Activities in Family	Trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-); Kdo hydrolase (EC 3.2.1.124); Exo-α-sialidase (EC 3.2.1.18); Anhydrosialidase (EC 4.2.2.15);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (11188); Uniprot accession (128); PDB accession (186); 3D entries (29); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
Syncc9605_0061		Synechococcus sp. CC9605	ABB33840.1
KR49_09385		Synechococcus sp. KORDI-49	AII46653.1
SynPROS71_00279		Synechococcus sp. PROS-7-1	QNI84117.1
SynTAK9802_00065 (fragment)		Synechococcus sp. TAK9802	QNI60386.1
PXH66_13760		Synoicihabitans lomoniglobus LMO-M01	WED63400.1
TF3313_0675		Tannerella forsythia 3313	BAR48245.1
TF3313_2017		Tannerella forsythia 3313	BAR49484.1
BFO_0701		Tannerella forsythia 92A2	AEW20449.1
sialidase (NanH;TF0036; BFO_2207)	3.2.1.18	Tannerella forsythia 92A2	AEW22573.1	G8UIQ1	7QXO[A,B] 7QY8[A,B] 7QY9[A,B] 7QYJ[A,B] 7QYP[A,B] 7QZ3[A,B]
TFKS16_0644		Tannerella forsythia KS16	BAR50943.1
TFKS16_1972		Tannerella forsythia KS16	BAR52188.1
ElP_14200 (fragment)		Tautonia plasticadhaerens ElP	QDV33547.1
ElP_14770 (Neda_1)		Tautonia plasticadhaerens ElP	QDV33601.1
ElP_29880		Tautonia plasticadhaerens ElP	QDV35086.1
ElP_26890 (Neda_2)		Tautonia plasticadhaerens ElP	QDV34793.1
KIH39_02460		Telmatocola sphagniphila SP2T	QVL32801.1
KIH39_13315		Telmatocola sphagniphila SP2T	QVL29850.1
MARIT_2686 (SiaA)		Tenacibaculum maritimum	SFZ84307.1
MARIT_2686 (SiaA)		Tenacibaculum maritimum	SFZ84307.1
B9C57_11355		Tenacibaculum maritimum TM-KORJJ	QCD63079.1
B9C57_11355		Tenacibaculum maritimum TM-KORJJ	QCD63079.1
U5C87_00495		Terrabacter sp. C0L_2	WVM96848.1
neuraminidase		Terriglobus albidus ORNL	QEE31157.1
FTW19_21345		Terriglobus albidus ORNL	QEE30300.1
neuraminidase		Terriglobus roseus DSM 18391	AFL86731.1
neuraminidase		Terriglobus roseus GAS232	SDF06571.1
neuraminidase		Terriglobus roseus GAS232	SDE92571.1
AciPR4_2821		Terriglobus saanensis SP1PR4	ADV83594.1
BW733_14130 (fragment)		Tessaracoccus flavescens SST-39T	AQP51794.1
RPIT_12385		Tessaracoccus flavus RP1T	AQP45501.1
TLA_TLA_02790 (NedA)		Tessaracoccus lapidicaptus	VEP41667.1
J7D54_12245		Tessaracoccus sp. MC1865	QTO37190.1
BKM78_13850		Tessaracoccus sp. T2.5-30	AQX16876.1
Mal48_03580		Thalassoglobus polymorphus Mal48	QDT31127.1
Mal48_11610 (Neda_1)		Thalassoglobus polymorphus Mal48	QDT31923.1
Mal48_42880 (Neda_2)		Thalassoglobus polymorphus Mal48	QDT35015.1
Mal48_47550 (NanB)		Thalassoglobus polymorphus Mal48	QDT35478.1
Mal48_17610		Thalassoglobus polymorphus Mal48	QDT32514.1
Mal48_31220		Thalassoglobus polymorphus Mal48	QDT33866.1
NOG13_01940		Thermocaproicibacter melissae MDTJ8	WBY64498.1
THTE_2055		Thermogutta terrifontis R1	ASV74657.1
THTE_2789		Thermogutta terrifontis R1	ASV75391.1
THTE_1431		Thermogutta terrifontis R1	ASV74033.1
INP52_01970		Thermophilibacter immobilis LZLJ-2	QOY61003.1
WDB91_12590		Thioclava sp. GXIMD2076	WYI71944.1
NQ543_02890		Thomasclavelia spiroformis DSM 1552	UWO90208.1
GT409_02585		Tichowtungia aerotolerans S-5007	QHI70861.1
GT409_08170		Tichowtungia aerotolerans S-5007	QHI69430.1
KP613_10290		Treponema denticola ASLM	WYM95168.1
exo-neuraminidase (TdNeu;TDE0471)	3.2.1.18	Treponema denticola ATCC 35405	AAS10966.1 NP_971085.1	Q73QH2
E4N79_11140		Treponema denticola CD-1	UTC88656.1
OE909_11230		Treponema denticola KCOM 3500	UYT07525.1
E4N90_10975		Treponema denticola OKA3	UTD08437.1
E4N80_10705		Treponema denticola OMZ 823	UTD05914.1
neuraminidase		Treponema denticola OMZ 850	UTC98674.1
neuraminidase		Treponema denticola OMZ 852	UTC93693.1
HO345_12770		Treponema denticola OMZ 854	UTD13788.1
E4N85_10845		Treponema denticola OMZ 898	UTC96197.1
neuraminidase		Treponema denticola OMZ 905	UTD01080.1
neuraminidase		Treponema denticola OMZ 910	UTC89568.1
neuraminidase		Treponema denticola OT2B	UTC86084.1
DWB79_09675		Treponema medium ATCC 700293	QSH98011.1
C5N99_10445		Treponema medium T19	QSH93000.1
IFE08_03215		Treponema pedis KS1	QOW61412.1
IFE08_09805		Treponema pedis KS1	QOW62199.1
TPE_0275		Treponema pedis str. T A4	AGT42771.1
TPE_2363		Treponema pedis str. T A4	AGT44837.1
neuraminidase		Treponema pedis T3552B	QSI05476.1
DYQ05_01305 (fragment)		Treponema pedis T3552B	QSI03648.1
FUT84_11840		Treponema phagedenis B31.4	QEK01776.1
FUT82_13880		Treponema phagedenis B36.5	QEJ98971.1
FUT79_12915		Treponema phagedenis B43.1	QEJ96011.1
HW453_09735		Treponema phagedenis KS-1	QLC59043.1
HPJ96_12070		Treponema phagedenis KS1	QKS93204.1
DWQ65_07850		Treponema phagedenis Reiter	QSH99974.1
FUT81_12310		Treponema phagedenis S11.1	QEK10134.1
FUT83_12180		Treponema phagedenis S2.3	QEK04479.1
FUT80_09325		Treponema phagedenis S8.5	QEK06889.1
C5O78_01445		Treponema phagedenis T320A	QSH93737.1
HYB91_10475		Treponema sp. B152	UTD10925.1
ABK01_07635		Treponema sp. OMZ 305	UTC58142.1
ABH09_05830		Treponema sp. OMZ 803 BF2M	UTC54156.1
GWP43_06145		Treponema sp. OMZ 804	QHX44502.1
GWP40_06880		Treponema sp. OMZ 806	QUY18082.1
E4N65_05820		Treponema sp. OMZ 855	UTC51834.1
E4N69_05715		Treponema sp. OMZ 906	UTC56554.1
U0034_29080		Trinickia caryophylli HAMBI_2159	WQE15771.1
QPC17_07720		Trueperella bernardiae UMB8254	WIM07626.1
NCTC13354_01304 (NedA)		Trueperella bialowiezensis NCTC13354	VEI13587.1
NCTC13354_01448 (NanA)		Trueperella bialowiezensis NCTC13354	VEI13727.1
neuraminidase		Trueperella bonasi DSM 17163	AGI95981.1
INS88_07035 (fragment)		Trueperella pecoris 15A0121	QOR45039.1
INS88_10410		Trueperella pecoris 15A0121	QOR45638.1
INS88_02360		Trueperella pecoris 15A0121	QOR46081.1
HLG82_02750		Trueperella pecoris 19M2397	QOQ38473.1
HLG82_07370		Trueperella pecoris 19M2397	QOQ39277.1
HLG82_09985		Trueperella pecoris 19M2397	QOQ39735.1
INS90_10850		Trueperella pecoris 19OD0592	QOR47712.1
INS90_07290		Trueperella pecoris 19OD0592	QOR47074.1
INS90_02465		Trueperella pecoris 19OD0592	QOR48174.1
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