Glycoside Hydrolase Family 33

Activities in FamilyTrans-sialidase (EC 2.4.1.-);
2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-);
Kdo hydrolase (EC 3.2.1.124);
Exo-α-sialidase (EC 3.2.1.18);
Anhydrosialidase (EC 4.2.2.15);
Mechanism Retaining e
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (11188); Uniprot accession (128); PDB accession (186); 3D entries (29); cryst (0)
| 1 | ... | 94 | 95 | 96 | 97 | 98 | 99 | 100 | 101 | 102 | ... | 105 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 NanP   Trueperella pyogenes AAK98800.1    
 sialidase (NanH) 3.2.1.18 Trueperella pyogenes AAK15462.1 Q9AHP2  
 QEV13_06645   Trueperella pyogenes 09KM1269 WHU60328.1    
 QEV13_03745   Trueperella pyogenes 09KM1269 WHU61758.1    
 QEV21_03880   Trueperella pyogenes 13KM1326 WHU59762.1    
 QEV10_06395   Trueperella pyogenes 13OD0707 WHU56388.1    
 QEV10_03755   Trueperella pyogenes 13OD0707 WHU57820.1    
 NPCBM/NEW2 domain-containing protein, partial (fragment)   Trueperella pyogenes 20121 UVH27469.1    
 M5C92_09525   Trueperella pyogenes 22/KM0800 UVJ59599.1    
 M5C92_06865   Trueperella pyogenes 22/KM0800 UVJ59095.1    
 DBV13_04120 (fragment)   Trueperella pyogenes Arash114 AWA43258.1    
 DBV13_04125 (fragment)   Trueperella pyogenes Arash114 AWA43259.1    
 K5713_06910   Trueperella pyogenes EMSSI21 UVJ53150.1    
 M1F28_09185   Trueperella pyogenes EMSSI48 UVJ57653.1    
 M1F28_06570   Trueperella pyogenes EMSSI48 UVJ57156.1    
 M1F27_06745   Trueperella pyogenes EMSSI54 UVJ55123.1    
 neuraminidase (NanP) (fragment)   Trueperella pyogenes FL-1 ARA90381.1    
 neuraminidase (NanH)   Trueperella pyogenes FL-1 ARA90380.1    
 HEP79_08040   Trueperella pyogenes jx18 QIU87169.1    
 HEP79_04865   Trueperella pyogenes jx18 QIU86624.1    
 DDE06_09730   Trueperella pyogenes TP-2849 AWG17066.1    
 DDE06_06825   Trueperella pyogenes TP-2849 AWG16543.1    
 EB776_07725   Trueperella pyogenes TP1 AZR01201.1    
 EB776_05110   Trueperella pyogenes TP1 AZR00725.1    
 EB775_03470   Trueperella pyogenes TP2 AZR02452.1    
 EB775_00845   Trueperella pyogenes TP2 AZR01983.1    
 EBQ11_01545   Trueperella pyogenes TP3 AZR04057.1    
 EBQ11_09420   Trueperella pyogenes TP3 AZR05421.1    
 EBQ10_06315   Trueperella pyogenes TP4 AZR06946.1    
 EBQ10_03405   Trueperella pyogenes TP4 AZR06434.1    
 DC090_07800   Trueperella pyogenes TP4479 AWG04339.1    
 DC090_04895   Trueperella pyogenes TP4479 AWG03812.1    
 X956_00875 (fragment)   Trueperella pyogenes TP8 AJC68877.1    
 X956_03635   Trueperella pyogenes TP8 AJC69304.1    
 J4179_02290   Trueperella sp. 15IMD0307 QTG75913.1    
 J4179_06825   Trueperella sp. 15IMD0307 QTG74938.1    
 J4179_09835   Trueperella sp. 15IMD0307 QTG75479.1    
 P0M28_29470   Tunicatimonas pelagia NBRC 107804 WKN43175.1    
 GMBLW1_06220   Tuwongella immobilis VTS04048.1    
 GMBLW1_20260   Tuwongella immobilis VTR99890.1    
 GMBLW1_44930   Tuwongella immobilis VTS06759.1    
 GMBLW1_20260   Tuwongella immobilis MBLW1 VIP01934.1    
 GMBLW1_44930   Tuwongella immobilis MBLW1 VIP04700.1    
 GMBLW1_06220   Tuwongella immobilis MBLW1 VIP03338.1    
 RM788_01160   Umezawaea sp. Da 62-37 WNV86928.1    
 HGMM_F10C03C23   uncultured Acidobacteriota bacterium BAL53855.1    
 ORF (fragment)   uncultured bacterium APO34972.1    
 ORF (fragment)   uncultured bacterium APO32020.1    
 GH33, Sialidase   uncultured bacterium VDS02392.1    
 GH33, Sialidase   uncultured bacterium VTZ55340.1    
 sialidase   uncultured bacterium Rlip1 ACM91104.1    
 Sialidase26   unidentified bacterium     6MRV[A]
6MRX[A,B,C,D]
6MYV[A,B,C,D]
6MRV[B]
 ETAA1_45180 (NedA)   Urbifossiella limnaea ETA_A1 QDU22536.1    
 ETAA1_26700   Urbifossiella limnaea ETA_A1 QDU20713.1    
 CYK25_000920 (fragment)   Varibaculum cambriense UMB0796 WIK88815.1    
 CYK25_000925 (fragment)   Varibaculum cambriense UMB0796 WIK88816.1    
 IMCC26134_04605   Verrucomicrobia bacterium IMCC26134 AKC83918.1    
 CMV30_05015   Verrucomicrobiota bacterium HZ-65 ATC63364.1    
 CMV30_08310   Verrucomicrobiota bacterium HZ-65 ATC63952.1    
 HUT12_14855   Verrucosispora sp. NA02020 QKW13939.1    
 PYE67_10335   Vibrio aestuarianus U17 WGK84770.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 DYL72_11630   Vibrio anguillarum J360 AZS25596.1    
 DYL72_11630   Vibrio anguillarum J360 AZS25596.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 NanH   Vibrio cholerae 17674 QBJ27574.1    
 NanH   Vibrio cholerae 17674 QBJ27574.1    
 NanH   Vibrio cholerae 18470 QBJ27573.1    
 NanH   Vibrio cholerae 18470 QBJ27573.1    
 EZZ25_09390   Vibrio cholerae 20000 QBJ29517.1    
 EZZ25_09390   Vibrio cholerae 20000 QBJ29517.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 A5F7A4
P0C6E9
P37060
1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 A5F7A4
P0C6E9
P37060
1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 A1552VC_01566 (NanH)   Vibrio cholerae A1552 AWB74302.1    
 A1552VC_01566 (NanH)   Vibrio cholerae A1552 AWB74302.1    
 J9265_07660   Vibrio cholerae A1552 QTV01065.1    
 J9265_07660   Vibrio cholerae A1552 QTV01065.1    
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2    
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2
AAW31751.1
   
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 GTF72_05390   Vibrio cholerae C6706 QJS92106.1    
 GTF72_05390   Vibrio cholerae C6706 QJS92106.1    
 IT766_07430   Vibrio cholerae C6706 QPC52482.1    
 IT766_07430   Vibrio cholerae C6706 QPC52482.1    
 ASZ81_01775   Vibrio cholerae CRC1106 APF56916.1    
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