 Q9EA42  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Colorado/23619/99(H3N2)) AAG10750.1 Q9E300  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/England/195852/1992(H1N1)) AAF77046.1 Q9IGP9  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Hong Kong/4/1976(H3N2)) (SW/HONG KONG/4/76) BAA00621.1 Q09105  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Indiana/9K035/99 (H1N2)) AAF75996.1 Q9IGR8  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Iowa/15/1930(H1N1)) AAF77044.1 Q9IBI2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Iowa/533/99 (H3N2)) AAG01768.1 Q9EA29  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Iowa/569/99 (H3N2)) AAG01777.1 Q9EA27  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Iowa/8548-1/98) AAD51246.1 Q9QJC3  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Minnesota/593/99 (H3N2)) AAG01786.1
AAG01786.2		 Q9EA23  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Minnesota/9088-2/98 (H3N2)) AAD51245.1 Q9Q0L0  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Nebraska/209/98 (H3N2)) AAG01759.1 Q9EA31  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/New Jersey/11/1976(H1N1)) AAF77043.1 Q9IGQ0  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/North Carolina/35922/98 (H3N2)) AAD51243.1 Q9Q0L2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/NorthCarolina/16497/99(H3N2)) AAG10751.1 Q9E2Z9  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Oklahoma/18717/99(H3N2)) AAG10748.1 Q9E302  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Ontario/00130/97(H3N2)) AAG01750.1 Q9EA36  
 neuraminidase 3.2.1.18 Influenza A virus (A/swine/Ontario/01911-1/99 (H4N6)) AAG17431.2 Q9E147  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Texas/4199-2/98(H3N2)) AAD51244.1 Q9Q0L1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Swine/Wisconsin/14094/99(H3N2)) AAG10749.1 Q9E301  
 neuraminidase 3.2.1.18 Influenza A virus (A/Teal/Hong Kong/W312/97(H6N1)) AAF87509.1 Q9IGN8  
 neuraminidase 3.2.1.18 Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) (A/TERN/AUSTRALIA/G70C/75) AAA43353.1 P03472.1 1A14[N]
1BJI[A]
1F8B[A]
1F8C[A]
1F8D[A]
1F8E[A]
1INY[A]
1L7F[A]
1L7G[A]
1L7H[A]
1MWE[A]
1NCA[N]
1NCB[N]
1NCC[N]
1NMC[A,N]
1NNA[A]
1NNB[A]
1NNC[A]
1XOE[A]
1XOG[A]
2C4A[A]
2C4L[A]
2QWA[A]
2QWB[A]
2QWC[A]
2QWD[A]
2QWE[A]
2QWF[A]
2QWG[A]
2QWH[A]
2QWI[A]
2QWJ[A]
2QWK[A]
3NN9[A]
4NN9[A]
5NN9[A]
6NN9[A]
7NN9[A]
 neuraminidase (NA) 3.2.1.18 Influenza A virus (A/Tokyo/3/1967(H2N2)) AAB05621.1
AAO46245.1		 P06820.2 1ING[A]
1INH[A]
1INW[A]
1INX[A]
1IVC[A]
1IVD[A]
1IVE[A]
1IVF[A]
1IVG[A]
1NN2[A]
2BAT[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/udorn/1972(H3N2)) (A/UDORN/72) AAA43419.1 P03483.2
Q20MD3		  
 neuraminidase 3.2.1.18 Influenza A virus (A/USSR/90/1977(H1N1)) (A/USSR/90/77) AAA43449.1 P03469.2  
 neuraminidase 3.2.1.18 Influenza A virus (A/Victoria/3/1975(H3N2)) (X-47) AAB03361.1 P03482.1  
 neuraminidase 3.2.1.18 Influenza A virus (A/Viet Nam/1203/2004(H5N1)) AAT73329.1
AAW80723.1
ABP52008.1		 Q6DPL2 2HTY[A,B,C,D,E,F,G,H]
2HU0[A,B,C,D,E,F,G,H]
2HU4[A,B,C,D,E,F,G,H]
3CKZ[A]
3CL2[A,B,C,D,E,F,G,H]
 neuraminidase 3.2.1.18 Influenza A virus (A/Weiss/1943(H1N1)) AAF77045.1 Q9IBI1  
 neuraminidase 3.2.1.18 Influenza A virus (A/whale/Maine/1/1984(H13N9)) (A/WHALE/MAINE/1/84) (H1N9) AAA43575.1 P05803.1 1NCD[N]
1NMA[N]
1NMB[N]
2B8H[A]
 neuraminidase 3.2.1.18 Influenza A virus (A/Wilson-Smith/1933(H1N1)) (A/WSN/33) AAA43397.1 P03470.2  
 neuraminidase 3.2.1.18 Influenza A virus H3N2 VIRUS (A/KITAKYUSHU/159/93) AAC63468.1 O91744.1  
 neuraminidase 3.2.1.18 Influenza A virus H3N2 VIRUS (A/NIIGATA/137/96) AAC63470.1 O91745.1  
 neuraminidase 3.2.1.18 Influenza B virus AAA43749.1
NP_056663.1		 P03474.1 1B9S[A]
1INF[A]
1INV[A]
1IVB[A]
1NSB[A]
1NSC[A]
1NSD[A]
1VCJ[A]
 neuraminidase 3.2.1.18 Influenza B virus AAA43729.1 P16191.1  
 neuraminidase 3.2.1.18 Influenza B virus AAA43731.1
AAA43737.1		 P16193  
 neuraminidase 3.2.1.18 Influenza B virus AAA43735.1 P16195.1  
 neuraminidase 3.2.1.18 Influenza B virus AAA43741.1 P16201.1  
 neuraminidase 3.2.1.18 Influenza B virus AAA43743.1 P16203.1  
 neuraminidase 3.2.1.18 Influenza B virus AAA43745.1 P16205.1  
 neuraminidase 3.2.1.18 Influenza B virus AAA43747.1 P16207.1  
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) AAA43733.1 P27907.1 1A4G[A,B]
1A4Q[A,B]
 neuraminidase 3.2.1.18 Influenza B virus (B/BEIJING/1/87) CAB71147.1 Q9IW64  
 neuraminidase 3.2.1.18 Influenza B virus (B/Kanagawa/73) AAB26739.1
BAA03410.1		 Q90032  
 neuraminidase 3.2.1.18 Influenza B virus (B/Nashville/6/89) AAA43739.1
AAD42327.2		 P16199.1
Q9WPR0		  

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2012-01-31 © Copyright 1998-2012
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