Known Activities	glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); β-glucosidase (3.2.1.21); endo-β-1,6-galactanase (EC:3.2.1.164)
Mechanism	Retaining
Clan	GH-A
3D Structure Status	( β / α ) 8
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
Note	Following St John et al. [FEBS Letters 584:4435-4441 (2010); PMID: 20932833] several GH5 subfamilies have been reassigned to GH30. The subfamilies in GH30 are now indicated.
External resources	CAZypedia; Gaucher Disease; InterPro; PFAM; PRINTS;
Statistics	GenBank accession (514); Uniprot accession (247); PDB accession (29); 3D entries (6); cryst (1)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
glucuronoxylan xylanohydrolase (feraxanase) / xylanase C (XynC;YnfF;BSU18150)	3.2.1.136 3.2.1.8	Bacillus subtilis subsp. subtilis str. 168	CAA97612.1 CAB13698.1 NP_389697.1	Q45070	3GTN[A,B] 3KL0[A,B,C,D] 3KL3[A,B,C,D] 3KL5[A,B,C,D]	8
BF1510		Bacteroides fragilis NCTC 9343	CAH07216.1	Q5LF82	3CLW[A,B,C,D,E,F]	4
glucuronoxylanase / glucuronoxylan-specific endo-β-1,4-xylanase (XynA)	3.2.1.136 3.2.1.8	Erwinia chrysanthemi D1	AAB53151.1	Q46961	1NOF[A] 2Y24[A]	8
STM4426 (SrfJ)		Salmonella typhimurium LT2 SGSC 1412; ATCC 700720	AAL23246.1 NP_463287.1	Q9KIJ7	2WNW[A,B]	1
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
acid β-glucosidase 1 / glucocerebrosidase 1 (Gba1;Gba;GC;GCase;LOC82008) (lysosomal)	3.2.1.45	Homo sapiens	AAA35873.1 AAA35877.1 AAA35880.1 AAC51820.1 AAC63056.1 AAH03356.1 AAQ41981.1 AAQ41982.1 AAT13636.1 AAT13637.1 AAV20581.1 AAY03281.1 AAY03324.1 ABL21565.1 ACH14936.1 ACJ92748.1 ACM85831.1 ACM85831.1 ACM97663.1 BAA02545.1 BAF84600.1 BAG58248.1 BAG60020.1 BAH12898.1 BAH13232.1 BAH13357.1 BAH13365.1 BAH13467.1 BAH13605.1 CAC41172.1 CAC41173.1 CAD12720.1 CAD12721.1 CAE85438.1 CAI95090.1 NP_000148.1	B2R6A7 P04062.3	1OGS[A,B] 1Y7V[A,B] 2F61[A,B] 2J25[A,B] 2NSX[A,B,C,D] 2NT0[A,B,C,D] 2NT1[A,B,C,D] 2V3D[A,B] 2V3E[A,B] 2V3F[A,B] 2VT0[A,B] 2WCG[A,B] 2WKL[A,B] 2XWD[A,B] 2XWE[A,B] 3GXD[A,B,C,D] 3GXF[A,B,C,D] 3GXI[A,B,C,D] 3GXM[A,B,C,D] 3KE0[A,B] 3KEH[A,B]	1
exo-xylanase IV (XYN IV)	3.2.1.-	Hypocrea jecorina	AAP64786.1 AAV25955.1		cryst	7

Last update: 2012-01-31 © Copyright 1998-2012
AFMB - CNRS - Universités Aix-Marseille I & II