Glycoside Hydrolase Family 30

Activities in Familyβ-1,6-glucosidase (EC 3.2.1.-);
Glucuronoxylan endo-β-1,4-xylanase (EC 3.2.1.-);
Xylan exo-β-1,4-xylobiosidase (EC 3.2.1.-);
Glucuronoarabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.136);
[inverting] oligosaccharide reducing-end xylanase (EC 3.2.1.156);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Baicalin β-glucuronidase (EC 3.2.1.167);
β-glucosidase (EC 3.2.1.21);
Galactan exo-1,6-β-galactobiohydrolase (non-reducing end) (EC 3.2.1.213);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
β-D-fucosidase (EC 3.2.1.38);
β-glucosylceramidase (EC 3.2.1.45);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (7002); Uniprot accession (68); PDB accession (82); 3D entries (16); cryst (1)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 non-reducing terminal-specific xylobiohydrolase (AcXbh30A; HcXyn30A; Clocl_1795) 3.2.1.- Acetivibrio clariflavus DSM 19732 AEV68404.1 G8LU16
7N6H[A,B] 1.28
7N6O[A,B] β-D-Xylp-(1-4)-β-D-Xylp
1.50
10
 glucuronoxylan xylanohydrolase (CtXyn30;CtXynGH30;Cthe_3012) (Xyn30A)   Acetivibrio thermocellus ATCC 27405 ABN54208.1  
4CKQ[A] 1.40
4UQ9[A] 1.77
4UQA[A] 1.52
4UQB[A] 1.68
4UQC[A] D-1,4-deoxy-Glcp
1.30
4UQD[A] 1.25
4UQE[A] 1.28
5A6L[A] β-D-Xylp-(1-4)-β-D-Xylp
1.80
5A6M[A] β-D-Xylp-(1-4)-β-D-Xylp
1.17
8
 glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC; BsXynC; YnfF; BSU18150) 3.2.1.8
3.2.1.136
Bacillus subtilis subsp. subtilis str. 168 CAA97612.1
AIY93125.1
AQR81806.1
AQR86020.1
CAB13698.1
NP_389697.1
A0A6M4JGU4
Q45070
3GTN[A,B] 2.68
3KL0[A,B,C,D] 1.64
3KL3[A,B,C,D] α-D-GlcpA
β-D-GlcpA
2.33
3KL5[A,B,C,D] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-1)-<non_carb>
α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp
2.59
8
 BF1510   Bacteroides fragilis NCTC 9343 CAH07216.1  
3CLW[A,B,C,D,E,F] 2.20
4
 endo-β-1,6-glucanase (BT3312; BT_3312) 3.2.1.75 Bacteroides thetaiotaomicron VPI-5482 AAO78418.1
NP_812224.1
Q8A2J3
5NGK[A,B,C] 1.90
5NGL[A,B,C] β-D-Glcp-(1-1)-<non_carb>
<carb_like_NOJ>
1.85
3
 xylanase (CaXyn30A; CAP0119; CA_P0119) (Xyn30A) 3.2.1.8 Clostridium acetobutylicum ATCC 824 AAK76864.1
NP_149282.1
Q97TI2
5CXP[A] 1.77
8
 glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA; EcXyn30A) (Xyn30A) 3.2.1.8
3.2.1.136
Dickeya chrysanthemi D1 AAB53151.1 Q46961
1NOF[A] 1.42
2Y24[A] β-D-Xylp-(1-4)[α-D-GlcpA4Me-(1-2)]-β-D-Xylp-(1-4)-β-D-Xylp
1.39
8
 glucuronoxylan-specific xylanase (Xyn30D) 3.2.1.136 Paenibacillus barcinonensis BP-23 AEY82463.1 H6WCZ0
4QAW[A,B,C,D,E,F,G,H] 2.40
8
 endo-β-1,4-xylanase (C7I;CpC7I;CpXyn30A;Cpap_2855) (Xyn30A) 3.2.1.8 Ruminiclostridium papyrosolvens DSM 2782 EGD48159.1 F1TBY8
4FMV[A] 2.01
8
 β-glucosidase / β-glucosylceramidase (SrfJ; STM4426) 3.2.1.45 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL23246.1
NP_463287.1
H9L4C2
Q9KIJ7
2WNW[A,B] 2.00
1
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 Homo sapiens AAA35880.1
AAA35873.1
AAA35877.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM97663.1
AID60277.1
AID60278.1
AID60279.1
AID60280.1
ASU47376.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
SJX47168.1
A0A068F579
A0A068F658
A0A068F753
A0A068FB60
A0A223PQI4
B2R6A7
B4DHT6
B4DMV8
B7Z6E6
B7Z6S9
B7Z731
B7Z7G9
P04062
1OGS[A,B] 2.0
1Y7V[A,B] <carb_like_INS>
2.40
2F61[A,B] 2.50
2J25[A,B] 2.9
2NSX[A,B,C,D] <carb_like_IFM>
2.11
2NT0[A,B,C,D] D-1-deoxy-GlcpNAc
1.79
2NT1[A,B,C,D] 2.30
2V3D[A,B] <carb_like_NBV>
1.96
2V3E[A,B] <carb_like_NND>
2.00
2V3F[A,B] 1.95
2VT0[A,B] <carb_like_CBU>
2.15
2WCG[A,B] <carb_like_MT5>
2.30
2WKL[A,B] 2.70
2XWD[A,B] <carb_like_LGS>
2.66
2XWE[A,B] <carb_like_AMF>
2.31
3GXD[A,B,C,D] 2.50
3GXF[A,B,C,D] <carb_like_IFM>
2.40
3GXI[A,B,C,D] 1.84
3GXM[A,B,C,D] 2.20
3KE0[A,B] 2.70
3KEH[A,B] 2.80
3RIK[A,B,C,D] <carb_like_3RI>
2.48
3RIL[A,B,C,D] <carb_like_3RK>
2.40
5LVX[A,B,C,D] 2.20
6MOZ[A,B] 2.10
6Q1N[A,B] 2.53
6Q1P[A,B] 2.80
6Q6K[A,B] 1.92
6Q6L[A,B] 1.81
6Q6N[A,B] 1.63
6T13[A,B,C,D] 1.85
6TJJ[AAA,BBB]
6TJK[AAA,BBB]
6TJQ[BBB]
6TN1[AAA]
6YTP[A]
6YTR[A]
6YUT[A]
6YV3[A]
6Z39[A]
6Z3I[A]
7NWV[A,B]
8AWK[A]
8AWR[A]
8AX3[A,B] 1.59
8P3E[A,B] D-1-deoxy-GlcpNAc
1.75
8P41[A,B] 1.83
1
 glucuronoxylanase A (Xyn30A; TCE0_047r17950) (Xyn30A) 3.2.1.156 Talaromyces cellulolyticus Y-94 GAM43270.1 A0A0B8MZ29
8IDP[A,B,C,D] 1.80
8IDQ[A,B,C,D] β-D-Xylp
1.70
7
 bifunctional endo-glucuronoxylanase and exo-xylobiohydrolase (TcXyn30B) B (Xyn30B; TCE0_018f06110) (Xyn30B) 3.2.1.37
3.2.1.-
Talaromyces cellulolyticus Y-94 GAM36763.1 A0A4V8H018
A0A510NXC4
6IUJ[A,B] 2.25
6KRL[A] 1.60
6KRN[A] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp
1.65
7
 endoxylanase C (TcXyn30C; TCE0_039f12750) 3.2.1.8 Talaromyces cellulolyticus Y-94 GAM40414.1 A0A6N4SL16
6M5Z[A,B] 1.65
7
 endo-β-1,4-xylanase (ExlA; TtExlA; TtXyn30A; MYCTH_38558) 3.2.1.8
3.2.1.-
Thermothelomyces thermophilus ATCC 42464 AEO55025.1
G2Q1N4.1
 
7NCX[A]
7O0E[A,B] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp
1.85
8C48[A,B]
8CBC[A,B]
8P67[A,B]
7
 exo-xylanase IV (Xyn4;XYN IV) 3.2.1.156 Trichoderma reesei Rut C30 AAP64786.1
AAV25955.1
 
cryst    
7
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