Glycoside Hydrolase Family 30

Activities in Familyβ-1,6-glucosidase (EC 3.2.1.-);
Glucuronoxylan endo-β-1,4-xylanase (EC 3.2.1.-);
Xylan exo-β-1,4-xylobiosidase (EC 3.2.1.-);
Glucuronoarabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.136);
[inverting] oligosaccharide reducing-end xylanase (EC 3.2.1.156);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Baicalin β-glucuronidase (EC 3.2.1.167);
β-glucosidase (EC 3.2.1.21);
Galactan exo-1,6-β-galactobiohydrolase (non-reducing end) (EC 3.2.1.213);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
β-D-fucosidase (EC 3.2.1.38);
β-glucosylceramidase (EC 3.2.1.45);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (7115); Uniprot accession (71); PDB accession (91); 3D entries (16); cryst (1)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 non-reducing terminal-specific xylobiohydrolase (AcXbh30A; HcXyn30A; Clocl_1795) 3.2.1.- pubmed
Acetivibrio clariflavus DSM 19732 AEV68404.1 G8LU16 7N6H[A,B]
7N6O[A,B]
10
 endoxylanase (AcXyn30B; Clocl_2746) 3.2.1.8
3.2.1.136
pubmed
pubmed
Acetivibrio clariflavus DSM 19732 AEV69300.1 G8M2Z1   12
 xylanase VI / D (XynD) 3.2.1.8 doi
Aeromonas caviae ME-1 AAB63573.1 O24852   8
 glucuronoarabinoxylan-specific endo-β-1,4-xylanase (XynC) (Xyn30A) 3.2.1.8
3.2.1.136
pubmed
pubmed
Bacillus licheniformis SVD1 BAL45490.1 H1ACZ7   8
 xylanase 5B (Xyn5B) 3.2.1.8 pubmed
Bacillus sp. BP7 ADM15019.1 E1ACF9   8
 glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC; BsXynC; YnfF; BSU18150) 3.2.1.8
3.2.1.136
pubmed
pubmed
Bacillus subtilis subsp. subtilis str. 168 CAA97612.1
AIY93125.1
AQR81806.1
AQR86020.1
CAB13698.1
NP_389697.1
A0A6M4JGU4
Q45070
3GTN[A,B]
3KL0[A,B,C,D]
3KL3[A,B,C,D]
3KL5[A,B,C,D]
8
 [fungal β-glucan] endo-β-1,6-glucanase (BcellWH2_02537;BACWH2_2367) 3.2.1.75 pubmed
Bacteroides cellulosilyticus WH2 ALJ59776.1 A0A0P0FQB6   3
 glucuronoxylanase (BoGH30; BoXyn30A; Xync_2;BACOVA_03432; Bovatus_03728) (Xyn30A) 3.2.1.136 pubmed
Bacteroides ovatus ATCC 8483 ALJ48333.1
EDO10799.1
A7M005   8
 endo-β-1,6-glucanase (BT3312; BT_3312) 3.2.1.75 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO78418.1
NP_812224.1
Q8A2J3 5NGK[A,B,C]
5NGL[A,B,C]
3
 β-xylosidase (BbXyl; XylB; XylBK-110) 3.2.1.37 pubmed
Bifidobacterium breve K-110 ABX45137.1 B1P195   2
 galactan exo-1,6-β-galactobiohydrolase (non-reducing end) (Bl1,6Gal; BLLJ_1841 3.2.1.213 pubmed
Bifidobacterium longum subsp. longum JCM 1217 BAJ67505.1 A0A401ETL2   5
 xylan endo-β-1,4-xylosidase (CGSCsYakCAS_04919) (Xyn30A) 3.2.1.8 pubmed
Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98597.1 D2KFJ5   8
 glucuronoxylanase (CrXyl30) 3.2.1.8 pubmed
Cellulosilyticum ruminicola MMBC-1 UZE89494.1 A0A9E8BZS4   8
 endo-β-1,6-glucanase (Cpin_4356; CpGlu30A) 3.2.1.75 pubmed
Chitinophaga pinensis DSM 2588 ACU61803.1 A0A979GT36   3
 xylanase (CaXyn30A; CAP0119; CA_P0119) (Xyn30A) 3.2.1.8 pubmed
Clostridium acetobutylicum ATCC 824 AAK76864.1
NP_149282.1
Q97TI2 5CXP[A] 8
 glucuronoxylanase (CaXyn30B; CAP0118; CA_P0118) (Xyn30B) 3.2.1.- pubmed
Clostridium acetobutylicum ATCC 824 AAK76863.1
NP_149281.1
Q97TI3   8
 glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA; EcXyn30A) (Xyn30A) 3.2.1.8
3.2.1.136
pubmed
pubmed
Dickeya chrysanthemi D1 AAB53151.1 Q46961 1NOF[A]
2Y24[A]
8
 laminarin-debranching β-1,6-glucosidase (FbGH30; FORMB_24730) 3.2.1.- pubmed
Formosa sp. Hel1_33_131 AOR29490.1 A0A1D7Y224   1
 β-glucuronidase (LcGUS30) 3.2.1.167 pubmed
Levilactobacillus brevis subsp. coagulans FERM BP-4693 BAO73305.1 A0A024F9Q4   9
 xylanase (Xyl2090;MROS_2090) 3.2.1.8 pubmed
Melioribacter roseus P3M-2 AFN75320.1 I6Z823   8
 glucuronoxylan-specific xylanase (Xyn30D) 3.2.1.136 pubmed
Paenibacillus barcinonensis BP-23 AEY82463.1 H6WCZ0 4QAW[A,B,C,D,E,F,G,H] 8
 glucuronoxylan-specific xylanase (Xyn30A) 3.2.1.8 pubmed
Paenibacillus favisporus CC02-N2 AHA38215.1 U6BPI6   8
 non-reducing terminal-specific xylobiohydrolase (PpXbh30A) 3.2.1.- pubmed
Paenibacillus psychroresistens WP_162463230.1     10
 endo-β-1,6-glucanase (PsGly30A) 3.2.1.75 pubmed
Paenibacillus sp. GKG WQB51303.1     3
 xylanase 3 (Xyn3) 3.2.1.8 doi
Paenibacillus sp. W-61 BAA13641.1 P70733   8
 β-glucosidase active on pNP-β-D-cellobioside (F592DRAFT_01930) 3.2.1.21 pubmed
Parabacteroides gordonii DSM 23371 WP_028726386.1 A0A0F5JMG3   6
 non-reducing terminal-specific xylobiohydrolase (PcXbh30A; Bccel_4177) 3.2.1.- pubmed
Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933 KNY28903.1 A0A0L6JSW0   10
 endo-β-1,4-xylanase (C7I;CpC7I;CpXyn30A;Cpap_2855) (Xyn30A) 3.2.1.8 pubmed
Ruminiclostridium papyrosolvens DSM 2782 EGD48159.1 F1TBY8 4FMV[A] 8
 xylanase (GH30A-CE;RUM_18530) (Xyn30A) 3.2.1.8 pubmed
Ruminococcus champanellensis 18P13 = JCM 17042 CBL17903.1 D4LE58   8
 endo-β-1,6-glucanase / laminarin-debranching β-1,6-glucosidase 30B (Sde_2994) (Gly30B) 3.2.1.75
3.2.1.-
pubmed
pubmed
Saccharophagus degradans 2-40 ABD82251.1 Q21GC8   3
 β-glucosidase / β-glucosylceramidase (SrfJ; STM4426) 3.2.1.45 pubmed
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL23246.1
NP_463287.1
H9L4C2
Q9KIJ7
2WNW[A,B] 1
 β-D-fucosidase A (FucA;PbFucA;Pb280;ORF0280;PBR_0285) 3.2.1.38 pubmed
Segatella baroniae B14 EFI72736.1
ZP_07060000.1
D8DV06   4
 β-D-fucosidase B (FucB;PbFucB;Pb281;ORF0281;PBR_0286) 3.2.1.38 pubmed
Segatella baroniae B14 EFI72737.1
ZP_07060001.1
D8DV07   4
 endo-β-1,6-galactanase (Sa1,6Gal5A;SAV5205) (1,6Gal5A) 3.2.1.164 pubmed
Streptomyces avermitilis MA-4680 = NBRC 14893 BAC72917.1
NP_826382.1
Q82CY3   5
 glucuronoxylan-specific xylanase (StXyn30A) (Xyn30A) 3.2.1.8 pubmed
Streptomyces turgidiscabies C56 WP_006381841.1 L7EXY1   8
 β-xylosidase (RuXyn2) 3.2.1.37 pubmed
uncultured rumen bacterium ADO20355.1 E3TBJ4   2
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 β-1,6-glucanase (Neg1; Afu8g07120; AFUA_8G07120) 3.2.1.75 pubmed
Aspergillus fumigatus Af293 EAL85472.1
XP_747510.1
Q4WBR2   3
 endo-β-1,6-xylanase (AnEngA; M747DRAFT_323760) 3.2.1.75 pubmed
Aspergillus niger ATCC 13496 RDH19634.1
XP_001389956.2
A0A370BVV5   3
 exo-β-1,4-xylanase (XylD) (acidic) 3.2.1.37 pubmed
Bispora sp. MEY-1 ADG62369.1 D6MYS9   7
 endo-β-1,6-glucanase (GH30A) 3.2.1.75 pubmed
Coprinopsis cinerea QLF98392.1 A0A7D5FSA5   3
 acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 pubmed
Homo sapiens AAA35880.1
AAA35873.1
AAA35877.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM97663.1
AID60277.1
AID60278.1
AID60279.1
AID60280.1
ASU47376.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
SJX47168.1
A0A068F579
A0A068F658
A0A068F753
A0A068FB60
A0A223PQI4
B2R6A7
B4DHT6
B4DMV8
B7Z6E6
B7Z6S9
B7Z731
B7Z7G9
P04062
1OGS[A,B]
1Y7V[A,B]
2F61[A,B]
2J25[A,B]
2NSX[A,B,C,D]
2NT0[A,B,C,D]
2NT1[A,B,C,D]
2V3D[A,B]
2V3E[A,B]
2V3F[A,B]
2VT0[A,B]
2WCG[A,B]
2WKL[A,B]
2XWD[A,B]
2XWE[A,B]
3GXD[A,B,C,D]
3GXF[A,B,C,D]
3GXI[A,B,C,D]
3GXM[A,B,C,D]
3KE0[A,B]
3KEH[A,B]
3RIK[A,B,C,D]
3RIL[A,B,C,D]
5LVX[A,B,C,D]
6MOZ[A,B]
6Q1N[A,B]
6Q1P[A,B]
6Q6K[A,B]
6Q6L[A,B]
6Q6N[A,B]
6T13[A,B,C,D]
6TJJ[AAA,BBB]
6TJK[AAA,BBB]
6TJQ[BBB]
6TN1[AAA]
6YTP[A]
6YTR[A]
6YUT[A]
6YV3[A]
6Z39[A]
6Z3I[A]
7NWV[A,B]
8AWK[A]
8AWR[A]
8AX3[A,B]
8P3E[A,B]
8P41[A,B]
9F9Z[A]
9FA3[A]
9FA6[A]
9FAD[A]
9FAL[A]
9FAY[A]
9FAZ[A]
9FB2[A]
9FDI[A]
1
 glucan endo-β-1,6-glucosidase (PUS30; LePus30A) (Pus30A) 3.2.1.75 pubmed
Lentinula edodes H600 BAK52530.1 F8WPI4   3
 xylanase (Mi-Xyl1;Xyl-1) 3.2.1.8 pubmed
Meloidogyne incognita AAF37276.1 Q9NHE0   8
 β-glucosidase 1 / β-glucocerebrosidase (Gba;GBA;Gba1) 3.2.1.45 pubmed
Mus musculus AAA37671.1
AAH06663.1
AAM66757.1
BAC38609.1
NP_032120.1
P17439   1
 β-1,6-glucanase (Neg1; Neg-1) 3.2.1.75 pubmed
Neurospora crassa IFO6068 BAB91213.1 Q7M4T0   3
 β-1,6-glucanase (Neg1;NCU04395.1/29E8.200) 3.2.1.75 pubmed
Neurospora crassa OR74A CAF06053.1
XP_323748.1
Q7M4T0   3
 endo-β-1,6-galactanase (6Gal; Nc6GAL; NCU09702.1) 3.2.1.164 pubmed
Neurospora crassa OR74A XP_330352.1
EAA29705.1
Q7S2S4   5
 endo-β-1-6-glucanase (PsEngA; Neg1; N7473_009603) 3.2.1.75 pubmed
Penicillium subrubescens IBT 31985 KAJ5886929.1
XP_057006672.1
    3
 β-glucosidase / β-xylosidase (Bgx1) 3.2.1.21 pubmed
Phytophthora infestans 88069 AAK19754.1 Q9AT27   1
 endo-β-1,6-xylanase (TeEngA; T310_9533) 3.2.1.75 pubmed
Rasamsonia emersonii CBS 393.64 KKA16817.1
XP_013323429.1
A0A0F4YF19   3
 glucuronoxylanase (SlXyn30A; AWJ20_568) (Xyn30A) 3.2.1.37
3.2.1.-
pubmed
pubmed
Sugiyamaella lignohabitans CBS 10342 ANB12318.1 A0A161HKM6   7
 endo-β-1,6-xylanase (TaEngA;UA08_02966) 3.2.1.75 pubmed
Talaromyces atroroseus IBT 11181 OKL62582.1
XP_020122703.1
A0A225ALZ8   3
 glucuronoxylanase A (Xyn30A; TCE0_047r17950) (Xyn30A) 3.2.1.156 pubmed
Talaromyces cellulolyticus Y-94 GAM43270.1 A0A0B8MZ29 8IDP[A,B,C,D]
8IDQ[A,B,C,D]
7
 bifunctional endo-glucuronoxylanase and exo-xylobiohydrolase (TcXyn30B) B (Xyn30B; TCE0_018f06110) (Xyn30B) 3.2.1.37
3.2.1.-
pubmed
pubmed
Talaromyces cellulolyticus Y-94 GAM36763.1 A0A4V8H018
A0A510NXC4
6IUJ[A,B]
6KRL[A]
6KRN[A]
7
 endoxylanase C (TcXyn30C; TCE0_039f12750) 3.2.1.8 pubmed
Talaromyces cellulolyticus Y-94 GAM40414.1 A0A6N4SL16 6M5Z[A,B] 7
 endo-β-1,4-xylanase active on arabinoxylan and glucuronoxylan (XynC; XYNC; GH30) 3.2.1.8 pubmed
Talaromyces purpureogenus ATCC MYA-38 AKH40280.1 A0A0F7KIJ8   7
 endo-β-1,4-xylanase (ExlA; TtExlA; TtXyn30A; MYCTH_38558) 3.2.1.8
3.2.1.-
pubmed
pubmed
Thermothelomyces thermophilus ATCC 42464 AEO55025.1
G2Q1N4.1
XP_003660270.1
  7NCX[A]
7O0E[A,B]
8C48[A,B]
8CBC[A,B]
8P67[A,B]
7
 β-1,6-glucanase (BGN16.3; P2) 3.2.1.75 pubmed
Trichoderma harzianum CAC80492.1
ACM42429.1
B9VQ17
Q8J0I9
  3
 glucuronoxylan hydrolase (xylanase cleaving 4-Me-GlcA or GlcA-substituted xylan; TRIREDRAFT_69276) 3.2.1.- pubmed
Trichoderma reesei QM6a EGR45006.1 G0RV92   7
 exo-xylanase IV (Xyn4;XYN IV) 3.2.1.156 pubmed
Trichoderma reesei Rut C30 AAP64786.1
AAV25955.1
  cryst 7
 endo-β-1,6-galactanase (6GAL;Tv6GAL;Tv1,6Gal5A) (1,6Gal5A) 3.2.1.164 pubmed
Trichoderma viride BAC84995.1 Q76FP5   5
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