Activities in Family	α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); α-mannosidase (EC 3.2.1.24); α-1,3-glucosidase (EC 3.2.1.84); sucrase-isomaltase (EC 3.2.1.48) (EC 3.2.1.10); α-xylosidase (EC 3.2.1.177); α-glucan lyase (EC 4.2.2.13); isomaltosyltransferase (EC 2.4.1.-); oligosaccharide α-1,4-glucosyltransferase (EC 2.4.1.161); α-N-acetylgalactosaminidase (EC 3.2.1.49); sulfoquinovosidase (EC 3.2.1.199)
Mechanism	Retaining
Clan	GH-D
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Asp
Catalytic Proton Donor	Asp
External resources	CAZypedia; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (16235); Uniprot accession (1017); PDB accession (122); 3D entries (28); cryst (0)

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Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-glucosidase (AglA;PTO0092)	3.2.1.20	Picrophilus torridus DSM 9790	AAT42677.1	Q6L2X4
α-glucosidase with α-mannosidase activity (MalA;SsMalA;Sso1_0793)	3.2.1.20 3.2.1.24	Saccharolobus solfataricus 98/2	AAC38215.1 ACX91047.1 AET42970.1	D0KQM8 G8GCW5 O59645	2G3M[A,B,C,D,E,F] 2G3N[A,B,C,D,E,F]
α-xylosidase (XylS;SS03022)	3.2.1.177	Saccharolobus solfataricus P2	CAB99206.1 AAK43123.1 CAC24044.1 NP_344333.1	Q9P999
α-glucosidase (MalA;SSO3051)	3.2.1.20	Saccharolobus solfataricus P2	AAK43151.1 AAO97625.1 ABJ38303.1 ABJ38315.1 ABJ38324.1 ACW20068.1 ACW20079.1 ACW20080.1 CAC24058.1 NP_344361.1	P0CD66
α-glucosidase (MalA;Saci_1160)	3.2.1.20	Sulfolobus acidocaldarius DSM 639	AAY80507.1	Q4J9M3
α-glucosidase (ST2525)	3.2.1.20	Sulfurisphaera tokodaii str. 7	BAB67639.1 BAK54817.1 NP_378530.1	F9VPH0 Q96XI8
α-glucosidase (AglA;Ta0298)	3.2.1.20	Thermoplasma acidophilum DSM 1728	CAC11443.1 NP_393778.1	Q9HLD0
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
6-α-glucosyltransferase (CtsZ;6GT)	2.4.1.-	Arthrobacter globiformis A19	BAD34980.1	Q6BD65
3-α-isomaltosyltransferase (CtsY;IMT)	2.4.1.-	Arthrobacter globiformis A19	BAD34979.1	Q6BD67
α-glucosidase (AG31A;BspAG31A)	3.2.1.20	Bacillus sp. SW20 / AHU 2001	BAQ19546.1
α-glucosidase II / oligo-α-1,6-glucosidase (BthG II)	3.2.1.10 3.2.1.20	Bacillus thermoamyloliquefaciens KP1071 (FERM-P8477)	BAA76396.1	Q9F234
α-N-acetylgalactosaminidase (BpGH31; CGC64_02900)	3.2.1.49	Bacteroides caccae ATCC 43185	ASM65008.1
α-xylosidase (Bovatus_03718; Yici_7;BACOVA_03422)	3.2.1.177	Bacteroides ovatus ATCC 8483	ALJ48323.1 EDO10789.1
α-xylosidase (Yici_5;BoGH31A;BACOVA_02646;Bovatus_03066)	3.2.1.177	Bacteroides ovatus ATCC 8483	ALJ47674.1		5JOU[A] 5JOV[A]
α-N-acetylgalactosaminidase (BpGH31)	3.2.1.49	Bacteroides plebeius DSM 17135	WP_007559952.1
α-galactosidase (HMPREF1071_02836)	3.2.1.22	Bacteroides salyersiae CL02T12C01	EIY61740.1
α-glucosidase (BT0339;BT_0339)	3.2.1.20	Bacteroides thetaiotaomicron VPI-5482	AAO75446.1 NP_809252.1	Q8AAX3	5F7C[A,B,C,D]
α-glucosidase (BT3299;BT_3299)	3.2.1.20	Bacteroides thetaiotaomicron VPI-5482	AAO78405.1 NP_812211.1	Q8A2K6	5DJW[A,B]
α-glucosidase / maltase-glucoamylase (Ro-aG1;RUMOBE_03919)	3.2.1.20	Blautia obeum ATCC 29174	ZP_01966167.1	A5ZY13	3FFJ[A,B] 3M46[A,B] 3M6D[A,B] 3MKK[A,B] 3N04[A,B] 3NQQ[A,B] 3NSX[A,B] 3NUK[A,B] 3NXM[A,B,C,D] 3PHA[A,B,C,D] 3POC[A,B] 6C9X[A,B] 6C9Z[A,B] 6CA1[A,B] 6CA3[A,B]
α-glucosidase (GluA;TTE0006)	3.2.1.20	Caldanaerobacter subterraneus subsp. tengcongensis MB4	AAM23323.1 NP_621719.1	Q8RDL1
oligosaccharide α-1,4-transglucosylase 31B (CjAgd31B;CJA_3248) (Agd31B)	2.4.1.161	Cellvibrio japonicus Ueda107	ACE84782.1	B3PEE6	4B9Y[A] 4B9Z[A] 4BA0[A] 5I23[A] 5I24[A] 5NPB[A] 5NPC[A] 5NPD[A] 5NPE[A]
α-xylosidase 31A (CjXyl31A;CJA_2706) (Xyl31A)	3.2.1.177	Cellvibrio japonicus Ueda107	ACE86259.1	B3PBD9	2XVG[A] 2XVK[A] 2XVL[A]
α-N-acetylgalactosaminidase (WOW_01747)	3.2.1.49	Enterococcus faecalis ATCC 10100	EOK08638.1		6M76[A] 6M77[A]
α-xylosidase (YicI;EcYicI;b3656)	3.2.1.177	Escherichia coli str. K-12 substr. MG1655	AAC76680.1 AAA62009.1 AIZ93543.1 ALI38655.1 AMC96544.1 AUG18368.1 AVI53824.1 AYG17401.1 NP_418113.1	P31434	1WE5[A,B,C,D,E,F] 1XSI[A,B,C,D,E,F] 1XSJ[A,B,C,D,E,F] 1XSK[A,B,C,D,E,F] 2F2H[A,B,C,D,E,F]
sulfoquinovosidase (SQase;YihQ;b3878)	3.2.1.199	Escherichia coli str. K-12 substr. MG1655	AAC76875.1 AAB03011.1 AIZ93343.1 ALI38454.1 AMC96746.1 AUG18567.1 AVI54027.1 AYG21326.1 NP_418314.1	P32138	5AED[A,B] 5AEE[A,B] 5AEG[A,B] 5OHT[A,B]
dextranase/6-α-glucosyltransferase (Fjoh_4430)	3.2.1.11 2.4.1.-	Flavobacterium johnsoniae UW101	ABQ07434.1	A5FBI1	6JR6[A,B,C,D] 6JR7[A,B,C,D] 6JR8[A,B,C,D]
cycloalternan-specific α-1,3-glucosidase / α-1,3-isomaltosidase (Kfla_1895)	3.2.1.204	Kribbella flavida DSM 17836	ADB30989.1	D2PPM7	5X3I[A,B] 5X3J[A,B] 5X3K[A,B]
3-α-isomaltosyltransferase (IMT;Kfla_4052)	2.4.1.-	Kribbella flavida DSM 17836	ADB33101.1	D2PSG3
α-xylosidase (XylQ)	3.2.1.177	Lactiplantibacillus pentosus MD353	AAC62251.1	P96793
α-1,3-glucosidase (LjAg31) (partial)	3.2.1.84	Lactobacillus johnsonii NBRC 13952	ACO57638.1	C1KIT5
cycloalternan-degrading enzyme (Lmo0182)	3.2.1.204	Listeria monocytogenes EGD-e	NP_463713.1 CAC98397.1	Q8YAE8
branching enzyme / α-6-glucosyltransferase (Lmo2444)	2.4.1.-	Listeria monocytogenes EGD-e	CAD00522.1 NP_465967.1	Q8Y4J4
cycloalternan-forming enzyme / 3-α-isomaltosyltransferase (CAFE;LmCAFE;Lmo2446)	2.4.1.-	Listeria monocytogenes EGD-e	CAD00524.1 NP_465969.1	Q8Y4J2	4KMQ[A] 4KWU[A] 5F7U[A] 5HPO[A] 5HXM[A] 5I0D[A,B]
6-α-glucosyltransferase (Ps6GT31A) (6GT31A)	2.4.1.-	Paenibacillus sp. 598K	BAV17026.1		5X7O[A,B] 5X7P[A,B] 5X7Q[A,B] 5X7R[A,B] 5X7S[A,B]
α-galactosidase (PhGal31A;Phep_2697) (Gal31A)	3.2.1.22	Pedobacter heparinus DSM 2366	ACU04898.1	C6Y0X1
α-galactosidase (PsGal31A) (Gal31A)	3.2.1.22	Pseudopedobacter saltans NBRC 100064	BAR72452.1		4XPO[A] 4XPP[A] 4XPQ[A] 4XPR[A] 4XPS[A]
isomaltosyltransferase (CtsW)	2.4.1.-	Sporosarcina globispora C11	BAB88401.1	Q8RQV2
3-α-isomaltosyltransferase (CtsY)	2.4.1.-	Sporosarcina globispora C11	BAB88403.1 ABJ31058.1	Q8RQV0
6-glucosyltransferase (CtsZ)	2.4.1.-	Sporosarcina globispora C11	BAB88404.1	Q8RQU9
3-α-isomaltosyltransferase (CtsY;IMT)	2.4.1.-	Sporosarcina globispora N75	BAC54957.1 ABJ31059.1	Q84IQ3
6-α-glucosyltransferase (CtsZ;6GT)	2.4.1.-	Sporosarcina globispora N75	BAC54958.1	Q84IQ2
α-glucosidase	3.2.1.20	Thermoanaerobacter ethanolicus JW 200	ABR26230.1
cycloalternan-specific α-1,3-glucosidase (CADE;TpCADE;TpLmo0182;CQ11_05330)	3.2.1.204	Trueperella pyogenes TP6375	AHU89502.1		5F7S[A,B] 5I0E[B] 5I0F[B] 5I0G[B]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α-glucosidase / α-1,3-glucosidase (Aig)	3.2.1.20 3.2.1.84	Acremonium implicatum	BAD08418.1	Q75QW0
α-glucosidase 1 (Aglu1;Aglu-1;At5g11720)	3.2.1.20	Arabidopsis thaliana	AAB82656.1 AAK96644.1 AAN72233.1 AAX04435.1 AED91714.1 CAB87690.1 NP_196733.1	O22444 Q9LYF8
α-glucosidase / α-xylosidase (AtXyl1;AXY3;AtGlu2;Aglu2;Aglu-2;At1g68560)	3.2.1.177 3.2.1.20	Arabidopsis thaliana	AAD37363.1 AAD05539.1 AAD49987.1 AAL09716.1 AAO11591.1 AEE34811.1 BAS22090.1 BAS22093.1 NP_177023.1	Q9S7Y7 Q9ZP26
α-glucosidase II (Rsw3;Aglu3;Aglu-3;At5g63840) (RSW3)	3.2.1.84	Arabidopsis thaliana	BAB11032.1 AED97803.1 ANM68707.1 NP_201189.1	Q9FN05
α-glucosidase (α-G I;α-GI)	3.2.1.20	Aspergillus awamori KT-11	BAD06006.1	Q76KT3
α-glucosidase B (AgdB)	3.2.1.20	Aspergillus nidulans	BAB39856.1	Q9C1S7
α-glucosidase (AgdB;AN8953.2)	3.2.1.20	Aspergillus nidulans FGSC A4	EAA63748.1	C8VLA3 G5EB11
α-glucosidase (AgdC;AN7345.2)	3.2.1.20	Aspergillus nidulans FGSC A4	ABF50883.1 EAA61716.1	C8VCK6 Q5AWI5
α-glucosidase (AgdE;AN0941.2)	3.2.1.20	Aspergillus nidulans FGSC A4	ABF50846.1 EAA65970.1
α-xylosidase (AgdD;AN7505)	3.2.1.177	Aspergillus nidulans FGSC A4	EAA62085.1 ABF50885.1	C8VBI7 Q5AW25
α-glucosidase (AgdA;AN2017.2)	3.2.1.20	Aspergillus nidulans FGSC A4	EAA64849.1 AAF17102.1	C8VLE5 G5EB03
α-glucosidase (Agl;ANG)	3.2.1.20	Aspergillus niger AHU 7322	BAM72725.1
α-xylosidase (AX;AxlA;Axl1;Aspni5|43342)	3.2.1.177	Aspergillus niger ATCC 1015	DAA35002.1
α-glucosidase (AgdA;An04g06920;AglU)	3.2.1.20	Aspergillus niger CBS 513.88	CAK44692.1	A2QJF7
α-glucosidase (AglA)	3.2.1.20	Aspergillus niger GN-3	BAA23616.1 AAB23581.1 BAF37801.1	A0PCH8 P56526
α-1,3-glucosidase II α-subunit (AoGls2a;G-II;AO090102000559)	3.2.1.84	Aspergillus oryzae RIB40	BAE61578.1	Q2UA37
α-glucosidase (AgdA;Agl; AO090003001209)	3.2.1.20	Aspergillus oryzae RIB40	BAA08125.1 BAA95702.1 BAE58289.1	Q12558
α-glucosidase (Agl;SBG)	3.2.1.20	Beta vulgaris	BAM74081.1 BAM72724.1		3W37[A] 3W38[A] 3WEL[A] 3WEM[A] 3WEN[A] 3WEO[A]
α-glucosidase (SBG)	3.2.1.20	Beta vulgaris	BAA20343.1 AAX04433.1	O04931
α-glucosidase II α-subunit (BmGIIa)	3.2.1.20	Bombyx mori	BAM78681.1
acidic α-glucosidase	3.2.1.20	Bos taurus	AAF81637.1 AAF81636.1 NP_776338.1	Q9MYM4
α-glucosidase ( Aagr-1;D2096.3/D2096.12)	3.2.1.20	Caenorhabditis elegans Bristol N2	AAA81491.1 AAO91743.1 NP_501419.1	Q19004
α-glucosidase (Aagr-3;F40F9.6;CELE_F40F9.6)	3.2.1.20	Caenorhabditis elegans Bristol N2	CAA94764.1 CAB54240.1 CCM09381.1 NP_505507.1	Q20239
α-glucosidase (Aagr-4;F52D1.1)	3.2.1.20	Caenorhabditis elegans Bristol N2	AAB71267.2 AAB71267.3 CCD70824.1 NP_508105.1	O17352
α-glucosidase (glucoamylase) (Gca1)	3.2.1.20	Candida albicans	AAC31968.1 AAV04403.1	O74254
α-glucosidase II (Rot2;CaO19.8589)	3.2.1.20 3.2.1.84	Candida albicans SC5314	EAK97887.1 AOW29468.1	Q5A4X3
α-1,3-glucosidase II α-subunit (GIIa;CTHT_0064960)	3.2.1.84	Chaetomium thermophilum var. thermophilum DSM 1495	EGS17181.1		5DKX[A] 5DKY[A] 5DKZ[A] 5DL0[A] 5JQP[A]
α-glucosidase (Gaa1)	3.2.1.20	Coturnix japonica	BAA25884.1 BAC15595.1	O73626
acid α-glucosidase (Gaa2;GAAII)	3.2.1.20	Coturnix japonica	BAA25890.2 BAC15596.1	O73632
α-glucosidase II (ModA;DDB_G0269154)	3.2.1.84	Dictyostelium discoideum	AAB18921.1	Q94502
α-1,4-glucan lyase isozyme 1 (GLq1;Ag111)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51910.1 AAR66623.1 ABA16064.1	Q9STC1	2X2H[A,B,C,D] 2X2I[A,B,C,D] 2X2J[A,B,C,D] 4AMW[A,B,C,D] 4AMX[A,B,C,D]
α-1,4-glucan lyase isozyme 2 (GLq2;Ag112)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51911.1 AAR66624.1 ABA16065.1	Q9STC0
α-1,4-glucan lyase isozyme 4 (GLs1;Ag114)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51909.1 AAP61561.1 ABA16068.1	Q9STC2
α-1,4-glucan lyase isozyme 5 (GLs2;Ag115) (partial)	4.2.2.13	Gracilariopsis lemaneiformis	CAB51913.1 AAP61562.1 ABA16069.1	Q9STB8
α-glucosidase (HdAgl1;HdAgl)	3.2.1.20	Haliotis discus hannai	BAN67474.1
α-glucosidase A (GAA) (lysosomal)	3.2.1.20	Homo sapiens	CAA68763.1 AAA52506.1 AAB33842.1 AAH40431.1 ABI53718.1 ACM80396.1 ACM84029.1 BAH13042.1 CAA38907.1 CAA68764.1 CAC12967.1 CAE85448.1 NP_000143.1	P10253 P10253 Q8IWE7	5KZW[A] 5KZX[A] 5NN3[A] 5NN4[A] 5NN5[A] 5NN6[A] 5NN8[A]
α-glucosidase II (GanAB;G2AN;KIAA0088 )	3.2.1.20 3.2.1.84	Homo sapiens	AAF66685.1 AAH17433.2 AAH17435.2 AAH65266.1 ACJ13667.1 BAA07642.1 BAG58624.1 BAG58692.1 BAG61688.1 BAG63965.1 CAA04006.1 XP_043268.1	Q14697 Q14697
maltase-glucoamylase (MgaM;Mga;MGAML)	3.2.1.20	Homo sapiens	AAC39568.2 AAI20873.1 AAL83560.1 NP_004659.1	O43451 Q8TE24	3TON[A,B] 3TOP[A,B]
maltase-glucoamylase (MgaM;Mga;MGAML)	3.2.1.20	Homo sapiens	AAC39568.2 AAI20873.1 AAL83560.1 AAP21875.1 NP_004659.1	O43451 Q86UM5 Q8TE24	2QLY[A] 2QMJ[A] 3CTT[A] 3L4T[A] 3L4U[A] 3L4V[A] 3L4W[A] 3L4X[A] 3L4Y[A] 3L4Z[A]
sucrase-isomaltase (SI)	3.2.1.10 3.2.1.48	Homo sapiens	AAT18166.1 AAI15035.1 AAI16453.1 AAI16454.1 AAI32835.1 AAI32861.1 AAT19036.1 ABH87017.1 ACM85129.1 ACP58672.1 CAA45140.1 NP_001032.1	P14410
sucrase-isomaltase (SI)	3.2.1.10 3.2.1.48	Homo sapiens	AAT18166.1 AAA60551.1 AAI15035.1 AAI16453.1 AAI16454.1 AAI32835.1 AAI32861.1 AAT19036.1 ABH87017.1 ACM85129.1 ACP58672.1 CAA45140.1 NP_001032.1	P14410	3LPO[A,B,C,D] 3LPP[A,B,C,D]
α-glucosidase	3.2.1.20	Hordeum vulgare	AAB02985.1 AAX04432.1	Q43763
α-glucosidase (Agl1;Agl97)	3.2.1.20	Hordeum vulgare subsp. vulgare	AAF76254.1 ACZ37234.1 ACZ37244.1 ACZ37249.1 BAJ89297.1	D1MDV2 Q9LLY2
α-1,4-glucan lyase (Agll1)	4.2.2.13	Morchella costata	CAB52260.1 AAE24522.1 AAR66625.1 ABA16066.1	Q9UVZ2
α-1,4-glucan lyase (Agll1)	4.2.2.13	Morchella vulgaris	CAB52201.1 AAE24523.1 AAR66626.1 ABA16067.1	Q9UVZ1
α-glucosidase (AgdA)	3.2.1.20	Mortierella alliacea YN-15	BAC57563.1	Q876Z7
α-glucosidase	3.2.1.20	Mucor javanicus	BAA11053.1	Q92442
α-glucosidase (GAA) (lysosomal)	3.2.1.20	Mus musculus	AAH10210.1 AAB06943.1 BAC34888.1 BAC40382.1 BAE23960.1 BAE27243.1 BAE30001.1 CAM15004.1 CAM15005.1 CAM15006.1 CAM15007.1 NP_032090.2	A2AFL4 P70699 P70699
membrane-bound maltase-glucoamylase (MGAM)	3.2.1.20	Mus musculus 129/Sv	ACH86011.1 AAP55844.1	B5THE2
membrane-bound maltase-glucoamylase (MGAM)	3.2.1.20	Mus musculus 129/Sv	ACH86011.1	B5THE2
sucrase-isomaltase (SI)	3.2.1.10 3.2.1.20 3.2.1.48	Oryctolagus cuniculus	AAA31459.1	P07768
sucrase-isomaltase (SI)	3.2.1.10 3.2.1.20 3.2.1.48	Oryctolagus cuniculus	AAA31459.1	P07768
α-glucosidase (Ong2;Ong-2;Ong3;OngX-H3;Os06g0675700)	3.2.1.20	Oryza sativa Japonica Group	BAD45910.1 BAF20261.1 BAS99103.1	Q0DA62 Q653V7
α-glucosidase (Ong1;OngX-H1;Os06g0676700)	3.2.1.20	Oryza sativa Japonica Group	BAD45913.1 BAD45516.1 BAF20267.1 BAS99109.1	Q653V4
α-xylosidase (Ong4;OngX-H4;Os01g0130400)	3.2.1.177	Oryza sativa Japonica Group	BAA99366.1 BAF03836.1 BAG95494.1 BAS70209.1	Q9LGC6
α-glucosidase	3.2.1.20	Penaeus vannamei	CAB85963.1	Q9NFY8
α-1,3-glucosidase (PAG;Pa_2_60)	3.2.1.20 3.2.1.84	Podospora anserina S mat+	CAP72574.1 CDP24969.1	B2B450
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