Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (139011); Uniprot accession (46); PDB accession (250); 3D entries (58); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)		Influenza A virus A/Florida/25/2022	USW61767.1
neuraminidase (NA)		Influenza A virus A/Florida/25/2022	UUV81566.1
neuraminidase (NA)		Influenza A virus A/Florida/26/2019	QDX12179.1
neuraminidase (NA)		Influenza A virus A/Florida/26/2022	USW61779.1
neuraminidase (NA)		Influenza A virus A/Florida/26/2022	UUV81578.1
neuraminidase (NA)		Influenza A virus A/Florida/27/2018	AWC06845.1
neuraminidase (NA)		Influenza A virus A/Florida/27/2019	QDX12203.1
neuraminidase (NA)		Influenza A virus A/Florida/27/2021	UZO39359.1
neuraminidase (NA)		Influenza A virus A/Florida/27/2022	UUV81602.1
neuraminidase (NA)		Influenza A virus A/Florida/27/2022	UUV81590.1
neuraminidase (NA)		Influenza A virus A/Florida/28/2018	AWC07406.1 AXY84379.1
neuraminidase (NA)		Influenza A virus A/Florida/28/2019	QCW16556.1
neuraminidase (NA)		Influenza A virus A/Florida/28/2022	USW60620.1
neuraminidase (NA)		Influenza A virus A/Florida/28/2022	UUV80602.1
neuraminidase (NA)		Influenza A virus A/Florida/29/2019	QCW17012.1
neuraminidase (NA)		Influenza A virus A/Florida/29/2022	USW61791.1
neuraminidase (NA)		Influenza A virus A/Florida/29/2022	UUV81614.1
neuraminidase (NA)		Influenza A virus A/Florida/30/2018	AWC07418.1 AXY84391.1
neuraminidase (NA)		Influenza A virus A/Florida/30/2019	QCW17023.1
neuraminidase (NA)		Influenza A virus A/Florida/30/2022	USW61803.1
neuraminidase (NA)		Influenza A virus A/Florida/30/2022	UUV81626.1
neuraminidase (NA)		Influenza A virus A/Florida/31/2018	AZF86788.1
neuraminidase (NA)		Influenza A virus A/Florida/31/2019	QDX12227.1 QDQ44235.1
neuraminidase (NA)		Influenza A virus A/Florida/31/2022	USW61815.1
neuraminidase (NA)		Influenza A virus A/Florida/31/2022	UUV81638.1
neuraminidase (NA)		Influenza A virus A/Florida/32/2018	AWI42413.1
neuraminidase (NA)		Influenza A virus A/Florida/32/2019	QCW17029.1
neuraminidase (NA)		Influenza A virus A/Florida/32/2022	UUV81650.1
neuraminidase (NA)		Influenza A virus A/Florida/33/2018	AWI42424.1
neuraminidase (NA)		Influenza A virus A/Florida/33/2019	QDX12239.1 QDQ44247.1
neuraminidase (NA)		Influenza A virus A/Florida/33/2022	UTR02936.1
neuraminidase (NA)		Influenza A virus A/Florida/33/2022	UUV81662.1
neuraminidase (NA)		Influenza A virus A/Florida/34/2018	AZF86694.1
neuraminidase (NA)		Influenza A virus A/Florida/34/2019	QDE06722.1 QDQ44259.1
neuraminidase (NA)		Influenza A virus A/Florida/34/2022	UTR02948.1
neuraminidase (NA)		Influenza A virus A/Florida/34/2022	UUV81674.1
neuraminidase (NA)		Influenza A virus A/Florida/35/2018	AWI42207.1
neuraminidase (NA)		Influenza A virus A/Florida/35/2019	QDE05459.1
neuraminidase (NA)		Influenza A virus A/Florida/35/2022	UTR02960.1
neuraminidase (NA)		Influenza A virus A/Florida/35/2022	UUV81686.1
neuraminidase (NA)		Influenza A virus A/Florida/36/2018	AWI46143.1
neuraminidase (NA)		Influenza A virus A/Florida/36/2019	QDE06734.1 QDQ44271.1
neuraminidase (NA)		Influenza A virus A/Florida/36/2022	UTR02972.1
neuraminidase (NA)		Influenza A virus A/Florida/36/2022	UUV81698.1
neuraminidase (NA)		Influenza A virus A/Florida/37/2018	AWI46155.1 AXV44059.1
neuraminidase (NA)		Influenza A virus A/Florida/37/2019	QDE05264.1
neuraminidase (NA)		Influenza A virus A/Florida/37/2022	UTR02984.1
neuraminidase (NA)		Influenza A virus A/Florida/37/2022	UTR02996.1
neuraminidase (NA)		Influenza A virus A/Florida/38/2018	AWI42435.1
neuraminidase (NA)		Influenza A virus A/Florida/38/2019	QDE05471.1 QFO38642.1
neuraminidase (NA)		Influenza A virus A/Florida/38/2022	UTQ95041.1
neuraminidase (NA)		Influenza A virus A/Florida/39/2018	AWR88640.1
neuraminidase (NA)		Influenza A virus A/Florida/39/2019	QDE06746.1 QDQ44283.1
neuraminidase (NA)		Influenza A virus A/Florida/39/2022	UTR03008.1
neuraminidase (NA)		Influenza A virus A/Florida/39/2022	UTR03020.1
neuraminidase (NA)		Influenza A virus A/Florida/40/2018	AWR88760.1
neuraminidase (NA)		Influenza A virus A/Florida/40/2019	QDE05274.1
neuraminidase (NA)		Influenza A virus A/Florida/40/2022	UUV88978.1
neuraminidase (NA)		Influenza A virus A/Florida/40/2022	UUV88966.1
neuraminidase (NA)		Influenza A virus A/Florida/41/2018	AXV44071.1 AZF86513.1
neuraminidase (NA)		Influenza A virus A/Florida/41/2019	QDQ44295.1
neuraminidase (NA)		Influenza A virus A/Florida/41/2022	UUV88990.1
neuraminidase (NA)		Influenza A virus A/Florida/41/2022	UUV89002.1
neuraminidase (NA)		Influenza A virus A/Florida/42/2018	AYG77440.1 AZF86814.1
neuraminidase (NA)		Influenza A virus A/Florida/42/2019	QDE05482.1
neuraminidase (NA)		Influenza A virus A/Florida/42/2022	UUV88124.1
neuraminidase (NA)		Influenza A virus A/Florida/43/2018	AWK90754.1
neuraminidase (NA)		Influenza A virus A/Florida/43/2019	QDE05214.1
neuraminidase (NA)		Influenza A virus A/Florida/43/2022	UUV89014.1
neuraminidase (NA)		Influenza A virus A/Florida/43/2022	UUV89026.1
neuraminidase (NA)		Influenza A virus A/Florida/44/2018	AWK69665.1 AWX41828.1
neuraminidase (NA)		Influenza A virus A/Florida/44/2019	QDE06758.1 QDQ44319.1
neuraminidase (NA)		Influenza A virus A/Florida/44/2022	UUV89050.1
neuraminidase (NA)		Influenza A virus A/Florida/44/2022	UUV89038.1
neuraminidase (NA)		Influenza A virus A/Florida/45/2018	AWK69677.1 AXV44083.1
neuraminidase (NA)		Influenza A virus A/Florida/45/2019	QDE06770.1 QDQ44331.1
neuraminidase (NA)		Influenza A virus A/Florida/45/2022	UUV89074.1
neuraminidase (NA)		Influenza A virus A/Florida/45/2022	UUV89062.1
neuraminidase (NA)		Influenza A virus A/Florida/46/2018	AWX41366.1
neuraminidase (NA)		Influenza A virus A/Florida/46/2019	QDE05487.1
neuraminidase (NA)		Influenza A virus A/Florida/46/2022	UUV89086.1
neuraminidase (NA)		Influenza A virus A/Florida/46/2022	UUV89098.1
neuraminidase (NA)		Influenza A virus A/Florida/47/2018	AWR88771.1
neuraminidase (NA)		Influenza A virus A/Florida/47/2019	QDE05504.1
neuraminidase (NA)		Influenza A virus A/Florida/47/2022	UUV89122.1
neuraminidase (NA)		Influenza A virus A/Florida/47/2022	UUV89110.1
neuraminidase (NA)		Influenza A virus A/Florida/48/2018	AWR88782.1
neuraminidase (NA)		Influenza A virus A/Florida/48/2019	QDE06782.1 QEI02127.1
neuraminidase (NA)		Influenza A virus A/Florida/48/2022	UTR03044.1
neuraminidase (NA)		Influenza A virus A/Florida/48/2022	UTR03032.1
neuraminidase (NA)		Influenza A virus A/Florida/49/2018	AZF87121.1
neuraminidase (NA)		Influenza A virus A/Florida/49/2019	QDE06794.1 QEI02139.1
neuraminidase (NA)		Influenza A virus A/Florida/49/2022	UUV89134.1
neuraminidase (NA)		Influenza A virus A/Florida/49/2022	UUV89146.1
neuraminidase (NA)		Influenza A virus A/Florida/50/2018	AZF87168.1
neuraminidase (NA)		Influenza A virus A/Florida/50/2019	QDR48170.1
neuraminidase (NA)		Influenza A virus A/Florida/50/2022	UUV89158.1
neuraminidase (NA)		Influenza A virus A/Florida/50/2022	UUV89170.1
neuraminidase (NA)		Influenza A virus A/Florida/51/2018	AXB51714.1 AZF87180.1
neuraminidase (NA)		Influenza A virus A/Florida/51/2019	QED95096.1 QEI02158.1
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