Glycoside Hydrolase Family 30

Activities in Familyendo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
NoteFollowing St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resourcesCAZypedia; Gaucher Disease; PRINTS;
Statistics GenBank accession (1766); Uniprot accession (263); PDB accession (46); 3D entries (11); cryst (1)
All (1632) Bacteria (1543) Eukaryota (87) unclassified (2) Structure (11 - 1 cryst) Characterized (38)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC;YnfF;BSU18150) 3.2.1.136
3.2.1.8
Bacillus subtilis subsp. subtilis str. 168 CAA97612.1
AIY93125.1
AQR81806.1
AQR86020.1
CAB13698.1
NP_389697.1
Q45070
3GTN[A,B] 2.68
3KL0[A,B,C,D] 1.64
3KL3[A,B,C,D] α-D-GlcpA
β-D-GlcpA
2.33
3KL5[A,B,C,D] α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-1)-<non_carb>
α-D-GlcpA4Me-(1-2)-β-D-Xylp-(1-4)-β-D-Xylp
2.59
8
 BF1510   Bacteroides fragilis NCTC 9343 CAH07216.1 Q5LF82
3CLW[A,B,C,D,E,F] 2.20
4
 endo-β-1,6-glucanase (BT3312;BT_3312) 3.2.1.75 Bacteroides thetaiotaomicron VPI-5482 AAO78418.1
NP_812224.1
Q8A2J3
5NGK[A,B,C] 1.90
5NGL[A,B,C] β-D-Glcp-(1-1)-<non_carb>
<carb_like_NOJ>
1.85
3
 xylanase (CAP0119) (Xyn30A) 3.2.1.8 Clostridium acetobutylicum ATCC 824 AAK76864.1
NP_149282.1
Q97TI2
5CXP[A] 1.77
8
 endo-β-1,4-xylanase (C7I;CpC7I;CpXyn30A;Cpap_2855) (Xyn30A) 3.2.1.8 Clostridium papyrosolvens DSM 2782 EGD48159.1  
4FMV[A] 2.01
8
 glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA) 3.2.1.136
3.2.1.8
Dickeya chrysanthemi D1 AAB53151.1 Q46961
1NOF[A] 1.42
2Y24[A] β-D-Xylp-(1-4)[α-D-GlcpA4Me-(1-2)]-β-D-Xylp-(1-4)-β-D-Xylp
1.39
8
 glucuronoxylan-specific xylanase (Xyn30D) 3.2.1.136 Paenibacillus barcinonensis BP-23 AEY82463.1  
4QAW[A,B,C,D,E,F,G,H] 2.40
8
 glucuronoxylan xylanohydrolase (CtXyn30;CtXynGH30;Cthe_3012) (Xyn30A)   Ruminiclostridium thermocellum ATCC 27405 ABN54208.1 A3DJS9
4CKQ[A] 1.40
4UQ9[A] 1.77
4UQA[A] 1.52
4UQB[A] 1.68
4UQC[A] D-1,4-deoxy-Glcp
1.30
4UQD[A] 1.25
4UQE[A] 1.28
5A6L[A] β-D-Xylp-(1-4)-β-D-Xylp
1.80
5A6M[A] β-D-Xylp-(1-4)-β-D-Xylp
1.17
8
 STM4426 (SrfJ)   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL23246.1
NP_463287.1
H9L4C2
Q9KIJ7
2WNW[A,B] 2.00
1
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
Subf
 acid β-glucosidase 1 / β-glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal) 3.2.1.45 Homo sapiens ASU47376.1
AAA35873.1
AAA35877.1
AAA35880.1
AAC51820.1
AAC63056.1
AAH03356.1
AAQ41981.1
AAQ41982.1
AAT13636.1
AAT13637.1
AAV20581.1
AAY03281.1
AAY03324.1
ABL21565.1
ACH14936.1
ACJ92748.1
ACM85831.1
ACM97663.1
AID60277.1
AID60278.1
AID60279.1
AID60280.1
ASU47376.1
BAA02545.1
BAF84600.1
BAG58248.1
BAG60020.1
BAH12898.1
BAH13232.1
BAH13357.1
BAH13365.1
BAH13467.1
BAH13605.1
CAC41172.1
CAC41173.1
CAD12720.1
CAD12721.1
CAE85438.1
CAI95090.1
NP_000148.1
B2R6A7
P04062
1OGS[A,B] 2.0
1Y7V[A,B] <carb_like_INS>
2.40
2F61[A,B] 2.50
2J25[A,B] 2.9
2NSX[A,B,C,D] <carb_like_IFM>
2.11
2NT0[A,B,C,D] D-1-deoxy-GlcpNAc
1.79
2NT1[A,B,C,D] 2.30
2V3D[A,B] <carb_like_NBV>
1.96
2V3E[A,B] <carb_like_NND>
2.00
2V3F[A,B] 1.95
2VT0[A,B] <carb_like_CBU>
2.15
2WCG[A,B] <carb_like_MT5>
2.30
2WKL[A,B] 2.70
2XWD[A,B] <carb_like_LGS>
2.66
2XWE[A,B] <carb_like_AMF>
2.31
3GXD[A,B,C,D] 2.50
3GXF[A,B,C,D] <carb_like_IFM>
2.40
3GXI[A,B,C,D] 1.84
3GXM[A,B,C,D] 2.20
3KE0[A,B] 2.70
3KEH[A,B] 2.80
3RIK[A,B,C,D] <carb_like_3RI>
2.48
3RIL[A,B,C,D] <carb_like_3RK>
2.40
5LVX[A,B,C,D]
1
 exo-xylanase IV (Xyn4;XYN IV) 3.2.1.- Trichoderma reesei Rut C30 AAP64786.1
AAV25955.1
 
cryst    
7
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