Known Activities	glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); β-glucosidase (3.2.1.21); endo-β-1,6-galactanase (EC:3.2.1.164)
Mechanism	Retaining
Clan	GH-A
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
Note	Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resources	CAZypedia; Gaucher Disease; InterPro; PFAM; PRINTS;
Statistics	GenBank accession (514); Uniprot accession (247); PDB accession (29); 3D entries (6); cryst (1)

Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
ALNC14_004340 (Alnc14c3g399)		Albugo laibachii Nc14	CCA14291.1			1
ORF		Amblyomma maculatum	AEO33650.1			1
ORF (fragment)		Amblyomma maculatum	AEO33785.1			1
ORF		Ascaris suum	ADY44488.1			1
β-1,6-glucanase (Neg1;Afu8g07120) (6625)	3.2.1.75	Aspergillus fumigatus Af293	XP_747510.1			3
An03g00500		Aspergillus niger CBS 513.88	CAK38027.1	A2QFR7		3
exo-β-1,4-xylanase (XylD)	3.2.1.-	Bispora sp. MEY-1	ADG62369.1	D6MYS9		7
Unknown (protein for MGC:137522)		Bos taurus	AAI12824.1 AAI12824.1	Q2KHZ8 Q2KHZ8		1
C33C12.3		Caenorhabditis elegans Bristol N2	AAB66056.2 ABV68956.1 CCD66449.1 CCD66450.1 NP_494207.1	O16580		1
C33C12.8		Caenorhabditis elegans Bristol N2	AAB66060.1 AAB66060.2 CCD66456.1 NP_494208.1	O16581		1
F11E6.1		Caenorhabditis elegans Bristol N2	CAA20283.1 CAB02924.1 CAC35807.1 CAC35813.1 CAD42642.1 CCD31056.1 NP_503118.1 NP_741501.1	Q9BH43 Q9XTB0		1
Y4C6B.6		Caenorhabditis elegans Bristol N2	AAD14768.2 CCD71128.1 NP_500785.1	Q9UB00		1
unknown		Dendroctonus ponderosae	AEE63066.1			1
CG31414		Drosophila melanogaster	AAN13955.1 AAN13955.2 AAN13955.3 AAY55431.1 AAY55467.1 AAY55519.1 NP_732892.1	Q8IMY3		1
CG31148		Drosophila melanogaster	AAF56165.2 AAL28266.1 NP_651172.1	Q9VCJ4		1
acid β-glucosidase 1 / glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal)	3.2.1.45	Homo sapiens	AAA35873.1 AAA35877.1 AAA35880.1 AAC51820.1 AAC63056.1 AAH03356.1 AAQ41981.1 AAQ41982.1 AAT13636.1 AAT13637.1 AAV20581.1 AAY03281.1 AAY03324.1 ABL21565.1 ACH14936.1 ACJ92748.1 ACM85831.1 ACM85831.1 ACM97663.1 BAA02545.1 BAF84600.1 BAG58248.1 BAG60020.1 BAH12898.1 BAH13232.1 BAH13357.1 BAH13365.1 BAH13467.1 BAH13605.1 CAC41172.1 CAC41173.1 CAD12720.1 CAD12721.1 CAE85438.1 CAI95090.1 NP_000148.1	B2R6A7 P04062.3	1OGS[A,B] 1Y7V[A,B] 2F61[A,B] 2J25[A,B] 2NSX[A,B,C,D] 2NT0[A,B,C,D] 2NT1[A,B,C,D] 2V3D[A,B] 2V3E[A,B] 2V3F[A,B] 2VT0[A,B] 2WCG[A,B] 2WKL[A,B] 2XWD[A,B] 2XWE[A,B] 3GXD[A,B,C,D] 3GXF[A,B,C,D] 3GXI[A,B,C,D] 3GXM[A,B,C,D] 3KE0[A,B] 3KEH[A,B]	1
GBA (pseudogene)		Homo sapiens	AAH00349.2 AAH30240.1 AAH92482.1 BAA02546.1 BAG52175.1 CAI95088.1 XP_034493.1			1
exo-xylanase IV (XYN IV)	3.2.1.-	Hypocrea jecorina	AAP64786.1 AAV25955.1		cryst	7
β-1,6-glucanase (Bgn16.3;P2)	3.2.1.75	Hypocrea lixii	ACM42429.1 CAC80492.1	Q8J0I9		3
endo-β-1,6-galactanase (6GAL;Tv1,6Gal5A) (1,6Gal5A)	3.2.1.164	Hypocrea rufa	BAC84995.1	Q76FP5		5
glucan endo-β-1,6-glucosidase (LePus30A) (Pus30A)	3.2.1.75 3.2.1.75	Lentinula edodes H600	BAK52530.1			3
Xyl38		Leptosphaeria maculans	AAO49459.1	Q873Z0		7
ORF		Leptosphaeria maculans v23.1.3	CBX93583.1	E4ZP54		7
ORF		Leptosphaeria maculans v23.1.3	CBX92400.1	E4ZM51		7
MG02126.4		Magnaporthe grisea 70-15	XP_365424.1			3
xylanase 2 (Xyl2) (fragment)		Meloidogyne incognita	ACC77826.1	C0IQA1		8
xylanase 3 (Xyl3) (fragment)		Meloidogyne incognita	ACC77827.1	C0IQA2		8
xylanase (Mi-Xyl1;Xyl-1)	3.2.1.8	Meloidogyne incognita	AAF37276.1	Q9NHE0		8
glucocerebrosidase (Gba)	3.2.1.45	Mus musculus	AAA37671.1 AAH06663.1 AAM66757.1 BAC38609.1 NP_032120.1	P17439.1		1
acid β-glucosidase		Mustela putorius furo	AER98953.1			1
MYCTH_38558		Myceliophthora thermophila ATCC 42464	AEO55025.1			7
MYCTH_2301720		Myceliophthora thermophila ATCC 42464	AEO56615.1			5
MYCTH_101800		Myceliophthora thermophila ATCC 42464	AEO57693.1			7
β-1,6-glucanase (Neg1;Neg-1)	3.2.1.75	Neurospora crassa IFO6068	BAB91213.1	Q7M4T0		3
β-1,6-glucanase (Neg1;NCU04395.1/29E8.200)	3.2.1.75	Neurospora crassa OR74A	CAF06053.1 XP_323748.1			3
endo-β-1,6-galactanase (6Gal;Nc6GAL;NCU09702.1)	3.2.1.164	Neurospora crassa OR74A	EAA29705.1 XP_330352.1			5
glucocerebrosidase (Gba)		Pan troglodytes	AAK18162.1 AAK18162.1	Q9BDT0 Q9BDT0		1
Pc22g13580		Penicillium chrysogenum Wisconsin 54-1255	CAP98646.1	B6HTL1		3
β-glucosidase / β-xylosidase (Bgx1)	3.2.1.21 3.2.1.37	Phytophthora infestans 88069	AAK19754.1	Q9AT27		1
PIIN_00485		Piriformospora indica	CCA77838.1			3
unnamed protein product		Podospora anserina S mat+	CAP64775.1	B2ALC8		5
Pa_5_3770		Podospora anserina S mat+	CAP64828.1	B2ALJ0		7
Pa_7_2000		Podospora anserina S mat+	CAP68494.1	B2AVS0		7
DKFZp469B0323		Pongo abelii	CAH90774.1	Q5R8E3		1
DKFZp469K1734		Pongo abelii	CAH91967.1 CAH91967.1	Q5R8E3 Q5R8E3		1
xylanase (Xyl1;Rs-XYL1)		Radopholus similis	ABZ78968.1	B3TJG3		8
Unknown protein for MGC:188451		Rattus norvegicus	AAI66732.1	B2RYC9		1
sr15243		Sporisorium reilianum SRZ2	CBQ69174.1			3
sr13131		Sporisorium reilianum SRZ2	CBQ72423.1			3
GBA		Sus scrofa	CAE06498.1 CAE06498.1	Q70KH2 Q70KH2		1
THITE_2117640		Thielavia terrestris NRRL 8126	AEO68216.1			3
THITE_2123443		Thielavia terrestris NRRL 8126	AEO71253.1			7
THITE_30409		Thielavia terrestris NRRL 8126	AEO71227.1			7
MGC84284 (fragment)		Xenopus laevis	AAH81165.1	Q66IW2		1

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