Glycoside Hydrolase Family 31

Activities in Familyα-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); α-mannosidase (EC 3.2.1.24); α-1,3-glucosidase (EC 3.2.1.84); sucrase-isomaltase (EC 3.2.1.48) (EC 3.2.1.10); α-xylosidase (EC 3.2.1.177); α-glucan lyase (EC 4.2.2.13); isomaltosyltransferase (EC 2.4.1.-); oligosaccharide α-1,4-glucosyltransferase (EC 2.4.1.161); sulfoquinovosidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorAsp
External resourcesCAZypedia; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (7464); Uniprot accession (1019); PDB accession (102); 3D entries (21); cryst (0)
All (6896) Archaea (87) Bacteria (6113) Eukaryota (687) unclassified (9) Structure (21) Characterized (123)
| 1 | 2 |
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-glucosidase (AglA;PTO0092) 3.2.1.20 Picrophilus torridus DSM 9790 AAT42677.1 Q6L2X4  
 α-glucosidase (MalA;Saci_1160) 3.2.1.20 Sulfolobus acidocaldarius DSM 639 AAY80507.1 Q4J9M3  
 α-glucosidase with α-mannosidase activity (MalA;SsMalA;Sso1_0793) 3.2.1.20
3.2.1.24
Sulfolobus solfataricus 98/2 AAC38215.1
ACX91047.1
AET42970.1
D0KQM8
G8GCW5
O59645
2G3M[A,B,C,D,E,F]
2G3N[A,B,C,D,E,F]
 α-xylosidase (XylS;SS03022) 3.2.1.177 Sulfolobus solfataricus P2 CAB99206.1
AAK43123.1
CAC24044.1
NP_344333.1
Q9P999  
 α-glucosidase (MalA;SSO3051) 3.2.1.20 Sulfolobus solfataricus P2 AAK43151.1
AAO97625.1
ABJ38303.1
ABJ38315.1
ABJ38324.1
ACW20068.1
ACW20079.1
ACW20080.1
CAC24058.1
NP_344361.1
P0CD66  
 α-glucosidase (ST2525) 3.2.1.20 Sulfolobus tokodaii str. 7 BAB67639.1
BAK54817.1
NP_378530.1
F9VPH0
Q96XI8
 
 α-glucosidase (AglA;Ta0298) 3.2.1.20 Thermoplasma acidophilum DSM 1728 CAC11443.1
NP_393778.1
Q9HLD0  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 6-α-glucosyltransferase (CtsZ;6GT) 2.4.1.- Arthrobacter globiformis A19 BAD34980.1 Q6BD65  
 3-α-isomaltosyltransferase (CtsY;IMT) 2.4.1.- Arthrobacter globiformis A19 BAD34979.1 Q6BD67  
 α-glucosidase (AG31A;BspAG31A) 3.2.1.20 Bacillus sp. SW20 / AHU 2001 BAQ19546.1    
 α-glucosidase II / oligo-α-1,6-glucosidase (BthG II) 3.2.1.10
3.2.1.20
Bacillus thermoamyloliquefaciens KP1071 (FERM-P8477) BAA76396.1 Q9F234  
 α-xylosidase (BoGH31;BACOVA_03422) 3.2.1.177 Bacteroides ovatus ATCC 8483 EDO10789.1    
 α-xylosidase (Yici_5;BoGH31A;BACOVA_02646;Bovatus_03066) 3.2.1.177 Bacteroides ovatus ATCC 8483 ALJ47674.1   5JOU[A]
5JOV[A]
 α-glucosidase (BT0339;BT_0339) 3.2.1.20 Bacteroides thetaiotaomicron VPI-5482 AAO75446.1
NP_809252.1
Q8AAX3 5F7C[A,B,C,D]
 α-glucosidase (BT3299;BT_3299) 3.2.1.20 Bacteroides thetaiotaomicron VPI-5482 AAO78405.1
NP_812211.1
Q8A2K6 5DJW[A,B]
 α-glucosidase / maltase-glucoamylase (Ro-?G1;RUMOBE_03919) 3.2.1.20 Blautia obeum ATCC 29174 ZP_01966167.1 A5ZY13 3FFJ[A,B]
3M46[A,B]
3M6D[A,B]
3MKK[A,B]
3N04[A,B]
3NQQ[A,B]
3NSX[A,B]
3NUK[A,B]
3NXM[A,B,C,D]
3PHA[A,B,C,D]
3POC[A,B]
 α-glucosidase (GluA;TTE0006) 3.2.1.20 Caldanaerobacter subterraneus subsp. tengcongensis MB4 AAM23323.1
NP_621719.1
Q8RDL1  
 oligosaccharide α-1,4-transglucosylase 31B (CjAgd31B;CJA_3248) (Agd31B) 2.4.1.161 Cellvibrio japonicus Ueda107 ACE84782.1 B3PEE6 4B9Y[A]
4B9Z[A]
4BA0[A]
5I23[A]
5I24[A]
5NPB[A]
5NPC[A]
5NPD[A]
5NPE[A]
 α-xylosidase 31A (CjXyl31A;CJA_2706) (Xyl31A) 3.2.1.177 Cellvibrio japonicus Ueda107 ACE86259.1 B3PBD9 2XVG[A]
2XVK[A]
2XVL[A]
 α-xylosidase (YicI;EcYicI;b3656) 3.2.1.177 Escherichia coli str. K-12 substr. MG1655 AAC76680.1
AAA62009.1
AIZ93543.1
ALI38655.1
AMC96544.1
NP_418113.1
P31434 1WE5[A,B,C,D,E,F]
1XSI[A,B,C,D,E,F]
1XSJ[A,B,C,D,E,F]
1XSK[A,B,C,D,E,F]
2F2H[A,B,C,D,E,F]
 sulfoquinovosidase (SQase;YihQ;b3878) 3.2.1.- Escherichia coli str. K-12 substr. MG1655 AAC76875.1
AAB03011.1
AIZ93343.1
ALI38454.1
AMC96746.1
NP_418314.1
P32138 5AED[A,B]
5AEE[A,B]
5AEG[A,B]
 α-xylosidase (YicI) 3.2.1.177 Escherichia coli str. K-12 substr. W3110 BAE77637.1
APC53756.1
   
 dextranase/6-α-glucosyltransferase (Fjoh_4430) 3.2.1.11
2.4.1.-
Flavobacterium johnsoniae UW101 ABQ07434.1 A5FBI1  
 cycloalternan-specific α-1,3-glucosidase / α-1,3-isomaltosidase (Kfla_1895) 3.2.1.- Kribbella flavida DSM 17836 ADB30989.1 D2PPM7  
 3-α-isomaltosyltransferase (IMT;Kfla_4052) 2.4.1.- Kribbella flavida DSM 17836 ADB33101.1 D2PSG3  
 α-1,3-glucosidase (LjAg31) (partial) 3.2.1.84 Lactobacillus johnsonii NBRC 13952 ACO57638.1 C1KIT5  
 α-xylosidase (XylQ) 3.2.1.177 Lactobacillus pentosus MD353 AAC62251.1 P96793  
 cycloalternan-degrading enzyme (Lmo0182) 3.2.1.- Listeria monocytogenes EGD-e NP_463713.1
CAC98397.1
Q8YAE8  
 branching enzyme / α-6-glucosyltransferase (Lmo2444) 2.4.1.- Listeria monocytogenes EGD-e CAD00522.1
NP_465967.1
Q8Y4J4  
 cycloalternan-forming enzyme / 3-α-isomaltosyltransferase (CAFE;LmCAFE;Lmo2446) 2.4.1.- Listeria monocytogenes EGD-e CAD00524.1
NP_465969.1
Q8Y4J2 4KMQ[A]
4KWU[A]
5F7U[A]
5HPO[A]
5HXM[A]
5I0D[A,B]
 6-α-glucosyltransferase (Ps6GT31A) (6GT31A) 2.4.1.- Paenibacillus sp. 598K BAV17026.1   5X7O[A,B]
5X7P[A,B]
5X7Q[A,B]
5X7R[A,B]
5X7S[A,B]
 α-galactosidase (PhGal31A;Phep_2697) (Gal31A) 3.2.1.22 Pedobacter heparinus DSM 2366 ACU04898.1 C6Y0X1  
 α-galactosidase (PsGal31A) (Gal31A) 3.2.1.22 Pseudopedobacter saltans NBRC 100064 BAR72452.1   4XPO[A]
4XPP[A]
4XPQ[A]
4XPR[A]
4XPS[A]
 isomaltosyltransferase (CtsW) 2.4.1.- Sporosarcina globispora C11 BAB88401.1 Q8RQV2  
 3-α-isomaltosyltransferase (CtsY) 2.4.1.- Sporosarcina globispora C11 BAB88403.1
ABJ31058.1
Q8RQV0  
 6-glucosyltransferase (CtsZ) 2.4.1.- Sporosarcina globispora C11 BAB88404.1 Q8RQU9  
 3-α-isomaltosyltransferase (CtsY;IMT) 2.4.1.- Sporosarcina globispora N75 BAC54957.1
ABJ31059.1
Q84IQ3  
 6-α-glucosyltransferase (CtsZ;6GT) 2.4.1.- Sporosarcina globispora N75 BAC54958.1 Q84IQ2  
 α-glucosidase 3.2.1.20 Thermoanaerobacter ethanolicus JW 200 ABR26230.1    
 cycloalternan-specific α-1,3-glucosidase (CADE;TpCADE;TpLmo0182;CQ11_05330) 3.2.1.- Trueperella pyogenes TP6375 AHU89502.1   5F7S[A,B]
5I0E[B]
5I0F[B]
5I0G[B]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-glucosidase / α-1,3-glucosidase (Aig) 3.2.1.20
3.2.1.84
Acremonium implicatum BAD08418.1 Q75QW0  
 α-glucosidase 1 (Aglu1;Aglu-1;At5g11720) 3.2.1.20 Arabidopsis thaliana AAB82656.1
AAK96644.1
AAN72233.1
AAX04435.1
AED91714.1
CAB87690.1
NP_196733.1
O22444
Q9LYF8
 
 α-glucosidase / α-xylosidase (AtXyl1;AXY3;AtGlu2;Aglu2;Aglu-2;At1g68560) 3.2.1.177
3.2.1.20
Arabidopsis thaliana AAD37363.1
AAD05539.1
AAD49987.1
AAL09716.1
AAO11591.1
AEE34811.1
BAS22090.1
BAS22093.1
NP_177023.1
Q9S7Y7
Q9ZP26
 
 α-glucosidase II (Rsw3;Aglu3;Aglu-3;At5g63840) (RSW3) 3.2.1.84 Arabidopsis thaliana BAB11032.1
AED97803.1
ANM68707.1
NP_201189.1
Q9FN05  
 α-glucosidase (α-G I;α-GI) 3.2.1.20 Aspergillus awamori KT-11 BAD06006.1 Q76KT3  
 α-glucosidase B (AgdB) 3.2.1.20 Aspergillus nidulans BAB39856.1 Q9C1S7  
 α-glucosidase (AgdB;AN8953.2) 3.2.1.20 Aspergillus nidulans FGSC A4 EAA63748.1 C8VLA3
G5EB11
 
 α-glucosidase (AgdC;AN7345.2) 3.2.1.20 Aspergillus nidulans FGSC A4 ABF50883.1
EAA61716.1
C8VCK6
Q5AWI5
 
 α-glucosidase (AgdE;AN0941.2) 3.2.1.20 Aspergillus nidulans FGSC A4 ABF50846.1
EAA65970.1
   
 α-xylosidase (AgdD;AN7505) 3.2.1.177 Aspergillus nidulans FGSC A4 EAA62085.1
ABF50885.1
C8VBI7
Q5AW25
 
 α-glucosidase (AgdA;AN2017.2) 3.2.1.20 Aspergillus nidulans FGSC A4 EAA64849.1
AAF17102.1
C8VLE5
G5EB03
 
 α-glucosidase (Agl;ANG) 3.2.1.20 Aspergillus niger AHU 7322 BAM72725.1    
 α-xylosidase (AX;AxlA;Axl1;Aspni5|43342) 3.2.1.177 Aspergillus niger ATCC 1015 DAA35002.1    
 α-glucosidase (AgdA;An04g06920;AglU) 3.2.1.20 Aspergillus niger CBS 513.88 CAK44692.1 A2QJF7  
 α-glucosidase (AglA) 3.2.1.20 Aspergillus niger GN-3 BAA23616.1
AAB23581.1
BAF37801.1
A0PCH8
P56526
 
 α-glucosidase II α-subunit P2 (Gls2A) 3.2.1.84 Aspergillus niger N402 ACF60497.1 B5AFM4  
 α-1,3-glucosidase II α-subunit (AoGls2a;G-II;AO090102000559) 3.2.1.84 Aspergillus oryzae RIB40 BAE61578.1 Q2UA37  
 α-glucosidase (AgdA;Agl; AO090003001209) 3.2.1.20 Aspergillus oryzae RIB40 BAA08125.1
BAA95702.1
BAE58289.1
Q12558  
 α-glucosidase (Agl;SBG) 3.2.1.20 Beta vulgaris BAM74081.1
BAM72724.1
  3W37[A]
3W38[A]
3WEL[A]
3WEM[A]
3WEN[A]
3WEO[A]
 α-glucosidase (SBG) 3.2.1.20 Beta vulgaris BAA20343.1
AAX04433.1
O04931  
 α-glucosidase II α-subunit (BmGII?) 3.2.1.20 Bombyx mori BAM78681.1    
 acidic α-glucosidase 3.2.1.20 Bos taurus AAF81637.1
AAF81636.1
NP_776338.1
Q9MYM4  
 α-glucosidase ( Aagr-1;D2096.3/D2096.12) 3.2.1.20 Caenorhabditis elegans Bristol N2 AAA81491.1
AAO91743.1
NP_501419.1
Q19004  
 α-glucosidase (Aagr-3;F40F9.6;CELE_F40F9.6) 3.2.1.20 Caenorhabditis elegans Bristol N2 CAA94764.1
CAB54240.1
CCM09381.1
NP_505507.1
Q20239  
 α-glucosidase (Aagr-4;F52D1.1) 3.2.1.20 Caenorhabditis elegans Bristol N2 AAB71267.2
AAB71267.3
CCD70824.1
NP_508105.1
O17352  
 α-glucosidase (Aagr-2:Msp-31;R05F9.12;ZK546.10) 3.2.1.20 Caenorhabditis elegans Bristol N2 AAA83174.3
AAA68743.1
CCD69278.1
NP_494897.3
Q21750  
 α-glucosidase (glucoamylase) (Gca1) 3.2.1.20 Candida albicans AAC31968.1
AAV04403.1
O74254  
 α-glucosidase II (Rot2;CaO19.8589) 3.2.1.20
3.2.1.84
Candida albicans SC5314 EAK97887.1
AOW29468.1
Q5A4X3  
 α-1,3-glucosidase II α-subunit (GII?;CTHT_0064960) 3.2.1.84 Chaetomium thermophilum var. thermophilum DSM 1495 EGS17181.1   5DKX[A]
5DKY[A]
5DKZ[A]
5DL0[A]
5JQP[A]
 α-glucosidase (Gaa1) 3.2.1.20 Coturnix japonica BAA25884.1
BAC15595.1
O73626  
 acid α-glucosidase (Gaa2;GAAII) 3.2.1.20 Coturnix japonica BAA25890.2
BAC15596.1
O73632  
 α-glucosidase II (ModA;DDB_G0269154) 3.2.1.84 Dictyostelium discoideum AAB18921.1 Q94502  
 α-1,4-glucan lyase isozyme 1 (GLq1;Ag111) 4.2.2.13 Gracilariopsis lemaneiformis CAB51910.1
AAR66623.1
ABA16064.1
Q9STC1 2X2H[A,B,C,D]
2X2I[A,B,C,D]
2X2J[A,B,C,D]
4AMW[A,B,C,D]
4AMX[A,B,C,D]
 α-1,4-glucan lyase isozyme 2 (GLq2;Ag112) 4.2.2.13 Gracilariopsis lemaneiformis CAB51911.1
AAR66624.1
ABA16065.1
Q9STC0  
 α-1,4-glucan lyase isozyme 4 (GLs1;Ag114) 4.2.2.13 Gracilariopsis lemaneiformis CAB51909.1
AAP61561.1
ABA16068.1
Q9STC2  
 α-1,4-glucan lyase isozyme 5 (GLs2;Ag115) (partial) (fragment) 4.2.2.13 Gracilariopsis lemaneiformis CAB51913.1
AAP61562.1
ABA16069.1
Q9STB8  
 α-glucosidase (HdAgl1;HdAgl) 3.2.1.20 Haliotis discus hannai BAN67474.1    
 α-glucosidase A (GAA) (lysosomal) 3.2.1.20 Homo sapiens CAA68763.1
AAA52506.1
AAB33842.1
AAH40431.1
ABI53718.1
ACM80396.1
ACM84029.1
BAH13042.1
CAA38907.1
CAA68764.1
CAC12967.1
CAE85448.1
NP_000143.1
P10253
P10253
Q8IWE7
5KZW[A]
5KZX[A]
5NN3[A]
5NN4[A]
5NN5[A]
5NN6[A]
5NN8[A]
 α-glucosidase II (GanAB;G2AN;KIAA0088 ) 3.2.1.20
3.2.1.84
Homo sapiens AAF66685.1
AAH17433.2
AAH17435.2
AAH65266.1
ACJ13667.1
BAA07642.1
BAG58624.1
BAG58692.1
BAG61688.1
BAG63965.1
CAA04006.1
XP_043268.1
Q14697
Q14697
 
 maltase-glucoamylase (MgaM;Mga;MGAML) 3.2.1.20 Homo sapiens AAC39568.2
AAI20873.1
AAL83560.1
NP_004659.1
O43451
Q8TE24
3TON[A,B]
3TOP[A,B]
 maltase-glucoamylase (MgaM;Mga;MGAML) 3.2.1.20 Homo sapiens AAC39568.2
AAI20873.1
AAL83560.1
AAP21875.1
NP_004659.1
O43451
Q86UM5
Q8TE24
2QLY[A]
2QMJ[A]
3CTT[A]
3L4T[A]
3L4U[A]
3L4V[A]
3L4W[A]
3L4X[A]
3L4Y[A]
3L4Z[A]
 sucrase-isomaltase (SI) 3.2.1.10
3.2.1.48
Homo sapiens AAT18166.1
AAI15035.1
AAI16453.1
AAI16454.1
AAI32835.1
AAI32861.1
AAT19036.1
ABH87017.1
ACM85129.1
ACP58672.1
CAA45140.1
NP_001032.1
P14410  
 sucrase-isomaltase (SI) 3.2.1.10
3.2.1.48
Homo sapiens AAT18166.1
AAA60551.1
AAI15035.1
AAI16453.1
AAI16454.1
AAI32835.1
AAI32861.1
AAT19036.1
ABH87017.1
ACM85129.1
ACP58672.1
CAA45140.1
NP_001032.1
P14410 3LPO[A,B,C,D]
3LPP[A,B,C,D]
 α-glucosidase 3.2.1.20 Hordeum vulgare AAB02985.1
AAX04432.1
Q43763  
 α-glucosidase (Agl1;Agl97) 3.2.1.20 Hordeum vulgare subsp. vulgare AAF76254.1
ACZ37234.1
ACZ37244.1
ACZ37249.1
BAJ89297.1
D1MDV2
Q9LLY2
 
 α-glucosidase 3.2.1.20 Litopenaeus vannamei CAB85963.1 Q9NFY8  
 α-1,4-glucan lyase (Agll1) 4.2.2.13 Morchella costata CAB52260.1
AAE24522.1
AAR66625.1
ABA16066.1
Q9UVZ2  
 α-1,4-glucan lyase (Agll1) 4.2.2.13 Morchella vulgaris CAB52201.1
AAE24523.1
AAR66626.1
ABA16067.1
Q9UVZ1  
 α-glucosidase (AgdA) 3.2.1.20 Mortierella alliacea YN-15 BAC57563.1 Q876Z7  
 α-glucosidase 3.2.1.20 Mucor javanicus BAA11053.1 Q92442  
 α-glucosidase (GAA) (lysosomal) 3.2.1.20 Mus musculus AAH10210.1
AAB06943.1
BAC34888.1
BAC40382.1
BAE23960.1
BAE27243.1
BAE30001.1
CAM15004.1
CAM15005.1
CAM15006.1
CAM15007.1
NP_032090.2
A2AFL4
P70699
P70699
 
 α-glucosidase II (?-GluII;AB;GanAB;GANAB;G2an;Kiaa0088 ) 3.2.1.20
3.2.1.84
Mus musculus AAC53182.1
AAH94437.1
AAI17889.1
AAI17890.1
AAI28070.1
BAB30982.1
BAC27099.1
BAC38370.1
BAC65483.1
BAE29025.1
NP_032086.1
A1A4T2
Q149A6
Q8BHN3
Q8BHN3
5F0E[A]
5H9O[A,C]
5HJO[A,C]
5HJR[A,C]
5IED[A]
5IEE[A]
5IEF[A]
5IEG[A]
 membrane-bound maltase-glucoamylase (MGAM) 3.2.1.20 Mus musculus 129/Sv ACH86011.1
AAP55844.1
B5THE2  
 membrane-bound maltase-glucoamylase (MGAM) 3.2.1.20 Mus musculus 129/Sv ACH86011.1 B5THE2  
 sucrase-isomaltase (SI) 3.2.1.10
3.2.1.20
3.2.1.48
Oryctolagus cuniculus AAA31459.1 P07768  
 sucrase-isomaltase (SI) 3.2.1.10
3.2.1.20
3.2.1.48
Oryctolagus cuniculus AAA31459.1 P07768  
 α-glucosidase (Ong2;Ong-2;Ong3;OngX-H3;Os06g0675700) 3.2.1.20 Oryza sativa Japonica Group BAD45910.1
BAF20261.1
BAS99103.1
Q0DA62
Q653V7
 
 α-glucosidase (Ong1;OngX-H1;Os06g0676700) 3.2.1.20 Oryza sativa Japonica Group BAD45913.1
BAD45516.1
BAF20267.1
BAS99109.1
Q653V4  
 α-xylosidase (Ong4;OngX-H4;Os01g0130400) 3.2.1.177 Oryza sativa Japonica Group BAA99366.1
BAF03836.1
BAG95494.1
BAS70209.1
Q9LGC6  
 α-1,3-glucosidase (PAG;Pa_2_60) 3.2.1.20
3.2.1.84
Podospora anserina S mat+ CAP72574.1
CDP24969.1
B2B450  
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