Glycoside Hydrolase Family 30

Known Activitiesglucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); β-glucosidase (3.2.1.21); endo-β-1,6-galactanase (EC:3.2.1.164)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; InterPro; PFAM; PRINTS;
Statistics GenBank accession (514); Uniprot accession (247); PDB accession (29); 3D entries (6); cryst (1)
All (409) Bacteria (353) Eukaryota (54) unclassified (2) Structure (6 - 1 cryst) Characterized (25) Subfamilies (368)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D Subf
 xylanase D (XynD) 3.2.1.8 Aeromonas caviae ME-1 AAB63573.1 O24852   8
 xylanase 3 (Xyn3) 3.2.1.8 Aeromonas caviae W-61 BAA13641.1 P70733   8
 xylanase 5B (Xyn5B) 3.2.1.8 Bacillus sp. BP7 ADM15019.1 E1ACF9   8
 glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC;YnfF;BSU18150) 3.2.1.136
3.2.1.8
Bacillus subtilis subsp. subtilis str. 168 CAA97612.1
CAB13698.1
NP_389697.1
Q45070 3GTN[A,B]
3KL0[A,B,C,D]
3KL3[A,B,C,D]
3KL5[A,B,C,D]
8
 β-xylosidase (BxyL) 3.2.1.37 Bifidobacterium adolescentis INT57 ABC55722.1 Q2MJJ7   2
 β-xylosidase (XylB) 3.2.1.37 Bifidobacterium breve K-110 ABX45137.1 B1P195   2
 glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA) 3.2.1.136
3.2.1.8
Erwinia chrysanthemi D1 AAB53151.1 Q46961 1NOF[A]
2Y24[A]
8
 endo-β-1,4-xylanase (XynA) 3.2.1.8 Erwinia chrysanthemi P860219 AAL16415.1 Q938A4   8
 β-fucosidase A (FucA;PbFucA;Pb280;ORF0280;PBR_0285) 3.2.1.38 Prevotella bryantii B14 EFI72736.1
ZP_07060000.1
    4
 β-fucosidase B (FucB;PbFucB;Pb281;ORF0281;PBR_0286) 3.2.1.38 Prevotella bryantii B14 EFI72737.1
ZP_07060001.1
    4
 endo-β-1,6-galactanase (Sa1,6Gal5A;SAV5205) (1,6Gal5A) 3.2.1.164 Streptomyces avermitilis MA-4680 BAC72917.1
NP_826382.1
    5
 β-xylosidase (RuXyn2) 3.2.1.37 uncultured rumen bacterium ADO20355.1 E3TBJ4   2
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D Subf
 β-1,6-glucanase (Neg1;Afu8g07120) (6625) 3.2.1.75 Aspergillus fumigatus Af293 XP_747510.1     3
 exo-β-1,4-xylanase (XylD) 3.2.1.- Bispora sp. MEY-1 ADG62369.1 D6MYS9   7
 acid β-glucosidase 1 / glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 Homo sapiens AAA35873.1
AAA35877.1
AAA35880.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM85831.1
ACM97663.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
B2R6A7
P04062.3
1OGS[A,B]
1Y7V[A,B]
2F61[A,B]
2J25[A,B]
2NSX[A,B,C,D]
2NT0[A,B,C,D]
2NT1[A,B,C,D]
2V3D[A,B]
2V3E[A,B]
2V3F[A,B]
2VT0[A,B]
2WCG[A,B]
2WKL[A,B]
2XWD[A,B]
2XWE[A,B]
3GXD[A,B,C,D]
3GXF[A,B,C,D]
3GXI[A,B,C,D]
3GXM[A,B,C,D]
3KE0[A,B]
3KEH[A,B]
1
 exo-xylanase IV (XYN IV) 3.2.1.- Hypocrea jecorina AAP64786.1
AAV25955.1
  cryst 7
 β-1,6-glucanase (Bgn16.3;P2) 3.2.1.75 Hypocrea lixii ACM42429.1
CAC80492.1
Q8J0I9   3
 endo-β-1,6-galactanase (6GAL;Tv1,6Gal5A) (1,6Gal5A) 3.2.1.164 Hypocrea rufa BAC84995.1 Q76FP5   5
 glucan endo-β-1,6-glucosidase (LePus30A) (Pus30A) 3.2.1.75
3.2.1.75
Lentinula edodes H600 BAK52530.1     3
 xylanase (Mi-Xyl1;Xyl-1) 3.2.1.8 Meloidogyne incognita AAF37276.1 Q9NHE0   8
 glucocerebrosidase (Gba) 3.2.1.45 Mus musculus AAA37671.1
AAH06663.1
AAM66757.1
BAC38609.1
NP_032120.1
P17439.1   1
 β-1,6-glucanase (Neg1;Neg-1) 3.2.1.75 Neurospora crassa IFO6068 BAB91213.1 Q7M4T0   3
 β-1,6-glucanase (Neg1;NCU04395.1/29E8.200) 3.2.1.75 Neurospora crassa OR74A CAF06053.1
XP_323748.1
    3
 endo-β-1,6-galactanase (6Gal;Nc6GAL;NCU09702.1) 3.2.1.164 Neurospora crassa OR74A EAA29705.1
XP_330352.1
    5
 β-glucosidase / β-xylosidase (Bgx1) 3.2.1.21
3.2.1.37
Phytophthora infestans 88069 AAK19754.1 Q9AT27   1

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.





Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II