Activities in Family	α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); α-mannosidase (EC 3.2.1.24); α-1,3-glucosidase (EC 3.2.1.84); sucrase-isomaltase (EC 3.2.1.48) (EC 3.2.1.10); α-xylosidase (EC 3.2.1.177); α-glucan lyase (EC 4.2.2.13); isomaltosyltransferase (EC 2.4.1.-); oligosaccharide α-1,4-glucosyltransferase (EC 2.4.1.161); sulfoquinovosidase (EC 3.2.1.-)
Mechanism	Retaining
Clan	GH-D
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Asp
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (8947); Uniprot accession (1017); PDB accession (109); 3D entries (22); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
CG33080 (fragment)		Drosophila teissieri TTl03	ADG51742.1
CG33080 (fragment)		Drosophila yakuba 01	ADG51683.1
Ecym_3060		Eremothecium cymbalariae DBVPG#7215	AET38572.1
AAR173C		Eremothecium gossypii ATCC 10895	AAS50540.1	Q75EA4
FAGOS_FAAR173C		Eremothecium gossypii FDAG1	AEY94827.1
AW171_hschr31662		Eremothecium sinecaudum ATCC 58844	AMD19809.1
glucosidase ii alpha subunit, partial (fragment)		Erysiphe pisi	APA31901.1
ORF (fragment)		Euptoieta claudia	AGI52407.1
ORF (fragment)		Eurema lisa	AGI52406.1
sucrase-isomaltase (SI)		Felis catus	BAG16411.1	B1Q4L3
sucrase-isomaltase (SI)		Felis catus	BAG16411.1	B1Q4L3
ORF (fragment)		Fernaldella fimetaria	AGI52404.1
α-glucosidase (fragment)		Fusarium fujikuroi	BAF91419.1	A8R5X7
FFUJ_13167		Fusarium fujikuroi IMI 58289	CCT66990.1
FFUJ_05374		Fusarium fujikuroi IMI 58289	CCT69486.1
FFUJ_06119		Fusarium fujikuroi IMI 58289	CCT70171.1
FFUJ_06320		Fusarium fujikuroi IMI 58289	CCT70355.1
FFUJ_06693		Fusarium fujikuroi IMI 58289	CCT70700.1
FFUJ_10405		Fusarium fujikuroi IMI 58289	CCT74357.1
FFUJ_02282		Fusarium fujikuroi IMI 58289	CCT65346.1
FFUJ_04183		Fusarium fujikuroi IMI 58289	CCT64583.1
unnamed protein product		Fusarium graminearum PH-1	CEF87825.1
unnamed protein product		Fusarium graminearum PH-1	SCB65060.1
unnamed protein product		Fusarium graminearum PH-1	CEF85426.1
unnamed protein product		Fusarium graminearum PH-1	CEF76992.1
unnamed protein product		Fusarium graminearum PH-1	CEF77226.1
unnamed protein product		Fusarium graminearum PH-1	CEF77613.1
unnamed protein product		Fusarium graminearum PH-1	CEF78272.1
FGRAMPH1_01T00389		Fusarium graminearum PH-1	SCB63990.1 CEF71994.1
FVRRES_13558		Fusarium venenatum A3/5	CEI41394.1
FVRRES_11150		Fusarium venenatum A3/5	CEI38459.1
FVRRES_00252		Fusarium venenatum A3/5	CEI63740.1
FVRRES_06454		Fusarium venenatum A3/5	CEI62018.1
FVRRES_05447		Fusarium venenatum A3/5	CEI61011.1
FVRRES_05232		Fusarium venenatum A3/5	CEI60796.1
FVRRES_00121 (fragment)		Fusarium venenatum A3/5	CEI63609.1
FVRRES_09554		Fusarium venenatum A3/5	CEI69477.1
FVRRES_05812		Fusarium venenatum A3/5	CEI61376.1
sucrase-isomaltase (fragment)		Gallus gallus	CAA70154.1	O42389
GH31-1		Gastrophysa viridula	AHH86054.1
ORF (fragment)		Gonometa rufobrunnea	AGI52410.1
α-1,4-glucan lyase isozyme 1 (GLq1;Ag111)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51910.1 AAR66623.1 ABA16064.1	Q9STC1	2X2H[A,B,C,D] 2X2I[A,B,C,D] 2X2J[A,B,C,D] 4AMW[A,B,C,D] 4AMX[A,B,C,D]
α-1,4-glucan lyase isozyme 2 (GLq2;Ag112)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51911.1 AAR66624.1 ABA16065.1	Q9STC0
α-1,4-glucan lyase isozyme 4 (GLs1;Ag114)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51909.1 AAP61561.1 ABA16068.1	Q9STC2
α-1,4-glucan lyase isozyme 5 (GLs2;Ag115) (partial) (fragment)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51913.1 AAP61562.1 ABA16069.1	Q9STB8
α-1,4-glucan lyase isozyme 3 (GLq3;Ag113) (fragment)		Gracilariopsis lemaneiformis	CAB51912.1	Q9STB9
α-glucosidase (HdAgl1;HdAgl)	3.2.1.20	Haliotis discus hannai	BAN67474.1
glucosidase (fragment)		Helicoverpa armigera GR	ADF43509.1	D5G3I0
ORF (fragment)		Heteranassa fraterna	AGI52401.1
MGAM2		Homo sapiens	XP_011514994.1
MGAM2		Homo sapiens	XP_011514994.1
α-glucosidase A (GAA) (lysosomal)	3.2.1.20	Homo sapiens	CAA68763.1 AAA52506.1 AAB33842.1 AAH40431.1 ABI53718.1 ACM80396.1 ACM84029.1 BAH13042.1 CAA38907.1 CAA68764.1 CAC12967.1 CAE85448.1 NP_000143.1	P10253 P10253 Q8IWE7	5KZW[A] 5KZX[A] 5NN3[A] 5NN4[A] 5NN5[A] 5NN6[A] 5NN8[A]
α-glucosidase II (GanAB;G2AN;KIAA0088 )	3.2.1.20 3.2.1.84	Homo sapiens	AAF66685.1 AAH17433.2 AAH17435.2 AAH65266.1 ACJ13667.1 BAA07642.1 BAG58624.1 BAG58692.1 BAG61688.1 BAG63965.1 CAA04006.1 XP_043268.1	Q14697 Q14697
maltase-glucoamylase (MgaM;Mga;MGAML)	3.2.1.20	Homo sapiens	AAC39568.2 AAI20873.1 AAL83560.1 NP_004659.1	O43451 Q8TE24	3TON[A,B] 3TOP[A,B]
maltase-glucoamylase (MgaM;Mga;MGAML)	3.2.1.20	Homo sapiens	AAC39568.2 AAI20873.1 AAL83560.1 AAP21875.1 NP_004659.1	O43451 Q86UM5 Q8TE24	2QLY[A] 2QMJ[A] 3CTT[A] 3L4T[A] 3L4U[A] 3L4V[A] 3L4W[A] 3L4X[A] 3L4Y[A] 3L4Z[A]
sucrase-isomaltase (SI)	3.2.1.10 3.2.1.48	Homo sapiens	AAT18166.1 AAI15035.1 AAI16453.1 AAI16454.1 AAI32835.1 AAI32861.1 AAT19036.1 ABH87017.1 ACM85129.1 ACP58672.1 CAA45140.1 NP_001032.1	P14410
sucrase-isomaltase (SI)	3.2.1.10 3.2.1.48	Homo sapiens	AAT18166.1 AAA60551.1 AAI15035.1 AAI16453.1 AAI16454.1 AAI32835.1 AAI32861.1 AAT19036.1 ABH87017.1 ACM85129.1 ACP58672.1 CAA45140.1 NP_001032.1	P14410	3LPO[A,B,C,D] 3LPP[A,B,C,D]
KIAA1161 (MGC:87539)		Homo sapiens	AAH70098.1 AAI10494.1 BAA86475.2 CAI15965.1	Q6NSJ0 Q9ULQ9
GanC (FLJ00088)		Homo sapiens	AAN74756.1 AAH59406.1 AAH93833.1 AAI12052.1 AAN74755.1 AAN74757.1 AAN74758.1 AAO14993.1 BAB84863.1 BAB84863.2 NP_937784.2	Q8TET4
α-glucosidase	3.2.1.20	Hordeum vulgare	AAB02985.1 AAX04432.1	Q43763
α-glucosidase (Agl1)		Hordeum vulgare subsp. spontaneum	ACZ37245.1	D1MDW3
α-glucosidase (Agl1)		Hordeum vulgare subsp. spontaneum	ACZ37246.1	D1MDW4
α-glucosidase (Agl2)		Hordeum vulgare subsp. vulgare	BAG72143.1
Agl3		Hordeum vulgare subsp. vulgare	BAG72144.1
Agl4		Hordeum vulgare subsp. vulgare	BAG72145.1
predicted protein		Hordeum vulgare subsp. vulgare	BAK05419.1
predicted protein		Hordeum vulgare subsp. vulgare	BAJ97257.1
α-glucosidase (Agl1;Agl97)	3.2.1.20	Hordeum vulgare subsp. vulgare	AAF76254.1 ACZ37234.1 ACZ37244.1 ACZ37249.1 BAJ89297.1	D1MDV2 Q9LLY2
ORF		Hypocrella siamensis MTCC 10142	ANH56431.1
ORF		Hypocrella siamensis MTCC 10142	ANH56461.1
ORF		Hypocrella siamensis MTCC 10142	ANH56510.1
ORF		Hypocrella siamensis MTCC 10142	ANH56427.1
ORF		Hypocrella siamensis MTCC 10142	ANH56499.1
ORF (Sp15)		Ictalurus punctatus	AHH38618.1
ORF (GanaB)		Ictalurus punctatus	AHH38955.1
KAFR_0G02180 (Kafr0g02180)		Kazachstania africana CBS 2517	CCF59252.1
KNAG_0M00730 (Knag0m00730)		Kazachstania naganishii CBS 8797 type strain:CBS 8797	CCK72926.1
KLLA0F09735g		Kluyveromyces lactis NRRL Y-1140	CAG98230.1	Q6CKL7
KLMA_20272		Kluyveromyces marxianus DMKU3-1042	BAO38730.1
KMAR_20262		Kluyveromyces marxianus NBRC 1777	BAP70274.1
ATY40_BA7502369 (Rot2)		Komagataella pastoris ATCC 28485	ANZ75517.1
AT249_GQ6700850 (Rot2)		Komagataella phaffii ATCC 76273	AOA62140.1
PP7435_Chr2-0493 (Rot2)		Komagataella phaffii CBS 7435	CCA38181.1 SOP80799.1
PAS_chr2-1_0778		Komagataella phaffii GS115	CAY69434.1 AOA67561.1	C4R1R0
KLTH0H06336g		Lachancea thermotolerans CBS 6340	CAR30293.1
LbrM18_V2.0110		Leishmania braziliensis MHOM/BR/75/M2904	CAM37985.1	A4H9B4
LbrM35_V2.4340		Leishmania braziliensis MHOM/BR/75/M2904	CAM44186.1	A4HPS8
LDBPK_180090		Leishmania donovani BPK282A1	CBZ33316.1
LDBPK_364300		Leishmania donovani BPK282A1	CBZ38867.1
LinJ18.0090		Leishmania infantum JPCM5	CAM67062.1
LinJ36.7060		Leishmania infantum JPCM5	CAM73155.1
LmjF18.0090		Leishmania major strain Friedlin	CAJ03446.1	Q4QE33
LmjF36.4100		Leishmania major strain Friedlin	CAJ09376.1	Q4Q105
LMXM_18_0090		Leishmania mexicana MHOM/GT/2001/U1103	CBZ25517.1
LMXM_36_4100		Leishmania mexicana MHOM/GT/2001/U1103	CBZ26267.1
LPMP_180090		Leishmania panamensis MHOM/PA/94/PSC-1	AIN97190.1
LPMP_354210		Leishmania panamensis MHOM/PA/94/PSC-1	AIO02554.1
GH31-1		Leptinotarsa decemlineata	AHH86055.1
ORF		Leptosphaeria maculans JN3	CBX96756.1	E4ZZG1
ORF		Leptosphaeria maculans JN3	CBX97527.1	E5A171
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