Activities in Family	endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
Note	Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resources	CAZypedia; Gaucher Disease; PRINTS;
Statistics	GenBank accession (6113); Uniprot accession (56); PDB accession (72); 3D entries (15); cryst (1)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
non-reducing terminal-specific xylobiohydrolase (AcXbh30A; Clocl_1795)	3.2.1.-	Acetivibrio clariflavus DSM 19732	AEV68404.1	G8LU16	7N6H[A,B] 1.28 7N6O[A,B] β-D-Xylp-(1-4)-β-D-Xylp 1.50	10
glucuronoxylan xylanohydrolase (CtXyn30;CtXynGH30;Cthe_3012) (Xyn30A)		Acetivibrio thermocellus ATCC 27405	ABN54208.1		4CKQ[A] 1.40 4UQ9[A] 1.77 4UQA[A] 1.52 4UQB[A] 1.68 4UQC[A] D-1,4-deoxy-Glcp 1.30 4UQD[A] 1.25 4UQE[A] 1.28 5A6L[A] β-D-Xylp-(1-4)-β-D-Xylp 1.80 5A6M[A] β-D-Xylp-(1-4)-β-D-Xylp 1.17	8
glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC; BsXynC; YnfF; BSU18150)	3.2.1.136 3.2.1.8	Bacillus subtilis subsp. subtilis str. 168	CAA97612.1 AIY93125.1 AQR81806.1 AQR86020.1 CAB13698.1 NP_389697.1	A0A6M4JGU4 Q45070	3GTN[A,B] 2.68 3KL0[A,B,C,D] 1.64 3KL3[A,B,C,D] α-D-GlcpA β-D-GlcpA 2.33 3KL5[A,B,C,D] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-1)-<non_carb> α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp 2.59	8
BF1510		Bacteroides fragilis NCTC 9343	CAH07216.1		3CLW[A,B,C,D,E,F] 2.20	4
endo-β-1,6-glucanase (BT3312; BT_3312)	3.2.1.75	Bacteroides thetaiotaomicron VPI-5482	AAO78418.1 NP_812224.1	Q8A2J3	5NGK[A,B,C] 1.90 5NGL[A,B,C] β-D-Glcp-(1-1)-<non_carb> <carb_like_NOJ> 1.85	3
xylanase (CAP0119) (Xyn30A)	3.2.1.8	Clostridium acetobutylicum ATCC 824	AAK76864.1 NP_149282.1	Q97TI2	5CXP[A] 1.77	8
glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA)	3.2.1.136 3.2.1.8	Dickeya chrysanthemi D1	AAB53151.1	Q46961	1NOF[A] 1.42 2Y24[A] β-D-Xylp-(1-4)[α-D-GlcpA4Me-(1-2)]-β-D-Xylp-(1-4)-β-D-Xylp 1.39	8
glucuronoxylan-specific xylanase (Xyn30D)	3.2.1.136	Paenibacillus barcinonensis BP-23	AEY82463.1	H6WCZ0	4QAW[A,B,C,D,E,F,G,H] 2.40	8
endo-β-1,4-xylanase (C7I;CpC7I;CpXyn30A;Cpap_2855) (Xyn30A)	3.2.1.8	Ruminiclostridium papyrosolvens DSM 2782	EGD48159.1	F1TBY8	4FMV[A] 2.01	8
STM4426 (SrfJ)		Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	AAL23246.1 NP_463287.1		2WNW[A,B] 2.00	1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal)	3.2.1.45	Homo sapiens	AAA35880.1 AAA35873.1 AAA35877.1 AAC51820.1 AAC63056.1 AAH03356.1 AAQ41981.1 AAQ41982.1 AAT13636.1 AAT13637.1 AAV20581.1 AAY03281.1 AAY03324.1 ABL21565.1 ACH14936.1 ACJ92748.1 ACM85831.1 ACM97663.1 AID60277.1 AID60278.1 AID60279.1 AID60280.1 ASU47376.1 BAA02545.1 BAF84600.1 BAG58248.1 BAG60020.1 BAH12898.1 BAH13232.1 BAH13357.1 BAH13365.1 BAH13467.1 BAH13605.1 CAC41172.1 CAC41173.1 CAD12720.1 CAD12721.1 CAE85438.1 CAI95090.1 NP_000148.1 SJX47168.1	A0A068F579 A0A068F658 A0A068F753 A0A068FB60 A0A223PQI4 B2R6A7 B4DHT6 B4DMV8 B7Z6E6 B7Z6S9 B7Z731 B7Z7G9 P04062	1OGS[A,B] 2.0 1Y7V[A,B] <carb_like_INS> 2.40 2F61[A,B] 2.50 2J25[A,B] 2.9 2NSX[A,B,C,D] <carb_like_IFM> 2.11 2NT0[A,B,C,D] D-1-deoxy-GlcpNAc 1.79 2NT1[A,B,C,D] 2.30 2V3D[A,B] <carb_like_NBV> 1.96 2V3E[A,B] <carb_like_NND> 2.00 2V3F[A,B] 1.95 2VT0[A,B] <carb_like_CBU> 2.15 2WCG[A,B] <carb_like_MT5> 2.30 2WKL[A,B] 2.70 2XWD[A,B] <carb_like_LGS> 2.66 2XWE[A,B] <carb_like_AMF> 2.31 3GXD[A,B,C,D] 2.50 3GXF[A,B,C,D] <carb_like_IFM> 2.40 3GXI[A,B,C,D] 1.84 3GXM[A,B,C,D] 2.20 3KE0[A,B] 2.70 3KEH[A,B] 2.80 3RIK[A,B,C,D] <carb_like_3RI> 2.48 3RIL[A,B,C,D] <carb_like_3RK> 2.40 5LVX[A,B,C,D] 2.20 6MOZ[A,B] 2.10 6Q1N[A,B] 2.53 6Q1P[A,B] 2.80 6Q6K[A,B] 1.92 6Q6L[A,B] 1.81 6Q6N[A,B] 1.63 6T13[A,B,C,D] 1.85 6TJJ[AAA,BBB] 6TJK[AAA,BBB] 6TJQ[BBB] 6TN1[AAA] 6YTP[A] 6YTR[A] 6YUT[A] 6YV3[A] 6Z39[A] 6Z3I[A] 7NWV[A,B]	1
bifunctional endo-glucuronoxylanase and exo-xylobiohydrolase (TcXyn30B) B (Xyn30B; TCE0_018f06110) (Xyn30B)	3.2.1.37 3.2.1.-	Talaromyces cellulolyticus Y-94	GAM36763.1	A0A510NXC4	6IUJ[A,B] 2.25 6KRL[A] 1.60 6KRN[A] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp 1.65	7
endoxylanase C (TcXyn30C; TCE0_039f12750)	3.2.1.8	Talaromyces cellulolyticus Y-94	GAM40414.1	A0A6N4SL16	6M5Z[A,B] 1.65	7
endo-β-1,4-xylanase (TtXyn30A; MYCTH_38558)	3.2.1.8 3.2.1.-	Thermothelomyces thermophilus ATCC 42464	AEO55025.1 G2Q1N4.1		7NCX[A] 7O0E[A,B] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp 1.85	7
exo-xylanase IV (Xyn4;XYN IV)	3.2.1.156	Trichoderma reesei Rut C30	AAP64786.1 AAV25955.1		cryst	7
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