Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (139011); Uniprot accession (46); PDB accession (250); 3D entries (58); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)		Influenza A virus A/Connecticut/11/2019	QCG84238.1 QDX11884.1
neuraminidase (NA)		Influenza A virus A/Connecticut/11/2020	QIZ32152.1
neuraminidase (NA)		Influenza A virus A/Connecticut/11/2021	UZO36402.1
neuraminidase (NA)		Influenza A virus A/Connecticut/11/2021	UZO36346.1
neuraminidase (NA)		Influenza A virus A/Connecticut/11/2022	USW61147.1
neuraminidase (NA)		Influenza A virus A/Connecticut/11/2022	USW61135.1
neuraminidase (NA)		Influenza A virus A/Connecticut/12/2018	AVX28725.1
neuraminidase (NA)		Influenza A virus A/Connecticut/12/2019	QBY33903.1
neuraminidase (NA)		Influenza A virus A/Connecticut/12/2021	UZO38544.1
neuraminidase (NA)		Influenza A virus A/Connecticut/12/2021	UZO38532.1
neuraminidase (NA)		Influenza A virus A/Connecticut/12/2022	USW61171.1
neuraminidase (NA)		Influenza A virus A/Connecticut/12/2022	USW61159.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2018	AXY84319.1 AZF86717.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2019	QCW16858.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2020	QJA10851.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2021	UZO38568.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2021	UZO38556.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2022	USW61183.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13/2022	UUV81302.1
neuraminidase (NA)		Influenza A virus A/Connecticut/13338/2022	UVI03419.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2018	AWI42369.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2019	QCW13799.1 QDX11903.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2020	QJT24408.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2021	UZO38592.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2021	UZO38580.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2022	USW61195.1
neuraminidase (NA)		Influenza A virus A/Connecticut/14/2022	UUV81314.1
neuraminidase (NA)		Influenza A virus A/Connecticut/15/2018	AZF86813.1
neuraminidase (NA)		Influenza A virus A/Connecticut/15/2019	QDX11915.1 QDQ44055.1
neuraminidase (NA)		Influenza A virus A/Connecticut/15/2020	QJT24302.1
neuraminidase (NA)		Influenza A virus A/Connecticut/15/2021	UZO38604.1
neuraminidase (NA)		Influenza A virus A/Connecticut/15/2022	USW60634.1
neuraminidase (NA)		Influenza A virus A/Connecticut/15/2022	UUV81326.1
neuraminidase (NA)		Influenza A virus A/Connecticut/16/2018	AWI42380.1
neuraminidase (NA)		Influenza A virus A/Connecticut/16/2019	QCW16869.1
neuraminidase (NA)		Influenza A virus A/Connecticut/16/2020	QJT42365.1
neuraminidase (NA)		Influenza A virus A/Connecticut/16/2022	UTR02591.1
neuraminidase (NA)		Influenza A virus A/Connecticut/16/2022	UUV81338.1
neuraminidase (NA)		Influenza A virus A/Connecticut/17/2018	AWI42391.1
neuraminidase (NA)		Influenza A virus A/Connecticut/17/2019	QDX11920.1
neuraminidase (NA)		Influenza A virus A/Connecticut/17/2020	QJT42389.1
neuraminidase (NA)		Influenza A virus A/Connecticut/17/2022	UTR02603.1
neuraminidase (NA)		Influenza A virus A/Connecticut/17/2022	UUV81350.1
neuraminidase (NA)		Influenza A virus A/Connecticut/18/2018	AWI42226.1
neuraminidase (NA)		Influenza A virus A/Connecticut/18/2020	QKG62285.1
neuraminidase (NA)		Influenza A virus A/Connecticut/18/2022	UTR02615.1
neuraminidase (NA)		Influenza A virus A/Connecticut/18/2022	UUV81362.1
neuraminidase (NA)		Influenza A virus A/Connecticut/19/2018	AXY84115.1
neuraminidase (NA)		Influenza A virus A/Connecticut/19/2019	QCW16880.1
neuraminidase (NA)		Influenza A virus A/Connecticut/19/2020	QKG28273.1
neuraminidase (NA)		Influenza A virus A/Connecticut/19/2022	UTR02639.1
neuraminidase (NA)		Influenza A virus A/Connecticut/19/2022	UTR02627.1
neuraminidase (NA)		Influenza A virus A/Connecticut/20/2018	AXY84331.1
neuraminidase (NA)		Influenza A virus A/Connecticut/20/2019	QDE06523.1 QDX11939.1
neuraminidase (NA)		Influenza A virus A/Connecticut/20/2020	QKG28284.1
neuraminidase (NA)		Influenza A virus A/Connecticut/20/2022	UTR02663.1
neuraminidase (NA)		Influenza A virus A/Connecticut/20/2022	UTR02651.1
neuraminidase (NA)		Influenza A virus A/Connecticut/21/2018	AWK90721.1
neuraminidase (NA)		Influenza A virus A/Connecticut/21/2019	QDE06535.1 QDX11951.1
neuraminidase (NA)		Influenza A virus A/Connecticut/21/2020	QKG62309.1
neuraminidase (NA)		Influenza A virus A/Connecticut/21/2022	UTR02685.1
neuraminidase (NA)		Influenza A virus A/Connecticut/21/2022	UTR02673.1
neuraminidase (NA)		Influenza A virus A/Connecticut/22/2018	AWK69617.1
neuraminidase (NA)		Influenza A virus A/Connecticut/22/2019	QCW16891.1
neuraminidase (NA)		Influenza A virus A/Connecticut/22/2022	UUV88598.1
neuraminidase (NA)		Influenza A virus A/Connecticut/22/2022	UUV88610.1
neuraminidase (NA)		Influenza A virus A/Connecticut/23/2018	AWK69629.1
neuraminidase (NA)		Influenza A virus A/Connecticut/23/2019	QCW16693.1
neuraminidase (NA)		Influenza A virus A/Connecticut/23/2022	UUV88622.1
neuraminidase (NA)		Influenza A virus A/Connecticut/23/2022	UZO36646.1
neuraminidase (NA)		Influenza A virus A/Connecticut/24/2018	AWK90732.1
neuraminidase (NA)		Influenza A virus A/Connecticut/24/2019	QCW16899.1
neuraminidase (NA)		Influenza A virus A/Connecticut/24/2022	UUV88634.1
neuraminidase (NA)		Influenza A virus A/Connecticut/24/2022	UZO38616.1
neuraminidase (NA)		Influenza A virus A/Connecticut/25/2018	AZF87097.1
neuraminidase (NA)		Influenza A virus A/Connecticut/25/2019	QDX11963.1 QDQ44067.1
neuraminidase (NA)		Influenza A virus A/Connecticut/25/2022	UUV88646.1
neuraminidase (NA)		Influenza A virus A/Connecticut/25/2022	UZO38628.1
neuraminidase (NA)		Influenza A virus A/Connecticut/26/2018	AZF87073.1
neuraminidase (NA)		Influenza A virus A/Connecticut/26/2019	QDX11975.1 QDQ44079.1
neuraminidase (NA)		Influenza A virus A/Connecticut/26/2022	UUV88658.1
neuraminidase (NA)		Influenza A virus A/Connecticut/26/2022	UUV88670.1
neuraminidase (NA)		Influenza A virus A/Connecticut/27/2018	AWR88668.1
neuraminidase (NA)		Influenza A virus A/Connecticut/27/2019	QDE06554.1 QDQ44091.1
neuraminidase (NA)		Influenza A virus A/Connecticut/27/2022	UUV88682.1
neuraminidase (NA)		Influenza A virus A/Connecticut/27/2022	UUV88694.1
neuraminidase (NA)		Influenza A virus A/Connecticut/28/2018	AWR88683.1
neuraminidase (NA)		Influenza A virus A/Connecticut/28/2019	QDE06566.1 QEI02007.1
neuraminidase (NA)		Influenza A virus A/Connecticut/28/2022	UZO38640.1
neuraminidase (NA)		Influenza A virus A/Connecticut/28/2022	UZO38652.1
neuraminidase (NA)		Influenza A virus A/Connecticut/29/2018	AXB51033.1
neuraminidase (NA)		Influenza A virus A/Connecticut/29/2019	QDE05350.1
neuraminidase (NA)		Influenza A virus A/Connecticut/29/2022	UZN90856.1
neuraminidase (NA)		Influenza A virus A/Connecticut/29/2022	UZO38664.1
neuraminidase (NA)		Influenza A virus A/Connecticut/30/2018	AXB51044.1
neuraminidase (NA)		Influenza A virus A/Connecticut/30/2019	QDE05361.1
neuraminidase (NA)		Influenza A virus A/Connecticut/30/2022	UZO38688.1
neuraminidase (NA)		Influenza A virus A/Connecticut/30/2022	UZO38676.1
neuraminidase (NA)		Influenza A virus A/Connecticut/31/2017	AVP08524.1
neuraminidase (NA)		Influenza A virus A/Connecticut/31/2018	AXB51661.1 AXV44012.1
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